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Introduction: Darier and Ferrant dermatofibrosarcoma is a rare malignant cutaneous mesenchymal tumour, representing less than 0.1% of malignant tumours and less than 5% of soft tissue sarcomas in adults. The aim of this study was to describe the evolutionary profile of cases of dermato fibrosarcoma of Darier et Ferrant reported in the dermato-venereology department of the National Centre for Disease Control (CNAM). Patients and methods: This was a descriptive cross-sectional study conducted in the dermatology department of the National Centre for Disease Control Support between 1991 and 2016, a period of 25 years. Was included, all patient with a histologically confirmed dermatofibrosarcoma notified in the registers of the CNAM histology laboratory or in the patient's medical file during the study period. Results: In total we collected 23 cases out of 5520 biopsied patients, i.e. a proportion of 0.41%. Males represented 60.8% with an average age of 40 years. The lesions were simple nodular in 12 of the 23 patients (52.2%), multi-nodular in 7 of the 23 patients (30.4%), nodulo-ulcerous and in patches in 4 of the 23 patients (17.4%). The lesions were located on the trunk in 60.8% of cases (image 1), on the head in 21.7% of cases and on the limbs in 17.5% of cases. The mean size of the lesions was 10×8cm with extremes of 3cm×3cm to 25cm×20cm. Management was exclusively surgical. Conclusion: DFSP is a rare tumour with a slow evolution, characterised by its rare metastasis but above all by its strong tendency to recurrence. The diagnosis is often evoked clinically and confirmed by histological study. The treatment of DFSP is surgical based on a large and deep lesion removal. Clinical monitoring allows early detection of recurrence, which is frequent in this disease.

Introduction: necrotizing fasciitis (FN) is a medico-surgical emergency that often involves the vital prognosis. Despite its rarity in children, necrotizing fasciitis is complicated by septic shock in 74 cases out of 100 and it is a serious infection, fatal in about 30% of cases. The aim of this work was to study the risk factors for necrotizing fasciitis in children. Methodology: This was a case-control study interesting children aged 0-15 years seen in dermatological consultation and included in accordance with the objectives of the study for a given period from January 1, 2020 to December 30, 2021. Diagnosis of necrotizing fasciitis was based on clinical and histological. Results: During the study period, 2501 children were seen in dermatological consultation, of which 20 had necrotizing fasciitis, ie a hospital frequency of 0.80%. These twenty cases of necrotizing fasciitis were matched with 20 controls by age, sex, hospital, date of admission. The age of children with necrotizing fasciitis ranged between 3 and 15 years, and the average age was 11.7 years. Preschool children (3-5 years old) accounted for 5%, school-age children (6-10 years old) accounted for 25% and adolescents accounted for 70%. The cases were divided into 11 boys (55%) and 9 girls (45%), the sex ratio was 1.22. The average duration of evolution of necrotizing fasciitis in children was 7.6 days with extremes ranging from 3 to 12 days. Conclusion: Many factors in our study were associated with the occurrence of necrotizing fasciitis in children, led by NSAIDs, traditional medications and traumatic wounds. In view of these results obtained in our study carried out under unfavorable conditions, it is necessary that cohort studies be carried out in order to confirm our results.

Summary: Sister Mary Joseph nodule is a metastatic localization with a generally abdominal-pelvic origin and secondary to a primary adenocarcinoma in 90% of cases. We report an observation of Sister Mary Joseph nodule revealing a primary adenocarcinoma of the colon in a young adult with multiple pathologies. Observation: A 57-year-old patient, followed for hepatitis B, HIV1+, and benefiting from a therapeutic regimen (Tenofovir+Lamivudine+Dolutegravir) since 2019 and later a hyperthyroidism of incidental discovery. For one year he has had a firm nodular ulceration measuring 07 cm in its longest axis, with a reddish-pink appearance and whitish deposits, a haemorrhagic ooze on contact, and located at the umbilicus. Also, a tongue laden with whitish coatings that are easily removed with a tongue depressor and the inner surface of the cheeks and palate are erythematous. Bilateral exophthalmos abolished vocal vibrations in both lung bases; two hard left inguinal adenopathies adhering to the deep plane, painless, 3 cm in diameter each. He also described episodes of alternating constipation and diarrhoea accompanied by abdominal pain, coughing, physical asthenia and weight loss (40% loss in 2 years). Anatomopathology of a fragment of the nodule revealed a well-differentiated adenocarcinoma whose tumour cells were of colorectal origin and expressed CK20 and CK8/18. Colonoscopy revealed a multilobed polyploid tumour of the ascending colon and histology concluded that it was a liberkuhnian adenocarcinoma. A chest CT scan revealed pulmonary and abdominal-pelvic metastases and the diagnosis of a Sister Mary Joseph nodule revealing a colonic and metastatic adenocarcinoma was made. The patient was referred to the oncology department for palliative care after the surgical opinion. Conclusion: The nodule of Sister Marie Joseph is a cutaneous metastasis revealing a cancer of the abdominopelvic sphere. This rare and characteristic tumour deserves to be known by practitioners .......

Introduction: Infertility can have serious psychological and social repercussions on the life of a couple. Hysterosalpingography and laparoscopy are necessary exams for the exploration of tubal infertility. The aim of this study was to determine the concordance between these two exams in our daily practice. Patients and Methods: Our study was retrospective, cross-sectional, descriptive and comparative. It took place from January 2020 to August 2022 at the 'GRACE' medical clinic. Data were collected using a survey form and obtained from the patients' records, hysterosalpingography results and operative reports. Data were analyzed with SPSS version 20.0 software. Results: A total of 33 patients met our inclusion criteria. They had a mean age of 29.61+/-6.11 years with a minimum age of 18 years and a maximum of 42 years. Pelvic adhesions were the most common lesions found at laparoscopy. Hysterosalpingography was more specific (Sp=83.33%) than sensitive (Se=60%) in the diagnosis of proximal tubal obstructions. The sensitivity of hysterosalpingography was higher (Se=72.22%) than its specificity (Sp=20%) in the diagnosis of distal tubal obstructions. The concordance rate between the two exams (kappa) was 44% in the diagnosis of proximal tubal obstructions and 8.1% in the case of distal tubal obstructions. Conclusion: Our results corroborate those of the literature. Rather than substituting one for the other, hysterosalpingography and laparoscopy remain complementary examinations in the diagnosis of tubal infertility.

Sirenomelia is a rare form of caudal dysgenesis generally incompatible with life due to the severe renal malformations associated. In Africa, it is associated with mystico-religious considerations and witchcraft and sometimes exposes the family to a violent stigmatization. The transgressions of socio-cultural prohibitions by parents would be the cause of the occurrence of this malformation. Its etiology is still very controversial. We report the observation of a case born at the University Teaching Hospital ‘Pr BSS’ of Kati, this is the first Malian case reported in the literature.