1. Effect of rs1344706 in the ZNF804A gene on the brain network
- Author
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Chen, Xiongying, Zhang, Zhifang, Zhang, Qiumei, Zhao, Wan, Zhai, Jinguo, Chen, Min, Du, Boqi, Deng, Xiaoxiang, Ji, Feng, Wang, Chuanyue, Xiang, Yu-Tao, Wu, Hongjie, Dong, Qi, Chen, Chuansheng, and Li, Jun
- Subjects
Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Brain Disorders ,Neurosciences ,Schizophrenia ,Mental Health ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Analysis of Variance ,Brain ,Connectome ,Female ,Genotype ,Humans ,Image Processing ,Computer-Assisted ,Kruppel-Like Transcription Factors ,Magnetic Resonance Imaging ,Male ,Neural Pathways ,Oxygen ,Polymorphism ,Single Nucleotide ,Psychiatric Status Rating Scales ,Young Adult ,ZNF804A ,Functional magnetic resonance imaging ,Degree centrality ,Brain network ,PCC/PCU ,Biological psychology ,Clinical and health psychology - Abstract
ZNF804A rs1344706 (A/C) was the first SNP that reached genome-wide significance for schizophrenia. Recent studies have linked rs1344706 to functional connectivity among specific brain regions. However, no study thus far has examined the role of this SNP in the entire functional connectome. In this study, we used degree centrality to test the role of rs1344706 in the whole-brain voxel-wise functional connectome during the resting state. 52 schizophrenia patients and 128 healthy controls were included in the final analysis. In our whole-brain analysis, we found a significant interaction effect of genotype × diagnosis at the precuneus (PCU) (cluster size = 52 voxels, peak voxel MNI coordinates: x = 9, y = - 69, z = 63, F = 32.57, FWE corrected P
- Published
- 2018