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The significant contribution of the clustering algorithm for diagnosis of the clinical condition through medical data consideration is must in the healthcare sector. The currently existing techniques implement the Fuzzy Logic in clustering and have been found by research gap which describes that less focus on the medical data clustering. Thus, this paper introduced a novel algorithm where the enhancement of fuzzy logic is performed to achieve better computational ability in the processing of highly complex medical data such as microarray data. The introduced algorithm is implemented for disease diagnosis and classification. The outcomes of the proposed algorithm are compared with recent approaches like the genetic algorithm, support vector machine (SVM), and artificial neural network (ANN). On analyzing these comparative results found that the proposed clustering model achieved significant performance in response time and classification of disease with better accuracy.

In many diseases classification an accurate gene analysis is needed, for which selection of most informative genes is very important and it require a technique of decision in complex context of ambiguity. The traditional methods include for selecting most significant gene includes some of the statistical analysis namely 2-Sample-T-test (2STT), Entropy, Signal to Noise Ratio (SNR). This paper evaluates gene selection and classification on the basis of accurate gene selection using structured complex decision technique (SCDT) and classifies it using fuzzy cluster based nearest neighborclassifier (FC-NNC). The effectiveness of the proposed SCDT and FC-NNC is evaluated for leave one out cross validation metric(LOOCV) along with sensitivity, specificity, precision and F1-score with four different classifiers namely 1) Radial Basis Function (RBF), 2) Multi-layer perception(MLP), 3) Feed Forward(FF) and 4) Support vector machine(SVM) for three different datasets of DLBCL, Leukemia and Prostate tumor. The proposed SCDT &FC-NNC exhibits superior result for being considered more accurate decision mechanism.