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Your search keyword '"Destruxin E"' showing total 3 results
Start Over Descriptor "Destruxin E" Topic general medicine
3 results on '"Destruxin E"'

1. A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae

Author

Alfonso Espada, Juan A. Hueso-Rodríguez, María I. Albarrán, Alfonso Rivera-Sagredo, María Jesús Vázquez, and E. Diez

Subjects
Metarhizium, Vacuolar Proton-Translocating ATPases, Time Factors, ATPase, Saccharomyces cerevisiae, Metarhizium anisopliae, Osteoclasts, Bioengineering, Fungus, Biochemistry, Microbiology, Inhibitory Concentration 50, Depsipeptides, Structural isomer, Animals, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, General Chemistry, General Medicine, biology.organism_classification, Small molecule, Destruxin E, Fermentation, biology.protein, Molecular Medicine, Chickens
Abstract

In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H + -ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.

Published
2006

2. New destruxins from the marine-derived fungus Beauveria felina

Author

Aline M. Vita-Marques, Tim S. Bugni, Chris M. Ireland, Lara Durães Sette, Daniel V. LaBarbera, Roberto G. S. Berlinck, Mirna H. R. Seleghim, Simone Possedente de Lira, and Sandra Regina Pombeiro Sponchiado

Subjects
Stereochemistry, Fungus, Fungal Proteins, chemistry.chemical_compound, Mice, Cell Line, Tumor, Depsipeptides, Drug Discovery, Animals, Humans, Beauveria, Amino Acids, Derivatization, Antibiotics, Antitubercular, Pharmacology, chemistry.chemical_classification, Depsipeptide, Fungal protein, Residue (complex analysis), Antibiotics, Antineoplastic, biology, Molecular Structure, Spectrum Analysis, Butanone, Absolute configuration, General Medicine, Mycobacterium tuberculosis, Mycotoxins, biology.organism_classification, Amino acid, Destruxin E, chemistry, Beauveria felina, Proton NMR, Antibacterial activity
Abstract

Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [beta-Me-Pro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(R),4(S)-5-chloro-2,4-dihydroxypentanoic acid residue in 1 could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis.

Published
2006

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