1. Human biomonitoring of multiple mycotoxins in hair: first large-scale pilot study
- Author
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A. Narváez, Y. Rodríguez-Carrasco, A. Ritieni, and J. Mañes
- Subjects
integumentary system ,technology, industry, and agriculture ,Public Health, Environmental and Occupational Health ,food and beverages ,Toxicology ,Food Science - Abstract
Human biomonitoring (HBM) represents the most accurate approach for assessing the exposure to mycotoxins, but traditional matrices fail to provide information about long-term exposure due to the rapid excretion rates and short half-lives of mycotoxins. Hair emerges as a promising matrix considering that contaminants can form stable links with hair components, such as keratins and melanin. Hence, the aim of the present study was to monitor the presence of up to ten mycotoxins (aflatoxins and Fusarium mycotoxins) in human hair samples (n=100) through a high-performance liquid chromatography coupled to Q-TOF high resolution mass spectrometry. A prevalence of 43% at concentrations ranging from 2.7 to 106.1 ng/g was observed, being enniatins and aflatoxin B1 the most prevalent compounds. Co-occurrence of up to three mycotoxins was observed in 42% of the positive samples. Retrospective untargeted analysis of hair samples tentatively identified up to 128 mycotoxins and related metabolites. These results confirm the accumulation of toxicologically relevant mycotoxins in hair matrix, thus standing as a suitable matrix for assessing long-term exposure.
- Published
- 2022