1. Exceptional Bone Metastasis of Basal Cell Carcinoma in Gorlin-Goltz Syndrome
- Author
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Tatiana Lamon, Laurent Balardy, Gabor Abellan van Kan, Bruno Vellas, Stéphane Gérard, Benjamin Losfeld, and Nicolas Meyer
- Subjects
Male ,Patched Receptors ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Basal Cell Nevus Syndrome ,Pain ,Bone Neoplasms ,Receptors, Cell Surface ,Nevoid basal-cell carcinoma syndrome ,Dermatology ,White People ,Metastasis ,medicine ,Humans ,Basal cell carcinoma ,Neoplasm Metastasis ,skin and connective tissue diseases ,Malignant Skin Neoplasm ,integumentary system ,business.industry ,fungi ,Bone metastasis ,Middle Aged ,medicine.disease ,Focal dermal hypoplasia ,Focal Dermal Hypoplasia ,Radiography ,Falx cerebri ,stomatognathic diseases ,Carcinoma, Basal Cell ,business - Abstract
Background: Basal cell carcinoma (BCC), the most prevalent form of cancer worldwide, is a malignant skin neoplasm. It is locally invasive, with an exceptional incidence of reported metastasis. It can also be part of the Gorlin-Goltz syndrome, an autosomal dominant genetic disorder with high penetrance and variable expressivity, which is principally characterized by cutaneous BCC, odontogenic keratocysts, palmar and/or plantar pits, and falx cerebri calcification. Observation: We report the exceptional clinical observation of a 54-year-old man presenting bone metastasis from BCC in Gorlin-Goltz syndrome. Conclusion: Less than 300 cases of metastatic BCC have been reported in the literature. The present case is the second associated with Gorlin-Goltz syndrome.
- Published
- 2009