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Start Over Author "Walter Octaviano Bernis-Filho" Topic gastric mucosa
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1. Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy Estudos da distribuição e recorrência do Helicobacter spp. na mucosa gástrica de cães após terapia tríplice

Author

Thiago Pires Anacleto, Luiz Roberto Lopes, Nelson Adami Andreollo, Walter Octaviano Bernis Filho, Maria Cristina Costa Resck, and Adriano Macedo

Subjects
Infecção por Helicobacter, Endoscopia, Mucosa Gástrica, Cães, Helicobacter infections, Endoscopy, Gastric Mucosa, Dogs, Surgery, RD1-811
Abstract

PURPOSE: To analyze the triple antimicrobial therapy in positive Helicobacter spp. dogs and to investigate recurrence. METHODS: A total of 20 dogs underwent endoscopy followed by gastric biopsy using the rapid urease test and histopathology stained with Giemsa. Ten animals were treated with triple therapy recommended for humans and divided into control and experimental group. The control group was kept in isolation while the experimental group was placed in contact with positive animals during 60 days. RESULTS: The prevalence of infection in animals in this experiment was 100%, and more frequent in the fundus and the gastric body. Therapy for 7 days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of the animals. Recurrence of the infection in 80% of dogs in the experimental group, while the control group remained eradicated after 60 days. CONCLUSION: Crowded environments associated with close contact with dogs infected with helicobacter are a determinant for transmission of Helicobacter spp. between canines.OBJETIVO: Avaliar a eficácia da terapia tríplice em cães naturalmente infectados pelo Helicobacter spp. e investigar a recorrência da infecção pelo contato com animais infectados. MÉTODOS: Foram utilizados 20 cães, submetidos à endoscopia digestiva alta seguida de biopsia gástrica usando teste rápido da urease e histopatologia corada pelo Giemsa. Dez animais foram tratados com terapia tríplice preconizada para humanos e divididos em grupo controle e experimental. O grupo controle foi mantido em isolamento enquanto que o grupo experimento foi colocado em contato com os animais positivos durante 60 dias. RESULTADOS: A prevalência da infecção nos animais deste experimento foi de 100%, e mais frequente no fundo e corpo gástrico. A terapia durante 7 dias empregando claritromicina, amoxicilina e lansoprazol foi eficaz em 100% dos animais. Houve recorrência da infecção em 80% dos cães do grupo experimental, enquanto que o grupo controle manteve-se erradicado após 60 dias. CONCLUSÃO: Ambientes aglomerados associado a íntimo contato com cães infectados por helicobactérias é fator determinante para transmissão do Helicobacter spp. entre caninos.

Published
2011
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2. Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy

Author

Walter Octaviano Bernis Filho, Maria Cristina Costa Resck, Luiz Roberto Lopes, Thiago Pires Anacleto, Nelson Adami Andreollo, and Adriano Macedo

Subjects
medicine.medical_specialty, Cães, Rapid urease test, Infecção por Helicobacter, Gastroenterology, Helicobacter Infections, Dogs, Anti-Infective Agents, Recurrence, Helicobacter, Metronidazole, Internal medicine, Organometallic Compounds, Prevalence, medicine, Animals, Dog Diseases, Gastric biopsy, Mucosa Gástrica, Close contact, A determinant, Gastric body, biology, business.industry, Amoxicillin, Endoscopy, biology.organism_classification, Gastric Mucosa, Drug Therapy, Combination, Surgery, Endoscopia, business, Helicobacter infections, medicine.drug
Abstract

Purpose: To analyze the triple antimicrobial therapy in positive Helicobacter spp. dogs and to investigate recurrence. Methods: A total of 20 dogs underwent endoscopy followed by gastric biopsy using the rapid urease test and histopathology stained with Giemsa. Ten animals were treated with triple therapy recommended for humans and divided into control and experimental group. The control group was kept in isolation while the experimental group was placed in contact with positive animals during 60 days. Results: The prevalence of infection in animals in this experiment was 100%, and more frequent in the fundus and the gastric body. Therapy for 7 days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of the animals. Recurrence of the infection in 80% of dogs in the experimental group, while the control group remained eradicated after 60 days. Conclusion: Crowded environments associated with close contact with dogs infected with helicobacter are a determinant for transmission of Helicobacter spp. between canines. Key works: Helicobacter infections. Endoscopy. Gastric Mucosa. Dogs. RESUMO Objetivo: Avaliar a eficacia da terapia triplice em caes naturalmente infectados pelo Helicobacter spp. e investigar a recorrencia da infeccao pelo contato com animais infectados. Metodos: Foram utilizados 20 caes, submetidos a endoscopia digestiva alta seguida de biopsia gastrica usando teste rapido da urease e histopatologia corada pelo Giemsa. Dez animais foram tratados com terapia triplice preconizada para humanos e divididos em grupo controle e experimental. O grupo controle foi mantido em isolamento enquanto que o grupo experimento foi colocado em contato com os animais positivos durante 60 dias. Resultados: A prevalencia da infeccao nos animais deste experimento foi de 100%, e mais frequente no fundo e corpo gastrico. A terapia durante 7 dias empregando claritromicina, amoxicilina e lansoprazol foi eficaz em 100% dos animais. Houve recorrencia da infeccao em 80% dos caes do grupo experimental, enquanto que o grupo controle manteve-se erradicado apos 60 dias. Conclusao: Ambientes aglomerados associado a intimo contato com caes infectados por helicobacterias e fator determinante para transmissao do Helicobacter spp. entre caninos. Descritores: Infeccao por Helicobacter . Endoscopia. Mucosa Gastrica. Caes.

Published
2011

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