4,317 results on '"Ferric Compounds"'
Search Results
2. C-Diazeniumdiolate Graminine in the Siderophore Gramibactin Is Photoreactive and Originates from Arginine
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Christina Makris, Jeffrey R. Carmichael, Hongjun Zhou, and Alison Butler
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Prevention ,Oximes ,Chemical Sciences ,Organic Chemistry ,Siderophores ,Molecular Medicine ,General Medicine ,Biological Sciences ,Nitric Oxide ,Arginine ,Ligands ,Ferric Compounds ,Biochemistry - Abstract
Siderophores are synthesized by microbes to facilitate iron acquisition required for growth. Catecholate, hydroxamate, and α-hydroxycarboxylate groups comprise well-established ligands coordinating Fe(III) in siderophores. Recently, a C-type diazeniumdiolate ligand in the newly identified amino acid graminine (Gra) was found in the siderophore gramibactin (Gbt) produced by Paraburkholderia graminis DSM 17151. The N-N bond in the diazeniumdiolate is a distinguishing feature of Gra, yet the origin and reactivity of this C-type diazeniumdiolate group has remained elusive until now. Here, we identify l-arginine as the direct precursor to l-Gra through the isotopic labeling of l-Arg, l-ornithine, and l-citrulline. Furthermore, these isotopic labeling studies establish that the N-N bond in Gra must be formed between the Nδ and Nω of the guanidinium group in l-Arg. We also show the diazeniumdiolate groups in apo-Gbt are photoreactive, with loss of nitric oxide (NO) and H+ from each d-Gra yielding E/Z oxime isomers in the photoproduct. With the loss of Gbt's ability to chelate Fe(III) upon exposure to UV light, our results hint at this siderophore playing a larger ecological role. Not only are NO and oximes important in plant biology for communication and defense, but so too are NO-releasing compounds and oximes attractive in medicinal applications.
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- 2022
3. Progress in bioleaching: fundamentals and mechanisms of microbial metal sulfide oxidation – part A
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Mario Vera, Axel Schippers, Sabrina Hedrich, and Wolfgang Sand
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Minerals ,Metals ,Polymers ,Iron ,Thiosulfates ,Ferrous Compounds ,General Medicine ,Protons ,Sulfides ,Ferric Compounds ,Applied Microbiology and Biotechnology ,Sulfur ,Biotechnology - Abstract
Bioleaching of metal sulfides is performed by diverse microorganisms. The dissolution of metal sulfides occurs via two chemical pathways, either the thiosulfate or the polysulfide pathway. These are determined by the metal sulfides’ mineralogy and their acid solubility. The microbial cell enables metal sulfide dissolution via oxidation of iron(II) ions and inorganic sulfur compounds. Thereby, the metal sulfide attacking agents iron(III) ions and protons are generated. Cells are active either in a planktonic state or attached to the mineral surface, forming biofilms. This review, as an update of the previous one (Vera et al., 2013a), summarizes some recent discoveries relevant to bioleaching microorganisms, contributing to a better understanding of their lifestyle. These comprise phylogeny, chemical pathways, surface science, biochemistry of iron and sulfur metabolism, anaerobic metabolism, cell–cell communication, molecular biology, and biofilm lifestyle. Recent advances from genetic engineering applied to bioleaching microorganisms will allow in the future to better understand important aspects of their physiology, as well as to open new possibilities for synthetic biology applications of leaching microbial consortia.Key points•Leaching of metal sulfides is strongly enhanced by microorganisms•Biofilm formation and extracellular polymer production influences bioleaching•Cell interactions in mixed bioleaching cultures are key for process optimization
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- 2022
4. Zinc-doped ferric oxyhydroxide nano-layer enhances the bactericidal activity and osseointegration of a magnesium alloy through augmenting the formation of neutrophil extracellular traps
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Mei Li, Dongdong Zhang, Feng Peng, Juning Xie, Xianrong Zhang, Shi Qian, Yu Zhang, Xuanyong Liu, and Bin Yu
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Staphylococcus aureus ,Surface Properties ,Biomedical Engineering ,General Medicine ,Extracellular Traps ,Ferric Compounds ,Biochemistry ,Anti-Bacterial Agents ,Rats ,Corrosion ,Biomaterials ,Zinc ,Coated Materials, Biocompatible ,Osseointegration ,Absorbable Implants ,Alloys ,Animals ,Magnesium ,Molecular Biology ,Biotechnology - Abstract
Implant-associated infections (IAI) and osseointegration disorders are the most common complications in orthopedics. Studies have shown that neutrophils surrounding implants play a vital role in regulating these complications. Although magnesium (Mg) and its alloys are considered promising biodegradable bone implants, their role in neutrophil-mediated antibacteria has not yet been examined. Considering the rapid corrosion of Mg, it is necessary to develop methods to inhibit its corrosion. To solve these issues, a zinc-doped ferric oxyhydroxide nano-layer modified plasma electrolytic oxidation (PEO)-coated Mg alloy (PEO-FeZn) was developed in this study, and its antibacterial, immune anti-infective, and osteogenic ability were systematically evaluated. The results showed that PEO-FeZn nano-layer enhanced the corrosion resistance, biocompatibility, bactericidal activity, and osteoblastic differentiation activity of the Mg alloy. Moreover, PEO-FeZn nano-layer inhibited immune evasion-related gene expression and contributed to the formation of neutrophil extracellular traps (NETs) by activating the extracellular release of DNA fibers and granule proteins, and thereby suppressing bacterial invasion and promoting osseointegration in vivo in Staphylococcus aureus (S. aureus)-infected rat femurs. Overall, the findings of this study could serve as a reference for the fabrication of highly biocompatible and corrosion resistant Mg alloys to address the challenges of IAI and osseointegration disorders. STATEMENT OF SIGNIFICANCE: The widely used metallic biomaterials usually come with the risk of IAI. As the first responder around the biomaterials, neutrophils could form NETs to defense against microorganism and promote tissue remodeling. Therefore, biomaterials addressing antibacterial and neutrophils-modulatory strategies are highly necessary in reducing IAI. To solve these issues, we grew PEO-FeZn nano-layers in situ on Mg alloy using a simple and green technique. The nano-layer not only enhanced the corrosion resistance and biocompatibility of Mg alloy, but also elevated the antibacterial and osteogenesis capability. Moreover, nano-layer contributed to NETs formation, thereby suppressing bacterial invasion and even promoting osseointegration in S.aureus-infected femurs. Accordingly, this functionalized multilayer coating with antibacterial immunity represents a novel therapeutic strategy for IAI and weak osseointegration.
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- 2022
5. Extracellular polymeric substance induces biogenesis of vivianite under inorganic phosphate-free conditions
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Xinrui, Hao, Jie, Tang, Xiaoyun, Yi, Kun, Gao, Qian, Yao, Chunhua, Feng, Weilin, Huang, and Zhi, Dang
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Minerals ,Shewanella ,Environmental Engineering ,Extracellular Polymeric Substance Matrix ,Iron ,Environmental Chemistry ,Phosphorus ,Ferrous Compounds ,General Medicine ,Ferric Compounds ,Ecosystem ,Phosphates ,General Environmental Science - Abstract
Vivianite is often found in reducing environments rich in iron and phosphorus from organic debris degradation or phosphorus mineral dissolution. The formation of vivianite is essential to the geochemical cycling of phosphorus and iron elements in natural environments. In this study, extracellular polymeric substances (EPS) were selected as the source of phosphorus. Microcosm experiments were conducted to test the evolution of mineralogy during the reduction of polyferric sulfate flocs (PFS) by Shewanella oneidensis MR-1 (S. oneidensis MR-1) at EPS concentrations of 0, 0.03, and 0.3 g/L. Vivianite was found to be the secondary mineral in EPS treatment when there was no phosphate in the media. The EPS DNA served as the phosphorus source and DNA-supplied phosphate could induce the formation of vivianite. EPS impedes PFS aggregation, contains redox proteins and stores electron shuttle, and thus greatly promotes the formation of minerals and enhances the reduction of Fe(III). At EPS concentration of 0, 0.03, and 0.3 g/L, the produced HCl-extractable Fe(II) was 107.9, 111.0, and 115.2 mg/L, respectively. However, when the microcosms remained unstirred, vivianite can be formed without the addition of EPS. In unstirred systems, the EPS secreted by S. oneidensis MR-1 could agglomerate at some areas, resulting in the formation of vivianite in the proximity of microbial cells. It was found that vivianite can be generated biogenetically by S. oneidensis MR-1 strain and EPS may play a key role in iron reduction and concentrating phosphorus in the oligotrophic ecosystems where quiescent conditions prevail.
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- 2022
6. Chemical Analysis of Hematite Ore Collected from Pokhari, Nawalparasi, Nepal
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Ram Bahadur Gharti, Hari Bhakta Oli, and Deval Prasad Bhattarai
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Nepal ,Article Subject ,Iron ,General Medicine ,Ferric Compounds ,General Biochemistry, Genetics and Molecular Biology ,General Environmental Science - Abstract
Iron is the principal raw material for steel industries and Hematite is a principal ore of iron. Quantitative and qualitative estimation of iron in its ores is a crucial factor before its extraction. In this work, quantitative chemical analysis of iron was carried out from the collected seventy-two hematite samples from Pokhari, Nawalparasi. Sampling of the hematite ore was performed by channel sampling method. Chemical analysis was carried out by gravimetric, titrimetric, UV-Vis spectrophotometric and atomic absorption spectroscopic methods. The findings of different parameters in percentage areas follows: loss on ignition (1.76 ± 0.17), silica (47.06 ± 4.01), and iron (36.75 ± 2.50) by titrimetric analysis. Based on the chemical analysis, the Fe content in the collected hematite sample is in intermediate range. Thus, for the profitable iron extraction, other factors such as coverage of ores, extraction costs, and market value should be considered.
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- 2022
7. Shewanella shenzhenensis sp. nov., a novel Fe(III)-reducing bacterium with abundant possible cytochrome genes, isolated from mangrove sediment
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Xueying, Zhang, Guiqin, Yang, Sijie, Yao, and Li, Zhuang
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DNA, Bacterial ,Base Composition ,Shewanella ,Nucleotides ,Fatty Acids ,Sequence Analysis, DNA ,General Medicine ,Sodium Chloride ,Catalase ,Ferric Compounds ,Microbiology ,Bacterial Typing Techniques ,RNA, Ribosomal, 16S ,Cytochromes ,Citrates ,Molecular Biology ,Phospholipids ,Phylogeny - Abstract
A facultative anaerobic bacterium, designated as A25
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- 2022
8. Sulfur defect and Fe(III) (hydr)oxides on pyrite surface mediate tylosin adsorption in lake water: effect of solution chemistry and dissolved organic matter
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Qian Zhang, Jinwen Zhou, Lishan Zhang, Shan Zhong, Xuan Ru, and Xiaohua Shu
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Oxygen ,Health, Toxicology and Mutagenesis ,Water ,Environmental Chemistry ,Tylosin ,Oxides ,Ferrous Compounds ,General Medicine ,Dissolved Organic Matter ,Ferric Compounds ,Pollution ,Sulfur ,Anti-Bacterial Agents - Abstract
Pyrite affects the adsorption of tylosin (TYL) due to their coexistence in the lake system. As well as the reactivity groups of S-S-H, S-OH, and Fe-OH, defects also have the possibilities to influence the adsorption of organic contaminants. However, the role of these active sites in antibiotic adsorption on pyrite has not been deeply studied. Besides, pH, N, P, dissolved oxygen, and dissolved organic matter (DOM) fluctuate greatly in lake at different seasons, which may change the surface characteristics of pyrite. Hence, the adsorption of TYL on natural pyrite considered solution chemistry and DOM in lake water was explored in this study. The fitting results of the kinetic and isotherm models showed that the adsorption included physical and chemical interactions. The neutral initial solution pH was conductive to TYL adsorption owing to the combined result of electrostatic and cover of Fe-oxyhydroxide. NO
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- 2022
9. Elucidating the origin mechanism of a morphology-dependent layered double hydroxide catalyst toward organic contaminant oxidation via persulfate activation
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Rongyao Wang, Yanjun Yu, Ruijuan Zhang, Xiaohua Ren, and Weilin Guo
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Oxygen ,Nickel ,Sulfates ,Iron ,Health, Toxicology and Mutagenesis ,Hydroxides ,Environmental Chemistry ,Ferrous Compounds ,General Medicine ,Reactive Oxygen Species ,Ferric Compounds ,Oxidation-Reduction ,Pollution - Abstract
Understanding how the morphology of a layered double hydroxide (LDH)-based catalyst alters its catalytic activity provides an available strategy for the rational design and fabrication of high-efficiency catalysts at a micro-scale. Herein, three nickel-iron layered double hydroxide (NiFe-LDH) catalysts including 2D-plate-like hexagon (P-NiFe-LDH), 2D/3D-flower-like solid sphere (FS-NiFe-LDH), and 2D/3D-flower-like hollow sphere (FH-NiFe-LDH) with regulable oxygen vacancies (OVs) were fabricated via a morphological regulation method of Ostwald ripening. The experimental results demonstrated that the three types of NiFe-LDH exhibited different abilities to activate persulfate (PS) for the abatement of acid orange 7 (AO7) with a sequence of FH-NiFe-LDH FS-NiFe-LDH P-NiFe-LDH. Particularly, the FH-NiFe-LDH with a hollow structure exhibited the most considerable activity with the first-order rate constant up to k = 0.02639 min
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- 2022
10. Phosphorus sorption capacity of various iron-organic matter associations in peat soils
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Weilin Yang, Wu Xiang, Zhengyu Bao, Chunlei Huang, Ming Ma, Xinzhe Lu, Lingyang Yao, and Yong Wang
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Soil ,Minerals ,Iron ,Health, Toxicology and Mutagenesis ,Environmental Chemistry ,Phosphorus ,Adsorption ,General Medicine ,Ferric Compounds ,Pollution ,Humic Substances - Abstract
This study was carried out to evaluate the contribution of different types of iron-organic matter associations (Fe-OM) to the phosphorus sorption capacity of peatland. Humic substance (HS) and particulate organic matter (POM) were isolated from peat soils, and different types of iron-organic matter associations (Fe-HS and Fe-POM) were prepared. Then, isothermal adsorption experiments were carried out on the synthesized Fe-OM and iron-contained peat soils. The morphology structure of Fe-HS associations is amorphous like that of ferrihydrite. The theoretical maximum adsorption capacity (Q
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- 2022
11. Fe-Cu binary oxide loaded zeolite as heterogeneous Fenton catalyst for degradation of carbamazepine at near-neutral pH
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Xiaobiao, Zhu, Hao, Li, Xiaohan, Shang, and Tiefei, He
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Health, Toxicology and Mutagenesis ,Oxides ,Hydrogen Peroxide ,General Medicine ,Hydrogen-Ion Concentration ,Oxidants ,Ferric Compounds ,Pollution ,Catalysis ,Carbamazepine ,Zeolites ,Environmental Chemistry ,Environmental Pollutants ,Ferrous Compounds ,Oxidation-Reduction - Abstract
In this study, Fe-Cu binary oxide was loaded on zeolite (Fe/Cu/zeolite) to be used as heterogeneous Fenton catalyst, and the catalytic degradation of carbamazepine (CBZ) were optimized at near-neutral pH. The results showed that the Fe and Cu oxide, mainly Fe
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- 2022
12. Goethite and lepidocrocite catalyzing different double-oxidant systems to degrade chlorophenol
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Dan Zhong, Weinan Feng, Wencheng Ma, Xinyue Liu, Jun Ma, Ziyi Zhou, Xuan Du, and Fu He
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Minerals ,Drinking Water ,Health, Toxicology and Mutagenesis ,Hydrogen Peroxide ,General Medicine ,Oxidants ,Ferric Compounds ,Pollution ,Environmental Chemistry ,Environmental Pollutants ,Oxidation-Reduction ,Iron Compounds ,Water Pollutants, Chemical ,Chlorophenols - Abstract
Goethite and lepidocrocite, as the main compositions of pipe deposits in the water distribution network, could be used as a catalyst for advanced oxidation processes (AOPs). This research utilizes them to activate PDS/H
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- 2022
13. Synthesis and optimization of spherical nZVI (20–60 nm) immobilized in bio-apatite-based material for efficient removal of phosphate: Box-Behnken design in a fixed-bed column
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Mohammad Javad Amiri
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Anions ,Apatites ,Health, Toxicology and Mutagenesis ,Environmental Chemistry ,Adsorption ,General Medicine ,Ferric Compounds ,Pollution ,Water Pollutants, Chemical ,Phosphates ,Water Purification - Abstract
In the present study, bio-apatite/nZVI composite was synthesized through Fe(III) reduction with sodium borohydride and was fully characterized by FTIR, XRD, SEM-EDX, TEM, BET, BJH, and pH
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- 2022
14. Migration and transformation of Sb are affected by Mn(III/IV) associated with lepidocrocite originating from Fe(II) oxidation
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Liangkai Wang, Weiyong Zhan, Qian Sun, Hongwei Zhang, Yalu Shao, and Hua Zhong
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Antimony ,Reaction mechanism ,Environmental Engineering ,chemistry.chemical_element ,Oxides ,Sorption ,General Medicine ,engineering.material ,Ferric Compounds ,chemistry ,Mn oxide ,engineering ,Environmental Chemistry ,Ferrous Compounds ,Lepidocrocite ,Oxidation-Reduction ,General Environmental Science ,Nuclear chemistry - Abstract
Antimony (Sb) is a recognized priority pollutant with toxicity that is influenced by its migration and transformation processes. Oxidation of Fe(II) to Fe(III) oxides, which is a common phenomenon in the environment, is often accompanied by the formation of Mn(III/IV) and might affect the fate of Sb. In this study, incorporated Mn(III) and sorbed/precipitated Mn(III/IV) associated with lepidocrocite were prepared by adding Mn(II) during and after Fe(II) oxidation, respectively, and the effects of these Mn species on Sb fate were investigated. Our results indicated that the association of these Mn species with lepidocrocite obviously enhanced Sb(III) oxidation to Sb(V), while concomitantly inhibiting Sb sorption due to the lower sorption capacity of lepidocrocite for Sb(V) than Sb(III). Additionally, Mn oxide equivalents increased in the presence of Sb, indicating that Sb oxidation by Mn(III/IV) associated with lepidocrocite was a continuous recycling process in which Mn(II) released from Mn(III/IV) reduction by Sb(III) could be oxidized to Mn(III/IV) again. This recycling process was favorable for effective Sb(III) oxidation. Moreover, Sb(V) generated from Sb(III) oxidation by Mn(III/IV) enhanced Mn(II) sorption at the beginning of the process, and thus favored Mn(III/IV) formation, which could further promote Sb(III) oxidation to Sb(V). Overall, this study elucidated the effects of Mn(III/IV) associated with lepidocrocite arisen from Fe(II) oxidation on Sb migration and transformation and revealed the underlying reaction mechanisms, contributing to a better understanding of the geochemical dynamics of Sb.
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- 2022
15. Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines
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Tarczykowska, Agata, Engström, Niklas, Dobermann, Darja, Powell, Jonathan, Scheers, Nathalie, Engström, Niklas [0000-0003-2399-985X], Scheers, Nathalie [0000-0001-8812-9025], and Apollo - University of Cambridge Repository
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Iron ,Adenocarcinoma ,Iron Chelating Agents ,Amphiregulin ,Ferric Compounds ,Catalysis ,Cell Line ,Inorganic Chemistry ,IGF1R ,IFNGR1 ,Humans ,ferric pyrophosphate ,Physical and Theoretical Chemistry ,Molecular Biology ,Edetic Acid ,Spectroscopy ,Janus Kinases ,IL-6 ,Interleukin-6 ,Organic Chemistry ,General Medicine ,COX-2 ,Computer Science Applications ,STAT Transcription Factors ,Cyclooxygenase 2 ,Salts ,iron ,amphiregulin ,Iron Compounds ,Biomarkers ,Signal Transduction - Abstract
Peer reviewed: True, Funder: internal university funding, We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell lines. Here, we further screened these iron compounds, plus four other iron chelates and six iron salts (i.e., 12 oral iron compounds in total), for their effects on biomarkers of cancer and inflammation. Ferric pyrophosphate and ferric EDTA were the main inducers of amphiregulin and its receptor monomer, IGFr1. Moreover, at the maximum iron concentrations investigated (500 µM), the highest levels of amphiregulin were induced by the six iron chelates, while four of these also increased IGfr1. In addition, we observed that ferric pyrophosphate promoted signaling via the JAK/STAT pathway by up-regulating the cytokine receptor subunit IFN-γr1 and IL-6. For pro-inflammatory cyclooxygenase-2 (COX-2), ferric pyrophosphate but not ferric EDTA elevated intracellular levels. This, however, did not drive the other biomarkers based on COX-2 inhibition studies and was probably downstream of IL-6. We conclude that of all oral iron compounds, iron chelates may particularly elevate intracellular amphiregulin. Ferric pyrophosphate additionally induced COX-2, probably because of the high IL-6 induction that was observed with this compound.
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- 2023
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16. Glycol chitosan/iron oxide/polypyrrole nanoclusters for precise chemodynamic/photothermal synergistic therapy
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Edgar Daniel Quiñones, Ting-Yu Lu, Kuan-Ting Liu, Yu-Jui Fan, Er-Yuan Chuang, and Jiashing Yu
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Chitosan ,Photothermal Therapy ,Polymers ,Structural Biology ,Cell Line, Tumor ,Pyrroles ,General Medicine ,Ferric Compounds ,Molecular Biology ,Biochemistry - Abstract
Noninvasive photothermal therapy (PTT) represents a promising direction for more modern and precise medical applications. However, PTT efficacy is still not satisfactory due to the existence of heat shock proteins (HSPs) and poorly targeted delivery. Herein, the design of a nanosystem with improved delivery efficacy for anticancer treatment employing the synergetic effects of reactive oxygen species (ROS)-driven chemodynamic therapy (CDT) to inactivated HSPs with photothermal-hyperthermia was therefore achieved through the development of pH-targeting glycol chitosan/iron oxide enclosed core polypyrrole nanoclusters (GCPI NCs). The designed NCs effectively accumulated toward cancer cells due to their acidic microenvironment, initiating ROS generation via Fenton reaction at the outset and performing site-specific near infrared (NIR)-photothermal effect. A comprehensive analysis of both surface and bulk material properties of the CDT/PTT NCs as well as biointerface properties were ascertained via numerous surface specific analytical techniques by bringing together heightened accumulation of CDT/PTT NCs, which can significantly eradicate cancer cells thus minimizing the side effects of conventional chemotherapies. All of these attributes act in synergy over the cancer cells succeeding in fashioning NC's able to act as competent agents in the MRI-monitored enhanced CDT/PTT synergistic therapy. Findings in this study evoke attention in future oncological therapeutic strategies.
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- 2022
17. Equilibrium, kinetics and thermodynamic studies for the removal of arsenic from water using newly synthesized amino resin supported hydrous ferric oxide nano composite
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Abdul Majid, Channa, Sıtkı, Baytak, and Saima Qayoom, Memon
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Kinetics ,Environmental Engineering ,technology, industry, and agriculture ,Thermodynamics ,Water ,Adsorption ,General Medicine ,Hydrogen-Ion Concentration ,Ferric Compounds ,Water Pollutants, Chemical ,Arsenic ,Water Purification - Abstract
Arsenic (III) was treated by newly synthesized ferric oxide nano composite supported on amino resin (NXHFO). Amberlite XAD-4 was converted to amino derivative (NX) and HFO particles were prepared on its surface. Batch study was conducted to study the removal of arsenic from aqueous media. Uptake of similar to 98.5% was recorded at pH 4 using 50 mg of NXHFO while the agitation time was 30 min. Monolayer sorption capacity of NXHFO resin calculated from Langmuir sorption isotherm for As(III) ions was 32.3 mg g(-1). The sorption energy (E) calculated was 15 kJ mol(-1), suggesting that the uptake of arsenite onto the NXHFO surface was due to ion-exchange.
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- 2022
18. Capability of copper–nickel ferrite nanoparticles loaded onto multi-walled carbon nanotubes to degrade acid blue 113 dye in the sonophotocatalytic treatment process
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Tariq J. Al-Musawi, Nezamaddin Mengelizadeh, Mahmoud Taghavi, Zaccheus Shehu, and Davoud Balarak
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Nanotubes, Carbon ,Nickel ,Health, Toxicology and Mutagenesis ,Nanoparticles ,Environmental Chemistry ,General Medicine ,Azo Compounds ,Ferric Compounds ,Pollution ,Copper - Abstract
In this study, copper-nickel ferrite (CuNiFe
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- 2022
19. Magnesium ferrite-nitrogen–doped graphene oxide nanocomposite: effective adsorptive removal of lead(II) and arsenic(III)
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Manmeet Kaur, Manpreet Kaur, Dhanwinder Singh, Mingbao Feng, and Virender K. Sharma
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Ions ,Nitrogen ,Health, Toxicology and Mutagenesis ,Magnesium Compounds ,General Medicine ,Ferric Compounds ,Pollution ,Arsenic ,Nanocomposites ,Water Purification ,Kinetics ,Lead ,Environmental Chemistry ,Graphite ,Adsorption ,Water Pollutants, Chemical - Abstract
Magnetic nanocomposites have received immense interest as adsorbents for water decontamination. This paper presents adsorptive properties of nitrogen-doped graphene oxide (N-GO) with magnesium ferrite (MgFe
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- 2022
20. Oxidation of bioreduced iron-bearing clay mineral triggers arsenic immobilization
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Ziwang Zhao, Qingke Yuan, Ying Meng, and Fubo Luan
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Minerals ,Iron ,Health, Toxicology and Mutagenesis ,Clay ,Environmental Chemistry ,Ferrous Compounds ,General Medicine ,Ferric Compounds ,Oxidation-Reduction ,Pollution ,Arsenic - Abstract
Iron-bearing clay minerals and arsenic commonly coexist in soils and sediments. Redox oscillation from anoxic to oxic conditions can result in structural Fe(II) oxidation in clay minerals. However, the role of structural Fe(II) oxidation in clay minerals on arsenic immobilization is still unclear. In this study, we found that oxidation of structural Fe(II) in bioreduced clay mineral nontronite (NAu-2) triggered As(III) adsorption onto NAu-2. As(III) was adsorbed onto NAu-2 through ligand exchange with hydroxyl groups which were generated by the oxidation of structural Fe(II) in NAu-2. In addition, oxidation of structural Fe(II) led to the oxidation of As(III) to As(V), which further enhanced the adsorption of dissolved As(III) on NAu-2. Therefore, the adsorption capacity of As(III) onto oxidized NAu-2 was 1.6 times higher than that of native NAu-2. Oxidation of structural Fe(II) was a two-stage process that proceeded from exterior sites to interior sites, and the immobilization and oxidation of As(III) occurred predominantly at the rapid exterior structural Fe(II) oxidation stage. Our findings highlight that the oxidation of structural Fe(II) in iron-bearing clay minerals may play an important role in arsenic immobilization and transformation in the subsurface environment.
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- 2022
21. CuO nanoparticles decorated on hydroxyapatite/ferrite magnetic support: photocatalysis, cytotoxicity, and antimicrobial response
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Elaine Cristina Paris, João Otávio Donizette Malafatti, Ailton José Moreira, Lílian Cruz Santos, Camila Rodrigues Sciena, Alessandra Zenatti, Márcia Tsuyama Escote, Valmor Roberto Mastelaro, and Miryam Rincón Joya
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Staphylococcus aureus ,Light ,Health, Toxicology and Mutagenesis ,Water ,TRATAMENTO DE ÁGUA ,Hydrogen Peroxide ,General Medicine ,Ferric Compounds ,Pollution ,Catalysis ,Durapatite ,Anti-Infective Agents ,Escherichia coli ,Nanoparticles ,Environmental Chemistry ,Copper ,Ecosystem - Abstract
Photocatalysts supported in magnetic nanocomposites for application in environmental remediation processes have been evaluated for removing contaminants due to easy recovery and low toxicity to the ecosystem. In this work, copper oxide (CuO) nanoparticles with photocatalytic properties were decorated on magnetic support constituted by hydroxyapatite (HAP) and ferrite to achieve efficiency in contaminated water remediation under visible light irradiation. First, nanomaterials were obtained by precipitation route, allowing fast and straightforward synthesis. Then, CuO nanoparticles with 6 nm diameter were efficiently decorated on magnetic support (25 nm), showing a high ability to absorb visible light irradiation (bandgap) to promote electronic transition and charge separation. Under visible irradiation, CuO promotes the H
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- 2022
22. Biosynthesis and applications of iron oxide nanocomposites synthesized by recombinant Escherichia coli
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Jae Hwan Jung, Minkyung Cho, Tae Seok Seo, and Sang Yup Lee
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Escherichia coli ,Metal Nanoparticles ,Microbial Sensitivity Tests ,General Medicine ,Ferric Compounds ,Applied Microbiology and Biotechnology ,Anti-Bacterial Agents ,Nanocomposites ,Biotechnology - Abstract
Recombinant Escherichia coli (E. coli) strain that produces phytochelatin (PC) and/or metallothionein (MT) can synthesize various metal nanoparticles (NPs) by reducing metal ions. Here we report in vivo biosynthesis of iron oxide nanocomposites (NCs) using recombinant E. coli. We designed a strategy of biosynthesizing iron oxide NCs by first internalizing chemically synthesized iron oxide NPs, followed by the reduction of added metal ions on the surface of internalized NPs by PC and/or MT in E. coli. For this, chemically synthesized Fe
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- 2022
23. Removal of ibuprofen from synthetic wastewater using photocatalytic method in the presence of FeO photocatalyst supported on modified Iranian clinoptilolite
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Kiarash Seifi, Majid Mohadesi, and Ashkan Gouran
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Clinoptilolite ,Chemistry ,Health, Toxicology and Mutagenesis ,Ibuprofen ,General Medicine ,Iran ,Wastewater ,Ferric Compounds ,Pollution ,Catalysis ,Spectroscopy, Fourier Transform Infrared ,Photocatalysis ,medicine ,Zeolites ,Environmental Chemistry ,medicine.drug ,Nuclear chemistry - Abstract
This study investigated the removal of an organic drug called ibuprofen from the wastewater containing this drug. Iron oxide supported on modified Iranian clinoptilolite was used as the photocatalyst in the presence of the light of a solar lamp. XRD, SEM, EDAX and FT-IR analyses were performed to detect the prepared photocatalyst. The results of photocatalytic identification analyses proved the suitable loading of iron oxide supported on modified Iranian clinoptilolite. This study investigated the effect of initial concentration of ibuprofen (5–25 mg/L), photocatalyst concentration (100–300 mg/L), and process time (10–240 min) on the removal from ibuprofen from wastewater containing this drug. The experiments were performed in a setup in the presence of a solar lamp with a flux of 300 W/m2. The results indicated that with the initial ibuprofen concentration of 25 mg/L, photocatalyst concentration of 300 mg/L, and time of 210 min, the highest percentage of ibuprofen removal was 99.80%. Kinetic modeling was then performed using the Langmuir-Hinshelwood model, and a quasi-first-order kinetic model showed a good agreement with the results obtained. Finally, the recovery of the photocatalyst was investigated and the results showed that under optimal conditions about 91% of ibuprofen was removed after five re-uses of the photocatalyst.
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- 2022
24. Metal-phenolic networks as tuneable spore coat mimetics
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Pris Wasuwanich, Gang Fan, Benjamin Burke, and Ariel L. Furst
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Spores, Bacterial ,Phenols ,Metals ,Gallic Acid ,Biomedical Engineering ,Polyphenols ,General Materials Science ,General Chemistry ,General Medicine ,Ferric Compounds - Abstract
Bacillus subtilis are probiotic microbes that are difficult to formulate when they are not in their spore form. Using self-assembling coatings, these cells were successfully protected during the freeze-drying process.
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- 2022
25. Gamma radiation-induced synthesis of a novel chitosan/silver/Mn-Mg ferrite nanocomposite and its impact on cadmium accumulation and translocation in brassica plant growth
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M.I.A. Abdel Maksoud, Mohamad Bekhit, Dina M. El-Sherif, Ahmed R. Sofy, and Mahmoud R. Sofy
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Chitosan ,Silver ,Spectrum Analysis ,Plant Development ,Biological Transport ,Brassica ,Chemistry Techniques, Synthetic ,General Medicine ,Ferric Compounds ,Biochemistry ,Antioxidants ,Nanocomposites ,Gamma Rays ,Metals ,Structural Biology ,Reactive Oxygen Species ,Molecular Biology ,Cadmium - Abstract
Herein, a novel chitosan/silver/Mn
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- 2022
26. Improved utilization of active sites for phosphorus adsorption in FeOOH/anion exchanger nanocomposites via a glycol-solvothermal synthesis strategy
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Weiben Yang, Zhen Yang, Chenxu Yao, Qiong Tang, Yifan Sun, and Yi Zhang
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Environmental Engineering ,Solvothermal synthesis ,Oxide ,02 engineering and technology ,010501 environmental sciences ,Ferric Compounds ,01 natural sciences ,Nanocomposites ,Metal ,Glycols ,chemistry.chemical_compound ,Adsorption ,Catalytic Domain ,Environmental Chemistry ,0105 earth and related environmental sciences ,General Environmental Science ,Nanocomposite ,Phosphorus ,General Medicine ,021001 nanoscience & nanotechnology ,Decomposition ,Basic precipitation ,Kinetics ,chemistry ,Chemical engineering ,visual_art ,visual_art.visual_art_medium ,Hydroxide ,0210 nano-technology ,Water Pollutants, Chemical - Abstract
Metal oxide/hydroxide-based nanocomposite adsorbents with porous supporting matrices have been recognized as efficient adsorbents for phosphorus recovery. Aiming at satisfying increasingly restrictive environmental requirements involving improving metal site utilization and lowering metal leakage risk, a glycol-solvothermal confined-space synthesis strategy was proposed for the fabrication of FeOOH/anion exchanger nanocomposites (Fe/900s) with enhanced metal site utilization and reduced metal leakage risk. Compared to composites prepared using alkaline precipitation methods, Fe/900s performed comparably, with a high adsorption capacity of 19.05 mg-P/g with an initial concentration of 10 mg-P/L, a high adsorption selectivity of 8.2 mg-P/g in the presence of 500 mg-SO42−/L, and high long-term resilience (with a capacity loss of ~14% after five cycles), along with substantially lower Fe loading amount (4.11 wt.%) and Fe leakage percentage. Mechanistic investigation demonstrated that contribution of the specific FeOOH sites to phosphate adsorption increased substantially (up to 50.97% under the optimal conditions), in which Fe(III)-OH was the dominant efficient species. The side effects of an excessively long reaction time, which included quaternary ammonium decomposition, FeOOH aggregation, and Fe(III) reduction, were discussed as guidance for optimizing the synthesis strategy. The glycol-solvothermal strategy provides a facile solution to environmental problems through nanocrystal growth engineering in a confined space.
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- 2022
27. Dissolution of Mn-bearing dolomite drives elevated Cr(<scp>vi</scp>) occurrence in a Permian redbed aquifer
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Jeffrey P. Westrop, Zachary D. Tomlinson, Brandon M. Maples, Kato T. Dee, Andrew L. Swindle, Megan E. Elwood Madden, Qinhong Hu, and Andrew S. Elwood Madden
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Chromium ,Public Health, Environmental and Occupational Health ,Water ,Oxides ,General Medicine ,Management, Monitoring, Policy and Law ,Ferric Compounds ,Solubility ,Cations ,Clay ,Environmental Chemistry ,Coenzyme A ,Groundwater ,Water Pollutants, Chemical - Abstract
Municipalities in central Oklahoma, U.S.A. increasingly rely on water drawn from the Central Oklahoma Aquifer (COA) as surface water resources have not grown in proportion to population and current water demands. However, water drawn from certain regions of the COA frequently contains elevated levels of naturally occurring hexavalent chromium. Rock samples from the Norman Arsenic Test Hole Core (NATHC) were investigated to identify the mineralogic host(s) of Cr and mechanisms of Cr(VI) release
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- 2022
28. Adsorptive removal of pollutants from water using magnesium ferrite nanoadsorbent: a promising future material for water purification
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Md. Jamal Uddin and Yeon-Koo Jeong
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Materials science ,Health, Toxicology and Mutagenesis ,Oxide ,Iron oxide ,Magnesium Compounds ,chemistry.chemical_element ,Portable water purification ,Ferric Compounds ,Water Purification ,chemistry.chemical_compound ,Adsorption ,Specific surface area ,medicine ,Environmental Chemistry ,Magnesium ,General Medicine ,Pollution ,Kinetics ,chemistry ,Chemical engineering ,Environmental Pollutants ,Water treatment ,Water Pollutants, Chemical ,Activated carbon ,medicine.drug - Abstract
Nanoadsorbents having large specific surface area, high pore volume with tunable pore size, affordability and easy magnetic separation gained much popularity in recent time. Iron-based nanoadsorbents showed higher adsorption capacity for different pollutant removal from water among other periodic elements. Spinel ferrite nanomaterials among iron-bearing adsorbent class performed better than single iron oxide and hydroxides due to their large surface area, mesoporous pore, high pore volume and stability. This work aimed at focusing on water treatment using magnesium ferrite (MgFe2O4) nanomaterials. Synthesis routes, properties and pollutant adsorption were critically investigated to explore the performance of magnesium ferrite in water treatment. Structural and surface properties were greatly affected by the factors involved in different synthesis routes and iron and magnesium ratio. Complete removal of pollutants through adsorption was achieved using magnesium ferrite. Pollutant adsorption capacity of MgFe2O4 and its modified forms was found several folds higher than Fe2O3 and Fe3O4 nanomaterials. In addition, MgFe2O4 showed strong stability in water than other pure iron oxide and hydroxide. Modification with graphene oxide, activated carbon, biochar and silica was demonstrated to be beneficial for enhanced adsorption capacity. Complex formation was suggested as a dominant mechanism for pollutant adsorption. These nanomaterials could be a viable and competitive adsorbent for diverse pollutant removal from water.
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- 2021
29. Ferroptosis resistance determines high susceptibility of murine A/J strain to iron‐induced renal carcinogenesis
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Kiyoshi Mori, Shinya Toyokuni, Zhen Cheng, Guang Hua Li, Takashi Takahashi, and Shinya Akatsuka
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Male ,Nitrilotriacetic Acid ,Cancer Research ,Carcinogenesis ,SLC7A11 ,GPX4 ,medicine.disease_cause ,Ferric Compounds ,Lipid peroxidation ,Mice ,chemistry.chemical_compound ,iron ,Gene Regulatory Networks ,Sequence Deletion ,Kidney ,biology ,Homozygote ,General Medicine ,animal models ,Kidney Neoplasms ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Oncology ,Original Article ,lipocalins ,Injections, Intraperitoneal ,renal cell carcinoma ,Transferrin receptor ,Lipocalin-2 ,Species Specificity ,Receptors, Transferrin ,medicine ,Animals ,Ferroptosis ,Carcinoma, Renal Cell ,Cell damage ,Cyclin-Dependent Kinase Inhibitor p16 ,Cationic Amino Acid Transporter 1 ,Cyclin-Dependent Kinase Inhibitor p15 ,Original Articles ,Neoplasms, Experimental ,medicine.disease ,Molecular biology ,Ferritin ,Oxidative Stress ,chemistry ,Ferritins ,biology.protein ,Lipid Peroxidation - Abstract
Cancer susceptibility is a critical factor in the understanding of carcinogenesis. Intraperitoneal (i.p.) injection of an iron chelate, ferric nitrilotriacetate (Fe‐NTA), produces hydroxyl radicals via Fenton reaction to induce ferroptosis in renal proximal tubules. Rats or mice subjected to repeated i.p. injections of Fe‐NTA develop renal cell carcinoma (RCC). To elucidate the molecular mechanisms that cause susceptibility to renal carcinogenesis, we first established an inter‐strain difference in the susceptibility to Fe‐NTA‐induced renal carcinogenesis in mice. Based on a previous observation of a low incidence of RCC with this model in C57BL/6J strain mice, we investigated A/J strain mice here, which demonstrated significantly higher susceptibility to Fe‐NTA‐induced renal carcinogenesis. Homozygous deletion of the Cdkn2a/2b tumor suppressor locus was detected for the first time in A/J strain mice. Focusing on ferroptosis and iron metabolism, we explored the mechanisms involved that lead to the difference in RCC development. We compared the protective responses in the kidney of A/J and C57BL/6J strains after Fe‐NTA treatment. After 3‐week Fe‐NTA treatment, A/J mice maintained higher levels of expression of glutathione peroxidase 4 and xCT (SLC7A11), leading to a lower level of lipid peroxidation. Simultaneously, A/J mice had decreased expression of transferrin receptor and increased expression of ferritin to greater degrees than C57BL/6 mice. After a single Fe‐NTA injection, higher levels of oxidative cell damage and cytosolic catalytic Fe(II) were observed in C57BL/6J mice, accompanied by a greater increase in lipocalin‐2. Lipocalin‐2 deficiency significantly decreased oxidative renal damage. Our results suggest that a genetic trait favoring ferroptosis resistance contributes to high susceptibility to Fe‐NTA‐induced RCC in A/J strain., Cancer susceptibility is an important issue when considering cancer prevention. In this paper, we used an iron‐mediated oxidative stress‐induced renal carcinogenesis model in mice and found that ferroptosis resistance is an important factor determining cancer susceptibility.
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- 2021
30. Gum acacia PEG iron oxide nanocomposite (GA-PEG-IONC) induced pharmacotherapeutic activity on the Las R gene expression of Pseudomonas aeruginosa and HOXB13 expression of prostate cancer (Pc 3) cell line. A green therapeutic approach of molecular mechanism inhibition
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R. S. Arvind Bharani, S. Karthick Raja Namasivayam, R. Prasana, C. Valli Nachiyar, and Arul Maximus Rabel
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Male ,Catheters ,Biocompatibility ,Genes, vpr ,Antineoplastic Agents ,DNA Fragmentation ,Microbial Sensitivity Tests ,Cell morphology ,Ferric Compounds ,Biochemistry ,Nanocomposites ,Polyethylene Glycols ,Gum Arabic ,X-Ray Diffraction ,Structural Biology ,Gum acacia ,Spectroscopy, Fourier Transform Infrared ,PEG ratio ,Escherichia coli ,Humans ,Viability assay ,Molecular Biology ,Phylogeny ,Homeodomain Proteins ,Nanocomposite ,biology ,Caspase 3 ,Chemistry ,Prostatic Neoplasms ,Green Chemistry Technology ,Biological activity ,Gene Expression Regulation, Bacterial ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,Gene Expression Regulation, Neoplastic ,Biofilms ,PC-3 Cells ,Pseudomonas aeruginosa ,Spectrophotometry, Ultraviolet ,Reactive Oxygen Species ,Antibacterial activity - Abstract
Among the diverse nanomaterials, polymer-based nanocomposites are gained more attention due to their high efficacy, target biological activities, biodegradability and biocompatibility-gum acacia (GA) - a polymer obtained from acacia trees-is considering the multifunctional nanocomposite synthesis. Distinctive Physico-chemical and biocompatibility properties of gum acacia are utilised to prepare a highly stable, biologically active, eco-friendly Nanocomposite. In this current investigation, gum acacia - poly ethylene glycol grafted iron oxide nanocomposite (GA-PEG-IONC) was synthesised by in situ green science principles. The synthesised Nanocomposite was evaluated against the molecular mechanism of urinary tract pathogenic bacterial strains and prostate cancer cells (Pc 3). Nanocomposite prepared in this examination exhibited notable structural, functional stability with nanoarchitecture which was affirmed by Fourier transform infrared spectroscopy (FTIR), electron microscopic studies, atomic force microscopy (AFM), vibrating sample magnetometric analysis (VSM) and X-ray diffraction (XRD), Synthesised Nanocomposite brought about notable antibacterial activity against urinary tract pathogenic strains by recording potential inhibitory effect on the expression of Las R gene. Inhibition of Las R gene expression reduced notable effect on biofilm development. Anticancer activity against prostate cancer cells (Pc3) was investigated by measurement of HOXB13 gene expression level. Inhibition of HOXB13 gene expression by the IONC brought about structural, functional changes. HOXB13 gene expression inhibition reveals a remarkable cytotoxic effect by recording decreased cell viability. Morphometric analysis by phase-contrast and DAPI fluorescence staining demonstrates that the Nanocomposite prompted cell morphology anomalies or apoptotic changes. Nanocomposite treatment brought about a good sign of Apoptosis by recording enhanced caspase 3 and 9 activities, DNA fragmentation and elevated reactive oxygen species generation (ROS). Hemocompatibility studies were carried out to determine the biocompatibility of the Nanocomposite. Spectrophotometric estimation of plasma haemoglobin, microscopic examination of whole blood cells shows the Nanocomposite was not inciting any indication of toxicity. These findings infer that IONC synthesised in the present study is the promising contender for a broad scope of biomedical applications, especially as an antibacterial and anticancer agent.
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- 2021
31. Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder
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Raffaele Ferri, Maida Lynn Chen, Vidhi Kapoor, Lourdes M. DelRosso, Richard P. Allen, Maria Paola Mogavero, and Daniel L. Picchietti
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medicine.medical_specialty ,Periodic limb movement disorder ,Ferric Compounds ,FERRIC CARBOXYMALTOSE ,Restless Legs Syndrome ,Internal medicine ,mental disorders ,medicine ,Humans ,Restless legs syndrome ,Child ,Maltose ,Adverse effect ,Retrospective Studies ,biology ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Nocturnal Myoclonus Syndrome ,Ferritin ,Treatment Outcome ,Tolerability ,biology.protein ,Clinical Global Impression ,Serum iron ,business - Abstract
Iron supplementation is the most commonly considered treatment option for children with restless legs syndrome (RLS) or periodic limb movement disorder (PLMD); however, there is a scarcity of evidence on the effectiveness of intravenous preparations. In this study, we evaluated the effectiveness and tolerability of intravenous ferric carboxymaltose (IV FCM) on clinical symptoms and iron indices in children with RLS or PLMD.This was a single-center retrospective data analysis. Children with a diagnosis of RLS or PLMD, who underwent a single infusion of IV FCM, were included. Clinical Global Impression (CGI) Scale scores, serum ferritin, and serum iron profile at baseline and after eight weeks post infusion were obtained. Adverse effects were assessed.Thirty-nine children received IV FCM, 29 with RLS and 10 with PLMD. Pre-infusion CGI-Severity revealed moderate illness, with post-infusion CGI-Improvement between "very much improved" and "much improved". Ferritin increased from 14.6 μg/L±7.01 to 112.4 μg/L±65.86 (p 0.00001), together with improvements in iron, total iron binding capacity, and transferrin levels from baseline to post-treatment. When compared to children with RLS, those with PLMD had a similar improvement in clinical symptoms and laboratory parameters. Seven subjects (14.3%) experienced one or two adverse events; all were mild.Children with RLS and PLMD responded to IV iron supplementation with improvement in both clinical severity and laboratory parameters. Treatment was well tolerated. Although larger, randomized-controlled trials are needed, IV FCM appears to be a promising alternative to oral iron supplementation for the treatment of pediatric RLS or PLMD.
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- 2021
32. A safety evaluation of sucroferric oxyhydroxide for the treatment of hyperphosphatemia
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Markus Ketteler and Stuart M. Sprague
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Sucrose ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Ferric Compounds ,Gastroenterology ,Hyperphosphatemia ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,Drug Interactions ,Pharmacology (medical) ,Renal Insufficiency, Chronic ,Dialysis ,Chelating Agents ,business.industry ,General Medicine ,Serum phosphate ,medicine.disease ,Phosphate binder ,Clinical trial ,Drug Combinations ,Tolerability ,Hemodialysis ,business ,Kidney disease - Abstract
Introduction Hyperphosphatemia is a common complication as chronic kidney disease (CKD) progresses and most patients undergoing dialysis are prescribed oral phosphate binder therapy to control serum phosphate concentrations. Sucroferric oxyhydroxide is an iron-based phosphate binder approved for the treatment of hyperphosphatemia in CKD patients on dialysis. Areas covered This article reviews key safety and effectiveness data for sucroferric oxyhydroxide from both prospective clinical trials and real-world observational studies. Expert opinion Sucroferric oxyhydroxide potently binds dietary phosphate in the gastrointestinal (GI) tract, resulting in effective reduction of serum phosphate concentrations with a relatively low daily pill burden. Data from clinical trials and real-world observational studies show sucroferric oxyhydroxide has a favorable safety and tolerability profile. The most frequent side effects observed with sucroferric oxyhydroxide are GI-related, mainly discolored (black) stools and mild or moderate transient diarrhea, both of which are manageable. There is minimal systemic iron absorption from sucroferric oxyhydroxide, and therefore the drug is associated with a low risk of iron accumulation. Sucroferric oxyhydroxide also displays low potential for drug-drug interactions with other commonly prescribed oral medications. Overall, sucroferric oxyhydroxide offers an effective and well-tolerated treatment option for the management of hyperphosphatemia.
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- 2021
33. A novel transformation pathway of p-arsanilic acid in water by colloid ferric hydroxide under UVA light
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Tao Luo, Yi Wu, Jun Xia, Jing Xu, Mengling Ma, and Xiang Zhang
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Pollutant ,Arsanilic acid ,Ultraviolet Rays ,Chemistry ,Health, Toxicology and Mutagenesis ,Water ,General Medicine ,Photochemistry ,Ferric Compounds ,Pollution ,eye diseases ,Colloid ,chemistry.chemical_compound ,Transformation (genetics) ,Arsanilic Acid ,Ferric hydroxide ,Environmental Chemistry ,Colloids ,sense organs ,Spectroscopy ,Surface water ,Equilibrium constant - Abstract
Iron species that occur in natural surface water could affect the photochemical behavior of pollutants. Complexation between iron species and polycarboxylate or heavy metals has been widely reported, where the ligands could be oxidized via ligand-to-metal charge transfer (LMCT) by light inducement. Such complexation and photochemical reactions might also occur for low valance metal-containing organic compounds, which is worthy of investigation. This work studied the phototransformation of p-arsanilic acid (ASA), an organic arsenic compound that is widely used as a feed additive in the poultry industry, by colloidal ferric hydroxide (CFH) using black light lamps (λ = 365 nm) as the light source. The results revealed the contribution to ASA transformation at circumneutral conditions by CFH through an LMCT process, which is the same as that for As(III). The complexation between ASA and CFH was investigated using UV–vis spectroscopy. The estimated equilibrium constant for the CFH–ASA complex was log Kf271 = 4.22. The analysis of the photoproducts found the generation of both inorganic and organic arsenic. Our findings confirmed the similarities in the photochemical mechanisms of ASA and As(III) in the presence of CFH. The results help in further understanding the fate of organoarsenicals in the surface water environment.
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- 2021
34. Removal of antimonate (Sb(V)) from aqueous solutions and its immobilization in soils with a novel Fe(III)-modified montmorillonite sorbent
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Saeed Bagherifam, Eric D. van Hullebusch, Sridhar Komarneni, and Marija Stjepanović
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Antimony ,Langmuir ,Aqueous solution ,Health, Toxicology and Mutagenesis ,Extraction (chemistry) ,Water ,chemistry.chemical_element ,Sorption ,General Medicine ,Ferric Compounds ,Pollution ,antimony ,bioaccessibility ,bioavailability ,adsorption isotherms ,immobilization ,in situ stabilization ,Soil ,chemistry.chemical_compound ,Adsorption ,chemistry ,Bentonite ,Humans ,Soil Pollutants ,Environmental Chemistry ,Freundlich equation ,Antimonate ,Nuclear chemistry - Abstract
Over the past decades, contamination of terrestrial environments with antimony (Sb) has aroused a great deal of public concern. In this research, the efficacy of Fe(III)-modified montmorillonite (Mt) (Fe-Mt) for the removal of Sb(V) from aqueous solutions with Sb(V) concentration in the range of 0.2–1 mmol L−1 and immobilization of Sb(V) in soils spiked with 250 mg Sb(V) kg−1 was investigated. The immobilizing mechanisms of the modified clay were assessed by fitting the experimental sorption data with the Langmuir and Freundlich sorption models and a series of single and sequential extraction studies. The results showed that the adsorption data had a better fit with the Langmuir equation (R2: 0.99) and Fe-Mt could efficiently remove up to 95% of Sb(V) at lower concentration ranges. The concentrations of Sb(V) in exchangeable fraction of modified Community Bureau of Reference (BCR) sequential extraction and distilled water extracts of the amended soils decreased dramatically by up to 60% and 92%, respectively. Furthermore, the bioaccessibility of Sb(V) in simulated human gastric juice reduced remarkably by 52% to 60%, depending upon the soil fraction sizes. The results confirmed that Fe-Mt could be a promising candidate for the removal of Sb(V) from aqueous solutions and immobilization of Sb(V) in terrestrial environments.
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- 2021
35. Novel Fe(III)-Polybasic acid coordination polymer nanoparticles with targeted retention for photothermal and chemodynamic therapy of tumor
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Zhenzhong Zhang, Fan Shuting, Zhi Li, Cai Qingqing, Xiaoyu Zhao, Weiwei Cui, Xinhong Guo, Hu Wentao, Yuan Wu, Yizhe Wu, Haojin Wang, and Xinjie Lian
- Subjects
Male ,Biocompatibility ,Photothermal Therapy ,Coordination polymer ,Pharmaceutical Science ,Nanoparticle ,02 engineering and technology ,Ferric Compounds ,030226 pharmacology & pharmacy ,Theranostic Nanomedicine ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Coordination Complexes ,In vivo ,Cell Line, Tumor ,Neoplasms ,Animals ,Humans ,Polyethyleneimine ,Tissue Distribution ,Bovine serum albumin ,Tartrates ,chemistry.chemical_classification ,Drug Carriers ,Photosensitizing Agents ,biology ,Serum Albumin, Bovine ,General Medicine ,Polymer ,Hydrogen-Ion Concentration ,Photothermal therapy ,021001 nanoscience & nanotechnology ,Rats ,Disease Models, Animal ,Photochemotherapy ,chemistry ,biology.protein ,Biophysics ,Nanoparticles ,Female ,Drug Screening Assays, Antitumor ,0210 nano-technology ,Biotechnology ,Protein adsorption - Abstract
The development of Fe-coordination polymer-based nanoparticles, with safe and high anti-tumor effects, for the treatment of tumor is facing challenges such as limited resources and poor targeting. In this study, we prepared Fe-polyhydroxy coordination polymer nanoparticles (TA-Fe@MNPs), based on tartaric acid (TA)–Fe(III) coordination polymer as the new photothermal agent, mannose (M) as the target, and bovine serum albumin (BSA) and polyethyleneimine (PEI) as the carrier materials, and investigated them for targeting the multifunctional therapy of tumors. The TA-Fe@MNPs synthesized via a simple coordination of Fe3+ with TA, bovine serum albumin, and polyethyleneimine under ambient conditions exhibited an appropriate size (~125 nm), electrically neutral surfaces, good biocompatibility, and low normal cell toxicity. The TA-Fe@MNPs are the first to exhibit a remarkable photothermal performance. They also showed a pH-sensitive Fenton-like response that was further enhanced via glutathione response. Interestingly, after a single injection, the TA-Fe@MNPs could be retained at the tumor site for 36 h with an effective photothermal dose, which was attributed to the reduced protein adsorption and slow elimination in tumor cells with the aid of M modification and carrier materials, while that for the TA-Fe@NPs did so for only 2 h. Tumor ablation was demonstrated by in vivo photothermal and chemokinetic therapy using TA-Fe@MNPs, and their safety was evident from the weight changes and blood parameters. These results indicated that the TA-Fe@MNPs, as new photothermal and CDT agents, have the potential to be used in clinical tumor therapy nanoplatforms.
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- 2021
36. Randomized, placebo-controlled trial of ferric carboxymaltose in restless legs syndrome patients with iron deficiency anemia
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Yong Won Cho, Christopher J. Earley, Hyoeun Bae, Richard P. Allen, and Keun Tae Kim
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medicine.medical_specialty ,Placebo-controlled study ,Placebo ,Ferric Compounds ,FERRIC CARBOXYMALTOSE ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Restless Legs Syndrome ,Internal medicine ,mental disorders ,medicine ,Humans ,In patient ,Restless legs syndrome ,Maltose ,Adverse effect ,Anemia, Iron-Deficiency ,business.industry ,General Medicine ,medicine.disease ,Clinical trial ,Treatment Outcome ,030228 respiratory system ,Iron-deficiency anemia ,business ,030217 neurology & neurosurgery - Abstract
Objective Intravenous ferric carboxymaltose (FCM) has been shown to be efficacious in treating restless legs syndrome (RLS) symptoms in non-anemic patients. The aim of this study was to evaluate the effectiveness of FCM in treating RLS symptoms in patients who also had an iron deficiency anemia (IDA). Methods This is a randomized, double-blinded, placebo-controlled study. Subjects with RLS and IDA were enrolled. Subjects received an infusion of either 1500 mg FCM or placebo in Phase I. The primary outcomes were a change-from-baseline at week six on the International Restless Legs Syndrome Study Group scale (IRLS). Phase II of the study involved long-term (52 weeks) follow-up, for those who responded to treatment in the prior phase, with the potential for further treatment if symptoms returned. Results We enrolled 29 RLS patients with IDA (15 FCM and 14 placebo). At week six post-infusion, FCM compared to placebo group showed significant improvement from baseline in IRLS score (−13.47 ± 7.38 vs. 1.36 ± 3.59). Among secondary outcome variables, quality of sleep showed significant improvement from baseline in the FCM group. 61% of subjects remained off RLS medications at the Phase II, week-52 endpoint. There were no serious adverse events observed in the study. Conclusion The study showed significant efficacy and safety of FCM 1500 mg treatment both in the short term (6 weeks) and long term (52 weeks) in RLS patients with IDA.
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- 2021
37. Characterisation of iron oxide-containing pearlescent pigments used as food colourants: nano-labelling required in the EU?
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Birgit Hetzer, Volker Gräf, Elke Walz, and Ralf Greiner
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Titanium ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Food Coloring Agents ,Oxides ,Food Additives ,General Chemistry ,General Medicine ,Toxicology ,Ferric Compounds ,Food Science ,Follow-Up Studies - Abstract
Pearlescent pigments are used as colourants to increase the attractiveness of food products, especially in the patisserie and confectionery sector. They can be seen as composite materials and consist of thin potassium aluminium silicate (E 555, mica) platelets as carrier material, coated with a thin metal oxide layer of TiO
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- 2022
38. Phenol degradation in iron-based advanced oxidation processes through ferric reduction assisted by molybdenum disulfide
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Yingying You and Zhen He
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Molybdenum ,Environmental Engineering ,Phenol ,Health, Toxicology and Mutagenesis ,Iron ,Public Health, Environmental and Occupational Health ,General Medicine ,General Chemistry ,Pollution ,Ferric Compounds ,Environmental Chemistry ,Ferrous Compounds ,Oxidation-Reduction ,Water Pollutants, Chemical - Abstract
In the iron-based advanced oxidation processes (AOPs), direct use of Fe
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- 2022
39. Tolerability of Oral Supplementation with Microencapsulated Ferric Saccharate Compared to Ferrous Sulphate in Healthy Premenopausal Woman: A Crossover, Randomized, Double-Blind Clinical Trial
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Marina Friling, Ana María García-Muñoz, Tania Perrinjaquet-Moccetti, Desirée Victoria-Montesinos, Silvia Pérez-Piñero, María Salud Abellán-Ruiz, Antonio J. Luque-Rubia, Ana Isabel García-Guillén, Fernando Cánovas, and Eran Ivanir
- Subjects
Ferric Oxide, Saccharated ,Anemia, Iron-Deficiency ,iron supplementation ,AB-Fortis® ,microencapsulated iron ,ferric saccharate ,ferrous sulphate ,gastrointestinal side effects ,tolerability ,Iron ,Organic Chemistry ,Administration, Oral ,General Medicine ,Ferric Compounds ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Double-Blind Method ,Dietary Supplements ,Humans ,Female ,Ferrous Compounds ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy - Abstract
A single-center, crossover, randomized, double-blind, and controlled clinical study was conducted to assess the tolerability profile, especially with regard to gastrointestinal complaints, of oral supplementation with AB-Fortis®, a microencapsulated ferric saccharate (MFS), as compared with conventional ferrous sulphate (FS) in healthy premenopausal women. A dose of 60 mg/day of elemental iron was used. The test products were administered for 14 consecutive days with a washout period of two menstrual episodes and a minimum of one month between the two intervention periods. The subjects completed simple-to-answer questionnaires daily for 14 days during both the intervention and the washout periods, capturing the symptoms associated with oral iron supplementation and overall health aspects. Following product consumption, the incidences of symptoms, numbers of complaints/symptoms, overall intensity, and total days with symptoms were found to be significantly higher for FS consumption as compared to MFS. The better tolerability profile of MFS over FS was further substantiated when both products were compared to a real-life setting (i.e., the washout period). Overall, the administration of both study products was safe with no serious or significant adverse events reported. In summary, the current study shows the better tolerability of the MFS preparation when compared to that of the FS, presenting MFS as a well-tolerated and safe option for improving iron nutrition.
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- 2022
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40. Hierarchical Ti-MOF Microflowers for Synchronous Removal and Fluorescent Detection of Aluminum Ions
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Jianguo Zhou, Jieyao Song, Guangqiang Ma, Yongjian Li, Yanan Wei, Fei Liu, and Hongjian Zhou
- Subjects
Titanium ,Ions ,Clinical Biochemistry ,Biomedical Engineering ,Water ,General Medicine ,Ferric Compounds ,Analytical Chemistry ,luminescence ,metal-organic frameworks ,hierarchical nanostructures ,fluorescent sensors ,metal ions ,Instrumentation ,Engineering (miscellaneous) ,Metal-Organic Frameworks ,Biotechnology ,Aluminum - Abstract
Bifunctional luminescence metal-organic frameworks with unique nanostructures have drawn ongoing attention for simultaneous determination and elimination of metal ions in the aqueous environment, but still remain a great challenge. In this work, three-dimensional hierarchical titanium metal-organic framework (Ti-MOF) microflowers were developed by a secondary hydrothermal method for not only highly sensitive and selective detection of Al(III), but also simultaneously efficient decontamination. The resulting Ti-MOF microflowers with a diameter of 5–6 μm consisted of nanorods with a diameter of ∼200 nm and a length of 1–2 μm, which provide abundant, surface active sites for determination and elimination of Al(III) ions. Because of their substantial specific surface area and superior fluorescence characteristics, Ti-MOF microflowers are used as fluorescence probes for quantitative determination of Al(III) in the aqueous environment. Importantly, the specific FL enhancement by Al(III) via a chelation-enhanced fluorescence mechanism can be utilized for selective and quantitative determination of Al(III). The Al(III) detection has a linear range of 0.4–15 µM and a detection limit as low as 75 nM. By introducing ascorbic acid, interference of Fe(III) can be avoided to achieve selective detection of Al(III) under various co-existing cations. It is noteworthy that the Ti-MOF microflowers exhibit excellent adsorption capacity for Al(III) with a high adsorption capacity of 25.85 mg g−1. The rapid adsorption rate is consistent with a pseudo-second order kinetic model. Ti-MOF is a promising contender as an adsorbent and a fluorescent chemical sensor for simultaneous determination and elimination of Al(III) due to its exceptional water stability, high porosity, and intense luminescence.
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- 2022
41. Estimation of SPIO Nanoparticles Uptakes by Macrophages Using Transmission Electron Microscopy
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Adham Aleid, Khalid Alhussaini, Mohammed Almijalli, and Ali S. Saad
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Macrophages ,Organic Chemistry ,iron oxide nanoparticles ,drug delivery ,electron microscopy ,segmentation ,image processing ,General Medicine ,Magnetic Resonance Imaging ,Ferric Compounds ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Mice ,Microscopy, Electron, Transmission ,Humans ,Animals ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy - Abstract
Due to their interesting size-dependent magnetic characteristics and relative biocompatibility, magnetic superparamagnetic iron oxide (SPIO) nanoparticles have been widely exploited as probes for cell and subcellular structure identification, as well as medication and gene delivery. A thorough understanding of the mechanics of the interaction between nanoparticles and macrophages is vital in managing dynamic processes in nanomedicine. In this study, the interaction behavior and uptake of SPIO nanoparticles by M1- and M2-type macrophages were investigated. Mice monocytes were differentiated into M1 and M2 macrophages, and the uptake of SPIO nanoparticles was studied using a TEM microscope. A high resolution image of 1 nm resolution, an image processing technique, was developed to extract the SPIO-NPs from tomographic TEM microscopic images. Lysosomes appear to be the zones of high concentrations of SPIO inside macrophages. Lysosomes were first selected in each image, and then segmentation by the Otsu thresholding method was used to extract the SPIO-NPs. The Otsu threshold method is a global thresholding technique used to automatically differentiate SPIOs from the background. The SPIO-NPs appear in red colors, and the other pixels in the image are considered background. Then, an estimation of the SPIO-NP uptakes by lysosomes is produced. Higher uptake of all-sized nanoparticles was observed in M1- and M2-type macrophages. An accurate estimation of the number of SPIO-NPs was obtained. This result will help in controlling targeted drug delivery and assessing the safety impact of the use of SPIO-NPs in nanomedicine for humans.
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- 2022
42. Perioperative management with ferric carboxymaltose and tranexamic acid to reduce transfusion rate in gynaecological carcinoma surgery (TRANAFER-Study): study protocol for a single-blind, monocentre, randomised trial
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Gabriela Amstad, James Geiger, Laura Werlen, Celine Montavon, and Viola Heinzelmann
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Gynecologic Surgical Procedures ,Tranexamic Acid ,Iron ,Carcinoma ,Humans ,Anemia ,Blood Transfusion ,Female ,Single-Blind Method ,General Medicine ,Maltose ,Ferric Compounds ,Randomized Controlled Trials as Topic - Abstract
IntroductionRadical abdominal surgery is part of the standard treatment for women with advanced gynaecological carcinoma. The surgery often leads to intraoperative blood loss frequently exceeding 1000 mL. Approximately 50% of women undergoing radical surgery require blood transfusions. Perioperative blood transfusions have been shown to increase the risk of postoperative complications, delayed wound healing, increased length of stay, increased postoperative morbidity and mortality. Previous studies have demonstrated an association between perioperative anaemia and surgical morbidity and mortality. By reducing transfusions and improving recovery from surgery, preoperative diagnostic and management of perioperative anaemia is a great opportunity to optimise postoperative patient outcome.Methods and analysisThis is a single-blind, monocentre, randomised trial with four parallel groups (three therapeutic groups and one control group without treatment according to current standards of care) conducted in women undergoing radical gynaecological surgery. The primary study objective is to determine the effect of perioperative treatment with either intravenous iron, tranexamic acid or with a combination of both medicines on the reduction of intraoperative and postoperative red blood cell transfusions in gynaecological carcinoma patients. A total of N=126 women with gynaecological carcinoma will be recruited at the University Hospital Basel, Department of Gynaecology. Blood parameters will be measured at the recruitment, prior to surgery, 2 days after surgery and on the 21st–28th day after surgery. Recruitment started in August 2021.Ethics and disseminationThe study will be performed according to the guidelines of the Declaration of Helsinki and is approved by the Ethics Committee for Northwest and Central Switzerland in Basel (EKNZ Protocol ID 2020-01194). The results of this study will be published and presented in various scientific forums.Trial registration numberNCT03792464.
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- 2022
43. GO accelerate iron oxides formation and tetrabromobisphenol A removal enhancement in the GO loaded NZVI system
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Wenbing Wang, Qianling Dong, Yitao Mao, Yifan Zhang, Tiantian Gong, and Hui Li
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Health, Toxicology and Mutagenesis ,Iron ,Oxides ,General Medicine ,Adsorption ,Toxicology ,Pollution ,Ferric Compounds ,Water Pollutants, Chemical - Abstract
Tetrabromobisphenol A (TBBPA) is an emerging persistent organic pollutant, which is very difficult to remove by common methods. In this study, the GO-load nanoscale zero-valent iron (NZVI/GO) was fabricated and optimized to improve the reaction rate and removal efficiency for TBBPA reliably and efficiently. The results showed that GO-load significantly reduced the self-aggregation of NZVI and the aggregate size decreased by 50.00% (1400-700 nm). Meanwhile, GO significantly improved the reaction rate k
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- 2022
44. Effect of intraoperative intravenous ferric derisomaltose supplementation on reduction of postoperative anemia and transfusion in chronic kidney disease patients after total knee replacement
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Jae Hyun Kwon, Yong Hyun Cho, Won Jang, Sun Hee Kim, Hyun Cheol Ko, Woo Hyeong Ko, and Young Do Kim
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Hemoglobins ,Dietary Supplements ,Humans ,Anemia ,Blood Transfusion ,General Medicine ,Renal Insufficiency, Chronic ,Arthroplasty, Replacement, Knee ,Disaccharides ,Ferric Compounds ,Retrospective Studies - Abstract
Total knee replacement (TKR) is associated with a large amount of bleeding; therefore, the prevalence of postoperative anemia is high. In particular, patients with chronic kidney disease (CKD) are more vulnerable to postoperative anemia than are healthy individuals. Accordingly, the effect of intraoperative intravenous ferric derisomaltose (FDI) supplementation on postoperative anemia and blood transfusion volume reduction in patients with CKD was studied. Patients who underwent unilateral TKR between January 2019 and December 2020 were retrospectively reviewed. In analyzing the data, the patients fell into the CKD group (n = 85) and the non-CKD group (n = 106). Each group was divided into a group using FDI and a non-FDI group, and classified into 4 groups. The postoperative hemoglobin level for each postoperative day (POD) was determined as the primary outcome. In addition, the patient transfusion rate, volume of transfusion, and length of hospital stay were set as secondary study outcomes during the period from surgery to discharge. There was no statistically significant difference in hemoglobin levels on PODs 0, 1, 2, 7, and 14 in the CKD group. In the CKD group, the transfusion volume of the FDI group was 0.58 ± 0.91 units per person, which was statistically significantly lower than 1.28 ± 1.28 units of the non-FDI group (P = .01). In the CKD group, the transfusion rate of the FDI group was 30.2%, which was statistically significantly lower than that of the non-FDI group, which was 56.3% (P = .02). This study showed that intravenous FDI supplementation after TKR in CKD patients did not reduce postoperative anemia but was an effective and safe treatment to reduce transfusion volume and transfusion rate. There was no statistically significant difference in hemoglobin levels on POD 0, 1, 2, 7, and 14 in the non-CKD group. In the non-CKD group, the transfusion volume of the FDI group was 0.46 ± 0.88 units per person, which was lower than the 0.56 ± 0.91 units of the non-FDI group, but it was not statistically significant (P = .59). In the non-CKD group, the transfusion rate of the FDI group was 23.0%, which was lower than that of the non-FDI group, which was 31.3%, but it was not statistically significant (P = .37).
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- 2022
45. Effects of biochar on anaerobic treatment systems: Some perspectives
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Liqiu Zhang, Zhuokun Chen, Shishu Zhu, Shugeng Li, and Chunhai Wei
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Environmental Engineering ,Renewable Energy, Sustainability and the Environment ,Charcoal ,Iron ,Bioengineering ,General Medicine ,Anaerobiosis ,Waste Management and Disposal ,Ferric Compounds - Abstract
Many anaerobic activities involve carbon, nitrogen, iron, and sulfur cycles. As a well-developed porous material with abundant functional groups, pyrolytic biochar has been widely researched in efforts to promote microbial activities. However, the lack of consensus on the biochar mechanism has limited its practical application. This review summarizes the effects of different pyrolysis temperatures, particle sizes, and dosages of biochar on microbial activities and community in Fe(III) reduction, anaerobic digestion, nitrogen removal, and sulfate reduction systems. It was found that biochar could promote anaerobic activities by stimulating electron transfer, alleviating toxicity, and providing suitable habitats for microbes. However, it inhibits microbial activities by releasing heavy metal ions or persistent free radicals and adsorbing signaling molecules. Finding a balance between the promotion and inhibition of biochar is therefore essential. This review provides valuable perspectives on how to achieve efficient and stable use of biochar in anaerobic systems.
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- 2022
46. Simultaneous nitrogen and phosphorus removal from municipal wastewater by Fe(III)/Fe(II) cycling mediated partial-denitrification/anammox
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Chengkun Kao, Qiong Zhang, Jianwei Li, Ruitao Gao, Wenyu Li, Xiyao Li, Shuying Wang, and Yongzhen Peng
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Environmental Engineering ,Nitrates ,Bacteria ,Sewage ,Renewable Energy, Sustainability and the Environment ,Nitrogen ,Nitrogen Dioxide ,Bioengineering ,Phosphorus ,General Medicine ,Wastewater ,Ferric Compounds ,Anaerobic Ammonia Oxidation ,Bioreactors ,Denitrification ,Ferrous Compounds ,Waste Management and Disposal ,Oxidation-Reduction ,Nitrites - Abstract
The efficient removal of nitrogen and phosphorus remains challenging for traditional wastewater treatment. In this study, the feasibility for enhancing the partial-denitrification and anammox process by Fe (III) reduction coupled to anammox and nitrate-dependent Fe (II) oxidation was explored using municipal wastewater. The nitrogen removal efficiency increased from 75.5 % to 83.0 % by adding Fe (III). Batch tests showed that NH
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- 2022
47. Iron oxide nanoparticles for biomedical applications: an updated patent review (2015-2021)
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Zeyuan Mao, Xin Li, Pengfei Wang, and Hailong Yan
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Pharmacology ,Patents as Topic ,Drug Discovery ,Humans ,Nanoparticles ,Magnetic Iron Oxide Nanoparticles ,General Medicine ,Magnetite Nanoparticles ,Ferric Compounds - Abstract
Iron oxide nanoparticles (IONPs) hold the edges of great magnetic properties and fine nanoparticle characteristics, making them an attractive therapeutic agent. In the past seven years, more in-depth investigations were devoted to the intrinsic structure, magnetic properties, and biological effects of IONPs, expanding the range of their therapeutic application scenes.This review focuses on the development of IONPs for biomedical applications from the angle of the patent literature reported during the period 2015-2021.While the magnetic properties of IONPs have been extensively explored, the precise control of IONP behavior through external magnetic fields remains a challenge. Further digging into the biological effects of IONPs will facilitate the development of IONP-based immune therapies. Long-term reliable safety evaluations are of necessity and significance to promote the process of clinical translation.
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- 2022
48. How Do Metalloproteins Tame the Fenton Reaction and Utilize •OH Radicals in Constructive Manners?
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Binju Wang, Xuan Zhang, Wenhan Fang, Carme Rovira, and Sason Shaik
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Peroxidases ,Metalloproteins ,General Medicine ,General Chemistry ,Heme ,Hydrogen Peroxide ,Ferric Compounds ,Oxidation-Reduction ,Copper - Abstract
ConspectusThis Account describes the manner whereby nature controls the Fenton-type reaction of O-O homolysis of hydrogen peroxide and harnesses it to carry out various useful oxidative transformations in metalloenzymes. H
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- 2022
49. Cobalt Ferrite Magnetic Nanoparticles for Tracing Mesenchymal Stem Cells in Tissue: A Preliminary Study
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Željka Večerić-Haler, Nika Kojc, Karmen Wechtersbach, Martina Perše, and Andreja Erman
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Organic Chemistry ,Mesenchymal Stem Cells ,Cobalt ,General Medicine ,Acute Kidney Injury ,Mesenchymal Stem Cell Transplantation ,Ferric Compounds ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Mice ,Animals ,Nanoparticles ,mesenchymal stem cells ,metal nanoparticles ,markers ,tissue injury ,Cisplatin ,Physical and Theoretical Chemistry ,Magnetite Nanoparticles ,Molecular Biology ,Spectroscopy - Abstract
Therapy with mesenchymal stem cells (MSCs) is promising in many diseases. Evaluation of their efficacy depends on adequate follow-up of MSCs after transplantation. Several studies have shown that MSCs can be labeled and subsequently visualized with magnetic nanoparticles (NPs). We investigated the homing of MSCs labeled with magnetic cobalt ferrite NPs in experimentally induced acute kidney injury in mice. To explore the homing of MSCs after systemic infusion into mice, we developed a pre-infusion strategy for optimal tracing and identification of MSCs with polyacrylic acid-coated cobalt ferrite (CoFe2O4) NPs by light and transmission electron microscopy (TEM) in various organs of mice with cisplatin-induced acute kidney injury and control mice. By correlative microscopy, we detected MSCs labeled with NPs in the lungs, spleen, kidney, and intestine of cisplatin-treated mice and in the lungs and spleen of control mice. Our results confirm that labeling MSCs with metal NPs did not affect the ultrastructure of MSCs and their ability to settle in various organs. This study demonstrates the usefulness of cobalt ferrite NPs in ex vivo visualization of MSCs and offers correlative microscopy as a useful method in routine histopathology laboratories for tracing MSCs in paraffin-embedded tissue.
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- 2022
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50. Ferric citrate for the treatment of hyperphosphatemia and anemia in patients with chronic kidney disease: a meta-analysis of randomized clinical trials
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Li Li, Xin Zheng, Jin Deng, Junlin Zhou, Jihong Ou, and Tao Hong
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Hyperphosphatemia ,Nephrology ,Humans ,Anemia ,General Medicine ,Renal Insufficiency, Chronic ,Critical Care and Intensive Care Medicine ,Ferric Compounds ,Phosphates ,Randomized Controlled Trials as Topic - Abstract
Hyperphosphatemia and anemia, which are common complications of chronic kidney disease (CKD), can independently contribute to cardiovascular events. Several previous studies have found that the iron-based phosphate binder, ferric citrate (FC), could be beneficial to both hyperphosphatemia and anemia.Relevant literature from PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials (CCRCT) and MEDLINE databases were searched up to 21 February 2022, in order to conduct a meta-analysis to investigate the efficacy, safety and economic benefits of ferric citrate treatment in CKD patients with hyperphosphatemia and anemia. The meta-analysis was conducted independently by two reviewers using the RevMan software (version 5.3).In total, this study included 16 randomized clinical trials (RCT) involving 1754 participants. The meta-analysis showed that ferric citrate could significantly reduce the serum phosphorus in CKD patients compared to the placebo control groups (MD -1.76 mg/dL, 95% CI (-2.78, -0.75);Collectively, our review suggests that iron-based phosphate binder, ferric citrate is an effective and safe treatment option for CKD patients with hyperphosphatemia and anemia. More importantly, this alternative treatment may also less expensive. Nevertheless, more scientific studies are warranted to validate our findings.
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- 2022
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