1. The prognostic value of radiomic features from pre- and post-treatment 18 F-FDG PET imaging in patients with nasopharyngeal carcinoma.
- Author
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Kim SJ, Choi JY, Ahn YC, Ahn MJ, and Moon SH
- Subjects
- Humans, Nasopharyngeal Carcinoma diagnostic imaging, Nasopharyngeal Carcinoma therapy, Nasopharyngeal Carcinoma pathology, Positron Emission Tomography Computed Tomography methods, Positron-Emission Tomography, Prognosis, Retrospective Studies, Fluorodeoxyglucose F18, Nasopharyngeal Neoplasms diagnostic imaging, Nasopharyngeal Neoplasms therapy
- Abstract
Positron emission tomography/computed tomography (PET/CT) with
18 F-fluorodeoxyglucose (FDG) is widely used for management of nasopharyngeal carcinoma (NPC). Combining the radiomic features of pre- and post-treatment FDG PET images may improve tumor characterization and prognostic predication. We investigated prognostic value of radiomic features from pre- and post-radiotherapy FDG PET images in patients with NPC. Quantitative radiomic features of primary tumors were extracted from the FDG PET images of 145 NPC patients and the delta values were also calculated. The study population was divided randomly into two groups, the training and test sets (7:3). A random survival forest (RSF) model was adopted to perform analyses of progression-free survival (PFS) and overall survival (OS). There were 37 (25.5%) cases of recurrence and 16 (11.0%) cases of death during a median follow-up period of 54.5 months. Both RSF models with clinical variables and radiomic PET features for PFS and OS showed comparable predictive performance to RSF models with clinical variables and conventional PET parameters. Tumoral radiomic features of pre- and post-treatment FDG PET and the corresponding delta values may predict PFS and OS in patients with NPC., (© 2023. The Author(s).)- Published
- 2023
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