1. Effects of prostaglandin-E1on ST segment elevation and regional myocardial blood flow during experimental myocardial ischaemia in dogs
- Author
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Richard C. Talbot, Michael F. Oliver, Ole D. Mjøs, Alex Ungar, and Rudolph A. Riemersma
- Subjects
medicine.medical_specialty ,Clinical Biochemistry ,Coronary Disease ,Fatty Acids, Nonesterified ,Anterior Descending Coronary Artery ,Biochemistry ,Electrocardiography ,chemistry.chemical_compound ,Dogs ,Coronary Circulation ,Isoprenaline ,Internal medicine ,Occlusion ,medicine ,Animals ,ST segment ,Prostaglandin E1 ,business.industry ,Myocardium ,Prostaglandins E ,Hemodynamics ,Isoproterenol ,General Medicine ,Blood flow ,Blood pressure ,chemistry ,Anesthesia ,Catecholamine ,Cardiology ,lipids (amino acids, peptides, and proteins) ,business ,medicine.drug - Abstract
The effects of prostaglandin E1 (PGE1) on myocardial ischaemia (as measured by epicardial ST segment changes), myocardial flow and substrate exchange has been studied in dogs. Myocardial ischaemia was induced by intermittent external clipping of a branch of the left anterior descending coronary artery. During occlusion with a continuous intravenous infusion of isoprenaline, elevated epicardial ST segments (∑ST), were raised to 46 ± 6 mV (mean ± SEM). Pretreatment with PGE1 reduced ∑ST to 34 ± 6 mV (P
- Published
- 1977
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