1. Compounds isolated from the pericarp of Zanthoxylum bungeanum and inhibitory activity against LPS-induced NO production in RAW264.7.
- Author
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Liu, Jing-Yi, Wang, Yi-Fan, Dai, Yan-Qiu, Huang, Shuai, Xie, Jiang, Chen, Lin, and Zhou, Xian-Li
- Subjects
PHYTOTHERAPY ,INFLAMMATION prevention ,LIPOPOLYSACCHARIDES ,BIOLOGICAL models ,IN vitro studies ,ANTI-inflammatory agents ,ANIMAL experimentation ,WESTERN immunoblotting ,MACROPHAGES ,GENE expression ,CELLULAR signal transduction ,FRUIT ,RESEARCH funding ,PLANT extracts ,NITRIC oxide ,MOLECULAR structure ,CELL lines ,CHROMATOGRAPHIC analysis ,DATA analysis software ,MICE ,SPECTRUM analysis ,PHARMACODYNAMICS - Abstract
Seventeen compounds were isolated and identified from the ethyl acetate part of Zanthoxylum bungeanum Maxim., including one new compound 18-acetyloxyneocryptotanshinone (1) and 16 known compounds (2–17). Their structures were elucidated by extensive spectroscopy. The absolute configuration of 1 was confirmed by electronic circular dichroism (ECD). All compounds were evaluated for the inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, of which 1 and 10 exhibited the most significant inhibitory effect, with IC
50 of 17.29 and 10.27 μM, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2023
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