1. Novel coumarin-based pyrazoline derivatives organogels for Fe3+ detection and application in cell imaging.
- Author
-
Yang, Yun-Shang, Yang, Chen, Zhang, Ying-Peng, Guo, Hui-Chen, Cao, Jing-Qi, and Xue, Ji-Jun
- Subjects
- *
CELL imaging , *COUMARINS , *CELL nuclei , *AQUEOUS solutions , *GELATION , *IRON ions - Abstract
Two novel coumarin-based pyrazoline derivatives have been designed and synthesized as organogel factors. Organogelators Z 1–2 both have gelation behavior in alcohol solution and DMSO. Gel- tert -butanol Z 1–2 (CGC = 1.84%, 1.41%) fluoresce blue and yellow-green under ultraviolet irradiation, respectively. Z 1–2 both exhibit selectivity for response to Fe3+ in THF-deionized aqueous (V: V = 9:1) solution, meanwhile display high sensitivity. Notably, introducing diethylamino at 7-position the coumarin unit increases the detection line range in Z 2. Furthermore, Z 2 not only has a good biocompatibility in living cells but also the sensing behavior of Fe3+ in the cell nucleus. The coordination mechanism of gelators Z 1–2 and Fe3+ were performed at the DFT level. [Display omitted] • Two novel coumarin-based pyrazoline organogelators Z 1–2 have designed and synthesized. • The Z 1–2 can both form fluoresce organogels in tert-butanol (CGC=1.84%, 1.41%). • The Z 1–2 can both response to Fe3+ in aqueous solution and organogels with selectivity and sensitivity. • The Z 2 can detect Fe3+ in living cells. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF