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A series of fluorescein-based β-C-glycosyl ketones were synthesized through aldol condensation of β-C-glycosyl ketones with fluorescein monoaldehyde under ambient reaction conditions in good yields. Formation of the expected product has been confirmed through different spectral techniques. Fluorescein-based β-C-glycosides show moderate anti-oxidant activities with maximum inhibitory activity of 60%., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected d-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

[Display omitted] • Zebrafish imaging studies of coumarin probe for Cu2+ sensor. • Photophysical studies of coumarin-based Cu2+ fluorescent sensor. • Absorption spectrum of fluorescein probe for Cu2+ ion. • Prokaryotic bioimaging study of pyrene-based Cu2+ sensor. • Carbon dot for rhodamine B-based Cu2+ sensor. Luminescent chemosensors for sensing Cu2+ have attracted a lot of attention in recent years due to their potential applications in biochemistry and environmental research. Based on host-guest interactions include van der Waals forces, hydrophobic contacts, electrostatic forces, coordination between metal ligands, and hydrogen bonds. They were made to allow for the selective detection of different species. It is immediately and easily detectable in biological and environmental systems, and the development of sensitive imaging technologies that can quickly monitor Cu2+ ions has attracted a lot of attention. Due to their inherent sensitivity, selectivity, and the ability for quick, real-time monitoring, they have proven to be helpful instruments for detecting metal ions. Small-molecule fluorescence probes can report on specific analytes in cells and other complex biological specimens by using selective, bio-orthogonal chemistry. The approaches for recognizing Cu2+ ions with small-molecule fluorescent probes are summarised in this article. [ABSTRACT FROM AUTHOR]

A multicomponent one-pot reaction involving propargyl glycosides, fluorescein monoaldehyde, and aromatic amines using Cu(I) as catalyst is described, which provides an efficient and practical route for the synthesis of several fluorescein-based quinolone glycoconjugates in good yields. All of the synthesized quinoline glycoconjugates showed moderate antioxidant activity as evaluated with commercially available 1,1-diphenyl-2-picryl hydrazyl (DPPH). [ABSTRACT FROM AUTHOR]

Abstract: Facile glycosylation of a fluorescein diol derivative with per-O-acetyl/benzoyl sugar derivatives using BF3·Et2O catalyst resulted in the formation of the expected glycosides in 54–66% yield. The biological screening of the glycosides against different microbes shows good inhibitory activity. The antioxidant activity of the fluorescein-based glycosides shows remarkable inhibition (IC50 ∼80%). [Copyright &y& Elsevier]

• Labeling reaction of reducing saccharides with FTSC and its application to living cells. • Antioxidant and Anti-cancer activities of fluorescein glycosides. • Synthesis of Fluorescein Grafted Cellulose Nanocrystals with Amino Acid Space. • Fluorescein chemosensors have been developed for selective fluorescence detection of TNP when excited by the visible light. • Photoactivatable fluorescein sensors for detecting mobile Zinc. • Thiol-specific fluorescent probe for Zebrafish imaging. Biosensors are analytical devices specifically designed to convert biological response into electrochemical, optical, acoustic and electronic signal. Generally, the principle and concept of biosensors facilitate the fabrication of advanced devices displaying potential biological applications. In particular, the Fluorescein based probes display a significant role in the development of optical biosensors. This review focus on the current advances in the fluorescence probes, including the development and challenges to enhance the sensing properties in the field of biosensors for next generation biological applications. Image, graphical abstract [ABSTRACT FROM AUTHOR]