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Start Over Author "Bik, To L" Topic gadd45 proteins
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1. GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations.

Author

Perugini, M, Iarossi, D G, Kok, C H, Cummings, N, Diakiw, S M, Brown, A L, Danner, S, Bardy, P, Bik To, L, Wei, A H, Lewis, I D, and D'Andrea, R J

Subjects
POLYMERASE chain reaction, ACUTE myeloid leukemia, DNA methylation, GADD45 proteins, HUMAN proteins
Abstract

The article presents a study which aims to assess DNA methylation in GADD45A in acute myeloid leukemia (AML) and co-occurrence with other mutations. The study used polymerase chain reaction (PCR) and Sequenom MassARRAY on bisulphite converted genomic DNA to determine GADD45A CpG1-4 methylation frequency. Results reveal that poor overall survival in AML was predicted in GADD45A methylation and G45Ame ability to predict poor outcome was independent of IDH1/2 and DNMT3A mutation.

Published
2013
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