1. Synthesis and properties of neutral gadolinium and technetium-99m-labeled complexes.
- Author
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Shen, Yan-Chun, Zhou, Xin, Xia, Xiao-Tian, Yan, Guo-Ping, Dong, Ju-Ping, Lan, Xiao-Li, Guo, Jun-Fang, and Zhang, Yong-Xue
- Subjects
GADOLINIUM ,TECHNETIUM ,COMPLEX compounds synthesis ,DIETHYLENETRIAMINEPENTAACETIC acid ,LIGANDS (Chemistry) ,DOPA ,ETHYL esters - Abstract
Diethylenetriaminepentaacetic di(L-dopa ethyl ester) ligand (DTPA-2LDEE) was synthesized by reaction between diethylenetriaminepentaacetic dianhydride (DTPAA) and L-dopa ethyl ester (LDEE). This ligand reacted with gadolinium chloride and sodium pertechnetate to make the corresponding neutral gadolinium complex Gd-DTPA-2LDEE and technetium-99m-labeled complex99mTc-DTPA-2LDEE, respectively. The ligand and complexes were characterized and their propertiesin vitroandin vivowere also evaluated. Gd-DTPA-2LDEE possessed higher relaxation effectiveness and lower cytotoxicity to human hepatoma HepG-2 cells than Gd-DTPA.99mTc-DTPA-2LDEE had enhanced single-photon emission computed tomography (SPECT) signal enhancements of the kidneys in rats and provided longer duration time than that of99mTc-DTPA. Therefore,99mTc-DTPA-2LDEE can be selectively excreted by the kidneys and used as a potential radioactive probe in SPECT. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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