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Your search keyword '"Kliuntina TV"' showing total 4 results
Start Over Author "Kliuntina TV" Topic gaba antagonists
4 results on '"Kliuntina TV"'

1. [The effect of perftoran on the resistance of mice to GABA receptor antagonists and on the antidote activity of anticonvulsant agents].

Author

Golovko AI, Kliuntina TV, Ivanov MB, Sofronov GA, Sviderskiĭ OA, and Shilov VV

Subjects
Animals, Bicuculline poisoning, Diazepam therapeutic use, Drug Evaluation, Preclinical, Drug Resistance, Drug Synergism, Fluorocarbons pharmacology, Male, Mice, Phenobarbital therapeutic use, Picrotoxin poisoning, Poisoning drug therapy, Receptors, GABA-A drug effects, Receptors, Muscarinic drug effects, Anticonvulsants therapeutic use, Antidotes therapeutic use, Fluorocarbons therapeutic use, GABA Antagonists poisoning
Abstract

Perfluorane (a phenobarbital-type inducer of the microsomal enzyme system) raised the resistance of mice to the toxic effect of picrotoxin and bicucullin in 7 days after injection. The antidote effect of diazepam and phenobarbital increased under such conditions. In experiments in vitro a modulatory effect of perftorane on the central muscarine and benzodiazepine receptors was demonstrated.

Published
1996

2. [The effect of salicylates on the toxicity of GABAlytics for mice].

Author

Golovko AI, Sofronov GA, and Kliuntina TV

Subjects
Animals, Drug Interactions, Male, Mice, Protein Synthesis Inhibitors pharmacology, Receptors, GABA-A drug effects, Salicylic Acid, Serum Albumin biosynthesis, Serum Albumin metabolism, Aspirin pharmacology, Bicuculline toxicity, GABA Antagonists toxicity, Picrotoxin toxicity, Salicylates pharmacology
Published
1995

3. [The effect of 3-mercaptopropionic acid on the toxicity of GABA-lytics for mice].

Author

Golovko AI, Sofronov GA, and Kliuntina TV

Subjects
Animals, Brain drug effects, Brain metabolism, Bridged Bicyclo Compounds metabolism, Drug Synergism, Ligands, Male, Mice, Synaptic Membranes drug effects, Synaptic Membranes metabolism, Time Factors, gamma-Aminobutyric Acid metabolism, 3-Mercaptopropionic Acid pharmacology, Bicuculline toxicity, Bridged Bicyclo Compounds, Heterocyclic, GABA Antagonists, Picrotoxin toxicity, gamma-Aminobutyric Acid drug effects
Abstract

The influence of 3-mercaptopropionic acid (3-MPA) on toxicities of bicuculline and picrotoxin was evaluated in mice. It was demonstrated that 3-MPA pretreatment for 5 min increased the toxicities of bicuculline and picrotoxin by 26% and 31%, respectively. 3-MPA did not alter the binding of (3H)TBOB and (3H)GABA to synaptosomal brain membranes of intact mice. The changes in toxicity may be associated with increased binding of GABA-antagonists to their receptors due to decreased brain GABA.

Published
1993

4. [The effect of triorthocresyl phosphate on the toxicity of GABA-lytics for mice].

Author

Golovko AI, Sofronov GA, Nikolaeva TV, Pluzhnikov NN, and Kliuntina TV

Subjects
3-Mercaptopropionic Acid toxicity, Animals, Bicuculline toxicity, Brain drug effects, Brain metabolism, Bridged Bicyclo Compounds metabolism, Carboxylic Ester Hydrolases blood, Carboxylic Ester Hydrolases drug effects, Drug Interactions, In Vitro Techniques, Ligands, Male, Mice, Picrotoxin toxicity, Synaptic Membranes drug effects, Synaptic Membranes metabolism, gamma-Aminobutyric Acid metabolism, Bridged Bicyclo Compounds, Heterocyclic, GABA Antagonists, Tritolyl Phosphates pharmacology, gamma-Aminobutyric Acid drug effects
Abstract

The toxicity of the picrotoxin bicuculline, but not of 3-mercaptopropionic acid increased in mice pretreated with triorthocresyl phosphate (TOCP). TOCP decreased the affinity of brain GABA receptors of intact mice for [3H] GABA. The binding of [3H]-t-butylcycloorthobenzoate was unchanged. The increased toxicity of GABA-antagonists may be associated with inhibition of blood carboxylesterases. The possibility of direct influence of TOCP and its metabolites on the GABA/benzodiazepine receptor complex cannot be excluded.

Published
1993

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