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Adli sosyal çalışmacılar, yargı içerisinde soruşturma süreçlerinde ve mahkemelerde bilirkişi olarak görev yapmaktadır ve uzmanlık bilgisi ile yaptığı değerlendirmelerle yargı kararlarına etki etmektedir. Bu araştırmanın temel amacı adli sosyal çalışmacıların bilirkişilik görevlerini hâkimlerin bakış açısıyla incelemektir. Araştırmaya adli yargıda görev yapan 60 hâkim katılmıştır. Araştırma verilerinin toplanmasında araştırmacılar tarafından hazırlanan ve 13 sorudan oluşan soru formu yüz yüze yapılan görüşmelerle doldurularak yanıtlar aranmaya çalışılmıştır. Tarama modelli bir araştırma şeklinde tasarlanan araştırmada, elde edilen yanıtlar SPSS 21 paket programı kullanılarak analiz edilmiş ve veriler frekans dağılımları şeklinde analiz edilmiştir. Araştırma sonucuna göre; adli sosyal çalışmacılardan mahkemelerde sözlü değerlendirme yaparak ve rapor düzenleyerek bilirkişilik yaptığı, bilirkişi olarak düzenledikleri raporların mahkeme kararlarına önemli düzeyde etki ettiği, korunmaya ihtiyacı olan çocuk, suça sürüklenen çocuk, velayet düzenlemesi, kişisel ilişki kurulması, aile hukukundan doğan yükümlülüğün ihlali, evlat edinme ve vasi tayini konularında bilirkişi olarak görüş ve değerlendirmelerine başvurulduğu ve adli sosyal çalışmacıların bilirkişilik görevlerini yerine getirirken çeşitli hususlarda yetersiz kaldıkları bulunmuştur. Elde edilen bulgular doğrultusunda sorunun çözümüne yönelik bazı öneriler sunulmuştur.

The approach presented in this study is about the calculation of the similarities among languages by using the new feature template to be obtained from the syntactic analysis phase. Studies were conducted on 6 different language sets from two different language families in order to show the calculability of similarity of languages with the help of the recommended new feature template. In the first study, triplet-pattern template which is obtained from the syntactic analysis of Turkey, Kazakh, and Uyghur Turkish languages from Turkic languages families belonging to the Ural-Altaic linguistic family, could be formed automatically through developed software, and also similarity analysis of the desired languages could be made thanks to a different module developed within the same software. Consequently, not only similar structural relations of the languages from the same language family but also structural differences among the languages can also be revealed. Even if the first aim is to determine the similarities among languages when developing an approach, the real aim of the desired structure is to form a system independent from the language. In order to show that the formed system has a structure independent from the language, another study was carried out. In the second study, the similarities among the languages were determined by using treebanks of English, Swedish and Norwegian from the Germen language family. When the language family is Turkic and the metrics are Jaccard, Dice, and Similarity Matching, the highest similarity is Turkish-Uyghur, and the values of the metrics are 25.21%, 40.27%, and 50.42%, respectively. When the language family is Germen, the highest similarity is Norwegian-Swedish, and the values of the metrics are 37.15%, 54.17%, and 74.3, respectively.

Gayrimenkul sektörünün hızlı ekonomik büyümesi nedeniyle, konut fiyatlarının tahmini geleceğe yönelik planlamalar için önemlidir. Bu çalışmanın amacı makine öğrenmesi yöntemlerini kullanarak bir konutun potansiyel fiyatını tahmin etmektir. Makine öğrenmesi yöntemleri olarak Yapay sinir ağları ve Polinomsal regresyon kullanılarak bunların tahmin performansları karşılaştırılmıştır. Makine öğrenmesi yöntemlerinin uygulanabilmesi için KNIME veri analiz platformu kullanılmıştır. Yöntemlerin başarısını ölçmek için R Kare performans metriği kullanılmıştır. Uygulama sonuçları, Yapay sinir ağları yönteminin Polinomsal regresyon yöntemine göre ev fiyatlarını daha yüksek doğrulukla tahmin ettiğini göstermektedir. Yapılan çalışmanın ev değerlendirilmesi için kullanılan uygulamaların geliştirilmesine ve bu alanda yapılan bilimsel çalışmalara katkı sağlayacağı düşünülmektedir. Sonraki çalışmalarda farklı yöntemler veya ev özniteliklerinin bulunduğu veri setleri kullanılarak çalışmanın genişletilmesi hedeflenmektedir.

Tarhana çorbası, yüksek besin değeri ile Türkiye’de tüketimi yaygın geleneksel bir gıdadır. Tarhana genellikle buğday unu, yoğurt ve domates, yeşil biber, soğan gibi sebzeler kullanılarak hazırlanır; ısıl işlem, fermantasyon ve kurutma başlıca uygulamalardır. Karabuğday, çölyak hastalarının tüketimi için önemli bir bileşendir. Su kefiri, probiyotik ürün tüketimi ve vegan bireyler için önemli potansiyele sahiptir. Bu çalışmanın amacı, fonksiyonel özellikleri geliştirilmiş tarhana üretimidir. Bunun için tarhana üretiminde balkabağı, karabuğday unu kullanılarak ve yoğurt yerine su kefiri fermantasyonu ile biyoaktif bileşenler artırılmıştır. Tarhanalar konvansiyonel yöntemle ve dondurularak kurutularak bileşen özellikleri belirlenmiştir. Tarhana hamuru fermantasyon sonrasında 30°C'de 48 saat konvansiyonel yöntemle (KKT) ve -55°C'de 24 saat dondurularak kurutulmuştur (DKT). Daha sonra tarhana örnekleri 100 µm düşük yoğunluklu polietilen torbalarda paketlenerek 4°C'de muhafaza edilmiştir. Raf ömrü süresince mikrobiyolojik analizler (Lactobacillus spp., Lactococcus spp. ve maya), kimyasal analizler (pH, % kurumadde, % kül), toplam fenolik madde, toplam antioksidan aktivite (DPPH ve TEAC), renk analizi ve tarhanalarda duyusal değerlendirme yapılmıştır. KKT örneklerinin mikrobiyal bileşimi 6,80 log kob/g Laktobasil, 6,40 log kob/g Laktokok ve 5,30 log kob/g maya’dır. DKT örnekleri 7,10 log kob/g Laktobasil; 7,0 kob/g Laktokok ve 5,20 log kob/g maya içermektedir. Su kefiri mikrobiyotası tarhana hamurunda gelişme göstermiştir. KKT ve DKT örneklerinde toplam fenolik madde sırasıyla 59,10 ve 55,52 mg/L GAE tespit edilmiştir. KKT ve DKT örneklerinin TEAC değerleri sırasıyla 38,2 ve 36,9 mM; DPPH değerleri sırasıyla 3,90 ve 12,30 mM’dır. Balkabağı, tarhana örneklerinin toplam antioksidan kapasitesini artırmıştır. Dondurularak kurutulan tarhanalarda duyusal beğeni daha yüksektir.

ünümüzde oldukça popüler olduğu gözlenen ve birçok demografik yapıdan bireyin kendisini, yeteneklerini, deneyimlerini sergileyebildiği bir platform olarak öne çıkan TikTok, video oluşturma ve paylaşmaya olanak tanırken, sıklıkla eğlence temalı içerikleri ile tanımlanmaktadır. Özellikle gençlerin yoğun kullandığı düşünülen platform, genç nesle ulaşmak adına çaba gösteren ve yeni medya tabanlı teknolojilere uyum sağlamaya çalışan medya kuruluşları ve gazetecilerin de dikkatini çekmiştir. Öyle ki birçok kuruluş resmi TikTok hesabı oluşturmuş ve platformda varlığını ortaya koymuştur. Uluslararası haber kuruluşlarının daha fazla ilgi gösterdiği TikTok platformunun habercilik potansiyeli Türkiye’de ise şu an (Mart 2022 itibariyle) yeni bir yönelim durumundadır. Bu bağlamda TRT Haber, Haber Global, Hürriyet.com.tr, Haber ATV, Show Ana Haber kuruluşlarının takipçi sayısı, beğeni sayısı ve aktif içerik üretimi noktasında öncü yönelimi dikkat çekmektedir. Bu nedenle bu çalışmada, basit rastlantısal örneklem ile seçilen ilgili ulusal medya kuruluşlarının resmi/onaylı TikTok hesapları içerik analizi kullanılarak incelenecek, TikTok’un ‘eğlence haber’ aracı potansiyeli de tartışılacaktır.

Type 1 diabetes (T1D) is an autoimmune disease with rising incidence. Pre- and manifest T1D is associated with intestinal barrier dysfunction, skewed microbiota composition, and serum dyslipidemia. The intestinal mucus layer protects against pathogens and its structure and phosphatidylcholine (PC) lipid composition may be compromised in T1D, potentially contributing to barrier dysfunction. This study compared prediabetic Non-Obese Diabetic (NOD) mice to healthy C57BL/6 mice by analyzing the intestinal mucus PC profile by shotgun lipidomics, plasma metabolomics by mass spectrometry and nuclear magnetic resonance, intestinal mucus production by histology, and cecal microbiota composition by 16 S rRNA sequencing. Jejunal mucus PC class levels were decreased in early prediabetic NOD vs C57BL/6 mice. In colonic mucus of NOD mice, the level of several PC species was reduced throughout prediabetes. In plasma, similar reductions of PC species were observed in early prediabetic NOD mice, where also increased beta-oxidation was prominent. No histological alterations were found in jejunal nor colonic mucus between the mouse strains. However, the β-diversity of the cecal microbiota composition differed between prediabetic NOD and C57BL/6 mice, and the bacterial species driving this difference were related to decreased short-chain fatty acid (SCFA)-production in the NOD mice. This study reports reduced levels of PCs in the intestinal mucus layer and plasma of prediabetic NOD mice as well as reduced proportions of SCFA-producing bacteria in cecal content at early prediabetes, possibly contributing to intestinal barrier dysfunction and T1D.

The analytical method was developed to evaluate the effectiveness of the procedure to clean the remains of the active pharmaceutical ingredients (APIs) from the equipment surface after manufacture of the final product. For this validation, High Performance Liquid Chromatographic (HPLC) method has been chosen. The HPLC chromatographic separations were achieved using C18 (150×4.6 mm), 5µm, column, employing buffer solution and organic solvent in the ratio of 70:30 (v:v) as mobile phase with the flow rate 1.0 ml/min. The column temperature was maintained at 25 °C and a detector wavelength of 225 nm was employed. Method validation study was conducted on eight separate surfaces. In this paper, stainless steel surface, one of the eight surfaces, was chosen since it is the most widely used surface during the manufacture of the finished product including immunomodulating agent. Validation study was studied between the linearity levels of 2.7% (LOQ% level) and 300%. The method was successfully validated by establishing specificity, linearity, precision (system precision, repeatability, and intermediate precision), accuracy, robustness, solution stability and limit of detection (LOD) & limit of quantification (LOQ) for immunomodulating agent raw material.

This study was aimed to determine the fertilization biology of the 'Arsel' olive cultivar obtained by hybridization breeding. For this reason, treatments of open pollination, cross pollination, and self-pollination were performed for 2 years and self-compatibility and appropriate pollinators of this new cultivar were investigated. Among the varieties included as pollinators (‘Memecik’, ‘Gemlik’, ‘Uslu’, ‘Ayvalık’ and ‘Eğriburun Nizip’), the highest fruit set was achieved with ‘Memecik’ and ‘Gemlik’ varietes in both years (2.64%, 1.37% and 1.75%, 1.39%). For this reason, ‘Memecik’ and ‘Gemlik’ cultivars were the best pollinator for ‘Arsel’ olive was thought. On the other hand, considering the statistical analyzes and productivity index values, ‘Arsel’ variety was found to be self-incompatible. However, the data also indicated that cross pollination was effective in increasing fruit set. Therefore, it is thought that the use of pollinator cultivar in orchard establishment would be beneficial in terms of yield. Pollen viability and germination tests were performed by using 2,3,5 Triphenyl Tetrazolium Chloride (TTC) and agar in petri (15% sucrose + 1% agar + 100 ppm H3BO3) methods in the study. The highest pollen viability rate was observed in ‘Memecik’ cultivar in 2020 and there isn’t statistical differences between olive cultivars in 2018. The highest pollen germination rate was observed in ‘Arsel’ cultivar in 2018. Accordingly, differences were determined between pollen viability and germination rates of examined olive cultivars in terms of years.

In the present study, nitrogen (N), phosphorus (P), carbon (C) levels and nutrient contents, N and P resorption were investigated in Diospyros kaki L., whose leaves has a strong antioxidant property and is cultivated in the Eastern Black Sea Region. The research was carried out at four different locations where Diospyros kaki was grown within the provincial borders of Trabzon. Leaf samples were taken from these selected locations monthly from May to December. Soil samples were taken from a depth of 0-20 cm from each locality. Soil N, P and C analysis were also determined. There were important differences in N (%) concentration and N (g dm-2) content values in terms of localities. N, P and C (%) concentration values significantly varied among months. Similarly, there were notable differences in N and P (g dm-2) values depending on months. Nitrogen and phosphorus resorption efficiency (RE) values were below stated boundaries at only 796 m. Nitrogen and phosphorus resorption proficiency (RP) values significantly varied between localities., Bu çalışmada; Doğu Karadeniz Bölgesi’nde yetişen ve güçlü antioksidan içeriğine sahip Diospyros kaki L.’nin azot (N), fosfor (P), karbon (C) düzeyleri ile besin içerikleri, N ve P rezorbsiyonu incelenmiştir. Çalışma Trabzon il sınırları içerisinde yer alan Diospyros kaki’nin yayılış gösterdiği dört farklı lokalitede gerçekleştirilmiştir. Belirlenen lokalitelerden Mayıs-Aralık ayları boyunca her ay yaprak örneği toplanmıştır. Her bir lokaliteden 20 cm derinlikten toprak örnekleri alınarak N, P ve C analizleri yapılmıştır. N (%) ve N (g dm-2) değerleri lokaliteler arasında, N (%), P (%), C (%), N (g dm-2) ve P (g dm-2) değerleri ise aylar arasında P < 0.01 seviyesinde önemli farklılıklar göstermiştir. N ve P rezorbsiyon kullanım verimliliği değerleri sadece 796 m’deki lokalitede belirtilen sınırların altındadır. N ve P rezorbsiyon kullanım yeterlilik değerlerinin ise lokaliteler arasında önemli oranda farklılık gösterdiği tespit edilmiştir.

Gaining communication skills, one of the life skills included in the science curriculum, plays an essential role in reducing the conflicts that may occur in individuals’ communication. The fact that pre-service science teachers have professional knowledge about this skill is an indication that they can teach this skill to their students. Based on this idea, the current research aims to examine the effect of the life skills education guidebook on the development of pre-service science teachers’ professional knowledge of communication skills. The simple experimental method with a single group pretest-posttest design was employed in the research. The research sample consists of 83 pre-service science teachers studying at a state university in the 2019-2020 academic year. The communication skills professional recognition test was used as the data collection tool. The data obtained were evaluated within the framework of the determined keywords and subjected to descriptive analysis. The pretest-posttest scores of the pre-service science teachers were compared with the Wilcoxon signed-rank test. The test result shows that the life skills education guidebook positively affects the development of the third-grade pre-service science teacher’s professional knowledge about communication skills. The qualitative data obtained show that the professional knowledge of science teacher candidates regarding communication skills has increased from the level that needs to be developed to a weakly acceptable level. It has been revealed that the lack of prior professional knowledge of the pre-service teachers regarding communication skills makes it challenging to learn new professional knowledge., Fen bilimleri dersi öğretim programında yer alan yaşam becerilerinden biri olan iletişim becerisini kazanmak, bireylerin iletişime geçmede meydana gelebilecek çatışmaların azaltılmasında önemli rol oynamaktadır. Fen bilgisi öğretmen adaylarının bu beceriye yönelik mesleki bilgiye sahip olmaları ise öğrencilerine bu beceriyi öğretebileceklerinin göstergesidir. Bu fikirden yola çıkarak mevcut araştırma, yaşam becerileri eğitimi kılavuzunun fen bilgisi öğretmen adaylarının iletişim becerisine yönelik mesleki bilgilerinin gelişimi üzerindeki etkisini incelemeyi amaçlamaktadır. Araştırmada tek gruplu ön test-son test tasarımlı basit deneysel yöntem kullanılmıştır. Araştırmanın örneklemini 2019-2020 akademik yılında bir devlet üniversitesinde öğrenim gören 83 fen bilgisi öğretmen adayı oluşturmaktadır. Araştırmada veri toplama aracı olarak iletişim becerisini mesleki tanıma testinden yararlanılmıştır. Elde edilen veriler, belirlenen anahtar kelimeler çerçevesinde değerlendirilerek betimsel analize tabi tutulmuştur. Fen bilgisi öğretmen adaylarının ön test ve son test puanları Wilcoxon işaretli sıralar testi ile karşılaştırılmıştır. Test sonucu yaşam becerileri eğitimi kılavuzunun üçüncü sınıf fen bilgisi öğretmen adaylarının iletişim becerisine yönelik mesleki bilgilerinin gelişimi üzerinde olumlu etkisi olduğunu göstermektedir. Elde edilen nitel veriler ise fen bilgisi öğretmen adaylarının iletişim becerisine yönelik mesleki bilgilerinin geliştirilmesi gereken düzeyden zayıf derecede kabul edilebilir düzeye çıktığını göstermektedir. Öğretmen adaylarının iletişim becerisine yönelik mesleki ön bilgilerinin yetersiz olmasının yeni mesleki bilgileri öğrenmeyi zorlaştırdığı ortaya çıkmıştır.

Üretim işletmelerinin kalite, esneklik, maliyet ve hız gibi performans kriterleri dahilinde rekabet güçlerini artırma amacı bulunmaktadır. Bu noktada etkin kararlar alma hususunda operasyonel performansı kontrol etmenin önemi ortaya çıkmaktadır. Üretim işletmelerinde dijital dönüşüm ile birlikte oluşan özellikle karmaşık ürün ortamlarında performansın kontrolü ve iyileştirilmesi için bilgi akışının izlenmesi bir gerekliliktir. Bu bağlamda Değer Akışı Haritalama (VSM), katma değeri olmayan faaliyetleri ortadan kaldırarak verimliliği en üst düzeye çıkarmak için kullanılan yalın tabanlı bir yöntemdir. Endüstri 4.0 (I4.0)'ın ortaya çıkmasıyla birlikte bu yaklaşım bazı değişikliklere uğramıştır. VSM, prensipte üretim ortamının sanallaştırılmasını sağlayarak fiziksel süreçleri dijital süreçlere dönüştürme konusunda öncül konumdadır. Bu nedenle, bu makalenin amacı, VSM yönteminin uygulamalarını I4.0 bağlamında gözden geçirmek ve bu tema için kavramsal bir çerçeve önermektir. Araştırmada, I4.0 teknolojileriyle entegre VSM yaklaşımlarının neler olduğu, I4.0 teknolojilerini VSM'yi nasıl desteklediği ve I4.0 bağlamında VSM'deki boşluklarının ve ana araştırma yönlerinin nasıl şekillendiği belirlenmek istenmektedir. Bu kapsamda, konu hakkında sistematik bir literatür taraması yapılarak 152 çalışma incelenmiştir. İncelenen çalışmalardan elde edilen kazanımlar ile bir sonuca ulaşılıp, I4.0 ile dönüşen VSM için kavramsal bir çerçeve oluşturulmaktadır.

Günümüzdeki teknolojik gelişmeler baş döndürücü hızda ilerlemeye devam etmektedir. Sanayi devriminden başlayarak, bilgisayarın keşfi ve sonrasında günümüze kadar gelen süreçte insan benzeri robotların veyahut insan gibi düşünebilen programların ortaya çıkması insanların diğer alanlarda olduğu gibi hukuk alanındaki rolünün de değişmeye başlamasına neden olmuştur. Yapay zekânın önemini kavrayan gelişmiş ülkeler bu alandaki araştırma ve geliştirme (AR-GE) faaliyetlerine ağırlık vermektedirler. Bu faaliyet alanlarından biri de yapay zekânın hukuk alanındaki kullanımıdır. Mahkemelerin iş yükü, yargı teşkilatındaki yapısal sorunlar ve hâkimlerin meslekî yetersizlikleri sebebiyle, insanın adaleti gereği gibi tesis etmesi giderek zorlaşmaktadır. İnsanın zihnen yaptıkları işlerde de yetenek sergilemeyi başaran yapay zekâ sistemlerinin, yargılama yapıp hüküm verme sanatına dair önemli gelişmeler sergilediği görülmektedir. Bu itibarla, çalışmanın birinci bölümünde kısa bir şekilde yapay zekâ tanımlanmakta ve tarihsel olarak önemli dönüm noktaları ele alınmaktadır. İkinci bölümde ise, yapay zekânın mahkemelerde kullanımına ilişkin genel bir çerçeve sunulduktan sonra uluslararası örneklerine yer verilmektedir. Üçüncü ve son bölümde ise, robot hâkimler ve geleceğine ilişkin tartışma yürütülmektedir.

Although land-based pollution is expressed as the most important pollution factor in the pollution of the seas (80%), the rate of pollution originating from ships (approximately 20%) is not to be underestimated. The fact that marine pollution is caused almost exclusively by ships requires investigation of the measures to be taken against marine pollution from ships and their applicability. As a matter of fact, the most important cause of pollution caused by ships is ballast water, and it has been determined that over 7,000 marine organisms are transported between ports with ballast waters on a global scale every day. Ballast water is used to maintain the balance of the ship on the water when the ships are not loaded. Considering that 90% of international trade is still provided by ships and 3-5 billion tons of ballast water is transported by approximately 85,000 ships every year with world maritime trade, the importance of pollution caused by ballast water becomes apparent. While ballast water is one of the elements that cause the transport of exotic marine and freshwater organisms between all seas of the world and cause pollution, the pollution in question is very effective especially in the aquaculture sector. Therefore, in this article, the connection of ballast water with fisheries management has been examined and solutions have been sought for the problems.

Diabetic retinopathy is a common diabetic microvascular problem. Its diagnosis and classification are based on visible changes in clinical fundus examination. However, the discovery of possible vitreous biomarkers in patients with proliferative and nonproliferative diabetic retinopathy may guide both the differentiation and degree of retinopathy. Biomarkers that will be accepted can be also a treatment target. Amphiregulin (AREG) promotes proliferative and regenerative activity and repairs most cell types by binding and activating epidermal growth factor receptors. Progranulin (PGRN) has complex functions in many physiological and pathological processes. Thus, this study aimed to report vitreous AREG and PGRN levels in patients with diabetes and proliferative retinopathy and compare the results with those without diabetes.Thirty-three eyes of 33 patients with proliferative diabetic retinopathy and 31 eyes of 31 patients without diabetes were included in this study. Vitreous humor samples were collected from all patients at the time of pars plana vitrectomy surgery immediately before the surgical procedure. Vitreous AREG and PGRN values were determined by the ELISA method.The mean AREG and PGRN values were similar in the groups (p=0.427, p=0.459, respectively).The results demonstrated that vitreous AREG and PGRN levels have no significant relationship with proliferative diabetic retinopathy.Diyabetik retinopati, diabetes mellitusun yaygın bir mikrovasküler komplikasyonudur. Hastalığın teşhisi ve sınıflandırılması, klinik fundus muayenesindeki gözle görülür değişikliklere dayanmaktadır. Ancak proliferatif diyabetik ve diyabetik olmayan retinopatili hastaların olası vitreus biyobelirteçlerin keşfedilmesi hem retinopatinin ayrımı hem de derecesi hakkında yol gösterici olabilir. Ayrıca kabul görecek biyomarkerler birer tedavi hedefi de olabilir. Amfiregülinin (AREG), epidermal büyüme faktörü reseptörlerini bağlayarak ve aktive ederek çoğu hücre tipinin çoğalmasını, yenilenmesini ve onarımını uyardığı bilinmektedir. Progranülin (PGRN), birçok fizyolojik ve patolojik süreçte karmaşık fonksiyonlara sahiptir. Bu çalışmada, proliferatif diyabetik retinopatili hastalarda vitreus AREG ve PGRN düzeylerinin raporlanması ve sonuçların diyabetik olmayan kişilerle karşılaştırılması amaçlandı.Bu çalışmaya 33 proliferatif diyabetik retinopatili hastanın 33 gözü ve 31 diyabetik olmayan bireyin 31 gözü dahil edildi. Pars plana vitrektomi ameliyatı sırasında cerrahi işlemden hemen önce tüm hastalardan vitreus örnekleri toplandı. Vitreus AREG ve PGRN seviyeleri ELISA yöntemi ile ölçüldü.Ortalama AREG ve PGRN seviyeleri gruplarda benzerdi (sırasıyla p=0,427, p=0,459).Vitreus AREG ve PGRN düzeylerinin proliferatif diyabetik retinopati ile anlamlı bir ilişkisinin olmadığı gösterildi.

To compare the demographic, clinical, and radiological features of patients with axial spondyloarthritis (axSpA) accompanying familial Mediterranean fever (FMF) to patients with each condition alone.Hacettepe University Hospital database was screened regarding ICD-10 codes for FMF (E85.0) and axSpA (M45). The diagnosis of FMF was confirmed by Tel-Hashomer criteria, and axSpA by the presence of sacroiliitis according to the modified New York criteria or active sacroiliitis on magnetic resonance imaging. As control groups, 136 gender-matched, consequent FMF patients without axSpA and 102 consequent axSpA patients without FMF previously treated with any biological agents were included in the analysis.In patients with FMF + axSpA compared to the axSpA group, age at axSpA symptom onset and age at diagnosis were lower [median with interquartile range (IQR): 21 (17-30) vs 27 (21-37), p 0.001; 23 (21-38) vs 32 (24-43) years, p = 0.001], moderate to severe hip disease and total hip replacement were more prevalent (23.4% vs 4.7%, p 0.001; 11.2% vs 2.8%, p = 0.016). In patients with FMF + axSpA compared to the FMF group, age at FMF symptom onset and age at diagnosis were higher [13 (6-30) vs 11 (5-18), p = 0.057; 23 (13-33) vs 18 (10-31) years, p = 0.033] and amyloidosis was more prevalent (6.6% vs 2.2%, p = 0.076). Although the M694V variant (in one or two alleles) was more prevalent in the FMF + axSpA group, the difference was not statistically significant.In patients with FMF + axSpA, the age of onset of axSpA was significantly earlier, moderate to severe hip involvement and amyloidosis were more common than in patients with each condition alone.

OBJECTIVE Bioresorbable flow diverters (BRFDs) could significantly improve the performance of next-generation flow diverter technology. In the current work, magnesium and iron alloy BRFDs were prototyped and compared in terms of porosity/pore density, radial strength, flow diversion functionality, and resorption kinetics to offer insights into selecting the best available bioresorbable metal candidate for the BRFD application. METHODS BRFDs were constructed with braided wires made from alloys of magnesium (MgBRFD) or iron (FeBRFD). Pore density and crush resistance force were measured using established methods. BRFDs were deployed in silicone aneurysm models attached to flow loops to investigate flow diversion functionality and resorption kinetics in a simulated physiological environment. RESULTS The FeBRFD exhibited higher pore density (9.9 vs 4.3 pores/mm2) and crush resistance force (0.69 ± 0.05 vs 0.53 ± 0.05 N/cm, p = 0.0765, n = 3 per group) than the MgBRFD, although both crush resistances were within the range previously reported for FDA-approved flow diverters. The FeBRFD demonstrated greater flow diversion functionality than the MgBRFD, with significantly higher values of established flow diversion metrics (mean transit time 159.6 ± 11.9 vs 110.9 ± 1.6, p = 0.015; inverse washout slope 192.5 ± 9.0 vs 116.5 ± 1.5, p = 0.001; n = 3 per group; both metrics expressed as a percentage of the control condition). Last, the FeBRFD was able to maintain its braided structure for > 12 weeks, whereas the MgBRFD was almost completely resorbed after 5 weeks. CONCLUSIONS The results of this study demonstrated the ability to manufacture BRFDs with magnesium and iron alloys. The data suggest that the iron alloy is the superior material candidate for the BRFD application due to its higher mechanical strength and lower resorption rate relative to the magnesium alloy.

Otoacariasis is the presence of ticks and mites in the ear canals of humans or animals, and particularly common in rural areas. This study aimed to present the clinical characteristics of patients that presented with ticks in their ear canal.The study was conducted with a total of 425 patients with 527 ticks in their ear canal at the Muş Malazgirt State Hospital Ear-Nose-Throat Clinic between June 2019 and June 2020. The removed ticks were examined at the parasitology laboratory of Van Yüzüncü Yıl University.Of the 425 cases included in the study, 72% (n=306) were female and 28% (n=119) were male (mean age 40±20, minimum-maximum: 4 months-81 years). A total of 527 ticks were removed in the one-year period. Three-hundred-and-fifty-one patients had adult or nymph ticks, and 74 patients had a larval form of the tick. Of the patients with adult or nymph tick, foreign body sensation was the dominant symptom in 68.7% (n=242), whereas pain was the dominant symptom in 62% (n=46) of those with larval tick. In the comparison between groups, foreign body sensation was statistically significantly higher in the adult tick group, and pain was higher in the larval tick group (p0.001). There were no systemic diseases related to the ticks in any of the cases.Ticks in the ear is endemic in Eastern Anatolia and poses a public health problem. Tick infestations could be minimized with various precautions and educating the general public on preventive methods. Our study is the largest series in the literature on cases with ear ticks.

COVID-19; Haematology; Nirmatrelvir COVID-19; Hematología; Nirmatrelvir COVID-19; Hematologia; Nirmatrelvir Background Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients. Methods This is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients receiving nirmatrelvir/ritonavir were compared to those who did not. A logistic regression was run to determine factors associated with nirmatrelvir/ritonavir administration in our sample. Mortality between treatment groups was assessed with Kaplan–Meier survival plots after matching all the patients with a propensity score. Additionally, a Cox regression was modelled to detect factors associated with mortality in patients receiving nirmatrelvir/ritonavir. Findings A total of 1859 patients were analysed, 117 (6%) were treated with nirmatrelvir/ritonavir, 1742 (94%) were treated otherwise. Of 117 patients receiving nirmatrelvir/ritonavir, 80% had received ≥1 anti-SARS-CoV-2 vaccine dose before COVID-19 onset, 13% of which received a 2nd vaccine booster. 5% were admitted to ICU. Nirmatrelvir/ritonavir treatment was associated with the presence of extrapulmonary symptoms at COVID-19 onset, for example anosmia, fever, rhinitis, or sinusitis (aOR 2.509, 95%CI 1.448–4.347) and 2nd vaccine booster (aOR 3.624, 95%CI 1.619–8.109). Chronic pulmonary disease (aOR 0.261, 95%CI 0.093–0.732) and obesity (aOR 0.105, 95%CI 0.014–0.776) were not associated with nirmatrelvir/ritonavir use. After propensity score matching, day-30 mortality rate in patients treated with nirmatrelvir/ritonavir was 2%, significantly lower than in patients with SARS-CoV-2 directed treatment other than nirmatrelvir/ritonavir (11%, p = 0.036). No factor was observed explaining the mortality difference in patients after nirmatrelvir/ritonavir administration. Interpretation Haematological malignancy patients were more likely to receive nirmatrelvir/ritonavir when reporting extrapulmonary symptoms or 2nd vaccine booster at COVID-19 onset, as opposed to chronic pulmonary disease and obesity. The mortality rate in patients treated with nirmatrelvir/ritonavir was lower than in patients with targeted drugs other than nirmatrelvir/ritonavir. EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223).

Nesneye yönelik programlamada, Nesne-İlişkisel Eşleme (Object-Relational Mapping – ORM) araçları sıklıkla kullanılmaktadır. Yazılım geliştiricilerin ORM seçimi yaparken en önemli seçim kriterlerinden birisi bu araçların sağladığı performanstır. ORM araçları üzerine yapılan performans araştırmalarının çoğu işlem süresi ve Rastgele Erişimli Bellek (Random-Access Memory – RAM) kullanım bilgileriyle sınırlı kalmış, Merkezi İşlem Birimi (Central Processing Unit – CPU) kullanım bilgilerine yer verilmemiştir. Ayrıca literatürde, platform bağımsız ve açık kaynak olarak üretilen yeni nesil .NET platformu olan .NET 6 ortamında yapılmış bir ORM performans çalışmasına rastlanılmamıştır. Bu çalışmada, belirtilen eksikliği gidermek ve yazılım geliştiricilere yol göstermek için .NET 6 ortamında belirli ORM araçlarının performans analizi gerçekleştirilmiştir. Çalışmada, işlem süresi ve RAM kullanım bilgilerinin yanında CPU kullanım bilgileri de yer almaktadır. Bu çalışmada başlıca ORM araçlarından Dapper, NHibernate ve Entity Framework Core (EF Core) ile kayıt okuma, ekleme, güncelleme, silme, arama ve sıralama işlemleri gerçekleştirilerek, işlem süresi, RAM ve CPU kullanımının ölçülebileceği bir yazılım geliştirilmiştir. Yapılan ölçümler sonucunda işlem süresi açısından; okuma, silme, arama ve sıralama işlemleri için Dapper; ekleme ve güncelleme işlemleri için EF Core en iyi sonuçları vermiştir. Kaynak kullanımı açısından Dapper’ın en iyi performansa sahip olduğu, EF Core ile NHibernate araçlarının sıralamalarının ise kayıt sayısı ve işlem türüne göre kendi aralarında değiştiği sonucuna varılmıştır., ORM tools are frequently used in projects developed by object-oriented programming paradigm. Software developers generally look at the performances of these tools when they select an ORM tool. Most of the performance studies on ORM tools are limited to processing time and RAM usage information, and CPU usage information is not included. Moreover, no ORM performance study has been found in the literature, conducted in .NET 6, which is an open-source and platform-independent new generation .NET platform. In this study, to close the mentioned gap in the literature and guide the software developers, we conduct research for analyzing performances of certain ORM tools in .NET 6. Our study includes CPU usage information as well as processing time and RAM usage information. We develop a software for measuring processing time, RAM and CPU usage while performing read, insert, update, delete, search and sort operations with Dapper, NHibernate and Entity Framework Core (EF Core) ORM tools. As a result, while Dapper is best in terms of processing time for read, delete, search and sort operations, EF Core has the best results for insert and update operations. We conclude that Dapper has the best performance in terms of resource usage, while the rankings of EF Core and NHibernate vary among themselves according to the number of records and operation type.

Ehrlichia canis is the primary etiologic agent of canine monocytic ehrlichiosis, a tick-transmitted disease of dogs. The aim of this study is to molecularly investigate the presence of E. canis and to reveal its prevalence in dogs in Siirt province. The animal material of the study is consisted of a total of 82 dogs. A region of the 16S ribosomal RNA gene of E. canis was targeted for PCR amplification. As a result of the conducted Nested-PCR, positivity was detected at the rate of 10.53% (4/38) in male dogs and 13.64% (6/44) in females, and Ehrlichia canis specific bands of size 389 bp were obtained in 10 (12.20%) dogs in total. The phylogenetic tree was constructed with the Maximum Likelihood (MCL) method, The nucleotide sequence was registered in the NCBI GenBank database with access numbers OK331365.1-OK331366. Early detection of the disease by means of hematological, serological, or molecular tests is very important in terms of prognosis. More studies should be performed to determine vector-disease relationships in this region about ticks that vector the disease.

The costs due to climate change have been increasing day by day. In addition to the risk of losing our planet’s natural assets due to the increasing destructiveness of climate-related natural disasters and extreme climate events, we are also faced with grave economic risks. For this reason, researchers have recently focused on environmental issues. Nevertheless, they generally have investigated developed countries and ignored developing and least developed countries such as African countries. The United Nations (2015) report highlights that African countries should be specially investigated. Hence, the paper analyzes whether the ecological footprint in the Economic Community of Central African States (ECCAS) and Economic Community of West African States (ECOWAS) converges for the period from 1961 to 2017. We employ Bahmani-Oskooee et al.’s (2014) panel unit root test with sharp and smooth breaks. The empirical findings demonstrate that the ecological footprint is stationary in ECCAS and ECOWAS. Stated in other words, the ecological footprint in these countries converges. Therefore, policymakers could implement similar policies to reduce the ecological footprint in these countries. This policy framework paves the way for an effective sustainable development. WOS:000862233000004 Q2 PubMed ID : 36180802

BackgroundSuccessful recanalization after endovascular thrombectomy serves as the primary endpoint in clinical trials and is a crucial predictor of long-term outcomes. Radiographic outcomes for various interventions have been shown to vary based on the type of interpreter, including the site interventionalist compared with an independent reader.ObjectiveTo compare angiographic outcomes in stroke thrombectomy procedures based on the type of reader.MethodsA systematic literature search was conducted in Medline, EMBASE, Scopus, and Web-of-Science through February 2022. We included primary studies that reported core laboratory-read and operator angiographic outcomes after mechanical thrombectomy for ischemic stroke. Furthermore, study-defined successful recanalization data were collected.ResultsEight studies were included with 4797 patients, 51.2% of whom were male. Four thousand, four hundred and thirty-one patients had core readings, and 4211 had operator readings. Study-defined successful recanalization was significantly higher for operator (84%, 3543/4211) examinations than for core laboratory-read (78.4%, 3476/4431) examinations (pConclusionOperator angiographic reads are statistically significantly higher than core laboratory-read readings following stroke thrombectomy, especially for complete recanalization. These differences should be considered when interpreting reports of angiographic outcomes after thrombectomy.

To predict breast cancer molecular subtypes with neural networks based on magnetic resonance imaging apparent diffusion coefficient (ADC) radiomics and to detect the relation of lesion size with the stability of radiomics features.This retrospective study included 221 consecutive patients (224 lesions) with breast cancer imaged between January 2015 and January 2020. Three sample size configurations were identified based on tumor size (experiment 1: all cases, experiment 2:1 cmOf the 851 radiomics features, 611 had ICC0.75, and 37 remained stable in the first experiment, 49 in the second, and 59 in the third based on CoV and VIF analysis. High accuracy was demonstrated by the Luminal B, HER2-enriched, and triple-negative models in the first experiment (80%), all models in the second experiment, and HER2-enriched and triple-negative models in the third experiment.A positive stability is indicated by an increased lesion size related to radiomics features. Neural networks may predict moleculer subtypes of breast cancers over 1 cmManyetik rezonans görüntülemede görünür difüzyon katsayısı (ADC) radyomiks verilerine dayalı sinir ağları ile meme kanseri moleküler alt tiplerini tahmin etmek ve lezyon boyutunun radyomiks özelliklerin stabilitesi ile ilişkisini saptamaktır.Bu retrospektif çalışma, Ocak 2015 ile Ocak 2020 tarihleri arasında görüntüleme yapılan meme kanserli hasta kohortunu (n=221, 224 lezyon) içermektedir. Lezyon boyutu ile radyomiks özelliklerinin stabilitesi arasındaki ilişkiyi incelemek için, tümör boyutuna dayalı (deney 1: tüm durumlar, deney 2:1 cmSekiz yüz elli bir radyomiks özelliğinden 611’i ICC0,75 idi. Bu özelliklerden CoV ve VIF analizi ile 37’si birincide, 49’u ikincide ve 59’u üçüncü deneyde sabit kaldı. İlk deneyde Luminal B, HER2 ile zenginleştirilmiş ve üçlü negatif alt tipler için geliştirilen tahmin modellerinin doğruluğu yüksekti (%80). İkinci deneyde tüm modeller ve üçüncü deneyde ise HER2 ile zenginleştirilmiş ve üçlü negatif modeller yüksek doğruluğa sahipti.Radyomiks özellikler, artan lezyon boyutuna bağlı olarak pozitif stabilite göstermektedir. Yapay sinir ağları, 1 cm

Aim: This study was carried out to examine the validity and reliability of the Turkish form of Student Satisfaction from the Student Outcomes Survey. Material and Methods: The sample of this methodological study consisted of 141 nursing students studying at the Nursing Faculty of a state university. “Student Information Form” and “Student Satisfaction from the Student Outcomes Survey” were used to collect data. The validity and reliability of this survey were evaluated with language, content, construct validity, internal consistency reliability, and test-retest reliability analyses. Results: Content validity was performed after language validity using the translation-back translation, and the content validity index score was determined as 1.0. In the exploratory factor analysis, this survey showed a three-factor structure and explained 64.56% of the total variance. The Cronbach's alpha coefficient was 0.947 for the total scale, 0.867 for the teaching, 0.823 for the evaluation, and 0.925 for the general skills and learning experiences sub-dimension. In reliability analysis against time, it was determined that there was a positive correlation between the two measurements (r=0.634, p

Akademik çalışmalarda terörizm korkusu, terör ve terörizmin kavramsal tanımlarının altında uzun süre alt başlık olarak kalmış ve üzerinde yeteri kadar çalışma gerçekleşmemiştir. Ancak günümüzde terör eylemlerinin şiddetinin ve sıklığının artması ile birlikte terörizm korkusu kavramı da önemli bir başlık haline gelmeye başlamıştır. Terörist saldırılarına maruz kalan toplumlar, eylemlerin yarattığı dehşete bağlı hissedilen korku atmosferi sonrasında öncelik sıralarına güvenlik kavramını yerleştirmektedirler. Terörizm korkusu bu bağlamda iletişim ve etkileşim düzeylerinde sorunlar yaşanmasına neden olmaktadır. Bu çalışmada terörizm korkusu kavramı detaylı şekilde ele alınmaktadır. Çalışmanın ilk kısmında terörizm korkusu, kavramsal bir perspektif üzerinden açıklanmaktadır. Terörizm ve terörizm korkusu kavramlarının literatürde nasıl ele alındığı, nedenleri, bağlantılı olduğu değişkenler vurgulanmaktadır. İkinci kısımda terörizm korkusunun yarattığı sonuçlar; üçüncü kısımda ise teröristlerin, bireylerde terörizm korkusu yaratma amacıyla kullandığı yöntemler, seçtiği hedefler ve kullandığı stratejiler açıklanmaktadır. Çalışmanın dördüncü ve beşinci kısmında çalışmanın konusu ve amacı kapsamında İstanbul’da yaşayan bireylerin terörizm korkusunu nasıl değerlendirdiklerinin tespiti üzerine gerçekleştirilen derinlemesine görüşmenin neticesinde elde edilen bulguların analizi yer almaktadır. Çalışmanın sonuç bölümünde ise terörizm korkusuna ve çalışmada elde edilen bulgulara yönelik genel bir değerlendirme yer almaktadır.

Microwave imaging of breast cancer is considered and a new microwave imaging prototype including the imaging algorithm, the antenna array, and the measurement configuration is presented. The prototype aims to project the geometrical features of the anomalies inside the breast to a single-slice image at the coronal plane depending on the complex dielectric permittivity variation among the tissues to aid the diagnosis.The imaging prototype uses a solid cylindrical dielectric platform, where a total of 24 optimized Vivaldi antennas are embedded inside to form a uniform circular antenna array. The center of the platform is carved to create a hollow part for placement of the breast and the multistatic, microwave scattering parameters are collected with the antenna array around the hollow center. The dielectric platform further enhances the microwave impedance matching against the breast fat tissue and preserves the vertical polarization during the measurements. In the imaging phase, a computationally efficient inverse electromagnetic scattering method-reverse time migration (RTM)-is considered and adapted in terms of scattering parameters to comply with the actual measurements.The prototype system is experimentally tested against tissue-mimicking breast phantoms with realistic dielectric permittivity profiles. The reconstructed single-slice images accurately determined the locations and the geometrical extents of the tumor phantoms. These experiments not only verified the microwave imaging prototype but also provided the first experimental results of the imaging algorithm.The presented prototype system implementing the RTM method is capable of reconstructing single-slice, nonanatomical images, where the hotspots correspond to the geometrical projections of the anomalies inside the breast.

To evaluate the prognostic significance of the new index designed by formulating neutrophil, lymphocyte, and platelet counts in patients with metastatic disease receiving immune checkpoint inhibitors (ICI) and its effect on the immune-related adverse events (irAEs).Cohort study.Department of Medical Oncology, University of Manisa Celal Bayar, University of Aydin Adnan Menderes, and University of Ege, and Izmir Kent Hospital, Turkey, from January 2016 to April 2020.Patients with metastatic disease receiving ICI sufficient follow-up data were included. Patients, who had received treatment for a minimum of 3 months, were evaluated for the response. Systemic immune-inflammation index (SII) was calculated as neutrophil (/L) × (lymphocyte (/L) / platelet (/L). The cut-off value was determined by examining the area under the receiver operating characteristic (ROC) curve for the SII value. The endpoints of this study included overall survival (OS) and progression-free survival (PFS).A total of 168, patients who received ICI in the metastatic stage, were evaluated. The OS of the patients with low SII scores was 110.8 months (95% CI, 88.2-133.5), while patients with high SII scores were 36.0 months (95% CI, 28.4-43.6) and reached statistical significance (p0.001). The results of univariate (HR=3.376, 95% CI, 1.986-5.739, p0.001 and multivariate (HR=2.792, 95% CI, 1.495-5.215, p=0.011) analyses were statistically significant as well.The SII score in patients with metastatic disease receiving ICI was closely related to the prognosis. Patients with a high SII score are associated with a worse prognosis, these patients develop fewer irAEs.Systemic immune inflammation index, Overall survival, Progression-free survival, İmmune checkpoint inhibitor, Pembrolizumab, Nivolumab.

To determine the relationship of the presence and amount of vasogenic edema with origin, type, and grade of primary cancer.Cross-sectional study.Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Radiology Clinic, Ankara, Turkey, from July 2017 to October 2021.Brain MRI scans of 292 patients were retrospectively evaluated. Age, gender, origin, type, and grade of primary cancer were determined. Metastasis type, and presence of vasogenic edema accompanying metastatic lesion were questioned. In cases of vasogenic edema accompanying metastatic lesions, the largest diameter of the vasogenic edema mass complex was measured in T2 sequences. In the contrast-enhanced series, the largest diameter of the metastatic lesion was measured, and the edema-mass ratio (EMR) was calculated by proportioning the diameter of the edema mass complex to the diameter of the mass.The frequency of vasogenic edema was found higher in patients with lung cancer compared to other primaries. The EMR was found statistically significantly higher in patients with primary lung cancer (p=0.001). This was particularly evident in the adenocarcinoma group. In the patient group with primary breast cancer, EMR was found significantly lower in patients with invasive ductal carcinoma. (IDC→1.95±0.66 vs. Other→2.48±0.52, Z=-2.301, p=0.021).The amount and presence of vasogenic edema in patients with brain metastases may differ according to the origin and type of primary tumour.Brain edema, Metastatic disease, Magnetic resonance imaging.

Bu araştırmanın amacı, tüketici etnosentrizmi kapsamında milli marka duyarlılığının tüketicilerin satın alma niyetine etkisi incelemektir. Buna ek olarak, araştırmada marka farkındalığının tüketicilerin satın alma niyetine etkisinin test edilmesi amaçlanmaktadır. Araştırmanın evrenini, sosyal medyada en fazla takipçi sayısına sahip Türk menşeili on beyaz eşya markasını Facebook ve Instagram’da aktif olarak takip eden kullanıcılar oluşturmaktadır. Çevrimiçi anketler vasıtasıyla 615 katılımcıdan elde edilen veriler, Yapısal Eşitlik Modellemesi (AMOS 24.0) kullanılarak analiz edilmiştir. Araştırma sonucunda, milli marka duyarlılığının tüketicilerin marka farkındalığı ve satın alma niyetleri üzerinde anlamlı bir etkiye sahip olduğu belirlenmiştir. Buna ek olarak, analiz sonuçları marka farkındalığının tüketicilerin satın alma niyetlerini pozitif etkilediğini göstermektedir. Dahası, araştırma sonucunda marka farkındalığının milli marka duyarlılığının tüketicilerin satın alma niyetlerine etkisinde aracılık rolüne sahip olduğu tespit edilmiştir. Bu araştırmada ulaşılan sonuçlar, Türk menşeili beyaz eşya markaları için milli marka hassasiyetine sahip tüketicilere yönelik pazarlama eylemlerinin marka farkındalığını artırmada ve tüketicileri satın almaya teşvik etmede işlevsel olduğunu göstermektedir. Anahtar kelimeler: Milli Marka Duyarlılığı, Marka Farkındalığı, Satın Alma Niyeti, Beyaz Eşya Sektörü.

Bu çalışma, Bursa Uludağ Üniversitesi Sosyal Bilimler Enstitüsünde Vejdi Bilgin ve Kemal Ataman'in danışmanlığında Merve Reyhan Baygeldi tarafından yazılan "Kültürel sermayeden sosyal sermayeye maneviyat ve din: Hükümlülerin manevi danışmanlık deneyimleri" adlı doktora tezine dayanılarak hazırlanmıştır. Dünyadaki diğer örneklerinde de olduğu gibi, Türkiye’de manevi danışmanlık, farklı modern mekânlara ve durumlara özgü sorunlarla dini referanslar sayesinde başa çıkmaya destek olmak için Diyanet İşleri Başkanlığı tarafından sunulan bir hizmettir. Bu makalede, Bursa H ve E Tipi Ceza İnfaz Kurumlarındaki hükümlülerin manevi danışmanlık deneyimleri incelenmektedir. Bunu gerçekleştirebilmek için nitel araştırma desenlerinden olgubilim tercih edilmiştir. Bu çerçevede, 18 hükümlünün sosyal sermayeleri bir lens görevi üstlenmiştir. Birebir görüşmelerden elde edilen veriler, MAXQDA programıyla kodlanarak içerik analizine tabi tutulmuştur. Buna göre üç tema tespit edildi. Bunlardan ilki; aile, eğitim, göç ve önceki cezaevi olmak üzere dört kategoriden oluşan hükümlülerin cezaevi öncesi sosyal sermaye temasıdır. İkinci tema; suç işlemeye karar verme, uyum süreci, gündelik pratikler, dış dünya ile ilişkiler, personellerle ilişkiler, iş kolları ve eğitim programları olmak üzere yedi kategoriden oluşan cezaevinde sosyal sermayedir. İşlevsellik arayışı, hoca söylemi ve koğuş kültürü olmak üzere üç kategoriden oluşan sosyal sermaye bağlamında manevi danışmanlık deneyimi, çalışmamızdaki son temadır. Nihai olarak, hükümlülerin genelde cezaevindeki programları özelde manevi da- nışmanlık uygulamasını, sosyal sermaye zemininde inşa edilen kârzarar hesabı kapsamında deneyimlediği tespit edilmiştir. Pastoral counseling is provided by The Religious Affairs Presidency in Turkey, to assist individuals in coping with challenges, unique to various modern places and situations utilizing religious references, similar to the other examples around the world. In this study, convicts’ experiences in pastoral counseling from Bursa H and E Type Penal Institutions are examined. The social capital of 18 inmates will be used as a lens to address these experiences. One of the qualitative study designs, phenomenology, has been chosen to expose the aforementioned framework. MAXQDA was used to code the data collected from one-on-one interviews, which were then submitted to content analysis. As a result, three major themes emerged. The first of them is the offenders' pre-prison social capital theme, which is divided into four categories: family, education, immigration, and past imprisonment. The second theme is social capital in prison, which is divided into seven categories: The decision to commit a crime, the adjustment process, everyday activities, contacts with the outside world, relationships with staff, labor branches, and training programs. The final theme in our research is pastoral counseling experience in the context of social capital, which is divided into three categories: functionality seeking, hoca discourse, and ward culture. Finally, it has been discovered that inmates generally experience prison services, particularly pastoral counseling, via the lens of profitloss calculations based on social capital.

Introduction: Birth satisfaction of mothers is important for maternal and newborn health. Objective: In this study, it was aimed to determine the practices related to childbirth in mother-friendly and non-mother-friendly hospitals and the birth satisfaction of mothers. Method: The study was conducted between April 2019 and December 2019 in the postpartum clinics of two hospitals in Istanbul. The sample of the study consisted of 265 mothers. The data of the study were collected using the "Introductory Information Form" and the "Birth Satisfaction Scale". Statistical significance level was taken as p < .05. Results: It was determined that 58.5% of the mothers who participated in the study were between the ages of 25-34, 36.5% were high school graduates, and 82.3% were not working. The first pregnancy of 21.5% of the mothers was the first birth of 32.1%. In the study, the rates of movement restriction and food intake restriction at birth were lower in those who gave birth in a mother-friendly hospital compared to those who gave birth in a non-mother-friendly hospital; the rates of induction, amniotomy fundus compression, episiotomy and meeting physical needs were higher and there was a significant difference between the groups (p < .05). There was no difference between the groups in terms of birth satisfaction scale mean scores (p > .05). Conclusion: It was determined that whether the hospital was mother-friendly or not did not affect birth satisfaction. It is recommended that the study be conducted in state hospitals and with a large sample., Giriş: Annelerin doğum memnuniyeti anne ve yenidoğan sağlığı açısından önemlidir. Amaç: Bu çalışmada, anne dostu olan ve olmayanhastanelerde doğuma ilişkin uygulamalar ve annelerin doğum memnuniyetlerinin belirlenmesi amaçlandı. Yöntem: Çalışma Nisan 2019 -Aralık 2019 tarihleri arasında İstanbul'daki iki hastanenin doğum sonu kliniklerinde gerçekleştirildi. Çalışmanın örneklemini 265 anneoluşturdu. Çalışmanın verileri “Tanıtıcı Bilgi Formu” ve “Doğum Memnuniyet Ölçeği” kullanılarak toplandı. İstatistiksel anlamlılık düzeyi p< .05 olarak alındı. Bulgular: Çalışmaya katılan annelerin %58.5’i 25-34 yaş aralığında, %36.5’i lise mezunu, %82.3’ünün çalışmadığıbelirlendi. Annelerin %21.5’inin ilk gebeliği, %32.1’inin ilk doğumuydu. Çalışmada anne dostu hastanede doğum yapanlarda, anne dostuolmayan hastanede doğum yapanlara göre doğumda hareket kısıtlaması ve besin alımı kısıtlaması oranları daha düşükken; indüksiyon,amniyotomi fundus kompresyonu, epizyotomi ve fiziksel ihtiyaçların karşılanması oranları daha yüksekti ve gruplar arasında anlamlı farksaptandı (p < .05). Doğum memnuniyet ölçeği puan ortalamaları açısından gruplar arasında fark saptanmadı (p > .05). Sonuç: Hastanenin annedostu olup olmaması doğum memnuniyetini etkilemediği belirlenmiştir. Çalışmanın devlete bağlı hastanelerde ve büyük örneklemle yapılmasıönerilir.

Aims: In this multicenter study, the authors aimed to determine the real-life efficacy and safety of first-line alectinib. Materials & methods: This retrospective trial included advanced-stage, ALK-positive non-small-cell lung cancer patients who were treated with first-line alectinib in terms of ALK-tyrosine kinase inhibitors, regardless of previous chemotherapy. The co-primary end points were progression-free survival both for all patients and for the treatment-naive population. The secondary end points were overall response rate, overall survival, rate of CNS progression and safety. Results & conclusion: A total of 274 patients (n = 177 for treatment-naive patients) were enrolled in the study. The median progression-free survival was 26 and 28.8 months for all patients and the treatment-naive group, respectively. The overall response rate, CNS progression rate and 1-year overall survival ratio were 77.9, 12.4 and 77%. Alectinib is a highly effective therapy with a favorable safety profile. Plain language summary The advancements in cancer treatment, particularly in the last two decades, have been promising. Non-small-cell lung cancer (NSCLC) is one of the most important diseases experiencing these promising developments. ALK positivity, which is caused by the rearrangement of different gene fragments between two chromosomes, affects about 5% of NSCLC patients. This provides a target for next-generation therapies. One of these targeted therapy drugs is alectinib. The authors examined the outcomes of 271 patients with body-disseminated NSCLC who received alectinib as initial targeted therapy. These patients were not chosen to participate in a clinical phase study. They were treated with an approved drug; the study also included 97 patients who had previously received chemotherapy. The median duration of survival without disease worsening was 26 months for all patients receiving alectinib treatment. This value was 28.8 months in 177 patients who had not received any treatment before alectinib. Regardless of disease status, 77% of all patients were found to be alive at the end of the first year. Alectinib treatment resulted in a significant improvement of the disease in approximately four out of five patients. The treatment's side effects were generally tolerable or manageable. Only four patients were reported to have discontinued their medication due to treatment-related side effects. These real-world findings are compatible with previous clinical research. Alectinib is an important first-line treatment option for patients with advanced, ALK-positive NSCLC. 35734870

The utilization of powdered photocatalysts can cause problems such as agglomeration and difficulty in separation in conventional applications. In this work, deposition of photocatalyst particles on a co-polymeric network was suggested to solve this issue. For this purpose, ferrite type perovskite BiFeO3 particles were immobilized on the sulphonated polystyrene-divinyl benzene seeds via a facile impregnation process and the heterostructured catalyst (BFO@co-STR/DVB) exhibited boosted removal performance towards tetracycline antibiotic. The co-polymer itself showed attractive adsorption (93% removal) towards tetracycline due to the robust π–π stacking or hydrophobic relationship. The photocatalytic performance of optimal BFO@co-STR/DVB catalyst had the greatest value of apparent rate constant (0.037 min-1), which was 6.16 times higher than that for bare BiFeO3 (0.006 min-1). Moreover, the heterostructured photocatalyst displayed the highest catalytic efficiency as 98.5% which was mainly assigned to the synergetic effect of adsorption and photocatalysis. Therefore, detailed adsorption mechanism was examined by applying three kinetic models and the pseudo-second order model (qe=88.9 mg/g; R2=0.993) was fitted well describing well the adsorption. The impact of perovskite amount on the polymer structure was also investigated. Apart from tetracycline molecule, the photocatalytic activity of the heterostructured catalyst with respect to different pharmaceutical (isoniazid) was also investigated and the adsorptive removal of isoniazid over the co-STR/DVB polymer was calculated as 80.0% while it significantly increased to 98.2% in the BFO@co-STR/DVB photocatalytic system. This study demonstrated the effective utilization of the perovskite deposited co-polymeric network in the field of “photocatalysis”.

The study was carried out to evaluate the combining ability and heterosis of seven parents and their 21 half-diallel F2 populations for yield and quality traits during the 2013-14 season in the randomized complete block design with three replications. Significant differences were observed among the genotypes, GCA (general combining ability) and SCA (specific combining ability) effects for all traits, except spike length. The best combiner parents were identified as Esperia and Pehlivan for grain yield, and Flamura85, Aldane and Selimiye for quality traits because of significant GCA and per se performance. The ranges of best parent heterosis were -12.71 to 8.23% for plant height, -15.46 to 8.36% for spike length, -16.62 to 24.80% for number of grains per spike, -23.61 to 36.50% for grain weight per spike, -17.13 to 8.84% for harvest index and -44.26 to 15.83 for grain yield, -17.61 to 8.38% for thousand grain weight, -18.55 to 8.44% for wet gluten content, -33.80 to 24.78% for gluten index, -20.24 to 15.23% for Zeleny sedimentation value, -15.58 to 10.00% for quality index and -8.96 to 6.87 for grain protein content. The three (Slm/Phl, F85/Slm and F85/Esp) and seven (F85/Phl, Sb/Fs, Fs/Slm, Esp/Slm, Fs/Phl, Esp/Sb and Sb/Slm) of F2 populations are offered a good opportunity in base material for selection of potential because of significant SCA effects and best parent heterosis for grain yield and quality traits respectively.

Purpose Atezolizumab has been shown to be effective and safe in randomized trial in the first-line treatment of extensive-stage small cell lung cancer (SCLC). However, there are limited real-life data on atezolizumab. In this study, we aimed to determine the real-life efficacy and safety of atezolizumab combined with chemotherapy in the first-line treatment of extensive-stage SCLC. Methods This trial is a retrospective multicenter study of the Turkish Oncology Group, which included extensive-stage SCLC patients who received atezolizumab combined with chemotherapy in a first-line treatment. The characteristics of the patients, treatment and response rates, and PFS and OS are presented. Factors associated with PFS and OS were analyzed by univariate and multivariate analysis. Results A total of 213 patients at the 30 oncology centers were included. The median number of chemotherapy cycle was 5 (1-8) and atezolizumab cycle was 7 (1-32). After median 11.9 months of follow-up, median PFS and OS was 6.8 months (95%CI 5.7-7.8), and 11.9 months (95%CI 11-12.7), respectively. The ORR was 61.9%. ECOG-PS (p = 0.002) and number of metastatic sites (p = 0.001) were associated with PFS and pack-year of smoking (p = 0.05), while ECOG-PS (p = 0.03) and number of metastatic sites (p = 0.001) were associated with OS. Hematological side effects were common and toxicities were manageable. Conclusion This real-life data confirm the efficacy and safety of atezolizumab in combination with chemotherapy in first-line treatment of extensive-stage SCLC.

Objective The pituitary gland is responsible for hormonal balance in the body, and disruption of hormonal balance in patients with pituitary adenoma (PA) indirectly affects the quality of life. This study aimed to examine the effects of yoga and combined aerobic and strength training (A+ST) on quality of life and related parameters such as sleep, fatigue, emotional state, sexual function, and cognitive status in women with PA. Design Ten women with PA were included in this randomized crossover study. Group 1 (n = 5, mean age: 52 ± 13.5 years) received A+ST for the first 6 weeks, a 2-week washout period, and yoga for the second 6 weeks. Group 2 (n = 5, mean age: 41.8 ± 14 years) received the yoga program first, followed by the A+ST program. Methods Participants were assessed using the following tools before and after each exercise intervention: Functional Assessment of Cancer Therapy–Brain (FACT-Br) (quality of life), Pittsburg Sleep Quality Index, Fatigue Severity Scale (FSS), Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), and Montreal Cognitive Assessment Scale (MOCA). Results FACT-Br scores were higher after the yoga program, HADS anxiety score was lower after the A+ST program, and MOCA scores increased after both exercise programs (P < 0.05). FSS score decreased after both exercise programs, but not significantly. In addition, nonsignificant decreases in HADS anxiety and depression scores and increased FSFI scores were observed after the yoga program. Conclusion A+ST and yoga have positive effects on the quality of life in PA. We recommend yoga and A+ST as a supportive therapy for this population that may face comorbidities after surgical and medical treatment. Our results indicate these patients may benefit from physiotherapist-guided exercise programs.

The use of flow diverters is a rapidly growing endovascular approach for the treatment of intracranial aneurysms. All FDA-approved flow diverters are composed of nitinol or cobalt-chromium, which will remain in the patient for the duration of their life. Bioresorbable flow diverters have been proposed by several independent investigators as the next generation of flow diverting devices. These devices aim to serve their transient function of occluding and healing the aneurysm prior to being safely resorbed by the body, eliminating complications associated with the permanent presence of conventional flow diverters. Theoretical advantages of bioresorbable flow diverters include (1) reduction in device-induced thrombosis; (2) reduction in chronic inflammation and device-induced stenosis; (3) reduction in side branch occlusion; (4) restoration of physiological vasomotor function; (5) reduction in imaging artifacts; and (6) use in pediatric applications. Advances made in the similar bioresorbable coronary stenting field highlight some of these advantages and demonstrate the feasibility and safety of bioresorbable endovascular devices in the clinic. The current work aims to review the progress of bioresorbable flow diverters, identify opportunities for further investigation, and ultimately stimulate the advancement of this technology.

Background/aim: to evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: a total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]). Results: a total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21-73] vs. 44 years [20-79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients. Conclusion: although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored., Hacettepe Rheumatology Society