1. Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection.
- Author
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Miyazawa M, Matsuda M, Yano M, Hara Y, Arihara F, Horita Y, Matsuda K, Sakai A, and Noda Y
- Subjects
- Adenocarcinoma chemistry, Adenocarcinoma pathology, Aged, Biomarkers, Tumor analysis, Biopsy, Female, Gastric Fundus chemistry, Gastric Fundus pathology, Humans, Immunohistochemistry, Male, Narrow Band Imaging, Neoplasm Staging, Stomach Neoplasms chemistry, Stomach Neoplasms pathology, Treatment Outcome, Adenocarcinoma surgery, Gastrectomy methods, Gastric Fundus surgery, Gastroscopy methods, Stomach Neoplasms surgery
- Abstract
Recently, a new disease entity termed gastric adenocarcinoma of fundic gland type (GA-FG) was proposed. We treated five cases of GA-FG with endoscopic submucosal dissection. All tumors were small and located in the upper third of the stomach. Four tumors were macroscopically identified as 0-IIa and one was identified as 0-IIb. Narrow-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the remainder. All tumors arose from the deep layer of the lamina propria mucosae and showed submucosal invasion. Lymphatic invasion was seen only in one case, while no venous invasion was recognized. All tumors were positive for pepsinogen-Iā and MUC6 by immunohistochemistry. None showed p53 overexpression, and the labeling index of Ki-67 was low in all cases. All cases have been free from recurrence or metastasis. Herein, we discussed the clinicopathological features of GA-FG in comparison with past reports.
- Published
- 2015
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