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For a variety of biometric cross-spectral tasks, Visible-Thermal (VT) facial pairs are used. However, due to a lack of calibration in the lab, photographic capture between two different sensors leads to severely misaligned pairs that can lead to poor results for person re-identification and generative AI. To solve this problem, we introduce our approach for VT image registration called Vista Morph. Unlike existing VT facial registration that requires manual, hand-crafted features for pixel matching and/or a supervised thermal reference, Vista Morph is completely unsupervised without the need for a reference. By learning the affine matrix through a Vision Transformer (ViT)-based Spatial Transformer Network (STN) and Generative Adversarial Networks (GAN), Vista Morph successfully aligns facial and non-facial VT images. Our approach learns warps in Hard, No, and Low-light visual settings and is robust to geometric perturbations and erasure at test time. We conduct a downstream generative AI task to show that registering training data with Vista Morph improves subject identity of generated thermal faces when performing V2T image translation.

Novel Categories Discovery (NCD) facilitates learning from a partially annotated label space and enables deep learning (DL) models to operate in an open-world setting by identifying and differentiating instances of novel classes based on the labeled data notions. One of the primary assumptions of NCD is that the novel label space is perfectly disjoint and can be equipartitioned, but it is rarely realized by most NCD approaches in practice. To better align with this assumption, we propose a novel single-stage joint optimization-based NCD method, Negative learning, Entropy, and Variance regularization NCD (NEV-NCD). We demonstrate the efficacy of NEV-NCD in previously unexplored NCD applications of video action recognition (VAR) with the public UCF101 dataset and a curated in-house partial action-space annotated multi-view video dataset. We perform a thorough ablation study by varying the composition of final joint loss and associated hyper-parameters. During our experiments with UCF101 and multi-view action dataset, NEV-NCD achieves ~ 83% classification accuracy in test instances of labeled data. NEV-NCD achieves ~ 70% clustering accuracy over unlabeled data outperforming both naive baselines (by ~ 40%) and state-of-the-art pseudo-labeling-based approaches (by ~ 3.5%) over both datasets. Further, we propose to incorporate optional view-invariant feature learning with the multiview dataset to identify novel categories from novel viewpoints. Our additional view-invariance constraint improves the discriminative accuracy for both known and unknown categories by ~ 10% for novel viewpoints.

Novel Categories Discovery (NCD) tackles the open-world problem of classifying known and clustering novel categories based on the class semantics using partial class space annotated data. Unlike traditional pseudo-label and retraining, we investigate NCD from the novel data probability matrix perspective. We leverage the connection between NCD novel data sampling with provided novel class Multinoulli (categorical) distribution and hypothesize to implicitly achieve semantic-based novel data clustering by learning their class distribution. We propose novel constraints on first-order (mean) and second-order (covariance) statistics of probability matrix features while applying instance-wise information constraints. In particular, we align the neuron distribution (activation patterns) under a large batch of Monte-Carlo novel data sampling by matching their empirical features mean and covariance with the provided Multinoulli-distribution. Simultaneously, we minimize entropy and enforce prediction consistency for each instance. Our simple approach successfully realizes semantic-based novel data clustering provided the semantic similarity between label-unlabeled classes. We demonstrate the discriminative capacity of our approaches in image and video modalities. Moreover, we perform extensive ablation studies regarding data, networks, and our framework components to provide better insights. Our approach maintains ~94%, ~93%, and ~85%, classification accuracy in labeled data while achieving ~90%, ~84%, and ~72% clustering accuracy for novel categories for Cifar10, UCF101, and MPSC-ARL datasets that matches state-of-the-art approaches without any external clustering.

Thermal facial imagery offers valuable insight into physiological states such as inflammation and stress by detecting emitted radiation in the infrared spectrum, which is unseen in the visible spectra. Telemedicine applications could benefit from thermal imagery, but conventional computers are reliant on RGB cameras and lack thermal sensors. As a result, we propose the Visible-to-Thermal Facial GAN (VTF-GAN) that is specifically designed to generate high-resolution thermal faces by learning both the spatial and frequency domains of facial regions, across spectra. We compare VTF-GAN against several popular GAN baselines and the first conditional Denoising Diffusion Probabilistic Model (DDPM) for VT face translation (VTF-Diff). Results show that VTF-GAN achieves high quality, crisp, and perceptually realistic thermal faces using a combined set of patch, temperature, perceptual, and Fourier Transform losses, compared to all baselines including diffusion.

Multi-state survival analysis (MSA) uses multi-state models for the analysis of time-to-event data. In medical applications, MSA can provide insights about the complex disease progression in patients. A key challenge in MSA is the accurate subject-specific prediction of multi-state model quantities such as transition probability and state occupation probability in the presence of censoring. Traditional multi-state methods such as Aalen-Johansen (AJ) estimators and Cox-based methods are respectively limited by Markov and proportional hazards assumptions and are infeasible for making subject-specific predictions. Neural ordinary differential equations for MSA relax these assumptions but are computationally expensive and do not directly model the transition probabilities. To address these limitations, we propose a new class of pseudo-value-based deep learning models for multi-state survival analysis, where we show that pseudo values - designed to handle censoring - can be a natural replacement for estimating the multi-state model quantities when derived from a consistent estimator. In particular, we provide an algorithm to derive pseudo values from consistent estimators to directly predict the multi-state survival quantities from the subject's covariates. Empirical results on synthetic and real-world datasets show that our proposed models achieve state-of-the-art results under various censoring settings.

Survival analysis, time-to-event analysis, is an important problem in healthcare since it has a wide-ranging impact on patients and palliative care. Many survival analysis methods have assumed that the survival data is centrally available either from one medical center or by data sharing from multi-centers. However, the sensitivity of the patient attributes and the strict privacy laws have increasingly forbidden sharing of healthcare data. To address this challenge, the research community has looked at the solution of decentralized training and sharing of model parameters using the Federated Learning (FL) paradigm. In this paper, we study the utilization of FL for performing survival analysis on distributed healthcare datasets. Recently, the popular Cox proportional hazard (CPH) models have been adapted for FL settings; however, due to its linearity and proportional hazards assumptions, CPH models result in suboptimal performance, especially for non-linear, non-iid, and heavily censored survival datasets. To overcome the challenges of existing federated survival analysis methods, we leverage the predictive accuracy of the deep learning models and the power of pseudo values to propose a first-of-its-kind, pseudo value-based deep learning model for federated survival analysis (FSA) called FedPseudo. Furthermore, we introduce a novel approach of deriving pseudo values for survival probability in the FL settings that speeds up the computation of pseudo values. Extensive experiments on synthetic and real-world datasets show that our pseudo valued-based FL framework achieves similar performance as the best centrally trained deep survival analysis model. Moreover, our proposed FL approach obtains the best results for various censoring settings.

Cancer patients experience high rates of chronic pain throughout the treatment process. Assessing pain for this patient population is a vital component of psychological and functional well-being, as it can cause a rapid deterioration of quality of life. Existing work in facial pain detection often have deficiencies in labeling or methodology that prevent them from being clinically relevant. This paper introduces the first chronic cancer pain dataset, collected as part of the Intelligent Sight and Sound (ISS) clinical trial, guided by clinicians to help ensure that model findings yield clinically relevant results. The data collected to date consists of 29 patients, 509 smartphone videos, 189,999 frames, and self-reported affective and activity pain scores adopted from the Brief Pain Inventory (BPI). Using static images and multi-modal data to predict self-reported pain levels, early models show significant gaps between current methods available to predict pain today, with room for improvement. Due to the especially sensitive nature of the inherent Personally Identifiable Information (PII) of facial images, the dataset will be released under the guidance and control of the National Institutes of Health (NIH)., Comment: Published as conference paper at the 35th Conference on Neural Information Processing Systems (NeurIPS 2021) Track on Datasets and Benchmarks

This paper illustrates five different techniques to assess the distinctiveness of topics, key terms and features, speed of information dissemination, and network behaviors for Covid19 tweets. First, we use pattern matching and second, topic modeling through Latent Dirichlet Allocation (LDA) to generate twenty different topics that discuss case spread, healthcare workers, and personal protective equipment (PPE). One topic specific to U.S. cases would start to uptick immediately after live White House Coronavirus Task Force briefings, implying that many Twitter users are paying attention to government announcements. We contribute machine learning methods not previously reported in the Covid19 Twitter literature. This includes our third method, Uniform Manifold Approximation and Projection (UMAP), that identifies unique clustering-behavior of distinct topics to improve our understanding of important themes in the corpus and help assess the quality of generated topics. Fourth, we calculated retweeting times to understand how fast information about Covid19 propagates on Twitter. Our analysis indicates that the median retweeting time of Covid19 for a sample corpus in March 2020 was 2.87 hours, approximately 50 minutes faster than repostings from Chinese social media about H7N9 in March 2013. Lastly, we sought to understand retweet cascades, by visualizing the connections of users over time from fast to slow retweeting. As the time to retweet increases, the density of connections also increase where in our sample, we found distinct users dominating the attention of Covid19 retweeters. One of the simplest highlights of this analysis is that early-stage descriptive methods like regular expressions can successfully identify high-level themes which were consistently verified as important through every subsequent analysis.

With the increased attention on thermal imagery for Covid-19 screening, the public sector may believe there are new opportunities to exploit thermal as a modality for computer vision and AI. Thermal physiology research has been ongoing since the late nineties. This research lies at the intersections of medicine, psychology, machine learning, optics, and affective computing. We will review the known factors of thermal vs. RGB imaging for facial emotion recognition. But we also propose that thermal imagery may provide a semi-anonymous modality for computer vision, over RGB, which has been plagued by misuse in facial recognition. However, the transition to adopting thermal imagery as a source for any human-centered AI task is not easy and relies on the availability of high fidelity data sources across multiple demographics and thorough validation. This paper takes the reader on a short review of machine learning in thermal FER and the limitations of collecting and developing thermal FER data for AI training. Our motivation is to provide an introductory overview into recent advances for thermal FER and stimulate conversation about the limitations in current datasets., Comment: Presented at AAAI FSS-20: Artificial Intelligence in Government and Public Sector, Washington, DC, USA

Deep learning models (aka Deep Neural Networks) have revolutionized many fields including computer vision, natural language processing, speech recognition, and is being increasingly used in clinical healthcare applications. However, few works exist which have benchmarked the performance of the deep learning models with respect to the state-of-the-art machine learning models and prognostic scoring systems on publicly available healthcare datasets. In this paper, we present the benchmarking results for several clinical prediction tasks such as mortality prediction, length of stay prediction, and ICD-9 code group prediction using Deep Learning models, ensemble of machine learning models (Super Learner algorithm), SAPS II and SOFA scores. We used the Medical Information Mart for Intensive Care III (MIMIC-III) (v1.4) publicly available dataset, which includes all patients admitted to an ICU at the Beth Israel Deaconess Medical Center from 2001 to 2012, for the benchmarking tasks. Our results show that deep learning models consistently outperform all the other approaches especially when the `raw' clinical time series data is used as input features to the models., Comment: Submitted to Journal of Biomedical Informatics (JBI). First two authors have equal contributions

Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep Learning models have shown superior performance for robust prediction in computational phenotyping tasks, but suffer from the issue of model interpretability which is crucial for clinicians involved in decision-making. In this paper, we introduce a novel knowledge-distillation approach called Interpretable Mimic Learning, to learn interpretable phenotype features for making robust prediction while mimicking the performance of deep learning models. Our framework uses Gradient Boosting Trees to learn interpretable features from deep learning models such as Stacked Denoising Autoencoder and Long Short-Term Memory. Exhaustive experiments on a real-world clinical time-series dataset show that our method obtains similar or better performance than the deep learning models, and it provides interpretable phenotypes for clinical decision making.