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Herein, the activities of the chlorine-containing compounds B 1-4 b and the hybrid polyketide-non ribosomal peptide-derived compound B 5 b were described. To the best of our knowledge, with the exception of compounds B 11 b , B 23 b , and B 24 b , all the other compounds were isolated from I Tolypocladium i sp. for the first time. Compounds B 2 b and B 5 b could strongly inhibit the growth of I S. aureus i ATCC 25923, I S. argenteus i DSM 28299, I B. subtilis i ATCC 6633, and I A. baumanii i ATCC 19606, while compounds B 1 b and B 3 b showed weak inhibition activities. Twenty-six compounds were isolated from the culture of strain YFCC1805002, the chemical structure of these isolated compounds were elucidated by comparing their spectral data including 1D and 2D NMR and ESI-MS with those reported in the literature. [Extracted from the article]