Author: "Joanna C. Chapman" / Topic: gastroenterology - Searchworks@Jio Institute Digital Library Search Results

Author: Jason I.E. Bruce, Kevin C. Pedley, Keith J. Lindley, Shanta J. Persaud, Albert Aynsley-Green, Mark J. Dunne, Karen E. Cosgrove, Austin C. Elliott, Peter H.G.M. Willems, Remko R. Bosch, Jan Joep E.M.M. De Pont, Rolf L.L. Smeets, Joanna C. Chapman, Carina Ämmälä, and Charlotte Kane
Subjects: Gastroenterology
Published: 1997
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Author: Charlotte Kane, Shanta J. Persaud, Mark J. Dunne, Austin C. Elliott, Jason I.E. Bruce, Remko R. Bosch, Albert Aynsley-Green, Carina Ämmälä, Joanna C. Chapman, Keith J. Lindley, Kevin C. Pedley, Jan Joep E.M.M. De Pont, Rolf L.L. Smeets, Peter H.G.M. Willems, and Karen E. Cosgrove
Subjects: Gastroenterology
Published: 1997
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Author: Joanna C. Chapman, Mark J. Dunne, Albert Aynsley-Green, Remko R. Bosch, Keith J. Lindley, Jan Joep E.M.M. De Pont, Rolf L.L. Smeets, Karen E. Cosgrove, Carina Ämmälä, Shanta J. Persaud, Austin C. Elliott, Peter H.G.M. Willems, Jason I.E. Bruce, Kevin C. Pedley, and Charlotte Kane
Subjects: Gastroenterology
Published: 1997
Full Text: View/download PDF

Author: Charlotte Kane, Remko R. Bosch, Jan Joep E.M.M. De Pont, Jason I.E. Bruce, Mark J. Dunne, Peter H.G.M. Willems, Rolf L.L. Smeets, Shanta J. Persaud, Austin C. Elliott, Albert Aynsley-Green, Carina Ämmälä, Joanna C. Chapman, Karen E. Cosgrove, Kevin C. Pedley, and Keith J. Lindley
Subjects: Gastroenterology
Published: 1997
Full Text: View/download PDF

Author: Albert Aynsley-Green, Karen E. Cosgrove, Shanta J. Persaud, Remko R. Bosch, Austin C. Elliott, Joanna C. Chapman, Keith J. Lindley, Carina Ämmälä, Mark J. Dunne, Charlotte Kane, Jason I.E. Bruce, Peter H.G.M. Willems, Rolf L.L. Smeets, Kevin C. Pedley, and Jan Joep E.M.M. De Pont
Subjects: Gastroenterology
Published: 1997
Full Text: View/download PDF

Author: Charlotte Kane, Mark J. Dunne, Remko R. Bosch, Jan Joep E.M.M. De Pont, Shanta J. Persaud, Albert Aynsley-Green, Carina Ämmälä, Austin C. Elliott, Karen E. Cosgrove, Joanna C. Chapman, Keith J. Lindley, Kevin C. Pedley, Rolf L.L. Smeets, Peter H.G.M. Willems, and Jason I.E. Bruce
Subjects: business.industry, Gastroenterology, Medicine, business
Published: 1997
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Author: Kevin C. Pedley, Shanta J. Persaud, Mark J. Dunne, Austin C. Elliott, Jan Joep E.M.M. De Pont, Joanna C. Chapman, Albert Aynsley-Green, Jason I.E. Bruce, Peter H.G.M. Willems, Karen E. Cosgrove, Remko R. Bosch, Charlotte Kane, Carina Ämmälä, Keith J. Lindley, and Rolf L.L. Smeets
Subjects: Gastroenterology
Published: 1997
Full Text: View/download PDF

Author: Carina Ämmälä, Mark J. Dunne, Albert Aynsley-Green, Joanna C. Chapman, Charlotte Kane, Keith J. Lindley, and Karen E. Cosgrove
Subjects: medicine.medical_specialty, Potassium Channels, medicine.medical_treatment, Cell, Stimulation, Biology, Ion Channels, Islets of Langerhans, Adenosine Triphosphate, Hyperinsulinism, Internal medicine, medicine, Animals, Humans, Insulin, Secretion, Ion channel, Pancreatic islets, Gastroenterology, Infant, Hypoglycemia, Cell biology, medicine.anatomical_structure, Endocrinology, Mechanism of action, medicine.symptom, Beta cell
Abstract: The regulation of insulin secretion from beta-cells of the pancreatic islets of Langerhans is a highly integrated process involving several plasma membrane ion channels. The key to our understanding of the normal process is the hypothesis that glucose-induced closure of K+ channels leads to a depolarization of the cell membrane potential and the opening of voltage-gated Ca2+ channels. Support for this is provided by direct electrophysiological recordings of ion channel activity, and by recent data that have revealed how gene defects in ion channel subunits leads to the loss of regulated insulin secretion. Here, we review the general features of stimulus-response coupling in beta-cells, and how novel initiatives are providing key insights into beta-cell pathogenesis.

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