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Background Nail involvement is frequently observed in various dermatoses including psoriasis, lichen planus, and alopecia areata. Vitiligo affects 0.1-4% of global population. It is associated with other autoimmune disorders having nail abnormalities. The frequency and nature of nail abnormalities in vitiligo are not known in our local population. Objective To determine the frequency and types of nail changes in patients of vitiligo. Methods This cross-sectional study was conducted in the Dermatology outpatient department of Jinnah Hospital Lahore, Pakistan for duration of six months. 240 cases of vitiligo, of both genders, ages between 15-50 years and with any duration of disease were enrolled. Results In our study population of 240 cases, 150 cases (62.5%) of vitiligo had nail changes. 40.67% (n=61) had longitudinal ridging, 12.67% (n=19) had leukonychia, 10.67% (n=16) had absent lunula, 5.33% (n=8) had trachonychia, 4.67% (n=7) had onycholysis, 4.67% (n=7) had clubbing and 4% (n=6) had splinter hemorrhages. Conclusion Nail changes were observed in more than sixty percent cases of vitiligo. Longitudinal ridging was the most common type of nail abnormality followed by leukonychia and absent lunula. [ABSTRACT FROM AUTHOR]