1. Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?
- Author
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Hue, Susan Swee-Shan, Suhail, Sufi Muhammad, Choo, Jason Chon Jun, Yusof, Nurhashikin, Loh, Alwin Hwai-Liang, and Salcido-Ochoa, Francisco
- Subjects
CELL physiology ,ELECTRON microscopy ,GENE expression ,GENES ,HOMEOSTASIS ,IMMUNOSUPPRESSION ,KIDNEY glomerulus ,NEPHROTIC syndrome ,T cells - Abstract
Minimal change disease constitutes a major cause of nephrotic syndrome. It is regarded as a non-immune-complex mediated primary glomerulopathy and pathogenetically is characterised by podocyte injury and effacement of foot processes; therefore, it is also classified as a type of podocytopathy. T cell dysfunction with increased levels of a soluble glomerular permeability factor has been proposed to play a major role in the pathogenesis of minimal change disease. It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary minimal change disease is still largely unclear. We here propose a theoretical model based on the available evidence. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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