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It is extremely difficult to synthesize in a paper the extremely wide diversity of the issues related to such a vast chapter such as the tumours in the ENT area and the cervical-facial region. The review analyses the variety of benign and malignant types of tumours, presenting various types of tumours on anatomical organs or regions, insisting with more extensive data from the literature on less frequent tumours or involving more distinct therapies, perhaps leading to a lack of balance and uniformity. Tumours are defined as excessive proliferation of abnormal cells that resemble more or less the tissue in which they develop and end up by acquiring biological autonomy. The study performed presents a batch of 425 patients diagnosed with benign tumours - 306 cases (72.0%) and 119 cases with ENT and cervical-facial malignant tumours that had extensions to the surrounding organs and metastatic adenopathies, admitted and treated at the Clinical Maxillofacial Surgery Clinic of the County Clinical Hospital between 1.01.2015 - 31.12.2018. The entire cancerous lesion is surgically removed together with a small surrounding healthy tissue area to ensure that all malignant cells have been removed. The purpose of the surgery is to remove all affected tissues without compromising the integrity of the structures in the other areas of the oral cavity. Tumours develop from the oropharynx: the tonsils, the base of the tongue, the soft palate, the pharyngeal posterior wall. Most often, the tumour affects the tongue floor, the mucous of the mouth and the tonsils.

The morphology and physiology of odonto-periodontal units, muscles, temporomandibular joints, maxillary bones, ligaments are in a constant balance, even if all these components are subject to continuous transformation. Affecting a systemic element will attract imbalances to other levels, and the therapeutic solution will require knowledge and understanding of the ensemble. A complete dental exam must allow identification of all factors responsible or likely to cause imbalance in the stomatognat system. The maxillary compression is an abnormality characterized by a transversal developmental deficiency in the upper jaw and / or the mandibular, showing morpho-functional changes that denote a complex disruption in the development of the dento-maxillary apparatus. The common modification of all the fractured cases is the insufficient development in a transversal sense, dental arcades (mono - or bimaxilar), along with facial and maxillary bone changes, disturbances of inter - maxillary or occlusion blocking, functional deficits and disturbances. The strictly mandibular compression situation is very rare and addresses cases by affecting growth at the condylian level. The study includes 27 cases with jaw compression and benefited from orthognat surgery in the Maxillofacial Surgery Clinic between 2015 - 2018. If untreated, the abnormality determines the appearance of many cavities especially in the front teeth, difficulty in performing dental hygiene will lead to chronic marginal periodontitis, the occurrence of abnormal contact between teeth with joint pain, decreased chewing field. The jaw compression is revealed by multiple facial and oral signs, as well as by functional changes. Orthognatic surgery is the only effective treatment for many patients in jaw compression.

The wide concept of health does not benefit of a single definition, but of multiple definitions and this plurality is related to the knowledge assimilated and the socio-economic dynamics. This is due to the fact that health is an ongoing process, its notion changing with the passage of time. Thus, at international level, health is nowadays defined considering multiple criteria. In the last decade, the analysis of relevant statistical data presents an unfavourable evolution for the three major components of population dynamics: natality, mortality and external migration, accompanied by the deterioration of the entire demographic construction and tendencies of heading towards an imminent demographic drift. Humans protect themselves against the microbial aggression by using their inborn barriers and mechanisms that are completed and modulated by acquired barriers and mechanisms. For a microorganism to reach the internal environment and generate an infectious process, it must get through and overcome these barriers. In order to overcome these barriers, the infectious agent must first adhere to the surface of epithelial cells and then pass through the epithelium. Local defence mechanisms help limit the infection and present the antigen to the regional lymphatic ganglions, contributing at the initiation of the immune response. On the other hand, the infectious agent present in the lymphatic system causes lymphangitis and satellite adenitis, which stand as a filter in the infections� way. The study included 127 patients with bacterial infections that were studied from 2014 to 2018. Infection can be caused by certain species of germs whose main feature is pathogenicity. Specific infections are caused by a foreign infectious agent that has accidentally reached the oral cavity causing oral lesions (appear in the secondary phase of the general infection). Specific infections are individualized, caused by a single microbe (monomicrobial) while the non-specific ones are associated (polymicrobial).

The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. The total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were determined in serum of thepatients. We noticed a significant lower mean of TAC levels (p[ 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. The MDA had significantly higher mean values (p[ 0.001) compared to the healthy group.The imbalance of antioxidant systems to oxidizing molecules plays an important role in the pathogenesis of CSOM with and without cholesteatoma.

Vogt-Koyanagi-Harada syndrome(VKH) is a multisystemic disorder characterized by granulomatous panuveitis and cutaneous, otorhynolaryngologic and neurologic involvement, due to an autoimmune reaction against melanocytic antigens. Autoinflammatory associations of VKH, including inflammatory bowel disease and psoriasis, were rarely described. SAPHO syndrome (an acronym for synovitis, acne, hyperostosis, pustulosis and osteitis) is a rare autoinflammatorymusculo-scheletal disease. This paper reports on a male patient presenting for long-lasting bone and joint pain, dysphagia,having a ten-year history of bilateral optic neuritiswhich required high-dose corticosteroids. Fundoscopy revealed diffuse chorioretinalnonpigmented atrophic lesions. Vitiligo, acne scars, clavicular deformity, recurrent chest pain and sacroiliitis pointed to a long-standing SAPHO syndrome and late-phase VKH. Blood tests found inflammation and anti-hepatitis C antibodies with repeatedly undetectable viremia. Bone scintigraphy with the characteristic bull�s head upper chest uptake and the radiographs confirmed SAPHO syndrome. The patient was treated with sulphasalazine and cyclosporin A, with alleviation of the articular and bony disease. In conclusion, SAPHO syndrome may add to the list of the diseases associated with VKH. Although VKH and SAPHO syndrome may have appeared coincidentally, a common pathogenesis involving an infectious trigger and IL-17 could be considered.

Three-dimensional printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. Nowadays, 3D printing is very well integrated in the surgical practice and research. Also, the field of head and neck reconstructive surgery is constantly evolving because of the three-dimensional printing, a technology which can be widely used in a variety of situations such as reconstruction of tissue defects, surgical planning, medical modeling and prosthesis. By using 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients and will also provide a rapid production of personalized patient-specific devices. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otorhinolaryngology.

Malignancies of the nasal cavity and the paranasal sinuses are rare, counting for less than 3 % of the ENT-cancers. The insidious onset of these tumours with non-specific symptoms often leads to a delayed diagnostic. Advanced disease stage combined with the complex anatomy of the sinonasal cavities and anterior skull base encouraged surgeons to extend beyond the boundaries the classic surgical techniques. Surgical approaches to anterior skull base lesions can be divided into open approches: craniofacial, subcranial, endoscopic techniques or combined approaches when a craniotomy is associated with an endonasal endoscopic approach. The indication must take into consideration the oncologic principles, histopathology exam, extent of disease and surgeon skill and experience. Combined approach should be taken into consideration for patients with extended disease or significant intraorbital or intracranial extension. For certain tumours that require a craniotomy for the superior, superolateral, and anterior extensions of the disease and also a nasal and paranasal sinus tumor that could be removed endoscopically, an endoscopic-assisted approach can be considered.