Search

Your search keyword '"Shemesh Z"' showing total 2 results
Start Over Author "Shemesh Z" Topic forskolin
2 results on '"Shemesh Z"'

2. Cyclic AMP signal transduction in posttraumatic stress disorder

Author

Richard P. Ebstein, Shestatsky M, Bernard Lerer, Shemesh Z, and Greenberg D

Subjects
Adult, Blood Platelets, medicine.medical_specialty, Prostaglandin, Adenylate kinase, Stress Disorders, Post-Traumatic, chemistry.chemical_compound, Chlorides, Internal medicine, Sodium fluoride, Receptors, Adrenergic, beta, medicine, Cyclic AMP, Aluminum Chloride, Humans, Platelet, Lymphocytes, Alprostadil, Aluminum Compounds, Forskolin, Cell Membrane, Colforsin, Isoproterenol, Middle Aged, Adenosine, Psychiatry and Mental health, Endocrinology, chemistry, Signal transduction, Cyclase activity, medicine.drug, Adenylyl Cyclases, Aluminum
Abstract

Cyclic adenosine 3',5'-monophosphate (cAMP) signal transduction was examined in lymphocytes and platelets obtained from patients with posttraumatic stress disorder. Intact lymphocytes from the posttraumatic patients (N = 10) showed significantly lower basal, isoproterenol-, and forskolin-stimulated cAMP levels than those from 10 healthy control subjects. In platelet membrane preparations, basal, forskolin-, aluminum chloride plus sodium fluoride-, and prostaglandin E1-stimulated adenylate cyclase activity levels were all significantly lower in the posttraumatic group than in the control group. The authors discuss the potential role of their findings as a biological marker for posttraumatic stress disorder.

Published
1987

Catalog

Books, media, physical & digital resources
See catalog results