1. Alkenylbenzoquinones and other compounds from the fruit of Maesa lanceolata exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities § .
- Author
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Seumo AS, Nanfack ARD, Ndontsa BL, Bitchagno GTM, Mbouangouere R, Lenta BN, Sewald N, Tane P, Tene M, and Ngouela SA
- Subjects
- Anti-Bacterial Agents analysis, Anti-Bacterial Agents pharmacology, Benzoquinones chemistry, Molecular Structure, Plant Extracts chemistry, Fruit chemistry, Maesa
- Abstract
A phytochemical study of the methanol extract of the fruit of Maesa lanceolata resulted in the isolation of a new alkenylbenzoquinone ( 1 ), alongside the known compounds ( Z )-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone ( 2 ), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone ( 3 ), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone ( 4 ), (2 S ,3 S ,4 R ,2' R ,9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol ( 5 ), monopalmitin (glyceryl palmitate) ( 6 ), lupeol ( 7 ), and 3- O -( β -D-glucopyranoside)- β -sitosterol ( 8 ). The structures of the compounds were established by the means of spectroscopic (1 D- and 2 D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities. Compound 2 showed moderate activity against Staphylococcus warneri (DSMZ 20036), while the other compounds were inactive. The two quinones 1 and 2 were significantly cytotoxic, with IC
50 values of 0.005 µ M and 12.5 µ M respectively, and were weakly active towards DPPH radical (IC50 >250 µ g/mL).- Published
- 2022
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