4 results on '"Arruda Sanchez, Tiago"'
Search Results
2. Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: An fMRI study.
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Arruda Sanchez, Tiago, Ramos, Lucas Rego, Araujo, Felipe, Schenberg, Eduardo Ekman, Yonamine, Mauricio, Lobo, Isabela, de Araujo, Draulio Barros, and Luna, Luis Eduardo
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BRAIN , *MAGNETIC resonance imaging , *FACE perception , *DESCRIPTIVE statistics , *EMOTION regulation , *HALLUCINOGENIC drugs , *PHARMACODYNAMICS - Abstract
Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. This study aimed to measure the emotional acute effect of Ayahuasca on brain response to implicit aversive stimulation using a face recognition task in functional magnetic resonance imaging (fMRI). Nineteen male experienced Ayahuasca users participated in this study in two fMRI sessions before and after 50 min of the Ayahuasca ingestion. Subjects were presented with pictures of neutral (A) and aversive (B) (fearful or disgusted) faces from the Pictures of Facial Affect Series. Subjects were instructed to identify the gender of the faces (gender discrimination task) while the emotional content was implicit. Subjective mood states were also evaluated before Ayahuasca intake and after the second fMRI session, using a visual analogue mood scale (VAMS). During the aversive stimuli, the activity in the bilateral amygdala was attenuated by Ayahuasca (qFDR<0.05). Furthermore, in an exploratory analysis of the effects after intake, Ayahuasca enhances the activation in the insular cortex bilaterally, as well as in the right dorsolateral prefrontal cortex (qFDR<0.05). In the psychometric VAMS scale, subjects reported attenuation of both anxiety and mental sedation (p < 0.01) during acute effects. Together, all reported results including neuroimaging, behavioral data and psychometric self-report suggest that Ayahuasca can promote an emotion regulation mechanism in response to aversive stimuli with corresponding improved cognition including reduced anxiety and mental sedation. [Display omitted] • Ayahuasca is a psychedelic of Amazonian origin with cerebral serotonergic action. • Ayahuasca use by experienced users reveal brain and behavioral changes. • Ayahuasca acts on emotional regulation that could explain its therapeutic potential. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Anterior Insular Resting‐State Functional Connectivity is Related to Cognitive Reserve in Multiple Sclerosis.
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Bizzo, Bernardo Canedo, Arruda‐Sanchez, Tiago, Tobyne, Sean M, Bireley, John Daniel, Lev, Michael Howard, Gasparetto, Emerson Leandro, and Klawiter, Eric C
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FUNCTIONAL connectivity , *NATALIZUMAB , *MULTIPLE sclerosis , *FUNCTIONAL magnetic resonance imaging , *MULTIPLE comparisons (Statistics) - Abstract
BACKGROUND AND PURPOSE: Cognitive dysfunction is common in multiple sclerosis (MS). The dorsal anterior insula (dAI) is a key hub of the salience network (SN) orchestrating access to critical cognitive brain regions. The aim of this study was to assess whole‐brain dAI intrinsic functional connectivity (iFC) using resting‐state functional MRI (rs‐fMRI) in people with MS and healthy controls (HC) and test the relationship between cognitive reserve (CR) and dAI iFC in people with MS. METHODS: We studied 28 people with relapsing‐remitting MS and 28 HC. CR index was quantified by combining premorbid IQ, leisure activities, and education level. For whole‐brain iFC analyses, the bilateral dAI were used as seeds. Individual subject correlation maps were entered into general linear models for group comparison and to analyze the effect of CR index on dAI iFC, controlling for multiple comparisons. The correlation between CR index and iFC was assessed using a linear regression model. RESULTS: rs‐fMRI analyses revealed a negative relationship between CR index and iFC within the left dAI and a left occipital cluster in people with MS including regions of the cuneus, superior occipital gyrus, and parieto‐occipital sulcus. The regression analysis showed that people with MS and a higher CR index had a statistically significantly reduced iFC within the left dAI and the cluster. CONCLUSIONS: CR is relevant to functional connectivity within one of the main nodes of the SN, the dAI, and occipital regions in MS. These results have implications for how CR may modulate the susceptibility to cognitive dysfunction in MS. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
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4. Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms
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Delaveau, Pauline, Arruda Sanchez, Tiago, Steffen, Ricardo, Deschet, Karine, Jabourian, Maritza, Perlbarg, Vincent, Gasparetto, Emerson Leandro, Dubal, Stéphanie, Costa E Silva, Jorge, Fossati, Philippe, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Universidade Federal do Rio de Janeiro (UFRJ), Hospital Santa Casa de Misericórdia do Rio de Janeiro, Institut de Recherches Internationales Servier [Suresnes] (IRIS), Laboratoire d'Imagerie Biomédicale (LIB), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de neurosciences translationnelles de Paris (NeurATRIS - IHU-A-ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Pontifical Catholic University of Rio de Janeiro (PUC), Instituto Brasileiro do Cérebro (INBRACER), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and HAL-UPMC, Gestionnaire
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task performance ,depressive disorder ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,fMRI ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,neural networks ,human activities ,[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,working memory - Abstract
International audience; Clinical remission of depression may be associated with emotional residual symptoms. We studied the association of emotional blunting, rumination with neural networks dynamics in remitted depressed patients and cognitive performance during an N-Back task. Twenty-six outpatients in remission of depression (Hamilton Depressive rating scale score
- Published
- 2017
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