Search

The article presents a study which investigates the overdose of extended-release oxymorphone hydrochloride tablets which resulted to death. It mentions the use of liquid chromatography, gas chromatography and mass spectrometry on the analysis of the concentrations of opiate in the blood and urine. Results show that the compounds temazepam, doxylamine and dextromethorphan are present in the urine samples.

Reports on the use of pattern recognition methods to classify gas chromatograms of weathered and unweathered jet fuels. Characterization of jet fuels; Use of discriminant functions.

A previous study suggested that small amounts of morphine are metabolically converted to hydromorphone. In the present study, morphine positive urine specimens obtained from a postmortem laboratory and a random urinalysis program were tested for morphine, codeine, hydromorphone, hydrocodone, oxymorphone, and oxycodone to assess the possibility that small amounts of hydromorphone are produced from the metabolism of morphine. The opioids were analyzed by gas chromatography–mass spectrometry as their respective trimethylsilyl derivatives following solid phase extraction. The limit of detection for hydromorphone was 5 ng/mL. A total of 73 morphine positive urine specimens were analyzed, with morphine concentrations ranging from 131 to 297,000 ng/mL. Hydromorphone was present at a concentration ≥5 ng/mL in 36 of these specimens at concentrations ranging from 0.02% to 12% of the morphine concentration. Hydrocodone was not detected in these specimens at the assay detection limit of 25 ng/mL. These results support earlier work suggesting that the detection of hydromorphone in urine specimens does not necessarily mean that exogenous hydromorphone or hydrocodone was used. [ABSTRACT FROM AUTHOR]

The article provides information on the case of a 47-year-old man whose death was caused by an abuse on sevoflurane. The presence of sevoflurane was confirmed using a headspace gas chromatography-mass spectrometry. The concentration of the heart blood sevoflurane was 16 mg/L, and the concentration of the peripheral blood sevoflurane was 8.0 mg/L. When the heart blood was examined, no other drugs or other volatile substances were confirmed. Moreover, cardiac arrhythmia due to sevoflurane toxicity was the cause of his death as ruled out by the examiner.

Investigates hydroxycarbazepine distribution in three postmortem cases by researchers from Baltimore, Maryland. Detection of the active metabolite of the anticonvulsant oxacarbazepine in the biological specimens submitted for toxicological analysis; Use of gas chromatography-nitrogen-phosphorus for the detection of the compound; Assertion from the medical examiner that the hydroxycarbazepine was an incidental finding to the cause of death.

Employs gas chromatography-mass spectrometry to monitor the excretion of total cannabinol in 4381 urine voids collected from seven participants through a controlled clinical study of multiple oral doses of cannabinol. Indication that terminal urinal elimination of cannabinol following oral administration was approximately two to three days.

The article focuses on the distribution of ether in two postmortem cases. Headspace gas chromatography-mass spectrometry in the selective ion monitoring mode was used to determine ether concentrations in the two cases. In the first case, the medical examiner ruled that the cause of death was asphyxia due to hanging. In case 2, the cause of death was asphyxia and the manner of death was suicide.