1. Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats.
- Author
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Xiong L, Liyue H, Fancai Z, Maoting L, Ya L, Ting H, Zhen Y, Shanshan Z, Wenwen G, and Yan T
- Subjects
- Animals, Hippocampus metabolism, Learning Disabilities psychology, Male, Maze Learning drug effects, Memory Disorders psychology, Phosphorylation drug effects, Rats, Sprague-Dawley, Flame Retardants adverse effects, Gene Expression drug effects, Halogenated Diphenyl Ethers adverse effects, Learning Disabilities chemically induced, Memory Disorders chemically induced, Receptors, AMPA genetics, Receptors, AMPA metabolism, Receptors, N-Methyl-D-Aspartate genetics, Receptors, N-Methyl-D-Aspartate metabolism, Spatial Learning drug effects, Spatial Memory drug effects
- Abstract
Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but the effects on adult animals are rare or controversial and the mechanism is not fully understood. In the present study, male adult Sprague-Dawley rats performed poor spatial learning and memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression of hippocampal glutamate receptor subunits NR1, NR2B and GluR1, the phosphorylation of NR2B subunit at Ser1301 (p-NR2B Ser1303) and GluR1 subunit at Ser831 (p-GluR1 Ser831) were all decreased, and the phosphorylation ratio of NR2B revealed an increasing trend after BDE 209 exposure. The present study provided evidence that BDE 209 could induce spatial learning and memory deficits in adult rats, and further explored the potential mechanism.
- Published
- 2018
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