1. Is HLA class II profile relevant for the study of large-scale differentially expressed genes in type 1 diabetes mellitus patients?
- Author
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Rassi DM, Junta CM, Fachin AL, Sandrin-Garcia P, Mello SS, Fernandes AP, Deghaide NN, Foss-Freitas MC, Foss MC, Sakamoto-Hojo ET, Passos GA, and Donadi EA
- Subjects
- Algorithms, Alleles, Case-Control Studies, Child, Cluster Analysis, Diabetes Mellitus, Type 1 diagnosis, Diabetes Mellitus, Type 1 immunology, Female, HLA-DQ Antigens genetics, HLA-DR Antigens genetics, Humans, Male, Metabolism genetics, Oligonucleotide Array Sequence Analysis, Diabetes Mellitus, Type 1 genetics, Gene Expression, Histocompatibility Antigens Class II genetics
- Abstract
We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM-1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human-leukocyte-antigen (HLA)-DRB1/DQB1 profile. The dendrogram obtained using the Cluster program grouped patients and controls into three clusters, one including individuals with no susceptibility alleles, another including individuals with at least three susceptibility alleles, and a third intermingling susceptibility/protective alleles. In addition to other variables, the results of the present article suggest that the major histocompatibility complex (MHC) class II profile may be of relevance for the study of a large-scale differentially expressed genes.
- Published
- 2006
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