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A new fluorescent molecular probe 1 was designed and constructed by combining bovine serum albumin (BSA) and N , N′ -bis(salicylidene)ethylenediamine (salen). Stimulated by Zn 2 + , tris, or EDTAH 2 Na 2 , the distance between BSA and salen was regulated, which was accompanied by an obvious change in the fluorescence intensity at 350 or 445 nm based on Förster resonance energy transfer. Moreover, based on the encoding binary digits in these inputs and outputs applying positive logic conventions, a monomolecular circuit integrating one OR, three NOT, and three YES gates, was successfully achieved. [ABSTRACT FROM AUTHOR]

Several logic gates, which are commonly designed with DNA or organic molecules, rely on only one output mode. Here, a new molecular device was designed and constructed by combining bovine serum albumin and 5-sulfosalicylic acid. When MoO 4 2― , Tris(hydroxymethyl)aminomethane, EDTAH 2 Na 2 , Al 3+ , Trichloroacetic acid are used as inputs, changes in the fluorescent intensity at 350 nm and 406 nm were observed via FRET. Four molecular devices as a half-adder and three digital logic circuits were successfully constructed on the unimolecular platform by employing emission properties at different wavelengths as outputs. The advantage of the combined system was that many different functional molecular devices could be designed and assembled by employing protein and various organic molecules in aqueous solution. [ABSTRACT FROM AUTHOR]