18 results on '"Wang, Zhenchang"'
Search Results
2. Baseline Functional Connectivity Features of Neural Network Nodes Can Predict Improvement After Sound Therapy Through Adjusted Narrow Band Noise in Tinnitus Patients
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Lv Han, Zeng Na, Liu Chunli, Chen Yuchen, Zhao Pengfei, Wang Hao, Cheng Xu, Zhang Peng, Wang Zheng, Yang Zhenghan, Gong Shusheng, and Wang Zhenchang
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tinnitus ,sound therapy ,functional magnetic resonance imaging ,functional connectivity ,degree centrality ,neural biomarker ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown neural connectivity alterations after the treatment of tinnitus. We aim to study the value of the baseline functional connectivity features of neural network nodes to predict outcomes of sound therapy through adjusted narrow band noise. The fMRI data of 27 untreated tinnitus patients and 27 matched healthy controls were analyzed. We calculated the graph-theoretical metric degree centrality (DC) to characterize the functional connectivity of the neural network nodes. Therapeutic outcomes are determined by the changes in the Tinnitus Handicap Inventory (THI) score after a 12-week intervention. The connectivity of 10 brain nodes in tinnitus patients was significantly increased at baseline. The functional connectivity of right insula, inferior parietal lobule (IPL), bilateral thalami, and left middle temporal gyrus was significantly modified with the sound therapy, and such changes correlated with THI changes in tinnitus patients. Receiver operating characteristic curve analyses revealed that the measurements from the five brain regions were effective at classifying improvement after therapy. After age, gender, and education correction, the adjusted area under the curve (AUC) values for the bilateral thalami were the highest (left, 0.745; right, 0.708). Our study further supported the involvement of the fronto-parietal-cingulate network in tinnitus and found that the connectivity of the thalamus at baseline is an object neuroimaging-based indicator to predict clinical outcome of sound therapy through adjusted narrow band noise.
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- 2019
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3. Impaired Inter-Hemispheric Functional Connectivity during Resting State in Female Patients with Migraine.
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Zhang, Yanan, Liu, Ni, Wang, Zhenjia, Liu, Junlian, Ren, Mengmeng, Hong, Yueying, Luo, Xuanzhi, Liu, Huilin, Huo, Jianwei, and Wang, Zhenchang
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MAGNETIC resonance imaging ,FUNCTIONAL connectivity ,FUNCTIONAL magnetic resonance imaging ,WOMEN patients ,MIGRAINE aura - Abstract
The application of voxel-mirrored homotopic connectivity (VMHC) analysis to study the central mechanism of migraine has been limited. Furthermore, little is known about inter-hemispheric functional connectivity (FC) alterations during resting state in female patients with migraine. This study aimed to investigate potential interictal VMHC impairments in migraine without aura (MwoA) patients and the relationship between connectivity alterations and clinical parameters. Resting-state functional magnetic resonance imaging data and clinical information were acquired from 43 female MwoA patients and 43 matched healthy controls. VMHC analysis was used to compare differences between these two groups, and brain regions showing significant differences were chosen as a mask to perform a seed-based FC group comparison. Subsequent correlation analysis was conducted to explore the relationship between abnormal inter-hemispheric FC and clinical data. Compared with healthy controls, female MwoA patients revealed significantly decreased VMHC in the bilateral cerebellum; cuneus; and lingual, middle occipital, precentral and postcentral gyri. Seed-based FC analysis indicated disrupted intrinsic connectivity in the cerebellum, and default mode, visual and sensorimotor network. These VMHC and FC abnormalities were negatively correlated with clinical indexes including duration of disease, migraine days and visual analogue scale. These inter-hemispheric FC impairments and correlations between abnormal VMHC and FC and clinical scores may improve our understanding of the central mechanism of female-specific migraine. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Distinct brain structural‐functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.
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Chen, Qian, Lv, Han, Wang, Zhaodi, Wei, Xuan, Liu, Jiao, Liu, Fang, Zhao, Pengfei, Yang, Zhenghan, Gong, Shusheng, and Wang, Zhenchang
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TINNITUS ,LARGE-scale brain networks ,SOUND therapy ,FUNCTIONAL magnetic resonance imaging ,DIFFUSION tensor imaging - Abstract
Topological properties, which serve as the core of the neural network, and their couplings can reflect different therapeutic effects in tinnitus patients. We hypothesized that tinnitus patients with different outcomes after sound therapy (narrowband noise) would have distinct brain network topological alterations. Diffusion tensor imaging and resting‐state functional magnetic resonance imaging (fMRI) were prospectively performed in 60 patients with idiopathic tinnitus and 57 healthy controls (HCs). Graph‐theoretical network analyses of structural connectivity (SC), functional connectivity (FC), and SC and FC coupling were performed. Associations between clinical performance and graph‐theoretical features were also analyzed. Treatment was effective (effective group; EG) in 28 patients and ineffective (ineffective group; IG) in 32 patients. For FC, the patients in the EG showed higher local efficiency than patients in the IG. For SC, patients in both the EG and IG displayed lower normalized characteristic path length, characteristic path length, and global efficiency than the HCs. More importantly, patients in the IG had higher coupling than the HCs, whereas there was no difference in coupling between patients in the EG and HCs. Additionally, there were significant associations between the SC features and clinical performance in patients in the EG. Our findings demonstrate that tinnitus patients exhibited significant brain network topological alterations, especially in the structural brain network. More importantly, patients who demonstrated different curative effects showed distinct SC‐FC topological coupling properties. SC‐FC coupling could be an indicator that could be used to predict prognoses in patients with idiopathic tinnitus before sound therapy. [ABSTRACT FROM AUTHOR]
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- 2022
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5. The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks
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Liu Chunli, Wang Zhenchang, Wang Zhaodi, Wang Xindi, Lv Han, Gong Shusheng, Zhao Pengfei, and Chen Qian
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Cingulate cortex ,Auditory perception ,medicine.medical_specialty ,Brain activity and meditation ,ALFF ,sound therapy ,Audiology ,03 medical and health sciences ,0302 clinical medicine ,Gyrus ,Medicine ,tinnitus ,030223 otorhinolaryngology ,medicine.diagnostic_test ,business.industry ,AcademicSubjects/SCI01870 ,Functional connectivity ,fMRI ,functional connectivity ,General Engineering ,medicine.anatomical_structure ,Original Article ,AcademicSubjects/MED00310 ,Sound therapy ,medicine.symptom ,business ,Functional magnetic resonance imaging ,030217 neurology & neurosurgery ,Tinnitus - Abstract
To determine the neural mechanism underlying the effects of sound therapy on tinnitus, we hypothesize that sound therapy may be effective by modulating both local neural activity and functional connectivity that is associated with auditory perception, auditory information storage or emotional processing. In this prospective observational study, 30 tinnitus patients underwent resting-state functional magnetic resonance imaging scans at baseline and after 12 weeks of sound therapy. Thirty-two age- and gender-matched healthy controls also underwent two scans over a 12-week interval; 30 of these healthy controls were enrolled for data analysis. The amplitude of low-frequency fluctuation was analysed, and seed-based functional connectivity measures were shown to significantly alter spontaneous local brain activity and its connections to other brain regions. Interaction effects between the two groups and the two scans in local neural activity as assessed by the amplitude of low-frequency fluctuation were observed in the left parahippocampal gyrus and the right Heschl's gyrus. Importantly, local functional activity in the left parahippocampal gyrus in the patient group was significantly higher than that in the healthy controls at baseline and was reduced to relatively normal levels after treatment. Conversely, activity in the right Heschl's gyrus was significantly increased and extended beyond a relatively normal range after sound therapy. These changes were found to be positively correlated with tinnitus relief. The functional connectivity between the left parahippocampal gyrus and the cingulate cortex was higher in tinnitus patients after treatment. The alterations of local activity and functional connectivity in the left parahippocampal gyrus and right Heschl’s gyrus were associated with tinnitus relief. Resting-state functional magnetic resonance imaging can provide functional information to explain and ‘visualize’ the mechanism underlying the effect of sound therapy on the brain., The alterations of local activity and functional connectivity in the left parahippocampal gyrus and right Heschl’s gyrus were associated with tinnitus relief after sound therapy., Graphical Abstract Graphical Abstract
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- 2020
6. Altered Neurovascular Coupling in Unilateral Pulsatile Tinnitus.
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Li, Xiaoshuai, Xu, Ning, Dai, Chihang, Meng, Xuxu, Qiu, Xiaoyu, Ding, Heyu, Zeng, Rong, Lv, Han, Zhao, Pengfei, Yang, Zhenghan, Gong, Shusheng, and Wang, Zhenchang
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PARIETAL lobe ,CEREBRAL circulation ,TEMPORAL lobe ,TINNITUS ,SPIN labels - Abstract
Objective: Altered cerebral blood flow (CBF) and regional homogeneity (ReHo) have been reported in pulsatile tinnitus (PT) patients. We aimed to explore regional neurovascular coupling changes in PT patients. Materials and Methods: Twenty-four right PT patients and 25 sex- and age-matched normal controls were included in this study. All subjects received arterial spin labeling imaging to measure CBF and functional MRI to compute ReHo. CBF/ReHo ratio was used to assess regional neurovascular coupling between the two groups. We also analyzed the correlation between CBF/ReHo ratio and clinical data from the PT patients. Results: PT patients exhibited increased CBF/ReHo ratio in left middle temporal gyrus and right angular gyrus than normal controls, and no decreased CBF/ReHo ratio was found. CBF/ReHo ratio in the left middle temporal gyrus of PT patients was positively correlated with Tinnitus Handicap Inventory score (r = 0.433, p = 0.035). Conclusion: These findings indicated that patients with PT exhibit abnormal neurovascular coupling, which provides new information for understanding the neuropathological mechanisms underlying PT. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Surface-Based Amplitude of Low-Frequency Fluctuation Alterations in Patients With Tinnitus Before and After Sound Therapy: A Resting-State Functional Magnetic Resonance Imaging Study.
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Wei, Xuan, Lv, Han, Chen, Qian, Wang, Zhaodi, Zhao, Pengfei, Liu, Chunli, Gong, Shusheng, Yang, Zhenghan, and Wang, Zhenchang
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FUNCTIONAL magnetic resonance imaging ,SOUND therapy ,FRONTAL lobe ,CINGULATE cortex ,DIAGNOSTIC imaging - Abstract
This study aimed to investigate abnormal tinnitus activity by evaluating brain surface-based amplitude of low-frequency fluctuation (ALFF) changes detected by resting-state functional magnetic resonance imaging (RS-fMRI) in patients with idiopathic tinnitus before and after 24 weeks of sound therapy. We hypothesized that sound therapy could gradually return cortical local brain function to a relatively normal range. In this prospective observational study, we recruited thirty-three tinnitus patients who had undergone 24 weeks of sound therapy and 26 matched healthy controls (HCs). For the two groups of subjects, we analyzed the spontaneous neural activity of tinnitus patients by cortical ALFF and detected its correlation with clinical indicators of tinnitus. Patients' Tinnitus Handicap Inventory (THI) scores were assessed to determine the severity of their tinnitus before and after treatment. Two-way mixed model analysis of variance and Pearson's correlation analysis were used in the statistical analysis. Student–Newman–Keuls tests were used in the post hoc analysis. Interaction effects between the two groups and between the two scans revealing local neural activity as assessed by ALFF were observed in the bilateral dorsal stream visual cortex (DSVC), bilateral posterior cingulate cortex (PCC), bilateral anterior cingulate and medial prefrontal cortex (ACC and MPC), left temporo-parieto-occipital junction (TPOJ), left orbital and polar frontal cortex (OPFC), left paracentral lobular and mid cingulate cortex (PCL and MCC), right insular and frontal opercular cortex (IFOC), and left early visual cortex (EVC). Importantly, local functional activity in the left TPOJ and right PCC in the patient group was significantly lower than that in the HCs at baseline and was increased to relatively normal levels after treatment. The 24-week sound therapy tinnitus group demonstrated significantly higher ALFF in the left TPOJ and right PCC than in the tinnitus baseline group. Also, compared with the HC baseline group and the 24-week HC group, the 24-week sound therapy tinnitus group demonstrated slightly lower or higher ALFF in the left TPOJ and right PCC, and there were no differences between the 24-week sound therapy tinnitus and HC groups. Decreased THI scores and ALFF changes in the abovementioned brain regions were not correlated. Taken together, surface-based RS-fMRI can provide more subtle local functional activity to explain the mechanism of tinnitus treatment, and long-term sound therapy had a normalizing effect on tinnitus patients. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Pretreatment intranetwork connectivity can predict the outcomes in idiopathic tinnitus patients treated with sound therapy.
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Chen, Qian, Lv, Han, Wang, Zhaodi, Wei, Xuan, Liu, Jiao, Zhao, Pengfei, Yang, Zhenghan, Gong, Shusheng, and Wang, Zhenchang
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SOUND therapy ,DEFAULT mode network ,LARGE-scale brain networks ,FUNCTIONAL magnetic resonance imaging ,SALIENCE network - Abstract
Previous studies demonstrated that brain morphological differences and distinct patterns of neural activation exist in tinnitus patients with different prognoses after sound therapy. This study aimed to explore possible differences in intrinsic network‐level functional connectivity (FC) in patients with different outcomes after sound therapy (narrow band noise). We examined intrinsic FC using resting‐state functional magnetic resonance imaging in 78 idiopathic tinnitus patients (including 35 effectively treated and 43 ineffectively treated) and 52 healthy controls (HCs) via independent component analysis. We also investigated the associations between the differences in FC and clinical variables. Analyses revealed significantly altered intranetwork connectivity in the auditory network (AUN) and some nonauditory‐related networks in the EG/IG patients compared to HCs; compared with EG patients, IG patients showed decreased intranetwork connectivity in the anterior default mode network (aDMN) and AUN. Meanwhile, robust differences were also evident in internetwork connectivity between some nonauditory‐related networks (salience network and executive control network; posterior default mode network and dorsal attention network) in the EG relative to IG patients. We combined intranetwork connectivity in the aDMN and AUN as an imaging indicator to evaluate patient outcomes and screen patients before treatment; this approach reached a sensitivity of 94.3% and a specificity of 76.7%. Our study suggests that tinnitus patients with different outcomes show distinct network‐level functional reorganization patterns. Intranetwork connectivity in the aDMN and AUN may be indicators that can be used to predict prognoses in patients with idiopathic tinnitus and screen patients before sound therapy. [ABSTRACT FROM AUTHOR]
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- 2021
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9. Disrupted neural activity in unilateral vascular pulsatile tinnitus patients in the early stage of disease: Evidence from resting-state fMRI
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Yan Fei, Wang Zhenchang, Dong Cheng, Lv Han, Liu Zhaohui, Li Ting, and Zhao Pengfei
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Adult ,Male ,medicine.medical_specialty ,Brain activity and meditation ,Rest ,Statistics as Topic ,Precuneus ,Inferior frontal gyrus ,Severity of Illness Index ,Functional Laterality ,Tinnitus ,Young Adult ,Internal medicine ,Neural Pathways ,Image Processing, Computer-Assisted ,medicine ,Humans ,Biological Psychiatry ,Pharmacology ,Brain Mapping ,medicine.diagnostic_test ,Resting state fMRI ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,Lobe ,Oxygen ,medicine.anatomical_structure ,Posterior cingulate ,Cardiology ,Female ,medicine.symptom ,Functional magnetic resonance imaging ,Psychology ,human activities ,Neuroscience - Abstract
Numerous studies have shown that neurological changes are important findings of tinnitus patients. Previous studies on tinnitus have indicated that patients with pulsatile tinnitus (PT) often show altered baseline brain activity in the resting state. This study used resting-state functional magnetic resonance imaging (rs-fMRI) to investigate changes in spontaneous brain activity among patients with unilateral pulsatile tinnitus in the early stage of disease (less than forty-eight months) and determined the relationship of these changes with clinical data. The PT patients (n = 34) and matched normal control subjects (n = 34) were enrolled in this study. Spontaneous brain activity was revealed by the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) values. Compared with normal controls, the patients with PT had significantly increased ReHo and ALFF in the posterior cingulate cortex, right inferior parietal lobule (IPL) and right cerebellum posterior lobe. The PT group showed increased ReHo in the posterior cingulate cortex (PCC), precuneus, right IPL, right superior frontal gyrus, some occipital areas and part of the right cerebellum posterior lobe. For ALFF, the increased clusters were in the PCC and precuneus and in some areas of the cerebellum posterior lobe, bilateral IPL and inferior frontal gyrus (IFG). Increased PT duration was correlated with increased ALFF in the bilateral inferior frontal gyrus (IFG) and precuneus. An increased THI score was correlated with ReHo and ALFF values in the precuneus. Taken together, the combined study of ReHo and ALFF measurements may yield a more comprehensive neurological pathophysiology framework for PT patients in the early stage of the disease.
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- 2015
10. Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study.
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Wei, Xuan, Lv, Han, Wang, Zhaodi, Liu, Chunli, Ren, Pengling, Zhang, Peng, Chen, Qian, Liu, Yawen, Zhao, Pengfei, Gong, Shusheng, Yang, Zhenghan, and Wang, Zhenchang
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SOUND therapy ,VOXEL-based morphometry ,TINNITUS ,CLINICAL trial registries ,COCHLEAR nucleus - Abstract
According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, few studies have reported on the morphological changes observed following sound therapy. To explore the brain anatomical alterations in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis before and after effective 12 weeks sound therapy. The protocol was registered on ClinicalTrials.gov, ID: NCT02774122. In this study, we collected data from 27 matched healthy control (HC) individuals and 27 idiopathic tinnitus patients before and after 12 weeks of sound therapy by using adjusted narrow band sound. 3.0T MRI system and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Mann–Whitney U Test, Wilcoxon Signed-Ranks test, and Pearson's correlation analysis were used in the statistical analysis. We found significantly decreased gray matter (GM) volume in the left thalami, right thalami, and cochlear nucleus among the tinnitus patients before sound therapy (baseline) compared to the HC group. However, we did not find significant differences in brain regions between the 12-week treatment and HC groups. According to the results of Wilcoxon Signed-Ranks test, the 12-week sound therapy group demonstrated significant greater brain volume compared with the baseline group among these brain regions. Decreased THI score and changed GM volume were not correlated. This is a useful study for observing the characteristics of neuroanatomical changes in patients with idiopathic tinnitus before and after sound treatment. The study characterized the effect of sound therapy on brain volume. It found that sound therapy had a normalizing effect on the bilateral thalami and cochlear nucleus. Clinical Trial Registration: www.ClinicalTrials.gov, NCT02774122. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Resting-state functional connectivity density mapping of etiology confirmed unilateral pulsatile tinnitus patients: Altered functional hubs in the early stage of disease
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Liu Zhaohui, Dong Cheng, Wang Zhenchang, Li Ting, Yan Fei, Lv Han, and Zhao Pengfei
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Adult ,Male ,Rest ,Statistics as Topic ,Precuneus ,Inferior frontal gyrus ,Auditory cortex ,Brain mapping ,Functional Laterality ,Tinnitus ,Young Adult ,Neural Pathways ,medicine ,Image Processing, Computer-Assisted ,Middle frontal gyrus ,Humans ,Brain Mapping ,Resting state fMRI ,medicine.diagnostic_test ,General Neuroscience ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,Oxygen ,medicine.anatomical_structure ,Posterior cingulate ,Female ,Psychology ,Functional magnetic resonance imaging ,Neuroscience - Abstract
Functional magnetic resonance imaging (fMRI) has been widely used to identify altered intrinsic local neural activities and global networks of tinnitus patients. In this study, functional connectivity density (FCD) mapping, a newly developed voxelwise data-driven method based on fMRI, was applied for the first time to measure the functional reorganization pattern in thirty-two unilateral pulsatile tinnitus (PT) patients in the early stage of disease (less than 48 months). FCD analysis was employed to compute short-range and long-range FCD values. A correlation analysis with clinical variables was also performed. Compared with normal controls, PT patients showed significantly increased short-range FCD, mainly in the precuneus (PCu), bilateral inferior frontal gyrus (IFG) and middle occipital gyrus (MOG), and increased long-range FCD in the PCu, posterior cingulate cortex (PCC), and bilateral middle frontal gyrus (MFG). In addition, correlation analysis showed positive correlations between PT duration and short-range FCD values in the right MOG. Positive correlations were also found between the disease duration and the long-range FCD value in the PCC. The increased short-/long-range FCD in bilateral dorsal visual areas indicated that the enhanced pathway between the auditory cortex and bilateral dorsal visual areas may have activated the "auditory occipital activations" (AOAs) pathway. The bilaterally altered FCD values in the dorsal visual areas reflected the cooperation of different brain areas. This study is a foundation of the connectivity research in PT patients. Our work may advance the understanding of the disrupted neural network of patients with PT.
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- 2015
12. Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study
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Liu Zhaohui, Li Rui, Li Ting, Zhao Pengfei, Dong Cheng, Wang Xiao, Yan Fei, Du Wang, Han Xiaoyi, Lv Han, Wang Zhenchang, and Guo Pengde
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Adult ,Male ,medicine.medical_specialty ,Article Subject ,Brain activity and meditation ,Rest ,Precuneus ,Inferior frontal gyrus ,behavioral disciplines and activities ,lcsh:RC321-571 ,Tinnitus ,Young Adult ,Internal medicine ,Neuroplasticity ,medicine ,Image Processing, Computer-Assisted ,Humans ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Aged ,Neuronal Plasticity ,medicine.diagnostic_test ,Resting state fMRI ,Brain ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Neurology ,Cardiology ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Functional magnetic resonance imaging ,Neuroscience ,Monte Carlo Method ,human activities ,Research Article - Abstract
Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n=42) and age-, sex-, and education-matched normal control subjects (n=42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.
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- 2014
13. Frequency-Dependent Neural Activity in Patients with Unilateral Vascular Pulsatile Tinnitus.
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Lv, Han, Zhao, Pengfei, Liu, Zhaohui, Wang, Guopeng, Zeng, Rong, Yan, Fei, Dong, Cheng, Zhang, Ling, Li, Rui, Wang, Peng, Li, Ting, Gong, Shusheng, and Wang, Zhenchang
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FUNCTIONAL magnetic resonance imaging ,BRAIN physiology ,TINNITUS ,PATHOLOGICAL physiology ,PATIENTS ,DIAGNOSIS - Abstract
Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that neurological changes are important findings in vascular pulsatile tinnitus (PT) patients. Here, we utilized rs-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) in forty patients with unilateral PT and forty age-, gender-, and education-matched normal control subjects. Two different frequency bands (slow-4, 0.027–0.073 Hz, and slow-5, 0.010–0.027 Hz, which are more sensitive to subcortical and cortical neurological signal changes, resp.) were analyzed to examine the intrinsic brain activity in detail. Compared to controls, PT patients had increased ALFF values mainly in the PCu, bilateral IPL (inferior parietal lobule), left IFG (inferior frontal gyrus), and right IFG/anterior insula and decreased ALFF values in the multiple occipital areas including bilateral middle-inferior occipital lobe. For the differences of the two frequency bands, widespread ALFF differences were observed. The ALFF abnormalities in aMPFC/ACC, PCu, right IPL, and some regions of occipital and parietal cortices were greater in the slow-5 band compared to the slow-4 band. Additionally, the THI score of PT patients was positively correlated with changes in slow-5 and slow-4 band in PCu. Pulsatile tinnitus is a disease affecting the neurological activities of multiple brain regions. Slow-5 band is more sensitive in detecting the alternations. Our results also indicated the importance of pathophysiological investigations in patients with pulsatile tinnitus in the future. [ABSTRACT FROM AUTHOR]
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- 2016
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14. Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study.
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Lv Han, Liu Zhaohui, Yan Fei, Li Ting, Zhao Pengfei, Du Wang, Dong Cheng, Guo Pengde, Han Xiaoyi, Wang Xiao, Li Rui, and Wang Zhenchang
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TINNITUS ,FUNCTIONAL magnetic resonance imaging ,BRAIN abnormalities ,BRAIN function localization ,CONTROL groups - Abstract
Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n = 42) and age-, sex-, and education-matched normal control subjects (n = 42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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15. Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa.
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Li, Weihua, Wang, Miao, Wu, Guowei, Wang, Jiani, Li, Xiaohong, Yang, Zemei, Chen, Qian, Yang, Zhenghan, Li, Zhanjiang, Zhang, Peng, Tang, Lirong, and Wang, Zhenchang
- Subjects
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BULIMIA , *FUNCTIONAL connectivity , *FUNCTIONAL magnetic resonance imaging , *SURFACE morphology , *TEMPORAL lobe - Abstract
Background: Bulimia nervosa is a recurrent eating disorder with uncertain pathogenesis. Recently, there has been growing interest in using neuroimaging techniques to explore brain structural and functional alterations in bulimia nervosa, but the findings of previous studies have a great number of inconsistencies. Methods: Here, we collected anatomical and resting‐state functional magnetic resonance imaging data from 43 bulimia nervosa patients and 34 matched healthy controls (HCs). We applied a surface‐based morphology analysis to explore brain cortical morphology differences and a novel surface‐based functional connectivity (FC) analysis to investigate functional abnormalities. Principal component analysis was performed to analyze the behavioral data of the participants. We further analyzed the relationships between abnormalities in cortical characteristics or FC and clinical features. Results: We observed increased greater sulcal depth in the right superior temporal gyrus (STG) and the right medial orbitofrontal cortex (mOFC) in bulimia nervosa patients than in the HCs. Additionally, the patients exhibited increased FC between the right STG and right ventral tegmental area but decreased function between the right mOFC and right putamen, which was significantly negatively correlated with the first principal component reflecting the severity of bulimia nervosa symptom. Conclusions: Our findings provide evidence of neuroanatomical and functional abnormalities in bulimia nervosa patients. Moreover, the FC between the right mOFC and right putamen was associated with symptom severity of bulimia nervosa, which may be a neural marker and involved in the neuropathological mechanism of bulimia nervosa. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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16. Lateralization effects on functional connectivity of the auditory network in patients with unilateral pulsatile tinnitus as detected by functional MRI.
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Lv, Han, Zhao, Pengfei, Liu, Xuehuan, Ding, Heyu, Liu, Liheng, Yang, Zhenghan, Gong, Shusheng, Wang, Zhenchang, Liu, Zhaohui, Wang, Guopeng, Xie, Jing, Zeng, Rong, and Chen, Yuchen
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TINNITUS , *AUDITORY selective attention , *FUNCTIONAL magnetic resonance imaging , *BIOLOGICAL neural networks , *BRAIN function localization - Abstract
Unilateral pulsatile tinnitus (PT) was proved to be a kind of disease with brain functional abnormalities within and beyond the auditory network (AN). However, changes in patterns of the lateralization effects of PT are yet to be established. Relationship between the AN and other brain networks in PT patients is also a scientific question need to be answered. In this study, we recruited 23 left-sided, 23 right-sided PT (LSPT, RSPT) patients and 23 normal controls (NC). We combined applied independent component analysis and seed-based functional connectivity (FC) analysis to investigate alteration feature of the FC of the AN by using resting-state functional magnetic resonance imaging (rs-fMRI). Compared with NC, LSPT patients demonstrated disconnected FC within the AN on both sides. Disrupted network integrity between AN and several brain functional networks, including executive control network, self-perceptual network and the limbic network, was also demonstrated in LSPT patient group bilaterally. In contrast, compared with NC, RSPT demonstrated decreased FC within the AN on the left side, but significant increased FC within the AN on the right side (symptomatic side). Enhanced FC between AN and executive control network, self-perceptual network and limbic network was also found mainly on the right side in patients with RSPT. Positive FC between the auditory network and the limbic network may be a reason to explain why RSPT patients are willing to be in the clinic. Briefly, LSPT exhibit disrupted network integrity in brain functional networks. But RSPT is featured by enhanced FC within AN and between networks, especially on the right (symptomatic) side. Corroboration of featured FC helps to reveal the pathophysiological changing process of the brain in patients with PT, providing imaging-based biomarker to distinguish PT from other kind of tinnitus. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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17. Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease.
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Lv, Han, Zhao, Pengfei, Liu, Zhaohui, Li, Rui, Zhang, Ling, Wang, Peng, Yan, Fei, Liu, Liheng, Wang, Guopeng, Zeng, Rong, Li, Ting, Dong, Cheng, Gong, Shusheng, and Wang, Zhenchang
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TINNITUS , *FUNCTIONAL magnetic resonance imaging , *NEURAL circuitry , *INSULAR cortex - Abstract
Abnormal neural activities can be revealed by resting-state functional magnetic resonance imaging (rs-fMRI) using analyses of the regional activity and functional connectivity (FC) of the networks in the brain. This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus. Compared with healthy controls, PT patients showed regional abnormalities mainly in the left middle occipital gyrus (MOG), posterior cingulate gyrus (PCC), precuneus and right anterior insula (AI). When these regions were defined as seeds, we demonstrated widespread modification of interaction between the auditory and non-auditory networks. The auditory network was positively connected with the cognitive control network (CCN), which may associate with tinnitus related distress. Both altered regional activity and changed FC were found in the visual network. The modification of interactions of higher order networks were mainly found in the DMN, CCN and limbic networks. Functional connectivity between the left MOG and left parahippocampal gyrus could also be an index to reflect the disease duration. This study helped us gain a better understanding of the characteristics of neural network modifications in patients with pulsatile tinnitus. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
18. Sound therapy can modulate the functional connectivity of the auditory network.
- Author
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Lv, Han, Chen, Qian, Wei, Xuan, Liu, Chunli, Zhao, Pengfei, Wang, Zhaodi, Yang, Zhenghan, Gong, Shusheng, You, Hong, and Wang, Zhenchang
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FUNCTIONAL connectivity , *SOUND therapy , *FUNCTIONAL magnetic resonance imaging , *INDEPENDENT component analysis , *AUDITORY cortex - Abstract
The functional connectivity of the auditory network is considered to be important in the development of tinnitus. We hypothesized that sound therapy, as a commonly used effective treatment for tinnitus, can modulate the functional connectivity of the auditory network. In this prospective observational study, we recruited 27 tinnitus patients who had undergone 12 weeks of sound therapy and 27 matched healthy controls. For the two groups of subjects, resting-state functional magnetic resonance imaging was acquired both at baseline and at the 12th week. We utilized independent component analysis and seed-based functional connectivity analysis to characterize the connectivity features of the auditory network. Interaction effects between the two groups and the two scans within the auditory network were observed, which were driven by increased functional connectivity in the left primary auditory cortex (PAC) and decreased values in the secondary auditory cortex (SAC) in tinnitus patients after treatment. Increased connections between the auditory network and limbic network, as well as decreased values with the bilateral thalami, were identified. The effects were mainly driven by the functional connectivity alterations of the SAC rather than that of the PAC. Significant positive correlations between the percent improvement in the Tinnitus Handicap Inventory (THI) score and the percentage change rates of functional connectivity between the SAC and bilateral thalami were observed. Our study contributes to the understanding of the mechanism of tinnitus and effective sound therapy, providing evidence to support the theory of a gain adaptation mechanism that quantifies the recovered gating function of the thalamus in tinnitus patients. • We hypothesized that sound therapy can modulate the functional connectivity (FC) of the auditory network. • This is the first longitudinal investigation that specifically analyzed the FC of the auditory network after therapy. • Results supported the theory of a gain adaptation mechanism of the tinnitus onset. • Secondary auditory cortex may be a better candidate for therapies applying neural suppression techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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