1. Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival.
- Author
-
Venkataraman, Girish, Song, Joo Y., Tzankov, Alexandar, Dirnhofer, Stephan, Heinze, Georg, Kohl, Maria, Traverse-Glehen, Alexandra, Eberle, Franziska C., Hanson, Jeffrey C., Raffeld, Mark A., Pittaluga, Stefania, and Jaffe, Elaine S.
- Subjects
- *
ECTOPIC tissue , *T cell receptors , *HODGKIN'S disease , *POLYMERASE chain reaction , *GENE expression , *CONFIDENCE intervals - Abstract
Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) rarely express T-cell-associated antigens (TCA), but the clinical significance of this finding is uncertain. Fifty cHLs expressing any TCA on the HRS cells (TCA-cHL) were identified in two cohorts (National Cancer Institute, n = 38; Basel, n = 12). Diagnostic pathology data were examined in all cases with additional T-celI receptor ~y rearrangements (TRG@) polymerase chain reaction (PCR) in a subset of cases. The outcome data were compared with a cohort of cHLs negative for TCA (n = 272). Primary end points examined were event-free survival (EFS) and overall survival (OS). The median age in the TCA-cHL group was 40 years (range, 10-85 years). Seventy percent presented in low stage (stage I/II) at presentation with nodular sclerosis (NS) histology predominating in 80% of cases. Among the TCA, CD4 and CD2 were most commonly expressed, seen in 80.4% and 77.4% of cases, respectively. TRG@ PCR was negative for clonal rearrangements in 29 of 31 cases. During a median follow up of 113 months, TCA expression predicted shorter OS (adjusted hazard.ratio [HRadj] = 3.32 [95% confidence interval (Cl): 1.61, 6.84]; P = .001) and EFS (HRadj 2.55 [95% Cl: 1.45, 4.49]; P = .001). TCA-cHL often display NS histology, lack T-celI genotype, and are independently associated with significantly shorter OS and EFS compared with TCA-negative cHLs. (Blood. 2013;121(10):1795-1804) [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF