8 results on '"Ranavolo, Alberto"'
Search Results
2. Multiscale Entropy Algorithms to Analyze Complexity and Variability of Trunk Accelerations Time Series in Subjects with Parkinson's Disease.
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Castiglia, Stefano Filippo, Trabassi, Dante, Conte, Carmela, Ranavolo, Alberto, Coppola, Gianluca, Sebastianelli, Gabriele, Abagnale, Chiara, Barone, Francesca, Bighiani, Federico, De Icco, Roberto, Tassorelli, Cristina, and Serrao, Mariano
- Subjects
PARKINSON'S disease ,ENTROPY ,GAIT disorders ,RECEIVER operating characteristic curves ,KOLMOGOROV complexity ,WALKING speed ,TIME series analysis ,MULTISCALE modeling - Abstract
The aim of this study was to assess the ability of multiscale sample entropy (MSE), refined composite multiscale entropy (RCMSE), and complexity index (CI) to characterize gait complexity through trunk acceleration patterns in subjects with Parkinson's disease (swPD) and healthy subjects, regardless of age or gait speed. The trunk acceleration patterns of 51 swPD and 50 healthy subjects (HS) were acquired using a lumbar-mounted magneto-inertial measurement unit during their walking. MSE, RCMSE, and CI were calculated on 2000 data points, using scale factors (τ) 1–6. Differences between swPD and HS were calculated at each τ, and the area under the receiver operating characteristics, optimal cutoff points, post-test probabilities, and diagnostic odds ratios were calculated. MSE, RCMSE, and CIs showed to differentiate swPD from HS. MSE in the anteroposterior direction at τ4 and τ5, and MSE in the ML direction at τ4 showed to characterize the gait disorders of swPD with the best trade-off between positive and negative posttest probabilities and correlated with the motor disability, pelvic kinematics, and stance phase. Using a time series of 2000 data points, a scale factor of 4 or 5 in the MSE procedure can yield the best trade-off in terms of post-test probabilities when compared to other scale factors for detecting gait variability and complexity in swPD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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3. Pelvic obliquity as a compensatory mechanism leading to lower energy recovery: Characterization among the types of prostheses in subjects with transfemoral amputation.
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Castiglia, Stefano Filippo, Ranavolo, Alberto, Varrecchia, Tiwana, De Marchis, Cristiano, Tatarelli, Antonella, Magnifica, Fabrizio, Fiori, Lorenzo, Conte, Carmela, Draicchio, Francesco, Conforto, Silvia, and Serrao, Mariano
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AMPUTATION , *PROSTHETICS , *PELVIC diseases , *RECEIVER operating characteristic curves , *GAIT in humans , *ARTIFICIAL limbs , *RESEARCH , *NEUROLOGICAL disorders , *CONVALESCENCE , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *GAIT disorders , *PHYSIOLOGICAL adaptation , *COMPARATIVE studies , *WALKING , *PELVIS , *KINEMATICS , *REHABILITATION ,FEMUR surgery - Abstract
Background: Subjects with transfemoral amputation (TFA) show an asymmetric gait pattern associated with a decreased ability to recover mechanical energy and an increased metabolic cost of walking.Research Question: This study aimed to identify the spatio-temporal and kinematic gait variables correlated with mechanical energy values in subjects with TFA and to observe the ability of the identified parameters to discriminate between TFA and controls according to the type of prosthesis.Methods: The gait of 40 subjects with TFA was evaluated with a motion 3-D optoelectronic system. Nine subjects wore a mechanical prosthesis (TFAm), seventeen a C-Leg prosthesis (TFAc), and fourteen a Genium prosthesis (TFAg). Spatio-temporal and pelvic kinematic parameters were measured. Energy recovery was measured relative to the whole-body center of mass (CoM) kinematics as the fraction of mechanical energy recovered during each walking step (R-step). Correlation tests and multiple linear regression analyses were used to evaluate the correlation and association between kinematic and energy variables, respectively. Receiver operating characteristics curves were plotted to assess the ability of the correlated parameter to distinguish subjects with TFA from controls, and optimal cutoff point values were calculated according to the type of prosthesis.Results: Among the spatio-temporal and kinematic parameters correlated to R-step, only pelvic obliquity of the prosthetic side was significantly associated with R-step. It showed an excellent ability to discriminate between TFA and controls. Furthermore, pelvic obliquity showed an excellent discriminative ability in identifying TFAm and TFAc and a good discriminative ability in identifying TFAg from controls.Significance: Pelvic obliquity plays an important role in energy recovery during gait for subjects using prosthetics. This information might be exploited to monitor the adaptation of subjects with TFA to prosthetic devices, to lower the energetic cost of walking potentially, and to reduce the long-term risks of secondary physical complications in prosthetic users. [ABSTRACT FROM AUTHOR]- Published
- 2020
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4. Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease.
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Serrao, Mariano, Chini, Giorgia, Caramanico, Guido, Bartolo, Michelangelo, Castiglia, Stefano Filippo, Ranavolo, Alberto, Conte, Carmela, Venditto, Teresa, Coppola, Gianluca, di Lorenzo, Cherubino, Cardinali, Patrizio, and Pierelli, Francesco
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PARKINSON'S disease ,REHABILITATION ,GAIT disorders ,THERAPEUTICS ,LEG - Abstract
Background: Gait disorders represent one of the most disabling features of Parkinson's disease, which may benefit from rehabilitation. No consistent evidence exists about which gait biomechanical factors can be modified by rehabilitation and which clinical characteristic can predict rehabilitation-induced improvements. Objectives: The aims of the study were as follows: (i) to recognize the gait parameters modifiable by a short-term rehabilitation program; (ii) to evaluate the gait parameters that can normalize after rehabilitation; and (iii) to identify clinical variables predicting improvements in gait function after rehabilitation. Methods: Thirty-six patients affected by idiopathic Parkinson's disease in Hoehn-Yahr stage 1–3 and 22 healthy controls were included in the study. Both clinical and instrumental (gait analysis) evaluations were performed before and after a 10-weeks rehabilitation treatment. Time-distance parameters, lower limb joint, and trunk kinematics were measured. Results: At baseline evaluation with matched speed, almost all gait parameters were significantly different between patients and healthy controls. After the 10-weeks rehabilitation, most gait parameters improved, and spatial asymmetry and trunk rotation normalized. Multiple linear regression of gender combined with Unified Parkinson's Disease Rating Scale-III predicted both ΔSpeed and ΔStep length of both sides; gender combined with Unified Parkinson's Disease Rating Scale-II predicted ΔCadence; age combined with Hoehn-Yahr score and disease duration predicted Δtrunk rotation range of motion. Conclusions: Impaired gait parameters are susceptible to improvement by rehabilitation, and younger men with Parkinson's disease who are less severely affected and at early disease stage are more susceptible to improvements in gait function after a 10-weeks rehabilitation program. [ABSTRACT FROM AUTHOR]
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- 2019
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5. Gait Pattern in Inherited Cerebellar Ataxias.
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Serrao, Mariano, Pierelli, Francesco, Ranavolo, Alberto, Draicchio, Francesco, Conte, Carmela, Don, Romildo, Fabio, Roberto, LeRose, Margherita, Padua, Luca, Sandrini, Giorgio, and Casali, Carlo
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GAIT disorders ,CEREBELLAR ataxia ,KINEMATICS ,MOVEMENT disorders ,CEREBELLUM diseases ,MOTOR neurons - Abstract
Our aim was to perform a comprehensive analysis of the global and segmental features of gait in patients with genetically confirmed inherited ataxias. Sixteen patients with autosomal dominant (spinocerebellar ataxia, SCA1 or 2) or recessive (Friedreich's ataxia, FRDA) ataxia were studied. We used a motion analysis system to record gait kinematic and kinetic data. We measured the mean values of global (time-distance parameters, COM displacement, support moment) and segmental gait parameters (joint displacement and inter-joint coordination), as both discrete and continuous variables, and their variability and correlations with International Cooperative Ataxia Rating Scale (ICARS) scores. We found a marked difference in all global gait parameters between the ataxic patients and the controls and close correlations between longer stride and stance duration and lower gait, posture and total ICARS scores. The only difference between the two patient groups was a shorter step length in the FRDA patients. As regards the segmental features, we found a significantly different waveform shape for all continuous kinematic and kinetic measures between the ataxic patients and the healthy controls, but only minor differences for the discrete measures. Intersegmental coordination evaluated using the continuous relative phase method revealed an irregular alternating joint behaviour without clear evidence of the synchronous pattern of alternating proximal/distal joint seen in healthy subjects. For almost all gait parameters we observed a markedly higher intra-subject variability in the ataxic patients versus the controls, which was strongly related to the clinical ICARS scores. Patients with chronic, progressive inherited ataxias lose the ability to 'stabilize' a walking pattern that can be repeated over time. The most peculiar aspect of the gait of inherited ataxia patients, regardless the different genetic forms, seems to be the presence of increased variability of all global and segmental parameters rather than an invariant abnormal gait pattern. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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6. Adaptive behaviour of the spinal cord in the transition from quiet stance to walking.
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Serrao, Mariano, Ranavolo, Alberto, Andersen, Ole K'seler, Conte, Carmela, Don, Romildo, Cortese, Francesca, Mari, Silvia, Draicchio, Francesco, Padua, Luca, Sandrini, Giorgio, and Pierelli, Francesco
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ELECTROMYOGRAPHY , *SPINAL cord , *GAIT disorders , *JOINT diseases , *ELECTRODIAGNOSIS - Abstract
Background: Modulation of nociceptive withdrawal reflex (NWR) excitability was evaluated during gait initiation in 10 healthy subjects to investigate how load- and movement-related joint inputs activate lower spinal centres in the transition from quiet stance to walking. A motion analysis system integrated with a surface EMG device was used to acquire kinematic, kinetic and EMG variables. Starting from a quiet stance, subjects were asked to walk forward, at their natural speed. The sural nerve was stimulated and EMG responses were recorded from major hip, knee and ankle muscles. Gait initiation was divided into four subphases based on centre of pressure and centre of mass behaviours, while joint displacements were used to categorise joint motion as flexion or extension. The reflex parameters were measured and compared between subphases and in relation to the joint kinematics. Results: The NWR was found to be subphase-dependent. NWR excitability was increased in the hip and knee flexor muscles of the starting leg, just prior to the occurrence of any movement, and in the knee flexor muscles of the same leg as soon as it was unloaded. The NWR was hip joint kinematics-dependent in a crossed manner. The excitability of the reflex was enhanced in the extensor muscles of the standing leg during the hip flexion of the starting leg, and in the hip flexors of the standing leg during the hip extension of the starting leg. No notable reflex modulation was observed in the ankle muscles. Conclusions: Our findings show that the NWR is modulated during the gait initiation phase. Leg unloading and hip joint motion are the main sources of the observed modulation and work in concert to prepare and assist the starting leg in the first step while supporting the contralateral leg, thereby possibly predisposing the lower limbs to the cyclical pattern of walking. [ABSTRACT FROM AUTHOR]
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- 2012
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7. Ability of a Set of Trunk Inertial Indexes of Gait to Identify Gait Instability and Recurrent Fallers in Parkinson's Disease.
- Author
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Castiglia, Stefano Filippo, Tatarelli, Antonella, Trabassi, Dante, De Icco, Roberto, Grillo, Valentina, Ranavolo, Alberto, Varrecchia, Tiwana, Magnifica, Fabrizio, Di Lenola, Davide, Coppola, Gianluca, Ferrari, Donatella, Denaro, Alessandro, Tassorelli, Cristina, Serrao, Mariano, and Ghaffari, Roozbeh
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PARKINSON'S disease ,GAIT in humans ,WALKING speed ,LYAPUNOV exponents ,LOGGERS ,UNITS of measurement ,GAIT disorders - Abstract
The aims of this study were to assess the ability of 16 gait indices to identify gait instability and recurrent fallers in persons with Parkinson's disease (pwPD), regardless of age and gait speed, and to investigate their correlation with clinical and kinematic variables. The trunk acceleration patterns were acquired during the gait of 55 pwPD and 55 age-and-speed matched healthy subjects using an inertial measurement unit. We calculated the harmonic ratios (HR), percent recurrence, and percent determinism (RQAdet), coefficient of variation, normalized jerk score, and the largest Lyapunov exponent for each participant. A value of ≤1.50 for the HR in the antero-posterior direction discriminated between pwPD at Hoehn and Yahr (HY) stage 3 and healthy subjects with a 67% probability, between pwPD at HY 3 and pwPD at lower HY stages with a 73% probability, and it characterized recurrent fallers with a 77% probability. Additionally, HR in the antero-posterior direction was correlated with pelvic obliquity and rotation. RQAdet in the antero-posterior direction discriminated between pwPD and healthy subjects with 67% probability, regardless of the HY stage, and was correlated with stride duration and cadence. Therefore, HR and RQA
det in the antero-posterior direction can both be used as age- and-speed-independent markers of gait instability. [ABSTRACT FROM AUTHOR]- Published
- 2021
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8. Reply to Comment 'Why Do Patients with Cerebellar Ataxia Not Use Environmental Cues for Reducing Unpredictability of Sudden Gait Stopping?' on 'Sudden Stopping in Patients with Cerebellar Ataxia'.
- Author
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Serrao, Mariano, Conte, Carmela, Casali, Carlo, Ranavolo, Alberto, Mari, Silvia, Fabio, Roberto, Perrotta, Armando, Coppola, Gianluca, Padua, Luca, Monamì, Stefano, Sandrini, Giorgio, and Pierelli, Francesco
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EDITORS ,MEDICAL publishing ,CEREBELLAR ataxia ,GAIT disorders ,ATAXIA ,CEREBELLUM diseases ,ANXIETY - Published
- 2013
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