21 results on '"Gonzalo P. Méndez"'
Search Results
2. Takayasu's arteritis and secondary membranous nephropathy: an exceptional association
- Author
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Gonzalo Labarca, Gonzalo P. Méndez, Daniel Enos, and Mariel Hernandez
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Male ,medicine.medical_specialty ,Takayasu's arteritis ,030232 urology & nephrology ,Renal function ,Case Report ,Gastroenterology ,Glomerulonephritis, Membranous ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Membranous nephropathy ,Internal medicine ,medicine ,Humans ,Arteritis ,Cyclophosphamide ,Creatinine ,business.industry ,Receptors, Phospholipase A2 ,General Medicine ,Middle Aged ,medicine.disease ,Takayasu Arteritis ,chemistry ,Albuminuria ,Prednisone ,medicine.symptom ,Neoplasm Recurrence, Local ,Vasculitis ,business ,Nephrotic syndrome ,030217 neurology & neurosurgery - Abstract
The association between Takayasu’s arteritis and membranous nephropathy is uncommon. We present the case of a 46-year-old man with Takayasu’s arteritis treated over 10 years by a multidisciplinary medical team. He had an atrophic left kidney due to arterial stenosis, with a basal creatinine of 1.59 mg/dL (140.55 µmol/l). Three years ago, he presented with full nephrotic syndrome, uncontrolled blood pressure, creatinine increases to 4.5 mg/dL (basal: 1.59 mg/dL), severe hypoalbuminaemia (1.4 g/dL) and albuminuria of 24.6 g per day. He underwent percutaneous biopsy of the right kidney that showed membranous nephropathy with negative PLA2R1 and positive IgG 1, 3 and 4 subclasses. After therapy with oral prednisone and cyclophosphamide, the patient’s kidney function improved, without recurrence of disease after 3 years of follow-up. Here, we present this extremely uncommon association of Takayasu’s arteritis and membranous nephropathy.
- Published
- 2023
3. Diagnosis of light chain cast nephropathy through immunostaining of the urine: Perfecting the 'liquid biopsy'
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Gonzalo Barrera, Rodrigo A. Sepúlveda, Gonzalo P. Méndez, Juan Pablo Huidobro E., Fiorella Anghileri, and Romina Reyes
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Immunofixation ,Pathology ,medicine.medical_specialty ,Paraproteinemias ,Urine ,Kidney ,Stain ,Nephropathy ,Biopsy ,medicine ,Humans ,Liquid biopsy ,Multiple myeloma ,Aged ,biology ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Nephrology ,biology.protein ,Female ,Immunoglobulin Light Chains ,Kidney Diseases ,Multiple Myeloma ,business - Abstract
Light chain (LC) cast nephropathy is the main cause of kidney injury and an important determinant of poor survival in patients with multiple myeloma (MM). It is usually suspected when an MM patient with elevated serum concentration of free LC presents kidney failure, but it often requires confirmation by kidney biopsy. We report the case of a 73-year-old woman who presented with fatigue, weight loss, and constipation. Laboratory exams revealed anemia, hypercalcemia, and kidney failure. Urine sediment analysis demonstrated irregular crystalline "waxy type" casts. With the hypothesis of LC cast nephropathy, immunostaining of the urine sediment was performed. The analysis revealed several rectangular and irregular casts with intense and bright stain for λ LCs only. A myelogram was performed, showing extensive occupation of the bone marrow by plasma cells; and immunofixation in urine and serum revealed monoclonal IgG-λ component, confirming the diagnosis of IgG-λ MM. This case highlights the potential utility of the urine sediment analysis and immuno-staining as a reliable non-invasive alternative method for diagnosis of cast nephropathy in patients with monoclonal gammopathies.
- Published
- 2021
4. Nefropatía aguda por fosfatos secundaria al uso de laxantes con fosfato de sodio: caso clínico-patológico
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Gonzalo P. Méndez, Rodrigo Tagle, Dalay Purto, Nicolas Severino, Eduardo Ávila, Cristina Cornejo, and Sofía Kutscher
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medicine.medical_specialty ,Kidney ,animal structures ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Laxative ,Acute kidney injury ,Colonoscopy ,General Medicine ,Acute Kidney Injury ,medicine.disease ,Gastroenterology ,Mixed connective tissue disease ,medicine.anatomical_structure ,Laxatives ,Internal medicine ,Biopsy ,medicine ,Moderate proteinuria ,Phosphate nephropathy ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Acute phosphate nephropathy (APN) is an acute renal failure secondary to the use of oral sodium phosphate (OSP) laxatives, with a high risk of progression to chronicity. We report a 60-year-old woman with mixed connective tissue disease whose serum creatinine increased up to 2.0 mg/dL in her regular control tests, without an evident causative factor. Kidney biopsy showed numerous intratubular calcium phosphate deposits, consistent with APN. She had a history of OSP laxative intake, and a sodium phosphate enema was used before a colonoscopy performed six months earlier. The temporal association between the use of OSP laxatives and acute kidney injury, should lead to the suspicion of APN. The urine sediment is generally normal or with mild to moderate proteinuria. The diagnosis is confirmed with a kidney biopsy. Until now, there is no specific treatment for APN, thus prevention is essential. In high-risk patients for developing APN, the administration of these laxatives should be avoided.
- Published
- 2021
5. Nefropatía por C1q: una rara variedad de síndrome nefrótico. Caso clínico
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Jorge Vega, Elisa Gutiérrez, Luis Bofill, and Gonzalo P. Méndez
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Pathology ,medicine.medical_specialty ,Proteinuria ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Immunofluorescence ,Podocyte ,Focal segmental glomerulosclerosis ,medicine.anatomical_structure ,Glomerulopathy ,medicine ,Mesangial proliferative glomerulonephritis ,Minimal change disease ,medicine.symptom ,business ,Nephrotic syndrome - Abstract
C1q nephropathy is a rare glomerulopathy characterized by mesangial deposition of the complement component C1q. These deposits can be isolated or associated with immunoglobulins or complement fractions, which are observed by immunofluorescence or immunohistochemical microscopy. In ultramicroscopy, dense mesangial deposits and alterations of the podocyte are observed. Clinically it presents as a nephrotic syndrome (NS) or by alterations of the urinalysis such as proteinuria and/or hematuria in children and young adults. In light microscopy, it is expressed with a morphological pattern of minimal change disease (MCD), mesangial proliferative glomerulonephritis or focal segmental glomerulosclerosis (FSGS). The NS during its evolution usually evolve in steroid resistance or steroid dependency, often requiring the association of immunosuppressants to obtain remission. We report a 14 years old male with a history of NS and its evolution under various treatments during a 12-year follow-up.
- Published
- 2020
6. Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance‐related lesions in Latin America
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Gonzalo P. Méndez, Dorotea Fantl, Vivianne Lois, Natalia Schutz, Paola Mur, Camila Peña, Daniela Zamora, Christine Rojas, Verónica Verri, Hernán López-Vidal, Grupo de estudio latinoamericano de mieloma múltiple, Gonzalo Correa, Guillermo Andrés Duque Silva, Claudia Shanley, Jhoanna Ramirez, Gustavo Glavic, Paola Ochoa, Eloisa Riva, José Tomás Gonzalez, Ricardo Valjalo, Alejandro Majlis, and Karen Jiset Saavedra Escobar
- Subjects
Adult ,Male ,medicine.medical_specialty ,Paraproteinemia ,Paraproteinemias ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Glomerulonephritis ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,Epidemiology ,medicine ,Humans ,Multiple myeloma ,Aged ,Retrospective Studies ,business.industry ,Amyloidosis ,General Medicine ,Middle Aged ,medicine.disease ,Regimen ,Latin America ,Nephrology ,Disease Progression ,Female ,Kidney Diseases ,Rituximab ,business ,Nephrotic syndrome ,Monoclonal Immunoglobulin Deposition Disease ,medicine.drug - Abstract
Background Monoclonal gammopathy of renal significance (MGRS)-related lesions are infrequent entities. There are no publications on these disorders in Latin America (LA). The aim of this study was to describe epidemiological and clinical characteristics of these patients in LA. Methods We performed a multicentre retrospective study. Patients with diagnosis of MGRS between 2012 and 2018 were included. Epidemiological and clinical data were collected from clinical records. Results Twenty-seven patients from Chile, Argentina, Ecuador and Uruguay were included. Half debuted with a nephrotic syndrome, and 32% required dialysis. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits was found in 33%, amyloidosis in 26% and monoclonal immunoglobulin deposition disease also in 26%. The immunoglobulin most frequently found in renal biopsies was IgG kappa. In 67% a paraprotein was found. Twenty patients received an anti-plasma cell regimen, and 3 a rituximab-based regimen (IgM-MGRS). Renal response (RR) was achieved in 56%. Early treatment (≤3 months) was associated with higher RR (75% vs 43%). Three patients relapsed within 21.5 months, and 3 progressed: 1 to multiple myeloma, 1 to systemic amyloidosis and another to systemic light-chain deposition disease. Two patients died, both due to infection during induction treatment. Conclusion There was a higher than expected frequency of patients requiring dialysis. The most common MGRS-related lesion was PGNMD. Early treatment was associated with better response. As a rare disease, increasing awareness and promoting early diagnosis are necessary in LA to improve outcomes. SUMMARY AT A GLANCE A collection of 27 cases of MGRS from Latin America with information on epidemiology, clinical characteristics, treatment and outcome of patients diagnosed of MGRS-related renal lesions.
- Published
- 2019
7. Correlación anátomo-clínica entre clases y subclases roliferativas de nefritis lúpica en biopsias renales: experiencia de un centro único
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David Oddó, Loreto Brevis, Gonzalo P. Méndez, and Sergio Vargas
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medicine.medical_specialty ,Biopsy ,Lupus nephritis ,Kidney ,Gastroenterology ,chemistry.chemical_compound ,Internal medicine ,Medicine ,Pathological ,Creatinine ,Proteinuria ,Lupus Erythematosus ,medicine.diagnostic_test ,business.industry ,Systemic ,General Medicine ,Arteriosclerosis ,medicine.disease ,Lupus Nephritis ,chemistry ,Renal pathology ,Renal biopsy ,medicine.symptom ,business - Abstract
Background Lupus nephritis (LN) is a complication of systemic lupus erythematosus that requires renal biopsy (RB). Proliferative classes III, IV-S, IV-G have especial clinical and pathological characteristics. Aim To determine the association between pathological features in RB with serum creatinine and urine protein levels. Material and Methods We analyzed 186 RB performed in adults aged 18 to 73 years, from a renal pathology reference center. Histopathological variables such as class and subclass of proliferative LN, endocapillary and extracapillary proliferation, activity and chronicity indexes, and vascular sclerosis were correlated with serum creatinine and urine protein levels, at the time of diagnosis. Results As compared with LN III, all the morphological and laboratory values were significantly more deteriorated in LN IV, with special focus on vascular sclerosis. Serum creatinine was the only variable that significantly differentiated LN IV-S from LN IV-G. Proteinuria was non-significantly higher in LN IV-G compared to LN IV-S. However, the difference became significant when proteinuria was compared between LN IV-G and LN III. Conclusions The significant difference in serum creatinine between LN IV-S and LN IV-G supports the concept that they are different subclasses. Proteinuria is a variable that differentiates classes III from IV-G, being significantly higher in the second. Severe arteriosclerosis is a constant and significant finding that differentiates LN III from LN IV. Thus, we propose its usefulness for distinguishing LN classes, and eventually, to be considered in the chronicity index.
- Published
- 2019
8. Recurrencia de Síndrome de Goodpasture con negativización de anticuerpos anti-membrana basal glomerular: Caso clínico
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Rodrigo Tagle, Gonzalo P. Méndez, Juan Pablo Huidobro E., Trinidad Arancibia, Alexandra Fischman, Javier Chahuan, and Sebastián Vázquez
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Pathology ,medicine.medical_specialty ,Disease ,urologic and male genital diseases ,Antibodies ,Glomerulonephritis ,Anti Glomerular Basement Membrane Disease ,Glomerular Basement Membrane ,Biopsy ,medicine ,Goodpasture syndrome ,Disease entity ,biology ,medicine.diagnostic_test ,urogenital system ,business.industry ,Renal tissue ,General Medicine ,medicine.disease ,Trimethoprim ,female genital diseases and pregnancy complications ,nervous system diseases ,biology.protein ,Antibody ,Single episode ,business ,medicine.drug - Abstract
Goodpasture Syndrome is described as a single episode disease entity. It is diagnosed with the demonstration of antiglomerular basement (anti-GBM) antibodies in plasma or renal tissue. Although the recurrence of anti-GBM disease is rare, it has been reported in up to 3% of cases. Recurrence with negative anti-GBM antibodies in plasma is even less frequent We report a 63 years old male in whom anti-GBM disease recurred without detectable anti-GBM antibodies in plasma, despite having positive antibodies at the onset.
- Published
- 2019
9. Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature
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Alejandro Majerson, Pablo A. Rojas, Cristián González, Gonzalo P. Méndez, and Ignacio F. San Francisco
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Adult ,medicine.medical_specialty ,Bladder Squamous Cell Carcinoma ,Urology ,medicine.medical_treatment ,Urinary system ,Case Report ,lcsh:RC870-923 ,Cystectomy ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Carcinoma ,Humans ,030219 obstetrics & reproductive medicine ,Hysterectomy ,Bladder cancer ,business.industry ,General Medicine ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Radical cystectomy ,Reproductive Medicine ,Urinary Bladder Neoplasms ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Lymphadenectomy ,Female ,business ,Pregnancy Complications, Neoplastic - Abstract
Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.
- Published
- 2021
10. Nefropatías secundarias a paraproteína: perfil clínico a partir de hallazgos histológicos
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Rodrigo A. Sepúlveda, Joaquín Sharp, Gonzalo P. Méndez, Cristián Juanet, Joaquín Jerez, and Daniel Ernst
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medicine.medical_specialty ,Paraproteinemia ,Nephrotic Syndrome ,medicine.diagnostic_test ,business.industry ,Paraproteinemias ,General Medicine ,medicine.disease ,Gastroenterology ,Nephropathy ,Nephritic syndrome ,Proteinuria ,Glomerulonephritis ,Internal medicine ,medicine ,Renal biopsy ,Paraproteins ,business ,Multiple Myeloma ,Nephrotic syndrome ,Multiple myeloma ,Kidney disease - Abstract
Background One of the devastating consequences of monoclonal gammopathies is the development of end-stage kidney disease, which can be prevented with an early diagnosis. Renal involvement can be secondary to saturation of paraproteins with intratubular precipitation or the glomerular deposition of paraproteins with secondary inflammation and destruction. These conditions can also be associated with monoclonal gammopathies that do not meet hematological treatment criteria, called monoclonal gammopathies of renal significance (MGRS). Aim To report a retrospective analysis of patients who underwent a renal biopsy and whose final diagnosis was a form of monoclonal gammopathy. Material and methods We reviewed the clinical and laboratory features and response to treatment of 22 patients aged 63 ± 12 years (55% women) with a pathological diagnosis of a nephropathy associated with paraproteinemia. Results The most common hematological diagnosis was amyloidosis in 50% of patients, followed by cast nephropathy. The predominant clinical presentations were proteinuria (without nephrotic syndrome) and nephritic syndrome. Classic criteria such as erythrocyte sedimentation rate > 100 mm/h and protein-albumin gap were unusual. Serum light chain quantification was the test with the best yield to detect paraproteins. Conclusions In this group of patients, light chains tend to affect the kidney more commonly than heavy chains. The prognosis of multiple myeloma is much worse than MGRS.
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- 2020
11. Intestinal isosporiasis in patients with acquired immunodeficiency syndrome (AIDS). Pathologic diagnosis in small intestinal mucosal biopsies
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David Oddó, Aarón Oddó, Gonzalo P. Méndez, and Yasmina Retamal
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Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Adolescent ,Duodenum ,Biopsy ,030106 microbiology ,030231 tropical medicine ,Isosporiasis ,Pathology and Forensic Medicine ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Microscopy, Electron, Transmission ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,In patient ,Chile ,Intestinal Mucosa ,Child ,Acquired Immunodeficiency Syndrome ,Isospora ,Merozoites ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Sporozoites ,Vacuoles ,Female ,business - Published
- 2018
12. Mujer joven, hija de padre con síndrome de Alport, debuta con síndrome nefrótico impuro
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Gonzalo P. Méndez, Daniela Navarrete, Emilio Roessler B, and Fernando González
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,General Medicine ,Image-Guided Biopsy ,medicine.disease ,business ,Nephritis - Published
- 2017
13. Hemoptisis recurrente asociada a falla renal y hematuria: otra de las mil caras de la enfermedad relacionada a IgG4
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Susana Michalland, Carolina Cuellar, Angela Rivera, Juan Carlos Maya, Gonzalo Correa, Daniel Erlij, and Gonzalo P. Méndez
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Hemoptysis ,Pathology ,medicine.medical_specialty ,Systemic disease ,Nephritis ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Interstitial nephritis ,General Medicine ,Disease ,urologic and male genital diseases ,medicine.disease ,Lung involvement ,medicine.anatomical_structure ,Immunoglobulin G ,medicine ,Lymph ,Renal biopsy ,medicine.symptom ,Interstitial ,business ,Pancreas - Abstract
IgG4 disease is a multi-systemic condition involving pancreas, salivary glands and lymph nodes. Less frequently, it causes interstitial nephritis and involves the lungs. We report a 58 years old male with a four years history of hemoptysis and renal dysfunction characterized by hematuria and proteinuria, responsive to steroidal therapy. The renal biopsy established the diagnosis of IgG4 associated interstitial nephritis. Lung involvement was considered secondary to the same systemic disease.
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- 2017
14. Hipofisitis linfoplasmocitaria y fibrosis retroperitoneal asociadas a un síndrome poliglandular autoinmune. Enfermedades relacionadas con IgG4. Caso clínico
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Gonzalo P. Méndez, Jorge Vega, Francisco J Guarda, Roberto Espinosa, and Roger Gejman
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medicine.medical_specialty ,endocrine system diseases ,Hypophysitis ,030209 endocrinology & metabolism ,Retroperitoneal fibrosis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Hypothyroidism ,Hypogonadotropic hypogonadism ,Internal medicine ,medicine ,Minimal change disease ,Autoimmune Hypophysitis ,business.industry ,Retroperitoneal Fibrosis ,General Medicine ,medicine.disease ,Sella turcica ,medicine.anatomical_structure ,Polyendocrinopathies ,Diabetes insipidus ,IgG4-related disease ,Immunoglobulin G4-Related Disease ,medicine.symptom ,business ,Nephrotic syndrome ,030217 neurology & neurosurgery ,Autoimmune - Abstract
We report a 23 year old woman presenting with a nephrotic syndrome due to minimal change disease, central diabetes insipidus, primary hypothyroidism, vitiligo and universal alopecia. Eleven years later, she presented secondary amenorrhea due to hypogonadotropic hypogonadism, with mild hyperprolactinemia and central adrenal insufficiency. A magnetic resonance imaging of the sella turcica showed a pituitary mass with suprasellar extension that was resected using a transsphenoidal approach. Pathology confirmed the presence of a lymphoplasmacytic hypophysitis. She needed a second surgical resection due to mass growth and neuro-ophthalmologic impairment. One year later, systemic lupus erythematosus, arterial hypertension and type 2 diabetes mellitus were diagnosed. Two years later, due to back pain, constipation and renal failure, retroperitoneal fibrosis was found, satisfactorily treated with glucocorticoids and colchicine. Hence, this clinical vignette shows the coexistence of autoimmune polyglandular syndrome with retroperitoneal fibrosis and lymphoplasmacytic hypophysitis. Tissue analysis showed the presence of IgG4 producing plasma cells in the pituitary and retroperitoneum, which constitute a basis for the diagnosis of IgG4 related disease.
- Published
- 2018
15. Diagnóstico de infección por VIH por el hallazgo incidental de alteraciones ultraestructurales en una biopsia renal: Report of one case
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M. Elizabeth Barthel, Jorge Vega, and Gonzalo P. Méndez
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Kidney ,Pathology ,medicine.medical_specialty ,Proteinuria ,Thin Membrane Nephropathy ,AIDS-Associated Nephropathy ,medicine.diagnostic_test ,urogenital system ,business.industry ,HIV ,Renal function ,General Medicine ,urologic and male genital diseases ,Asymptomatic ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,Biopsy ,medicine ,Microscopic hematuria ,medicine.symptom ,business ,Hematuria ,Thin glomerular basement membrane - Abstract
HIV infection has different clinical presentations. We report a 21 years old male with longstanding isolated microscopic hematuria attributed to thin glomerular basement membrane disease, who after 15 years of follow-up presented with significant proteinuria. A kidney biopsy was performed, revealing the presence of tubulo-reticular inclusions in the glomerular endothelial cells. This finding led to suspect an HIV infection, which was verified. Antiretroviral therapy, angiotensin-converting enzyme and angiotensin II receptor blockers were prescribed. At 6 years of diagnosis the patient is asymptomatic and has normal kidney function. Microscopic hematuria and low level proteinuria persists.
- Published
- 2016
16. Compromiso renal en vasculitis asociadas a anticuerpos anticitoplasma de neutrófilos. Recomendaciones de consenso de las Sociedades Chilenas de Nefrología y Reumatología
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Loreto Massardo, Andrés Wurgaft, Alberto Fierro, Sergio Palma, Leopoldo Ardiles, Verónica Aguirre, Mirentxu Iruretagoyena, Roberto Jalil, Emilio Roessler, Miriam Alvo, Francisco Silva, Gonzalo P. Méndez, and Annelise Goecke
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Nephrology ,medicine.medical_specialty ,Consensus ,business.industry ,medicine.medical_treatment ,Systemic Vasculitis ,Antineutrophil Cytoplasmic ,General Medicine ,Disease ,medicine.disease ,Kidney ,Rheumatology ,Antibodies ,Internal medicine ,medicine ,Renal replacement therapy ,Vasculitis ,business ,Kidney disease ,Systemic vasculitis ,Anti-neutrophil cytoplasmic antibody - Abstract
Renal involvement is a frequent complication in antineutrophil cytoplasmic antibodies (ANCA)associated vasculitides, adding morbidity and mortality, such as chronic kidney disease and the need for renal replacement therapy. With the aim of reaching a consensus on relevant issues regarding the diagnosis, treatment and follow-up of patients with these diseases, the Chilean Societies of Nephrology and Rheumatology formed a working group that, based on a critical review of the available literature and their experience, raised and answered consensually a set of questions relevant to the subject. This document includes aspects related to the clinical diagnosis, the histological characteristics, the therapeutic alternatives to induce and maintain the remission of the disease, relapse surveillance strategies and complementary therapies.
- Published
- 2018
17. Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast
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María Elena Navarro, Natalia Gómez, Francisco Domínguez, Gonzalo P. Méndez, and David Oddó
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In situ ,lcsh:R5-920 ,Pathology ,medicine.medical_specialty ,business.industry ,coryneform bacteria ,Case Report ,General Medicine ,Ductal carcinoma ,medicine.disease ,body regions ,03 medical and health sciences ,0302 clinical medicine ,Granulomatous lobular mastitis ,ductal carcinoma in situ ,030220 oncology & carcinogenesis ,Carcinoma ,medicine ,030211 gastroenterology & hepatology ,lcsh:Medicine (General) ,skin and connective tissue diseases ,business ,neoplasms ,breast - Abstract
The association of granulomatous lobular mastitis and carcinoma of the breast is very infrequent. We present the case of a 44-year-old woman with concurrent granulomatous lobular mastitis with coryneform bacteria and ductal carcinoma in situ in the same breast.
- Published
- 2019
18. Evolución de una vasculitis renal asociada a anticuerpos anti-citoplasma de neutrófilos (ANCA) durante un embarazo: Caso clínico
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Gonzalo P. Méndez and Jorge Vega
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Vasculitis ,medicine.medical_specialty ,Renal function ,Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ,urologic and male genital diseases ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Glomerulonephritis ,Internal medicine ,Biopsy ,medicine ,Cyclophosphamide ,030203 arthritis & rheumatology ,Pregnancy ,Proteinuria ,medicine.diagnostic_test ,business.industry ,Gestational age ,General Medicine ,medicine.disease ,Surgery ,Pregnancy Complications ,030211 gastroenterology & hepatology ,Amenorrhea ,Kidney Diseases ,medicine.symptom ,business - Abstract
ANCA mediated vasculitis mainly occur between the fourth and fifth decade of life; therefore, it is very uncommon to see pregnant patients with the disease. Vasculitis may affect significantly the course of pregnancy; in turn pregnancy can change the course of vasculitis. We report a 20 years old woman with ANCA-mediated renal vasculitis lasting 10 years who consulted with a pregnancy of 15 weeks. She was in remission and had amenorrhea attributed to ovarian toxicity due to cyclophosphamide. Pregnancy had an uneventful course with spontaneous delivery at the 37th week, giving birth to a healthy newborn. Proteinuria increased during the course of pregnancy with a mild deterioration of kidney function. During the year after delivery, she had nephrotic proteinuria and a worsening of renal function.
- Published
- 2016
19. Polyarthritis and membranoproliferative glomerulonephritis as paraneoplastic manifestation of Hodgkin's lymphoma: A case report and literature review
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Beatriz Calderón, Cristián Mella, Ximena Valladares, Emilio Roessler, Gonzalo P. Méndez, Angela Rivera, María Teresa Rivera, and Daniel Erlij
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Male ,Pathology ,medicine.medical_specialty ,Glomerulonephritis, Membranoproliferative ,Paraneoplastic Syndromes ,medicine.medical_treatment ,Hematologic Neoplasms ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Membranoproliferative glomerulonephritis ,medicine ,Classical Hodgkin lymphoma ,Humans ,030212 general & internal medicine ,030203 arthritis & rheumatology ,Chemotherapy ,business.industry ,Arthritis ,General Medicine ,Middle Aged ,medicine.disease ,Hodgkin's lymphoma ,Hodgkin Disease ,medicine.anatomical_structure ,Polyarthritis ,Bone marrow ,Differential diagnosis ,business - Abstract
Paraneoplastic syndromes can be presented in multiple ways, which include endocrinological, hematologic, rheumatologic and nephrologic manifestations. While most of the publications described solid tumors as responsible for these manifestations, hematologic neoplasms are important cause to consider as part of the differential diagnosis. We report the case of a 46 year-old man with seronegative symmetric polyarthritis of large and small joints associated with membranoproliferative glomerulonephritis with deposits of immune complexes and acute impairment of renal function, as part of a paraneoplastic syndrome secondary of a classical Hodgkin lymphoma with bone marrow invasion, which reversed completely with chemotherapy treatment.
- Published
- 2015
20. Síndrome hemolítico-urémico asociado al uso de gemcitabina: Caso clínico
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Gonzalo P. Méndez, Christian Parodi, Helmuth Goecke, and Jorge Vega
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medicine.medical_specialty ,Thrombotic microangiopathy ,Pancreatic neoplasms ,Anemia ,medicine.medical_treatment ,Gastroenterology ,Nephritic syndrome ,Pancreatic cancer ,Internal medicine ,medicine ,Dialysis ,medicine.diagnostic_test ,business.industry ,Hemolytic-uremic syndrome ,Antimetabolites, antineoplastic ,Acute kidney injury ,General Medicine ,medicine.disease ,Gemcitabine ,Surgery ,Renal biopsy ,business ,medicine.drug - Abstract
Gemcitabine is a widely used drug in the treatment of advanced pancreatic cancer and other malignancies. It is generally well tolerated and exceptionally its use has been associated with hemolytic-uremic syndrome, causing acute kidney injury, hypertension, chronic renal failure requiring dialysis, and death. We report a 60-year-old man with pancreatic carcinoma and regional lymph node invasion, whom after four months of therapy with gemcitabine and after dose number 11, suddenly developed an acute nephritic syndrome with moderate renal impairment, associated with severe anemia (hemoglobin 6.0 g/dL) and thrombocytopenia (20,000 mm³). Renal biopsy showed the classic findings of thrombotic microangiopathy Gemcitabine was discontinued and renal function and hematological parameters gradually improved.
- Published
- 2013
21. Nephrotic syndrome and acute tubular necrosis due to meloxicam use
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Gonzalo P. Méndez, Helmuth Goecke, Jorge Vega, and Francisco J Guarda
- Subjects
medicine.medical_specialty ,Nephrotic Syndrome ,Hyperkalemia ,Thiazines ,Critical Care and Intensive Care Medicine ,Meloxicam ,Gastroenterology ,Necrosis ,Prednisone ,Internal medicine ,medicine ,Humans ,Minimal change disease ,Acute tubular necrosis ,Aged ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Acute kidney injury ,General Medicine ,medicine.disease ,Surgery ,Thiazoles ,Kidney Tubules ,Nephrology ,Acute Disease ,Female ,medicine.symptom ,business ,Nephrotic syndrome ,medicine.drug ,Kidney disease - Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by patients all over the world. Five to eighteen percent of the patients who receive NSAIDs can suffer from kidney-related side effects. Among them, the most relevant are sodium and water retention, hyponatremia, worsening of hypertension or preexisting cardiac failure, hyperkalemia, acute kidney injury, chronic kidney disease, papillary necrosis, nephrotic syndrome (NS), and acute interstitial nephritis. We report the case of a 65-year-old woman who developed acute tubular necrosis and NS a few days after receiving 15 mg of meloxicam (MLX) for 3 days for tendinitis. Steroid therapy was begun with normalization of kidney function after 7 weeks of treatment. NS (minimal change disease) was characterized by frequent remissions and relapses as prednisone was lowered under 30 mg/day. Azathioprine (100 mg/day) was added on the fifth month of diagnosis and a complete remission was finally obtained 4 years after hospital admittance. In her last medical checkup, 8 years after her debut and receiving azathioprine (50 mg) and prednisone (5 mg/day), renal function was normal (creatinine 1.0 mg/dL and creatinine clearance 80 mL/min/1.73 m(2)), proteinuria was 150 mg/day and there was no hematuria or hypertension. The aim of communicating this case is to raise a warning about these renal side effects of MLX. After thorough review of literature, only one other report with the same findings was found.
- Published
- 2012
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