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Your search keyword '"Contrast media -- Chemical properties"' showing total 10 results
Start Over Descriptor "Contrast media -- Chemical properties" Topic gadolinium -- chemical properties
10 results on '"Contrast media -- Chemical properties"'

1. Hybrid gadolinium oxide nanoparticles: Multimodal contrast agents for in vivo imaging

Author

Bridol, Jean-Luc, Faure, Anne-Charlotte, Laurent, Sophie, Riviere, Charlotte, Billotey, Claire, Hiba, Bassem, Tillement, Olivier, Janier, Marc, Josserand, Veronique, Coll, Jean-Luc, Elst, Luce Vander, Muller, Robert, Roux, Stephane, and Perriat, Pascal

Subjects
Gadolinium -- Chemical properties, Gadolinium -- Magnetic properties, Nanoparticles -- Magnetic properties, Nanoparticles -- Chemical properties, Contrast media -- Chemical properties, Contrast media -- Magnetic properties, Chemistry
Abstract

Various luminescent hybrid nanoparticles with a paramagnetic gadolinium oxide core, which are encapsulated within a polysiloxane shell, are applied and used as multimodal contrast agents for in vivo fluorescence, as well as magnetic resonance imaging. The analysis reveals that all these particles are suited for dual modality imaging and hence can be freely circulated in the blood vessels without being accumulated in the lungs and liver.

Published
2007

2. Synthesis and relaxivity studies of a tetranuclear gadolinium(III) complex of DO3A as a contrast-enhancing agent for MRI

Author

Jebasingh, B. and Alexander, V.

Subjects
Gadolinium -- Chemical properties, Magnetic resonance imaging -- Usage, Contrast media -- Chemical properties, Contrast media -- Structure, Chemistry
Abstract

A synthesis to improve the water proton relativity for MRI application using a tetranuclear gadolonium(III) complex, [Gd(sub 4)(4)(H(sub 2)O)(sub 8)] of DO3A appended onto the pentaerythrityl framework was made. The utility of multimetal gadolonium(III) chelates in accelerating water proton relaxitivity and the relaxivity is based on 'molecular' relaxitivity of the tetramer.

Published
2005

3. Kinetics of yttrium-ligand complexation monitored using hyperpolarized [super 89]Y as a model for gadolinium in contrast agents

Author

Mieville, Pascal, Jannin, Sami, Helm, Lothar, and Bodenhausen, Geoffrey

Subjects
Contrast media -- Chemical properties, Gadolinium -- Chemical properties, Magnetization -- Analysis, Nuclear magnetic resonance spectroscopy -- Usage, Organometallic compounds -- Chemical properties, Organometallic compounds -- Magnetic properties, Organometallic compounds -- Structure, Yttrium -- Chemical properties, Yttrium -- Magnetic properties, Chemistry
Abstract

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) has enhanced [super 89]Y spin magnetization and has provided a way to monitor yttrium-ligand complexation on the fly by means of [super 89]Y NMR. The studies have shown an example of free yttrium [Y.sup.3+] being complexed with 1,4,7,10-tetrakis(acetamido)-1,4,7,10-tetraazacyclododecane (DOTAM) to form [[Y(DOTAM)([H.sub.2]O)].sup.3+] as a model for gadolinium in contrast agents.

Published
2010

4. Synthesis and physicochemical characterization of Gd-[C.sub.4]-thyroxin-DTPA, a potential MRI contrast agent. Evaluation of its affinity for human serum albumin by proton relaxometry, NMR diffusometry, and electrospray mass spectrometry

Author

Henoumont, C., Elst, L. Vander, Laurent, S., and Muller, R. N.

Subjects
Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Chemical properties, Magnetic resonance imaging -- Analysis, Mass spectrometry -- Usage, Serum albumin -- Chemical properties, Serum albumin -- Optical properties, Thyroxine -- Chemical properties, Thyroxine -- Optical properties, Chemicals, plastics and rubber industries
Published
2010

5. Nanoassembled capsules as delivery vehicles for large payloads of high relaxivity [Gd.sup.3+] agents

Author

Plush, Sally E., Woods, Mark, You-Fu Zhou, Kadali, Shyam B., Wong, Michael S., and Sherry, A. Dean

Subjects
Magnetic resonance imaging -- Analysis, Nanotechnology -- Research, Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Electric properties, Gadolinium -- Chemical properties, Gadolinium -- Optical properties, Chemistry
Abstract

Nanoassembled capsules (NACs) formed by using the MRI contrast agent GdDOT[P.sup.5-] in the internal polymer aggregate are described, the smaller of which has shown promise as potential MRI contrast agents. The greatest gains in relaxivity are observed for smaller NACs, for which water accessibility has remained high but molecular rotation of the [Gd.sup.3+] chelate is restricted.

Published
2009

6. Responsive MRI agents for sensing metabolism in vivo

Author

De Leon-Rodriguez, Luis M., Lubag, Angelo Josue M., Malloy, Craig R., Martinez, Gary V., Gillies, Robert J., and Sherry, A. Dean

Subjects
Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Chemical properties, Gadolinium -- Optical properties, Magnetic resonance imaging -- Analysis, Chemistry, Science and technology
Published
2009

7. Bioresponsive, cell-penetrating, and multimeric MR contrast agents

Author

Major, Jody L. and Meade, Thomas J.

Subjects
Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Chemical properties, Gadolinium -- Optical properties, Magnetic resonance imaging -- Analysis, Chemistry, Science and technology
Published
2009

9. Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: Implications for MRI contrast agents

Author

Pierre, Valerie C., Botta, Mauro, Aime, Silvio, and Raymond, Kenneth N.

Subjects
Gadolinium -- Chemical properties, Gadolinium -- Structure, Contrast media -- Chemical properties, Contrast media -- Structure, Water -- Chemical properties, Chemistry
Abstract

The increase of the hydration number of hydroxypyridonate-based Gd(super III) complexes by substituting the TAM podand with a moiety capable of hydrogen bonding a third water molecule close to the metal center is described. The resulting nine-coordinate Gd(super III) complex is the first displaying three inner sphere water molecules and high stability.

Published
2006

10. Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

Author

Puerta, David T., Botta, Mauro, Jocher, Christoph J., Werner, Eric J., Avedano, Stefano, Raymond, Kenneth N., and Cohen, Seth M.

Subjects
Gadolinium -- Chemical properties, Contrast media -- Chemical properties, Chelates -- Chemical properties, Chelates -- Structure, Chemistry
Abstract

A new class of pyrone-derived tripodal chelators that form stable and soluble Gd(super 3+) complexes with high relaxivity for use as magnetic resonance imaging contrast agents (MRI-CAs) is described. The compounds are among the most soluble with a q=2 value, and one of them can be readily and economically synthesized from the food additive maltol.

Published
2006

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