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Your search keyword '"Zhang, Yongru"' showing total 4 results
Start Over Author "Zhang, Yongru" Topic fluorescent dyes
4 results on '"Zhang, Yongru"'

1. A bifunctional fluorescent sensor for CCCP-induced cancer cell apoptosis imaging.

Author

Niu H, Zhang Y, Tang J, Zhu X, Ye Y, and Zhao Y

Subjects
HeLa Cells, Humans, Hydrogen-Ion Concentration, Limit of Detection, Microscopy, Confocal, Spectrometry, Fluorescence methods, Sulfur Dioxide analysis, Sulfur Dioxide metabolism, Apoptosis drug effects, Carbonyl Cyanide m-Chlorophenyl Hydrazone pharmacology, Fluorescent Dyes chemistry
Abstract

The detailed mechanism and the extent of pH/SO 2 changes during apoptosis remain unknown. The developed sensor NPCF for SO 2 and pH dual detection illustrates that SO 2 can reduce the inflammation caused by LPS and the acidification of the environment. The levels of SO 2 and pH change during carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced apoptosis.

Published
2020
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2. A three-channel fluorescent probe to image mitochondrial stress.

Author

Niu H, Tang J, Zhu X, Li Z, Zhang Y, Ye Y, and Zhao Y

Subjects
Carbon-13 Magnetic Resonance Spectroscopy, HeLa Cells, Humans, MCF-7 Cells, Mass Spectrometry, Mitochondria metabolism, Molecular Structure, Proton Magnetic Resonance Spectroscopy, Sulfur Dioxide metabolism, Fluorescent Dyes chemistry, Mitochondria physiology, Stress, Physiological
Abstract

Dual-recognition probes based on one reacting site inevitably encounter competition problems. Here, NPClA, a two-photon fluorescent probe based on a dual-site response for SO2/HOCl, was developed and applied in imaging mitochondrial stress.

Published
2020
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3. Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe.

Author

Hou JT, Wang B, Zhang Y, Cui B, Cao X, Zhang M, Ye Y, and Wang S

Subjects
Antineoplastic Agents chemistry, Apoptosis drug effects, Cell Proliferation drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Fluorescent Dyes chemistry, Fluorouracil chemistry, Humans, MCF-7 Cells, Molecular Structure, Optical Imaging, Peroxynitrous Acid chemistry, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Fluorescent Dyes pharmacology, Fluorouracil pharmacology, Peroxynitrous Acid biosynthesis
Abstract

We describe a colorimetric and fluorescent probe 3a to detect cellular peroxynitrite with high selectivity and sensitivity. 3a was successfully applied in the bioimaging of exogenous and endogenous peroxynitrite in living cells. The up-regulation of peroxynitrite in cancer cells and normal cells during 5-fluorouracil treatment was finally monitored.

Published
2020
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4. Reductive stress imaging in the endoplasmic reticulum by using living cells and zebrafish.

Author

Niu H, Zhang Y, Zhao F, Mo S, Cao W, Ye Y, and Zhao Y

Subjects
Animals, Coumarins chemical synthesis, Cysteine chemistry, Cysteine metabolism, Fluorescent Dyes chemical synthesis, Glutathione chemistry, Glutathione metabolism, Goats, HeLa Cells, Humans, Hypochlorous Acid chemistry, Hypochlorous Acid metabolism, Mice, Microscopy, Confocal methods, Microscopy, Fluorescence methods, Oxidation-Reduction, Pyrazoles chemical synthesis, Zebrafish, Coumarins chemistry, Endoplasmic Reticulum metabolism, Endoplasmic Reticulum Stress physiology, Fluorescent Dyes chemistry, Pyrazoles chemistry
Abstract

Excessive accumulation of reducing agents in the ER leads to a constitutively high UPR. And the co-function of GSH, Cys and HOCl in biological processes is not well understood. To address this, a TP probe, NPCC, was developed for monitoring reductive stress in the ER. It can also distinguish cancer cells from normal cells.

Published
2019
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