Search

The types of minimarkets Alfamart and Indomaret are retail businesses with a franchise concept that are currently experiencing rapid growth in Indonesia. The spread of minimarkets has entered residential areas. In this regard, this study aims to analyze the effect of the existence of Alfamart and Indomart on the existence of small stalls in the city of Palopo. The type of this research is field research with qualitative methods. The data collection techniques used are interviews, observation. Further analysis the data used is inductive. Based on the analysis of the data it is concluded that the existence of Alfamart and Indomaret in the city of Palopo has an impact on the income of the small shop in the city of Palopo. This causes unfair competition and even causes losses for small shop. Keywords: existence; Alfamart; Indomart; Small Stall

Product quality is a combination of features and characteristics. Determine how well the output can meet customer requirements, or evaluate how well the characteristics and properties meet their requirements. Product quality or quality is the main aspect that can attract customers. Customer satisfaction is a person's feeling of pleasure or disappointment that occurs when the performance (or results) of a product are compared to expected performance. The purpose of this study was to determine the effect of product quality on customer satisfaction in the city of Palopo. This research was carried out in the city of Palopo. This type of research uses quantitative research with a sample of 30 respondents, while the method used in this research is a questionnaire survey. Questionnaires are used as a data collection tool, the data used in this study uses primary data. Analysis of the data used to test the validity, reliability, partial test. The results of this study indicate that the product quality variable has a positive value on the customer satisfaction variable. It can be said that the higher the perception of customer satisfaction, the higher the level of product quality received by customers. Keywords: Product Quality; Customer Satisfaction

Penelitian ini bertujuan untuk mengetahui peran masyarakat mengelola dan mengembangkan objek wisata dalam meningkatkan pendapatan khususnya di Desa Bukit Harapan Kecamatan Bua Kabupaten Luwu Provinsi Sulawesi Selatan. Penelitian ini menggunakan metode kuantitatif. Sampel dalam penelitian ini yaitu masyarakat dan pengelola objek wisata yang ada di Desa Bukit Harapan, sampel dalam penelitian ini di tentukan secara acak proposional (propotional random sampling). Pengumpulan data menggunkan kuesioner dan di olah menggunakan SPSS. Hasil penelitian menunjukkan bahwa kurangnya partisapasi masyarakat di Desa Bukit Harapan dalam mengelola dan mengembangklan objek wisata yang ada sehingga salah satu dampak dari hal tersebut yaitu dapat meningkatkan pendapatan masyarakat tidak tercapai.

Penelitian ini bertujuan untuk mengetahui kondisi pertumbuhan ekonomi dan pendidikan dalam meningkatkan taraf hidup masyarakat pesisir khususnya di Kelurahan Benteng Kecamatan Wara Timur kota Palopo Provensi Sulawesi Selatan. Penelitian ini mengunakan metode Kuantitatif. Sampel dalam penelitian ini ditentukan secara acak proposional (propotional ramdom sampling) dengan 117 orang Responden. Pengumpulan data penelitian menggunakan kuesioner dan diolah menggunakan aplikasi SPSS. Hasil penelitian menunjukkan bahwa Pendapatan Masyarakat pesisir Pantai Benteng tinggi dan cukup untuk memenuhi kebutuhan hidup sehari-hari dan tingkat pendidikan nelayan tergolong tinggi yaitu tamat SMA/SMK Sederajat, beserta status kepemilikan rumah yang layak huni dengan Tingkat kesejahteraan keluarga yang cukup. sehingga dengan kondisi Ekonomi dan Pendidikan yang seperti ini sangat mempengaruhi peningkatan taraf hidup masyarakat pesisir di Pantai Benteng

Penelitian ini bertujuan untuk mengetahui dan menilai bagaimana peran Media Sosial dan E-Commerce bagi UMKM dalam meningkatkan Volume Penjualan. Objek dari penelitian ini adalah para pelaku UMKM yang ada di Kecamatan Belopa. Metode penelitian yang digunakan dalam penelitian ini adalah survei kuesioner, sampel dalam penelitian ini sebanyak 100 responden, pengambilan sampel dalam penelitian ini dilakukan secara acak (random sampling) menggunakan teknik sampling acak sederhana (simple random sampling). Kuesioner digunakan sebagai alat pengumpulan data, data yang digunakan dalam penelitian ini menggunakan data primer yang selanjutnya dikumpulkan, diperiksa, dan temuan disajikan secara deskriptif. Teknik analisis data yang digunakan adalah uji asumsi klasik, dan regresi linier berganda. Hasil penelitian menunjukkan bahwa terdapat pengaruh secara simultan variabel independent Media Sosial dan E-Commerce terhadap variabel dependent Peningkatan Volume Penjualan.

Tujuan penelitian ini yaitu untuk merumuskan analisis strategi daya saing badan usaha milik desa melalui pemanfaatan objek wisata. Penelitian ini menggunakan pendekatan kualitatif melalui wawancara mendalam terhadap beberapa informan. Adapun informan yang digunakan dalam penelitian ini yaitu berjumlah 15 informan, terdiri dari Kepala Desa, Pengelola BUMDesa, Tokoh Masyarakat, dan Pengunjung. Metode analisis yang digunakan untuk merumuskan analisis strategi daya saing BUMDesa yaitu analisis SWOT (Strength, Weakness, Opportunity, Threat). Sebelum melakukan tahapan analisis ini terlebih dahulu dilakukan uji kualitas data yaitu uji validitas dan uji reliabilitas. Penelitian ini menghasilkan dua belas rumusan analisis strategi daya saing BUMDesa melalui pemanfataan objek wisata untuk meningkatkan kesejahteraan masyarakat yaitu masing-masing enam strategi (S-T), dua strategi (S-O), dua strategi (W-O) dan dua rumusan strategi (W-T).

Salah satu metrik utama yang perlu dipertimbangkan ketika menilai kemajuan ekonomi suatu negara adalah pertumbuhan ekonomi. Kegiatan ekonomi pada hakikatnya adalah proses penggunaan faktor-faktor produksi untuk menghasilkan produk dan jasa, oleh karena itu perluasan ekonomi pada akhirnya akan menghasilkan lebih banyak orang yang memiliki pendapatan. Tujuan dari penelitian ini adalah untuk menganalisis bagaimana pengaruh variabel faktor internal (pemerintah dan masyarakat ) dan faktor eksternal ( wisatawan dan Investasi ) terhadap pertumbuhan ekonomi di kelurahan kambo. Metode penelitian yang akan di gunakan adalah metode kuantitatif dengan tehnik survei. Penelitian survei merupakan metode pengumpulan data yang dilakukan dalam bentuk kuesioner, kemudian di sebarluaskan kepada responden. Hasil penelitian menunjukkan bahwa secara keseluruhan variabel independen ( faktor internal dan faktor ekstrnal ) secara bersama sama memiliki pengaruh terhadap tingkat pertumbuhan ekonomi yang terjadi di kelurahan kambo. Hal ini di buktikan dengan hasil analisis regresi bahwa kedua variabel berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi

Saat meluncurkan sebuah UMKM, branding UMKM sangat penting. UMKM dapat meningkatkan penjualan dan menarik pelanggan dengan merek sendiri. Dengan membuat website untuk UMKM, membuat platform media sosial, dan memberikan logo yang bermakna, branding UMKM memungkinkan UMKM untuk dikenal oleh masyarakat umum. Tujuannya agar penjual memiliki merek atau merek sendiri, dan dengan logo produk yang dijual, mereka juga dapat dikenal oleh masyarakat umum. Oleh karena itu, logo sangat signifikan dalam UMKM. Agar UMKM Istana Gorengan memaksimalkan penjualan dan memperkenalkan produknya, maka diharuskan untuk menghasilkan konten untuk UMKM, membuat media sosial UMKM, website UMKM, dan membuat logo baru untuk UMKM

The inner Abruzzo region, corresponding to the province of L’Aquila, is a land of mountains and highlands in central Italy. Its environmental conditions greatly foster spontaneous mummification, and the area is well known for the human mummies found in the last decades. We present a newly discovered collection of mummified remains in the village of Calascio, located 1,210 meters above sea level, near Gran Sasso Mountain. Here, the Franciscan convent of Santa Maria delle Grazie was built in 1594. The preliminary survey of a crypt in the conventual church allowed us to observe wooden coffins with at least seven mummified bodies still in their clothes, and several bony remains. Most likely, the mummies date back to the second half of the 19th century, and belonged to laypersons. Preservation was certainly due to the cold dry environment of the crypt. The recovery of the entire series will take place through speleological techniques according to stratigraphic relationships, in order to trace a bioanthropological profile of this small community members.

This study aimed to examine the determinants of income for irrigated rice farming in Banyumas Regency. This research was used analytical descriptive method with the survey method for the technical implementation. Determination of the research location used purposive method, considering that the majority of the research locations were technically irrigated rice fields. Determination of irrigated rice farming income in Banyumas Regency used the Cobb-Douglass type UOP profit function (Unit Output Price of Cobb-Douglass Profit Function). The results showed that the income of irrigated rice farming in Banyumas Regency was negatively affected by the price of Urea fertilizer and the price of pesticide, and positively influenced by the area of land used for irrigated rice farming. Meanwhile, the price of seeds, Phonska & TSP fertilizer prices, labor wages, and depreciation of the equipment used did not significantly affect the income of irrigated rice farming in Banyumas Regency.

Makanan khas berasal dari Sulawesi Selatan, yang tepatnya berada di daerah Luwu dan Palopo adalah kapurung. Cita rasa tradisional ini terbuat dari bahan dasar tabaro yang salah satu komoditas yang relatif tidak dipengaruhi oleh musim yang terus berganti. Oleh karena itu, untuk meningkatkan tingkat konsumsi tabaro diperlukan pelatihan untuk membuat sesuatu yang bernilai ekonomi dan mempopulerkan makanan khas Luwu. Kegiatan dalam pelatihan ini menggunakan pendekatan persuasif edukatif yaitu melalui metode diskusi, dan praktek. Hasil dari pelatihan dapat disimpulkan bahwa masyarakat di Kabupaten Luwu dan Kota Palopo memberikan respon positif, memiliki keterampilan, kamampuan dan kemauan yang sangat tinggi dan terlihat menyenangkan ketika memberikan pelatihan. Kendala yang ditemukan tidak memiliki dorongan dari orang terdekat untuk mengembang usaha cilok tabaro. Oleh karena itu, diperlukan kegiatan pelatihan secara berkala dan berkelanjutan.

Objectives Familial cases of hematological malignancies are associated with germline mutations. In particular, heterozygous mutations of SRP72 correlate with the development of myelodysplasia and bone marrow aplasia in two families. The signal recognition particle 72 kDa protein (SRP72) is part of the SRP complex, responsible for targeting of proteins to the endoplasmic reticulum. The main objective of this study is to investigate the role of SRP72 in the hematopoietic system, thus explaining why a reduced dose could increase susceptibility to hematological malignancies. Methods We developed an Srp72 null mouse model and characterized its hematopoietic system using flow cytometry, bone marrow transplantations, and gene expression analysis. Results Heterozygous loss of Srp72 in mice is not associated with major changes in hematopoiesis, although causes mild reductions in blood and BM cellularity and minor changes within the stem/progenitor compartment. We did not observe any hematological disorder. Interestingly, gene expression analysis demonstrated that genes encoding secreted factors, including cytokines and receptors, were transcriptionally down-regulated in Srp72+/- animals. Conclusions The Srp72+/- mouse model only partially recapitulates the phenotype observed in families with inherited SRP72 lesions. Nonetheless, these results can provide mechanistic insights into why SRP72 mutations are associated with aplasia and myelodysplasia in humans.

The objectives are to know: (1) the impact of cooking oil price increasing to the feasibility of tempe chips home industry; (2) income decreasing of tempe chips home industry after cooking oil price increasing; (3)factors affecting the profit of tempe chips home industry; (4) strategy of the tempe chips home industry when the production cost increase as cooking oil price increase. The research area is Rawalo sub-district, Banyumas district. Data collected by census method of 49 tempe home industries. Analyses used are RIC ratio, 1C/Cratio, BEP production, BEP revenue, BEP price, and Unit-Output-Price Cobb-Douglas Profit Function. The results show that: (1) tempe chips home industries have to be maintained although cooking oil price increasing has increased the product's price also; (2) after cooking oil price increasing period, tempe chips home industry has decreasing income; (3) UOP Cobb-Douglas Profit Function shows that cooking oil price, soybean price, cassava powder price, production capacity, dummy variable of before and after increasing cooking oil price period affect the profit function of tempe chips home industry; (4) strategy have been practiced by tempe chips home industries tempe chips product's size, decrease the tempe chips per pack capacity, decrease the production capacity, decrease the production frequency, and add cassava in the processing of tempe making.

Tofu agroindustry in Banyumas Regency is the activity of the household who are still using relatively simple technology. In general, producer don’t know the factors that affect profits because they don’t consider in detail about the financial aspects of the business. The growing issue of making use of formalin in the tofu start early January 2006 has resulted in sales earnings of tofu producer the decline. Financial feasibility evaluation is required as a financial tool inspector companies, namely to know the success of the business that have beenrun. This study aimed to know the cost and income from agroindustry business in Banyumas Regency, to know the level of the revenue and cost (R/C), to calculates that production must be generated at least, to know the term capital in agroindustry in Banyumas Regency post issues formalin in tofu. Taking the data on January 2007 is done in the district of Cilongok, Banyumas Regency consideration is a regional industrial center of tofu in the Banyumas Regency. The research method is a method used by the design of the survey sample Simple Random Sampling and obtained 62 people respondents. The analysis of data used consist of the analysis of costs and revenue, R/C ratio analysis, break even point analysis, and Return on Invesment (ROI) analysis. The results of this research shows that the agroindustry business in the post-issue formalin in tofu in Banyumas Regency is profitable. The average income of each producer is Rp 78.626,33 per day. R/C value ratio of 1,46; while the actual volume of sales per day (63,70 kg) more than the production of the BEP (20,68 kg), with a term of capital at the latest 2,25 times the production process.

Primary IgA nephropathy (IgAN) is characterized by recurrent episodes of macroscopic hematuria accompanied by upper respiratory tract infections or persistent asymptomatic microscopic hematuria with or without proteinuria. IgAN may involve one or more members of a family. Three generations of a cohort of 110 patients with biopsy-proven IgAN, living in Southern Italy, were checked for urinalysis, and the relative risk (RR) of developing the disease was evaluated. A total of 19 unrelated familial, 37 suspected, and 54 sporadic cases of IgAN were identified. Renal survival was estimated by the Kaplan-Meier method for censored data and compared by use of the log-rank test. More than 50% of the patients with IgAN clustered in kindred with more than two probably affected relatives. In 19 unrelated IgAN families, 8 had single-generation (SG) and 11 multigenerational (MG) involvement showing a prevalent vertical transmission of the trait. The RR was 16 times higher in first-degree relatives (odds ratio [OR], 16.4; 95% confidence interval [CI], 5.7 to 47.8; P0.0001) and2 times higher, even if NS, in second-degree relatives (OR, 2.4; 95 % CI, 0.7 to 7.9; P = 0.145). The clinical and histologic picture of familial and sporadic IgAN appeared to be similar. The 20-yr renal survival rate from the apparent onset of the disease was significantly poorer in patients with familial (41%) than in patients with sporadic (94%) IgAN (P = 0.003). Furthermore, 15-yr renal survival from the time of renal biopsy was significantly worse in familial IgAN (P = 0.02); end-stage renal disease was present in 64% of familial and only in 8% of patients with sporadic IgAN. Finally, renal survival was significantly worse in patients belonging to families with SG rather than with MG involvement (P = 0.03). These data show, for the first time, that familial IgAN may be considered a nonbenign disease that occurs frequently in first-degree relatives. Familial IgAN has a poorer outcome than sporadic IgAN. Therefore, an accurate family history and urinalysis in all family members is urgently recommended in clinical practice. This procedure might avoid late referral of subjects with persistent and underestimated urinary abnormalities and late diagnosis of the disease.

Cladribine provides immunomodulation through selective targeting of lymphocyte subtypes. We report the results of a 96-week phase 3 trial of a short-course oral tablet therapy in patients with relapsing–remitting multiple sclerosis. We randomly assigned 1326 patients in an approximate 1:1:1 ratio to receive one of two cumulative doses of cladribine tablets (either 3.5 mg or 5.25 mg per kilogram of body weight) or matching placebo, given in two or four short courses for the first 48 weeks, then in two short courses starting at week 48 and week 52 (for a total of 8 to 20 days per year). The primary end point was the rate of relapse at 96 weeks. Among patients who received cladribine tablets (either 3.5 mg or 5.25 mg per kilogram), there was a significantly lower annualized rate of relapse than in the placebo group (0.14 and 0.15, respectively, vs. 0.33 ; P

1533-4406 (Electronic) 0028-4793 (Linking) Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't; BACKGROUND: Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement on imaging in a phase 2 study involving patients with multiple sclerosis. METHODS: In this 12-month, double-blind, double-dummy study, we randomly assigned 1292 patients with relapsing-remitting multiple sclerosis who had a recent history of at least one relapse to receive either oral fingolimod at a daily dose of either 1.25 or 0.5 mg or intramuscular interferon beta-1a (an established therapy for multiple sclerosis) at a weekly dose of 30 microg. The primary end point was the annualized relapse rate. Key secondary end points were the number of new or enlarged lesions on T(2)-weighted magnetic resonance imaging (MRI) scans at 12 months and progression of disability that was sustained for at least 3 months. RESULTS: A total of 1153 patients (89%) completed the study. The annualized relapse rate was significantly lower in both groups receiving fingolimod--0.20 (95% confidence interval [CI], 0.16 to 0.26) in the 1.25-mg group and 0.16 (95% CI, 0.12 to 0.21) in the 0.5-mg group--than in the interferon group (0.33; 95% CI, 0.26 to 0.42; P