1. Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991
- Author
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Thomas C. Calcaterra, Gregory Angier, Marc M. Kerner, Paul H. Ward, and Marilene B. Wang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Biopsy ,Disease ,Tertiary care ,California ,Tongue ,Humans ,Medicine ,Head and neck ,Schools, Medical ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Amyloidosis ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Surgery ,medicine.anatomical_structure ,Otorhinolaryngology ,Disease Presentation ,Female ,business ,Head ,Patient Base ,Neck - Abstract
Objective: To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients. Design: Retrospective review of biopsy specimens recorded as amyloidosis. Setting: Tertiary care referral center serving a diverse patient base. Patients: Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations. Outcome Measures: Good functional outcome and survival of patients with amyloidosis. Results: The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis. Conclusion: Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease. (Arch Otolaryngol Head Neck Surg. 1995;121:778-782)
- Published
- 1995