1. Glucose selective Surface Plasmon Resonance-based bis-boronic acid sensor.
- Author
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Stephenson-Brown, Alex, Wang, Hui-Chen, Iqbal, Parvez, Preece, Jon A., Long, Yitao, Fossey, John S., James, Tony D., and Mendes, Paula M.
- Subjects
SACCHARIDES ,SURFACE plasmon resonance ,BORONIC acids ,LIPOIC acid ,INTRAMOLECULAR catalysis ,FRUCTOSE - Abstract
Saccharides – a versatile class of biologically important molecules – are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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