1. Dual stimuli-responsive fungicide carrier based on hollow mesoporous silica/hydroxypropyl cellulose hybrid nanoparticles
- Author
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Shun He, Zhuo Zhang, Hu Wan, Fuxing Zhu, Donglin Li, Jianhong Li, Yunhao Gao, Chenggang Li, Ziping Guo, Yu Liu, and Xueyin Qin
- Subjects
Environmental Engineering ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,Nanoparticle ,Environmental pollution ,02 engineering and technology ,Cellulase ,010501 environmental sciences ,01 natural sciences ,Chromosome aberration ,chemistry.chemical_compound ,Ascomycota ,Environmental Chemistry ,Fourier transform infrared spectroscopy ,Cellulose ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Drug Carriers ,021110 strategic, defence & security studies ,biology ,Hydroxypropyl cellulose ,fungi ,Mesoporous silica ,Silicon Dioxide ,Pollution ,Controlled release ,Fungicides, Industrial ,chemistry ,biology.protein ,Nanoparticles ,Porosity ,Nuclear chemistry - Abstract
The controlled release of pesticides based on nanoparticle platforms has emerged as a new technology for increasing the efficiency of pesticides and for reducing environmental pollution because of their size-dependent and target-modifying properties. In the present study, pH/cellulase dual stimuli-responsive controlled-release formulations (PYR-HMS-HPC) were designed by grafting hydroxypropyl cellulose onto pyraclostrobin-loaded hollow mesoporous silica nanoparticles via an ester linkage. The PYR-HMS-HPC formulations were characterized by Fourier transform infrared spectroscopy, thermogravimetric analyzer, transmission electron microscope and scanning electron microscope. The results demonstrated that PYR-HMS-HPC with a loading capacity of 12.1 wt% showed excellent pyraclostrobin release behaviors in response to acidic environments and the introduction of cellulase, could effectively prevented pyraclostrobin from photolysis. Compared with commercial pyraclostrobin formulations, the PYR-HMS-HPC formulations showed much stronger and statistically significant fungicidal activity against Magnaporthe oryzae from 7 to 21 days. Furthermore, the Allium cepa chromosome aberration assay demonstrated that the PYR-HMS-HPC formulations reduced the genotoxicity of pyraclostrobin. These pH/cellulase dual stimuli-responsive controlled-release formulations are of great interest for sustainable on-demand crop disease protection.
- Published
- 2021
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