1. Polymorphism of DC-SIGN ( CD209) Promoter in Association with Clinical Symptoms of Dengue Fever.
- Author
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Oliveira, Layanna Freitas de, Lima, Clayton Pereira Silva de, Azevedo, Raimunda do Socorro Silva, Mendonça, Dafne Silva Furtado de, Rodrigues, Sueli Guerreiro, Carvalho, Valéria Lima, Pinto, Eliana Vieira, Maia, Andreza Lopes, Maia, Maria Helena Thomaz, Vasconcelos, Janaina Mota, Silva, Andrea Luciana Soares da, Nunes, Márcio Roberto Teixeira, Sena, Leonardo, Vasconcelos, Pedro Fernando, and Santos, Eduardo José Melo dos
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DENGUE , *SINGLE nucleotide polymorphisms , *PROMOTERS (Genetics) , *LECTINS , *VIREMIA , *ALLELES , *GENE expression , *MEDICAL research , *GENETICS - Abstract
C-type lectin DC-SIGN receptor, encoded by CD209, plays a key role in the infection of dendritic cells by dengue virus (DENV). Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis. A control sample of 72 individuals, rigorously selected through a clinical investigation for absence of past dengue fever (DF) was compared to a sample of 168 patients (156 classical DF; 12 dengue hemorrhagic fever), all residents from Pará, Brazil. However, the prevalence of symptoms showed a trend higher in the AA genotype (Wilcoxon test; Z=2.02; p=0.04). Hence, our findings indicate that the G allele downregulates the spectrum of symptoms during the early acute phase of DENV infection, putatively decreasing the viremia, as suggested in the literature. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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