1. Viable mpox virus in the environment of a patient room
- Author
-
Kalisvar Marimuthu, Judith Chui Ching Wong, Poh Lian Lim, Sophie Octavia, Xiaowei Huan, Yi Kai Ng, Jun Jing Yang, Stephanie Sutjipto, Kyaw Zaw Linn, Yin Xiang Setoh, Chong Hui Clara Ong, Jane Griffiths, Sharifah Farhanah, Thai Shawn Cheok, Nur Ashikin Binti Sulaiman, Sipaco Barbara Congcong, Erica Sena Neves, Liang Hui Loo, Luqman Hakim, Shuzhen Sim, Merrill Lim, Mohammad Nazeem, Shawn Vasoo, Kwok Wai Tham, Oon Tek Ng, Lee Ching Ng, Lee Kong Chian School of Medicine (LKCMedicine), School of Biological Sciences, National Centre for Infectious Diseases, Singapore, Tan Tock Seng Hospital, and National Environment Agency more...
- Subjects
Microbiology (medical) ,Infectious Diseases ,Environmental Contamination ,Medicine [Science] ,General Medicine ,Mpox Virus - Abstract
We conducted a prospective environmental surveillance study to investigate the air, surface, dust, and water contamination of a room occupied by a patient infected with mpox virus (MPXV) at various stages of the illness. The patient tested positive for MPXV from a throat swab and skin lesions. Environmental sampling was conducted in a negative pressure room with 12 unidirectional high efficiency particulate air filter (HEPA) air changes per hour and daily cleaning of the surfaces. A total of 179 environmental samples were collected on days 7, 8, 13, and 21 of illness. Among the days of sampling, air, surface, and dust contamination showed the highest contamination rates on day 7 and 8 of illness, with a gradual decline to the lowest contamination level by day 21. Viable MPXV was isolated from surfaces and dust samples and no viable virus was isolated from the air and water samples. Ministry of Health (MOH) National Environmental Agency (NEA) National Medical Research Council (NMRC) Published version This research is supported by the Singapore Ministry of Health’s (MOH) National Medical Research Council (NMRC) under its NMRC Collaborative Grant: Collaborative Solutions Targeting Antimicrobial Resistance Threats in Health Systems (CoSTAR-HS) (CG21APR2005), NMRC Clinician Scientist Award (MOH-000276), and NMRC Clinician Scientist Individual Research Grant (MOH-CIRG18Nov-0034). The study is also internally funded by the National Environment Agency. more...
- Published
- 2023
- Full Text
- View/download PDF