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We prepared a series of highly porous Polyrotaxane/sodium alginate, and Polyrotaxane/Chitosan foam alloys according to a sustainable pathway by using water as the only solvent. The foam alloys were further used as supporter materials for poly (ethylene glycol) (PEG) encapsulation, to fabricate shape-stable bio-based phase change materials (PCMs). The pore morphology and the internal interface between PEG and foam alloys were characterized by scanning electron microscope (SEM). Due to the good compatibility between foam alloys and PEG, the PCM performed perfect anti-leakage properties. The introduction of sodium alginate or Chitosan ensures the shape stability of the PCMs during the phase transition. The PCMs performed good cycle stability and showed ultra-high latent heat (171.6 J g−1–189.5 J g−1). Finally, we compared the typical indicators of this work with those reported in the literature, and the comparison highlighted that the present PCMs have the significant advantages: high melting enthalpy, convenient preparation and outstanding sustainability. Notably, the work provided a sustainable idea for the design of anti-leakage and shape-stable PEG-based PCMs. pre-print 1327 KB

Objective: In this study, we aimed to expand current knowledge of head and neck squamous cell carcinoma (HNSCC)-associated long noncoding RNAs (lncRNAs), and to discover potential lncRNA prognostic biomarkers for HNSCC based on next-generation RNA-seq. Methods: RNA-seq data of 546 samples from patients with HNSCC were downloaded from The Cancer Genome Atlas (TCGA), including 43 paired samples of tumor tissue and adjacent normal tissue. An integrated analysis incorporating differential expression, weighted gene co-expression networks, functional enrichment, clinical parameters, and survival analysis was conducted to discover HNSCC-associated lncRNAs. The function of CYTOR was verified by cell-based experiments. To further identify lncRNAs with prognostic significance, a multivariate Cox proportional hazard regression analysis was performed. The identified lncRNAs were validated with an independent cohort using clinical feature relevance analysis and multivariate Cox regression analysis. Results: We identified nine HNSCC-relevant lncRNAs likely to play pivotal roles in HNSCC onset and development. By functional enrichment analysis, we revealed that CYTOR might participate in the multistep pathological processes of cancer, such as ribosome biogenesis and maintenance of genomic stability. CYTOR was identified to be positively correlated with lymph node metastasis, and significantly negatively correlated with overall survival (OS) and disease free survival (DFS) of HNSCC patients. Moreover, CYTOR inhibited cell apoptosis following treatment with the chemotherapeutic drug diamminedichloroplatinum (DDP). HCG22, the most dramatically down-regulated lncRNA in tumor tissue, may function in epidermis differentiation. It was also significantly associated with several clinical features of patients with HNSCC, and positively correlated with patient survival. CYTOR and HCG22 maintained their prognostic values independent of several clinical features in multivariate Cox hazards analysis. Notably, validation either based on an independent HNSCC cohort or by laboratory experiments confirmed these findings. Conclusions: Our transcriptomic analysis suggested that dysregulation of these HNSCC-associated lncRNAs might be involved in HNSCC oncogenesis and progression. Moreover, CYTOR and HCG22 were confirmed as two independent prognostic factors for HNSCC patient survival, providing new insights into the roles of these lncRNAs in HNSCC as well as clinical applications.

Eosinophilic fasciitis (EF), a rare rheumatic disease, usually affects the limbs symmetrically and generally spares the hands and feet. Cases of unilateral hand involvement are rarely reported. Here, we report such a rare case. Ultrasonography demonstrated thickening of the overlying skin and subcutaneous tissue, peripheral deep fascia, myositis of lumbrical muscles and adductor pollicis muscle, and edema surrounding flexor digitorum tendons. It reminds us that EF should be considered in the differential diagnosis of unilateral painful hand swelling despite being uncommon. Ultrasonography can be used to aid the diagnosis and monitor therapeutic response in patients with EF.

With the development of computer science and multimedia technology, network act as an important role in adult education. The traditional adult education mode are not suitable the modern teaching modes need. To construct an adult education self-help study platform is urgent needed. This paper analyses the defects of the traditional adult education mode, rises a new education mode based on the internet, and realizes the framework design of the self-help study platform based on Internet.

To reduce the algorithm complexity and improve performance, comparison table is created, and then encrypted by a randomized ten-bit serial number. Serial number forms the first key named key1, and the encrypted comparison table forms the second key named key2. Watermarking image is transformed into a binary bit stream. By using tuples primary key, key1 and key2, each tuples unique Id is computed. According to the watermarking length, all tuples are divided into different groups. Using tuple Id, by searching the encrypted comparison table, each tuple group can embed one bit information of watermarking. Robustness and security of this algorithm are tested by experiment.

Mesoporous hydroxylapatite was prepared by Liquid phase precipitation method, using Polystyrene microspheres as template. Polystyrene microspheres mixed uniformly with the prepared hydroxylapatite slurry, then the mixture dryed and sintered at reasonable temperature, mesoporous hydroxylpatite ceramics were obtained. The phase constituent was analyzed by X-ray diffraction (XRD) and the microstructure was observed under scanning electron microscopy (SEM). The results showed that the prepared mesoporous hydroxylapatite ceramics were of high purity and their pores were evenly distributed, with big pore 0.8-1.0 um and small pore 30-80nm in diameter.

Due‐date performance (DDP) is a very important performance indicator for the companies. Thus, companies with a high hit rate would have greater competitive advantage; on the contrary, companies that delay customers' orders frequently would lose sales opportunities and reputations. Therefore, there were many academic studies and practical efforts to improve DDP in the past, but the problem of low hit rate still exists. In order to increase the hit rate, some companies have focused on reducing the variation, while others focus on production management, but is the real problem affecting the low rate variability or production management? This is indeed difficult to be validated through practice. Therefore, this study designed three scenarios, tested each scenario for 30 times, each test involved seven subjects. The tests were to provide counter‐evidence in the Job Shop environment without variation. If the variation is the main factor of affecting hit rate, the rate at this time should be good; otherwise, the assumption that variation is the main cause is rebutted. The results demonstrated that production management planning is the main cause, and the method of enhancing the hit rate is obtained during the test.