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In the reliability-based design optimization (RBDO) model, the mean values of uncertain variables are usually applied as design variables, and the cost is optimized subject to prescribed probabilistic constraints as defined by a nonlinear mathematical programming problem. Therefore, an RBDO solution that reduces the structural weight in non-critical regions provides not only an improved design, but also a higher level of confidence in the design. Solving such nested optimization problems is extremely expensive for large-scale multidisciplinary systems that are likewise computationally intensive. This article focuses on the study of a particular problem representing the failure mode of structural vibration analysis. A new method is proposed, called safest point, that can efficiently give the reliability-based optimum solution under frequency constraints, and then several probability distributions are developed, which are mathematically nonlinear functions, for the proposed method. Finally, the efficiency of the extended approach is demonstrated for probability distributions such as log-normal and uniform distributions, and its applicability to the design of structures undergoing fluid-structure interaction phenomena, especially the design process of aeroelastic structures, is also demonstrated. [ABSTRACT FROM AUTHOR]