1. HIF-1α in the Crosstalk Between Reactive Oxygen Species and Autophagy Process: A Review in Multiple Sclerosis
- Author
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Rezvan Asgari, Reza Yarani, Mohammad Sajad Emami Aleagha, and Pantea Mohammadi
- Subjects
0301 basic medicine ,chemistry.chemical_classification ,Reactive oxygen species ,Multiple Sclerosis ,Chemistry ,Multiple sclerosis ,Autophagy ,Cell Biology ,General Medicine ,Hypoxia-Inducible Factor 1, alpha Subunit ,medicine.disease ,Cell biology ,Pathogenesis ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Crosstalk (biology) ,030104 developmental biology ,0302 clinical medicine ,medicine ,Humans ,Pathophysiology of multiple sclerosis ,Reactive Oxygen Species ,030217 neurology & neurosurgery - Abstract
Cellular stress can lead to the production of reactive oxygen species (ROS) while autophagy, as a catabolic pathway, protects the cells against stress. Autophagy in its turn plays a pivotal role in the pathophysiology of multiple sclerosis (MS). In the current review, we first summarized the contribution of ROS and autophagy to MS pathogenesis. Then probable crosstalk between these two pathways through HIF-1α for the first time has been proposed with the hope of employing a better understanding of MS pathophysiology and probable therapeutic approaches.
- Published
- 2021