1. Resting-state brain activity in major depressive disorder patients and their siblings.
- Author
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Liu, Chun-Hong, Ma, Xin, Wu, Xia, Fan, Ting-Ting, Zhang, Yu, Zhou, Fu-Chun, Li, Li-Jun, Li, Feng, Tie, Chang-Le, Li, Su-Fang, Zhang, Dan, Zhou, Zhen, Dong, Jie, Wang, Yong-Jun, Yao, Li, and Wang, Chuan-Yue
- Subjects
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BRAIN stimulation , *DEPRESSED persons , *SIBLINGS , *ROBUST control , *BIOMARKERS , *PHENOTYPES , *MAGNETIC resonance imaging of the brain - Abstract
Abstract: Background: Major depressive disorder (MDD) is a highly heritable psychiatric disease, and the existing literature is not robust enough to allow us to evaluate whether MDD-associated biomarkers are state-independent heritable endophenotypes or state markers related to depression per se. Methods: Twenty two patients diagnosed with MDD, 22 siblings, as well as 26 gender-, age-, and education-matched healthy subjects, participated in the resting-state functional magnetic resonance imaging (fMRI) analysis. We compared the differences in the fractional amplitude of low-frequency fluctuation (fALFF) among the three groups and investigated the correlation between clinical measurements and fALFF in the regions displaying significant group differences. Results: Both the MDD and siblings groups showed an increased fALFF in the left middle frontal gyrus (l-MFG, Brodmann Area, BA 10) compared to the healthy controls. The MDD groups demonstrated an increased fALFF in the right dorsal medial frontal gyrus (r-DMFG, BA 9) and a decreased fALFF in the bilateral lingual gyrus relative to siblings and healthy controls. Limitations: Medication effects, an inability to control subjects' thoughts during imaging. Conclusions: Our results suggest that the dysfunction in the l-MFG may represent an imaging endophenotype which may indicate a risk for MDD. The r-DMFG may play a critical role in depressive symptomatology and may reveal therapeutic target for MDD. [Copyright &y& Elsevier]
- Published
- 2013
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