1. CD38-specific nanobodies allow
- Author
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Luca Julius, Pape, Julia, Hambach, Anna Josephine, Gebhardt, Björn, Rissiek, Tobias, Stähler, Natalie, Tode, Cerusch, Khan, Katja, Weisel, Gerhard, Adam, Friedrich, Koch-Nolte, and Peter, Bannas
- Subjects
Mice ,Epitopes ,Humans ,Animals ,Single-Domain Antibodies ,Multiple Myeloma ,ADP-ribosyl Cyclase 1 ,Fluorescent Dyes - Abstract
Recent studies have demonstrated the feasibility of CD38-specific antibody constructs forWe conjugated the CD38-specific nanobody JK36 to the near-infrared fluorescent dye Alexa Fluor 680. The capacity of JK36Fluorochrome-labeled nanobody JK36Our study demonstrates that a nanobody recognizing a distinct, non-overlapping epitope of CD38 allows the specific detection of myeloma cells under daratumumab therapy
- Published
- 2022