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Your search keyword '"Samuel E. McKinney"' showing total 3 results
Start Over Author "Samuel E. McKinney" Topic general biochemistry, genetics and molecular biology
3 results on '"Samuel E. McKinney"'

1. Some Normal Laboratory Values in the Dog

Author

John E. Baer, Samuel E. Mckinney, and Harold M. Peck

Subjects
Creatinine, Pathology, medicine.medical_specialty, Blood Cells, Mongrel dogs, Nitrogen, business.industry, Normal laboratory, Chemical data, Physiology, Blood Sedimentation, General Biochemistry, Genetics and Molecular Biology, Body Fluids, Electrolytes, chemistry.chemical_compound, Dogs, chemistry, Reference Values, Reference values, cardiovascular system, Animals, Medicine, business
Abstract

SummaryHematologic and clinical chemical data were obtained on 3 occasions in over 100 apparently healthy female mongrel dogs. Procedures are described and the normal ranges presented.

Published
1957
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2. Effect of antispasmodic and ganglionic blocking agents on mortality following electroshock convulsions in mice

Author

C.A. Stone, M. L. Torchiana, Katherine L. Meckelnburg, and Samuel E. Mckinney

Subjects
Ganglionic blocking agent, Benactyzine, Electroshock, medicine.drug_class, business.industry, Ganglionic Blockers, Parasympatholytics, Pharmacology, Pentolinium, General Biochemistry, Genetics and Molecular Biology, Chlorisondamine, Propantheline, Atropine, chemistry.chemical_compound, Mice, chemistry, Seizures, Mecamylamine, Anticholinergic, medicine, Animals, business, medicine.drug
Abstract

SummaryAbility of several antispasmodic and ganglionic blocking substances to produce immediate death following maximal electro-shock convulsions in mice has been demonstrated. With most agents studied (atropine, atropine methyl nitrate, benactyzine, mepiperphenidol, methantheline, propantheline, scopolamine, scopolamine methiodide, mecamylamine, chlorisondamine, pentolinium and hexamethonium), the post seizure lethal effect was produced in doses approximating that required to produce a peripheral anticholinergic effect in the same species (pupil dilatation). Neither atropine nor mecamylamine altered the electroconvulsive threshold.Respiratory failure appeared to be the cause of drug-induced post seizure deaths, but the mechanism of action was not revealed.

Published
1959

3. NEW METABOLIZABLE IMMUNOLOGIC ADJUVANT FOR HUMAN USE. 2. SHORT-TERM ANIMAL TOXICITY TESTS

Author

Maurice R. Hilleman, D. P. Metzgar, Harold M. Peck, A. F. Woodhour, and Samuel E. Mckinney

Subjects
Influenza vaccine, medicine.medical_treatment, Freund's Adjuvant, Guinea Pigs, Biology, Toxicology, General Biochemistry, Genetics and Molecular Biology, Mice, Human use, Adjuvants, Immunologic, Toxicity Tests, medicine, Animals, Humans, Peritoneal Cavity, Adjuvants, Pharmaceutic, Skin Tests, Muscles, Research, Haplorhini, Freund's adjuvant, Influenza Vaccines, Immunologic adjuvant, Toxicity, Immunology, Rabbits, Adjuvant
Abstract

SummaryA new immunologic adjuvant, called adjuvant 65, was assayed for toxicity, safety and irritancy in several species of animals. Clinical, gross and histomorphologic examinations were made. The reactions which resulted from adjuvant 65 vaccines were mild and inconsequential and far less than were obtained in comparable tests with Freund's incomplete mineral oil adjuvant vaccine. The comparative pathology for the 2 different kinds of adjuvant is presented and the theoretical and practical advantages of adjuvant 65 are discussed.

Published
1964

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