Author: "Tincu IF" / Topic: general medicine - Searchworks@Jio Institute Digital Library Search Results

38 results on '"Tincu IF"'

1. Photoluminescent Polymer Aerogels with R, G and B Emission

Author: Loredana Stan, Teodor Malutan, Irina Volf, Marcel Popa, Camelia E. Tincu, and Corneliu S. Stan
Subjects: Inorganic Chemistry, Polymers, Spectroscopy, Fourier Transform Infrared, Organic Chemistry, polymer complexes, polymeric aerogels, photoluminescent materials, porous materials, Water, General Medicine, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract: In this work, three new polymer aerogels based on 2-hydroxy ethyl methacrylate (HEMA) complexes with Eu(III), Tb(III) and La(III) are prepared and investigated. The polymer aerogels present strong photoluminescence with emissions located in the red, green and blue regions of the visible spectrum. Depending on the water content used during the preparation path, the consistency of the photoluminescent aerogels varies from rigid, regularly shaped monoliths to a flexible, fibrous material with very low density. The morpho-structural investigation was performed by FT-IR, XPS and SEM. Thermal behavior was also evaluated, while steady-state fluorescence spectroscopy, absolute PLQY and lifetime were used for the investigation of their luminescent properties. The impressive photoluminescent emission located in the red, green and blue areas of the visible spectrum is preserved irrespective of the selected porosity. Their photo-emissive properties, tunable porosity and the convenience of the preparation path could be some arguments for applications as photonic conversion mediums in special-purpose optoelectronic devices or sensors.
Published: 2022
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2. Efficacy of Noble Metal–alloy Endotracheal Tubes in Ventilator-associated Pneumonia Prevention: a Randomized Clinical Trial

Author: Radu Ciprian Tincu, Cristian Cobilinschi, Iulia Florentina Tincu, and Radu Alexandru Macovei
Subjects: Silver, Alloys, Intubation, Intratracheal, Humans, Pneumonia, Ventilator-Associated, General Medicine, Respiration, Artificial
Abstract: Endotracheal tube (ETT) is an important risk factor for the development of Ventilator-associated pneumonia (VAP), as it acts as a reservoir for infectious microorganisms and bypasses the host’s defenses. One of the preventive measures for VAP is endotracheal tube composition. It has been reported that biofilm formation is reduced by using ETTs coated with pure silver or silver compounds. However, noble metal-alloy ETTs have not been adequately studied.To evaluate the efficacy of noble metal alloy ETT (coated Bactiguard Infection Protection ETTs) in preventing VAP compared to standard non-coated ETTs in patients requiring ≥ 48 hours of mechanical ventilation and presenting for coma due to drug intoxication.Randomized controlled study.Participants were randomized using sealed envelopes with a concealed 1:1 allocation to either the intervention group or the control group. The intervention group used a noble metal–alloy ETT, while the control group received standard ETT. The primary outcomes were the incidence of VAP (per ventilated patients) and the duration of mechanical ventilation.Initially, a total of 188 patients were assessed for eligibility, and the final allocation group consisted of 180 patients, who were subsequently randomized into the intervention group (n = 97) and control group (n = 83). The incidence of VAP in the intervention and control groups was 27.83% and 43.16% (Noble metal-alloy ETT reduces the incidence of VAP, ventilation days, and ICU stay for patients in mechanical ventilation.
Published: 2022

3. Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles

Author: Camelia E. Iurciuc (Tincu), Marcel Popa, Leonard I. Atanase, Ovidiu Popa, Lacramioara Ochiuz, Paraschiva Postolache, Vlad Ghizdovat, Stefan A. Irimiciuc, Maricel Agop, Constantin Volovat, and Simona Volovat
Subjects: Curcumin, Fractals, Polymers, Pharmaceutical Science, General Medicine, Micelles, Polyethylene Glycols
Abstract: The physicochemical properties of "smart" or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery systems. Interactions between the structural units of any polymer-drug system imply mutual constraints at various scale resolutions and the nonlinearity is accepted as one of the most fundamental properties. The release kinetics, as a function of pH, of a model active principle, i.e., Curcumin, from nanomicelles obtained from amphiphilic pH-sensitive poly(2-vinylpyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) tailor-made diblock copolymers was firstly studied by using the Rietger-Peppas equation. The value of the exponential coefficient, n, is around 0.5, generally suggesting a diffusion process, slightly disturbed in some cases. Moreover, the evaluation of the polymer-drug system's nonstationary dynamics was caried out through harmonic mapping from the usual space to the hyperbolic one. The kinetic model we developed, based on fractal theory, fits very well with the experimental data obtained for the release of Curcumin from the amphiphilic copolymer micelles in which it was encapsulated. This model is a variant of the classical kinetic models based on the formal kinetics of the process.
Published: 2022

4. VARIATION OF CLINICAL PATTERNS OF COVID-19 DISEASE IN CHILDREN IN THE FIRST YEAR OF PANDEMIC

Author: A. Dorobantu, Luminita Spatariu, Andrei Zamfirescu, Pharmacy, Bucharest, Romania, Ana-Maria Davitoiu, Vlad Plesca, Doina Pleşca, Mirela Silvia Iancu, Eugenia Buzoianu, Iulia Florentina Tincu, Ioana Ghiorghiu, and Sorina Chindriş
Subjects: child, Coronavirus disease 2019 (COVID-19), pandemic, General Medicine, Disease, Biology, Pediatrics, RJ1-570, Variation (linguistics), Pandemic, sars-cov-2 infection, Medicine, Demography
Abstract: Introduction. SARS-CoV-2 infection has put humanity to the test since December 2019, quickly becoming a global public health problem. There is a significant difference between the pediatric population versus the adult population in terms of infection rate, modes of transmission, clinical manifestations. The study aimed to identify some patterns of clinical presentation of SARS-CoV-2 infection in the pediatric population in “Dr. Victor Gomoiu“ Children’s Clinical Hospital in 2020, also following any possible variations between the first two waves of the pandemic. Materials and methods. The study was based on the descriptive observational analysis of two groups of SARS-CoV-2 positive patients, corresponding to the two pandemic waves. Patients were classified into some clinical patterns, using the definition of suspected / confirmed case established by the National Institute of Public Health (INSP) and transmitted through the National Center for Surveillance and Control of Communicable Diseases (CNSCBT), as well as the recommendations of the international guidelines and protocols. Results. There are found to be present some mild clinical forms of the disease secondary to SARS-CoV-2 virus infection, most children showing digestive symptoms. Starting with August (Group 2) there is a significant increase in the number of cases, as well as the appearance of a larger number of cases that associated respiratory symptoms. Conclusions. The study is showing the low impact of the SARS-CoV-2 virus infection in the pediatric population, compared to adults, especially in the first wave of the pandemic, the children having been considered “the hidden victims” of the pandemic, rather than its face. It is considered necessary the long-term monitoring of SARS-CoV-2 infected children, as the remote consciousness of the infection having been incompletely elucidated. Analyzing the epidemiological data obtained in the study, we are concluding the need for some sustained global efforts to define, more clearly, the variations in the patterns of the presentation of SARS-CoV-2 infection in children, in the context of the evolution of the pandemic.
Published: 2021

5. Quantitative characterisation of extended-release tablets with quetiapine using NIR-chemometric methods

Author: Andrei Catalin Muntean, Ioan Tomuță, Teodora Drăgan, Pharmacy, Cluj-Napoca, Romania, A.L. Vonica-Tincu, and Luca Liviu Rus
Subjects: tea, Materials science, Chromatography, RM1-950, General Medicine, RS1-441, Pharmacy and materia medica, antioxidant potential, medicine, Quetiapine, Therapeutics. Pharmacology, caffeic acid, Extended release tablets, medicine.drug
Abstract: This study aims to develop and validate NIR-chemometric methods for quantifying the API (quetiapine) and two excipients in extended-release tablets without sample preparation. The calibration samples were prepared following an experimental design with three variables (quetiapine, HPMC and microcrystalline cellulose) and five levels (concentration 80-90-100-110-120% of API). The validation set included three concentration levels (90-100-110%). The best calibration algorithms have used the same pre-treatment method (SNV), and different factors: 7 PLS factors (R² -0,966 and RMSEP-6,84) for quetiapine, 8 PLS factors (R²-0,927 and RMSEP 6,84) for HPMC and 3 PLS factors (R²-0,983 and RMSEP-7,26) for microcrystalline cellulose. The methods were fully validated according to the ICH guidance using these calibration models. Regarding the trueness of the methods, the recovery was between 98.51 and 99.43 for quetiapine, between 98.61 and 100.85 for HPMC, and between 100.61 and 101.78 for microcrystalline cellulose. According to data obtained, the accuracy profile was ± 5 for quetiapine and HPMC, and ± 6 for microcrystalline cellulose. Linearity profile was also in establish intervals at accuracy and the R2 value was 0.983 for quetiapine, 0.948 for HPMC and 0.997 for microcrystalline cellulose. In conclusion, the developed NIR-chemometric methods have suitable reproducibility, accuracy, linearity and can be used for quantitative characterisation of extended-release tablets with quetiapine, with any sample preparation.
Published: 2021

6. A Trend towards Diaphragmatic Muscle Waste after Invasive Mechanical Ventilation in Multiple Trauma Patients—What to Expect?

Author: Liliana Mirea, Cristian Cobilinschi, Raluca Ungureanu, Ana-Maria Cotae, Raluca Darie, Radu Tincu, Oana Avram, Sorin Constantinescu, Costin Minoiu, Alexandru Baetu, and Ioana Marina Grintescu
Subjects: General Medicine
Abstract: Considering the prioritization of life-threatening injuries in trauma care, secondary dysfunctions such as ventilator-induced diaphragmatic dysfunction (VIDD) are often overlooked. VIDD is an entity induced by muscle inactivity during invasive mechanical ventilation, associated with a profound loss of diaphragm muscle mass. In order to assess the incidence of VIDD in polytrauma patients, we performed an observational, retrospective, longitudinal study that included 24 polytraumatized patients. All included patients were mechanically ventilated for at least 48 h and underwent two chest CT scans during their ICU stay. Diaphragmatic thickness was measured by two independent radiologists on coronal and axial images at the level of celiac plexus. The thickness of the diaphragm was significantly decreased on both the left and right sides (left side: −0.82 mm axial p = 0.034; −0.79 mm coronal p = 0.05; right side: −0.94 mm axial p = 0.016; −0.91 coronal p = 0.013). In addition, we obtained a positive correlation between the number of days of mechanical ventilation and the difference between the two measurements of the diaphragm thickness on both sides (r =0.5; p = 0.02). There was no statistically significant correlation between the body mass indexes on admission, the use of vitamin C or N-acetyl cysteine, and the differences in diaphragmatic thickness.
Published: 2023

7. Gender dysphoria in children and adolescents – a disease far from pediatric practice?

Author: Monica Livia Gheorghiu, Ana-Maria Davitoiu, Pharmacy, Bucharest, Romania, Doina Pleşca, Mirela Silvia Iancu, Sorina Chindriş, and Iulia Florentina Tincu
Subjects: child, Pediatric practice, treatment, business.industry, Gender dysphoria in children, transgene, gender dysphoria, General Medicine, Disease, Pediatrics, RJ1-570, adolescent, Medicine, business, Clinical psychology
Abstract: Gender dysphoria is not a condition that the Romanian pediatrician commonly encounters in his/her practice. However, in light of the progress made in order to diagnose early and establish a correct treatment, as well as in the evolving context of society, including the one of our country, medical cases will not be long in coming. This paper aims to briefly review, the main characteristics of the disease and the role that the pediatrician can play in the life of the patient already diagnosed or not yet, with gender dysphoria.
Published: 2020

8. Paraclinical management of SARS-CoV-2 infection in paediatric patient

Author: Sorina Chindriş, Pharmacy, Bucharest, Romania, Luminita Spatariu, Mirela Silvia Iancu, Iulia Florentina Tincu, and Ana-Maria Davitoiu
Subjects: medicine.medical_specialty, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pandemic, antibodies serologic tests, coronavirus, General Medicine, Pediatrics, rt-pcr tests, RJ1-570, children, Emergency medicine, Medicine, sars-cov-2 infection, business, Paediatric patients
Abstract: The world is facing, after a hundred years, a new pandemic – infection with the SARS-CoV-2 virus. Establishing a therapeutic protocol along with paraclinical infection management is the great challenge of the moment for healthcare professionals all around the world. This paper tries to stadialise the diagnosis methods and paraclinical investigations, establishing the time correspondence between this investigations and laboratory also radiological findings. The positive diagnosis of SARS-CoV-2 infection is made by using four methods of testing: RT-PCR molecular method, serological testing by chemiluminescence and ELISA, rapid tests for the determination of IgM and IgG antibodies. Laboratory findings are not disease-specific but studies have shown that lymphopenia occurs in 83% of paediatric hospitalized patients confirmed with SARS-CoV-2 infection. Imaging is not recommended for diagnosis or screening purposes in patients with suspected COVID-19, the predictive value of RT-PCR test is ten times higher than the results of pulmonary CT.
Published: 2020

9. Single Layer Graphene and Vertical Graphene as a Promising Candidate for Electrochemical Biosensors

Author: Mariaora Avram, Andrei Avram, Carmen Mihailaescu, Oana Tutunaru, Bianca Tincu, Elena Maria Anghel, and Vasilica Tucureanu
Subjects: Materials science, Process equipment, Graphene, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, Nanotechnology, General Chemistry, General Medicine, General Biochemistry, Genetics and Molecular Biology, law.invention, law, Petrochemistry, Materials Chemistry, Single layer graphene, Electrochemical biosensor, General Pharmacology, Toxicology and Pharmaceutics
Abstract: Recently, graphene as a material for sensors has attracted attention due to unique properties, such as: excellent electrical and thermal conductivity, chemical stability, high surface area and Young�s modulus ̴ 1GPa, very promising for electrochemical applications. Electrochemical sensors based on graphene have been used in many applications, such as: biomolecules, gases or metal ions detection. Here, we report the effect of morphology and orientation of graphene as electrode material with electrochemical method. We investigated the capacitive performance in the case of horizontal and vertical graphene sheets, synthetized by thermal chemical vapor deposition (CVD), respectively plasma enhanced chemical vapor deposition (PECVD). Graphene electrode is used in electrochemical cells with three electrodes as a working electrode. Raman spectroscopy was carried on the graphene films for quality and structure characterization. The working electrode was characterized by scanning electron microscopy (SEM), Raman spectroscopy and electrochemical method.
Published: 2020

10. Hemorrhagic Cardiac Tamponade—An Unusual Threat in the COVID-19 Recovery Phase

Author: Raluca Ungureanu, Cristian Cobilinschi, Ana-Maria Cotae, Raluca Darie, Radu Tincu, Sorin Constantinescu, Oana Avram, Horatiu Moldovan, Ioana Marina Grintescu, and Liliana Mirea
Subjects: cardiac tamponade, coronavirus, COVID-19, pericarditis, pericardial involvement, critical care, cardiovascular surgery, General Medicine
Abstract: Cardiac tamponade is a rare presentation in patients with COVID-19, which may be induced by the associated exacerbated inflammatory response. The onset of cardiac tamponade may be concomitant with the acute phase of the disease or may develop subsequently as a new health condition secondary to the disease. We report four cases of cardiac tamponade that occurred late after the acute phase of the disease. One of them may be considered a post-acute complication of the disease, and three of them may be classified as a new health condition induced by COVID-19. Only two cases had a history of severe respiratory distress due to COVID-19. In all four cases, pericardiocentesis was imposed, and surprisingly, in every case, hemorrhagic fluid was evacuated. In this case, series, immune-mediated etiology is supported by histopathological results, where the main identified feature was fibrous pericarditis with inflammatory infiltrate. Only one patient included in this report died, and three of them were discharged after anti-inflammatory treatment was initiated.
Published: 2022

11. Takotsubo Cardiomyopathy and β-Blocker Poisoning: A Case Report

Author: Nicoleta-Monica Popa-Fotea, Miruna Mihaela Micheu, Cosmin Mihai, Ruxandra State, Radu Tincu, and Alexandru Scafa-Udriste
Subjects: General Medicine
Abstract: β-blocker poisoning is frequently observed because of its primary use for the treatment of cardiovascular diseases. The management of β-blocker toxicity is dependent on the cardiovascular response and the severity of presentation. The present study describes the case of a patient with combined drug intoxication, β-blocker, digoxin, benzodiazepines, acetaminophen and opiates in a suicidal attempt. A 63-year-old female was found somnolent and in a confused state at her residence following intentional poly-drug ingestion. Upon presentation, she was found to be hemodynamically unstable and was thus treated with vasopressors. The toxicological screening performed upon presentation was positive for polydrug ingestion. On day 3, the patient developed chest pain and ST-segment elevation in anterior leads, while transthoracic echocardiographic assessment disclosed a non-dilated left ventricle with moderate dysfunction and akinesia of the apex. Coronary angiogram revealed normal coronary arteries and, subsequently, the diagnosis of Takotsubo cardiomyopathy (TTC) was suspected. Supportive treatment was initiated with favorable evolution and left ventricular ejection fraction normalization. The management of hemodynamic instability with vasopressors should be judiciously administered in the treatment of β-blocker poisoning, in view of the adverse effects on cardiac functions, including stress cardiomyopathy.
Published: 2022

12. Dielectrophoretic and Electrical Impedance Differentiation of Cancerous Cells Based on Biophysical Phenotype

Author: Catalin Tucureanu, Aurora Salageanu, Bianca Tincu, Iuliana Caras, Ina Turcan, Thomas Gabriel Schreiner, Valentin Vasile, Marius Olariu, and Marioara Avram
Subjects: Clinical Biochemistry, Cell, Peripheral blood mononuclear cell, Jurkat cells, Article, crossover frequency, medicine, Electric Impedance, Humans, dielectrophoresis, Chemistry, Constant phase element, Cell Differentiation, General Medicine, Dielectrophoresis, medicine.disease, Primary tumor, electrical impedance spectroscopy, Microelectrode, medicine.anatomical_structure, Phenotype, Dielectric Spectroscopy, Cancer cell, Biophysics, cancer cells, Leukocytes, Mononuclear, TP248.13-248.65, Biotechnology
Abstract: Here, we reported a study on the detection and electrical characterization of both cancer cell line and primary tumor cells. Dielectrophoresis (DEP) and electrical impedance spectroscopy (EIS) were jointly employed to enable the rapid and label-free differentiation of various cancer cells from normal ones. The primary tumor cells that were collected from two colorectal cancer patients, cancer cell lines (SW-403, Jurkat, and THP-1), and healthy peripheral blood mononuclear cells (PBMCs) were trapped first at the level of interdigitated microelectrodes with the help of dielectrophoresis. Correlation of the cells dielectric characteristics that was obtained via electrical impedance spectroscopy (EIS) allowed evident differentiation of the various types of cell. The differentiations were assigned to a “dielectric phenotype” based on their crossover frequencies. Finally, Randles equivalent circuit model was employed for highlighting the differences with regard to a series group of charge transport resistance and constant phase element for cancerous and normal cells.
Published: 2021

13. Attempts to Upcycle PET Wastes into Bio-based Long-lasting Insulating Materials

Author: Andrei Sarbu, Emeric Bartha, Stanca Capitanu, Alina Elena Coman, Steluta Apostol, Sorina Gare, Petru Filip, Robert Tincu, Simona Nica, and Monica-Mirela Duldner
Subjects: Long lasting, Process equipment, Waste management, Petrochemistry, Materials Science (miscellaneous), Process Chemistry and Technology, Materials Chemistry, General Engineering, Bio based, General Chemistry, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, General Biochemistry, Genetics and Molecular Biology
Abstract: Following the green chemistry principles, three series of polyols with tailored chemical structures were obtained from PET wastes degradation via glycolysis and/or aminolysis and subsequent esterification-transesterification and/or amidation reactions, using an organic catalyst. As cleaving agents there were used various mixtures of renewable or potentially renewable reagents, selected from those that can be obtained from biomass by already applied or investigated and eventually patented biochemical and/or chemical processes. The polyols were characterized by physical-chemical methods, 1H-NMR, 13C-NMR and FT-IR Spectroscopy, and tested in the synthesis of rigid polyurethane foams, showing appropriate properties for spray foams formation and leading to materials with properties similar to conventional spray foams.
Published: 2019

14. Application of a Multifunctional Additive in Cosmetic Preparations for Safe Preservation

Author: Andreea Loredana Vonica Tincu, Veronica Isabela Craciun, Claudiu Morgovan, Luca Liviu Rus, and Anca Maria Juncan
Subjects: Engineering, Process equipment, business.industry, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, General Chemistry, General Medicine, General Biochemistry, Genetics and Molecular Biology, Petrochemistry, Materials Chemistry, Biochemical engineering, General Pharmacology, Toxicology and Pharmaceutics, business
Abstract: The aim of this study is represented by the description and the selection of an alternative preservative complex, it�s application in the development and formulation of a moisturizer and the comparative study of the efficacy of the cosmetic formulation, versus a traditional preserved cosmetic cream. For an adecvate preservation of the moisturizing cream there was used comparatively, the alternative preservation system Dermosoft LP (Caprylyl Glycol, Glycerin, Glyceryl Caprylic, Phenylpropanol), and the traditional preservative Salinip (Phenoxyethanol, Methyl Paraben, Propyl Paraben, Ethyl Paraben, Butyl Paraben, Isobutyl Paraben). Dermosoft LP has comparable effects to traditional preservatives, and proven efficacy by microbiological Challenge test.
Published: 2019

15. Effects of Acute Organophosphate Poisoning on Glycemic Profile in Weanling Rats An experimental study

Author: Dana Tomescu, Paul Tiberiu Neagu, Camelia Cristina Diaconu, Alexandra Totan, Ovidiu Gabriel Bratu, Iulia Florentina Tincu, R.A. Macovei, Alexandru Emil Băetu, Anca Pantea Stoian, and C. Cobilinschi
Subjects: medicine.medical_specialty, business.industry, Materials Science (miscellaneous), Process Chemistry and Technology, General Engineering, Weanling, General Chemistry, General Medicine, medicine.disease, Organophosphate poisoning, General Biochemistry, Genetics and Molecular Biology, Endocrinology, Internal medicine, Materials Chemistry, medicine, General Pharmacology, Toxicology and Pharmaceutics, business, Glycemic
Abstract: Organophosphates (OP) are frequently used worldwide as pesticides in both agriculture and human households leaving toxic residues in food or living environment. OP act through acetylcholinesterase (AChE) inhibition and acute poisoning carries a higher risk of mortality due to parasympathetic overstimulation. Long-term exposure leads to nervous, hepatic or renal dysfunction. Chlorpyrifos, one of the most commonly used compound appears to cause hyperglycemia, insulin resistance and the risk of developing diabetes after prolonged exposure. The aim of this article was to assess the impact of acute OP poisoning on glycemic status in weanling mice.
Published: 2019

16. Alternative Options for Local Public Services Management in the Republic of Moldova

Author: Violeta Tincu
Subjects: General Medicine, Business, Public administration, The Republic
Abstract: The paper’s author analyzes several alternative options for local public services management in the Republic of Moldova, based on current legal framework and existing administrative practice. For this purpose, the need to choose an alternative management option was analyzed; alternative options were listed; and an analysis of each option was performed. The paper’s perceived need emerged from an existing situation, typical for the Moldovan local government, where management can only be one of the two traditional ones - direct or delegated, both generating enough problems (studied by the author in other publications). However, local government is often unaware of the fact that it has other perfectly legal alternative options. A reflection chart is included at the end of the paper in order to help local government select the optimum management option when it comes to the public services delivery.
Published: 2021

17. Forme alternative de gestionare a serviciilor publice locale în Republica Moldova

Author: Academia de Administrare Publica and Violeta Tincu
Subjects: General Medicine
Abstract: În prezentul articol autorul analizează unele forme alternative de gestionare a serviciilor publice locale în Republica Moldova, în baza prevederilor legislaţiei în vigoare şi a practicii administrative existente. În acest sens, a fost examinată necesitatea optării pentru alternativele de gestiune, efectuată o trecere în revistă a acestor alternative, precum şi s-a realizat analiza fiecărei astfel de forme alternative. Necesitatea unui astfel de studiu a fost dictată de faptul că pentru majoritatea autorităţilor administraţiei publice locale gestiunea nu poate îmbrăca decât una din cele două forme tradiţionale – directă sau delegată, ambele însă generând destule probleme în Republica Moldova (studiate de autor în publicaţii anterioare), autorităţile locale respective necunoscând faptul că au şi alte opţiuni perfect legale. La finele articolului se conţine o schemă de reflecţie pentru autorităţile administraţiei publice locale din Republica Moldova care ar putea să le ajute în alegerea modalităţii adecvate de organizare şi gestionare a serviciilor publice locale
Published: 2021

18. Prader-Willi Syndrome-Improvement of Cognitive Function through Noninvasive Ventilation in Children

Author: Doina-Anca Plesca, Ana-Maria Davitoiu, Catalin Cirstoveanu, Vlad Plesca, Iulia Florentina Tincu, Sorina Chindriş, Mihai Dimitriu, and Diana Ionescu
Subjects: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Short stature, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, medicine.diagnostic_test, business.industry, nutritional and metabolic diseases, Cancer, Magnetic resonance imaging, Cognition, General Medicine, medicine.disease, nervous system diseases, 030104 developmental biology, Magnetic hyperthermia, Neonatal hypotonia, Cardiology, Noninvasive ventilation, medicine.symptom, business, 030217 neurology & neurosurgery, Congenital disorder
Abstract: Prader-Willi Syndrome is a complex congenital disorder characterized by neonatal hypotonia, short stature, childhood...
Published: 2020

19. Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization

Author: Patrick Martin, Vincent Sol, Christine Jérôme, Leonard Ionuţ Atanase, Camelia-Elena Iurciuc-Tincu, Marcel Popa, Lacramioara Ochiuz, Unité Transformations & Agroressources [Université d'Artois] (UTA), Université d'Artois (UA)-Transformations et Agro-ressources (UT&A), and UniLaSalle-UniLaSalle
Subjects: Curcumin, Polymers, Administration, Oral, Biological Availability, 02 engineering and technology, Polysaccharide, Carrageenan, Biochemistry, [SPI.MAT]Engineering Sciences [physics]/Materials, Chitosan, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, Structural Biology, Polysaccharides, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Spectroscopy, Fourier Transform Infrared, medicine, Humans, Particle Size, Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Drug Carriers, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Medicine, Polymer, [CHIM.MATE]Chemical Sciences/Material chemistry, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Controlled release, Polyelectrolytes, Polyelectrolyte, Microspheres, Bioavailability, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, Swelling, medicine.symptom, 0210 nano-technology, Gels, Nuclear chemistry, [SPI.GCIV.EC]Engineering Sciences [physics]/Civil Engineering/Eco-conception
Abstract: Curcumin has essential therapeutic benefits, but it is insoluble in water and thus has low bioavailability. This study aimed to immobilize curcumin into new polysaccharide-based microparticles (gellan, i-carrageenan, and chitosan) to increase its stability and bioavailability. Curcumin-loaded complex microparticles were obtained from three polysaccharides, of different ionic character, by ionic cross-linking and polyelectrolyte complexation. The immobilization efficiency was between 85.75% and 97.25%. The microparticles were characterized morphologically by SEM, and it was observed that the microparticles containing the i-carrageenan had a more pronounced porosity of the matrix. The swelling degree values at pH = 7.4 were superior to those obtained at pH = 6.8 or pH = 2 and depend on both the cross-linking degree and particles morphology. The polysaccharides microparticles, curcumin, and constituent polysaccharides were characterized by FT-IR spectroscopy. The curcumin release kinetics was studied in three different pH media, and the release efficiency ranged between 65.1% and 97.9% at pH = 7.4, between 60.2% and 82.2% at pH = 6.8 and between 56.1% and 64.0% at pH = 2. These microparticles can be intended for oral administration, having as therapeutic target the colon, for the controlled release of curcumin, since they can overcome the gastric barrier without the degradation of the active principle, which is protected by the polymer matrix.
Published: 2020

20. CELIAC DISEASE CASE FINDING STRATEGY IN ROMANIAN SYMPTOMATIC CHILDREN

Author: Radu George Nicolaescu, Gabriela Lesanu, Cristina Becheanu, Bucharest Pharmacy, Iulia Florentina Tincu, Olivia Dragnescu, Daniela Păcurar, Raluca Maria Vlad, and Alexandra Coroleucă
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Romanian, General Medicine, Disease, language.human_language, RJ1-570, children, language, active screening, Case finding, Medicine, business, celiac disease
Abstract: Objectives. Pediatricians face various challenges in different stages of celiac disease (CD) diagnosis. Whom to test is intensely debated because of CD’s heterogenous clinical spectrum. The main purpose of the study was to identify symptoms or symptom associations that should initiate an active strategy of CD early diagnosis in Romanian children. Material and method. We conducted a prospective study in “Grigore Alexandrescu” Emergency Children’s Hospital. From March 2013 until February 2014, 249 children with symptoms/signs at risk of CD were included. Results. CD was diagnosed in 11 (1/21 patients evaluated). One in 12.6; 16; 18; 18.5 and 18.5 children respectively with chronic diarrhea, low stature, growth failure, recurrent abdominal pain and constipation had CD. Certain symptom associations increased the risk: classical symptom associations (chronic diarrhea and weight loss), as well as other associations: recurrent abdominal pain and weight loss, constipation and weight loss, constipation and refractory iron deficiency anemia. Conclusion. Active screening among patients with symptoms and especially symptom associations at risk of CD would improve diagnosis rates in pediatric CD.
Published: 2017

21. In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study

Author: Ahmad, T, Bouwman, RA, Grigoras, I, Aldecoa, C, Hofer, C, Hoeft, A, Holt, P, Fleisher, LA, Buhre, W, Pearse, RM, Ferguson, M, MacMahon, M, Shulman, M, Cherian, R, Currow, H, Kanathiban, K, Gillespie, D, Pathmanathan, E, Phillips, K, Reynolds, J, Rowley, J, Douglas, J, Kerridge, R, Garg, S, Bennett, M, Jain, M, Alcock, D, Terblanche, N, Cotter, R, Leslie, K, Stewart, M, Zingerle, N, Clyde, A, Hambidge, O, Rehak, A, Cotterell, S, Huynh, WBQ, McCulloch, T, Ben-Menachem, E, Egan, T, Cope, J, Halliwell, R, Fellinger, P, Haisjackl, M, Haselberger, S, Holaubek, C, Lichtenegger, P, Scherz, F, Schmid, W, Hoffer, F, Cakova, V, Eichwalder, A, Fischbach, N, Klug, R, Schneider, E, Vesely, M, Wickenhauser, R, Grubmueller, KG, Leitgeb, M, Lang, F, Toro, N, Bauer, M, Laengle, F, Haberl, C, Mayrhofer, T, Trybus, C, Buerkle, C, Forstner, K, Germann, R, Rinoesl, H, Schindler, E, Trampitsch, E, Bogner, G, Dankl, D, Duenser, M, Fritsch, G, Gradwohl-Matis, I, Hartmann, A, Hoelzenbein, T, Jaeger, T, Landauer, F, Lindl, G, Lux, M, Steindl, J, Stundner, O, Szabo, C, Bidgoli, J, Verdoodt, H, Forget, P, Kahn, D, Lois, F, Momeni, M, Pregardien, C, Pospiech, A, Steyaert, A, Veevaete, L, De Kegel, D, De Jongh, K, Foubert, L, Smitz, C, Vercauteren, M, Poelaert, J, Van Mossevelde, V, Abeloos, J, Bouchez, S, Coppens, M, De Baerdemaeker, L, Deblaere, I, De Bruyne, A, De Hert, S, Fonck, K, Heyse, B, Jacobs, T, Lapage, K, Moerman, A, Neckebroek, M, Parashchanka, A, Roels, N, Van Den Eynde, N, Vandenheuvel, M, Van Limmen, J, Vanluchene, A, Vanpeteghem, C, Wouters, P, Wyffels, P, Huygens, C, Vandenbempt, P, Van de Velde, M, Dylst, D, Janssen, B, Schreurs, E, Aleixo, FB, Candido, K, Batista, HD, Guimaraes, M, Guizeline, J, Hoffmann, J, Lobo, S, Marques Lobo, FR, Nascimento, V, Nishiyama, K, Pazetto, L, Souza, D, Rodrigues, RS, Vilela dos Santos, AM, Jardim, J, Sa Malbouisson, LM, Silva, J, do Nascimento Junior, P, Baio, TH, Pereira de Castro, GI, Watanabe Oliveira, HR, Amendola, CP, Cardoso, G, Ortega, D, Brotto, AF, De Oliveira, MC, Rea-Neto, A, Dias, F, Travi, ME, Zerman, L, Azambuja, P, Knibel, MF, Martins, A, Almeida, W, Neder Neto, C, Tardelli, MA, Caser, E, Machado, M, Aguzzoli, C, Baldisserotto, S, Tabajara, FB, Bettega, F, Rodrigues Junior, LHC, de Gasperi, J, Faina, L, Nolasco, MF, da Costa Fischer, BF, de Campos Ferreira, MF, Hartmann, C, Kliemann, M, Ribeiro, GLH, Fraga, JM, Netto, TM, Pozza, LV, Wendling, PR, Azevedo, C, Garcia, J, Lopes, M, Maia, B, Maselli, P, Melo, R, Mendes, W, Neves, M, Ney, J, Piras, C, Applewhaite, C, Carr, A, Chow, L, Duttchen, K, Foglia, J, Greene, M, Hinther, A, Houston, K, McCormick, TJ, Mikhayel, J, Montasser, S, Ragan, A, Suen, A, Woolsey, A, Yu, HC, Funk, D, Kowalski, S, Legaspi, R, McDonald, H, Siddiqui, F, Pridham, J, Rowe, B, Sampson, S, Thiessen, B, Zbitnew, G, Bernard, A, George, R, Jones, P, Moor, R, Siddiqui, N, Wolfer, A, Tran, D, Winch, D, Dobson, G, McCormick, T, Montasser, O, Hall, R, Baghirzada, L, Curley, G, Dai, SY, 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D, Zhang, R, Zhao, X, Bai, H-P, Liu, C-X, Liu, F-F, Ren, W, Wang, X-L, Xu, G-J, Li, B, Ou, Y, Tang, Y, Yao, S, Zhang, S, Kong, C-C, Liu, B, Wang, T, Lu, B, Xia, Y, Cai, F, Chen, P, Hu, S, Xu, Q, Hu, L, Jing, L, Liu, Q, Peng, ZD, Qiu, X, Ren, Q, Tong, Y, Wen, Y, Wu, Q, Xia, J, Xiong, X, Xu, S, Yang, T, Yin, N, Zeng, Q, Zhang, B, Zheng, K, Cang, J, Fan, Y, Fu, S, Ge, X, Guo, B, Huang, W, Jiang, L, Jiang, X, Shan, Q, Wang, F, Christiansen, IC, Granum, SN, Rasmussen, BS, Daugaard, M, Gambhir, R, Brandsborg, B, Steingrimsdottir, GE, Jensen-Gadegaard, P, Olsen, KS, Siegel, H, Eskildsen, KZ, Gatke, MR, Wibrandt, I, Heintzelmann, SB, Lange, KHW, Lundsgaard, RS, Amstrup-Hansen, L, Hovendal, C, Larsen, M, Lenstrup, M, Kobborg, T, Larsen, JR, Pedersen, AB, Smith, SH, Oestervig, RM, Rasmussen, L, Afshari, A, Andersen, C, Ekelund, K, Secher, EL, Beloeil, H, Lasocki, S, Venara, A, Biais, M, Ouattara, A, Sineus, M, Molliex, S, Legouge, ML, Wallet, F, Tesniere, A, Gaudin, C, Lehur, P, Forsans, E, de Rudnicki, S, Maudet, VS, Mutter, D, Sojod, G, Ouaissi, M, Regimbeau, J-M, Futier, E, Desbordes, J, Comptaer, N, el Manser, D, Ethgen, S, Lebuffe, G, Auer, P, Haertl, C, Deja, M, Legashov, K, Sonnemann, S, Wiegand-Loehnert, C, Falk, E, Habicher, M, Angermair, S, Laetsch, B, Schmidt, K, Von Heymann, C, Ramminger, A, Jelschen, F, Pabel, S, Weyland, A, Czeslick, E, Gille, J, Malcharek, M, Sablotzki, A, Lueke, K, Wetzel, P, Weimann, J, Lenhart, F-P, Reichle, F, Schirmer, F, Hueppe, M, Klotz, K, Nau, C, Schoen, J, Mencke, T, Wasmund, C, Bankewitz, C, Baumgarten, G, Fleischer, A, Guttenthaler, V, Hack, Y, Kirchgaessner, K, Maenner, O, Schurig-Urbaniak, M, Struck, R, van Zyl, R, Wittmann, M, Goebel, U, Harris, S, Veit, S, Andreadaki, E, Souri, F, Katsiadramis, I, Skoufi, A, Vasileiou, M, Aimoniotou-Georgiou, E, Katsourakis, A, Veroniki, F, Vlachogianni, G, Petra, K, Chlorou, D, Oloktsidou, E, Ourailoglou, V, Papapostolou, K, Tsaousi, G, Daikou, P, Dedemadi, G, Kalaitzopoulos, I, Loumpias, C, Bristogiannis, S, Dafnios, N, Gkiokas, G, Kontis, E, Kozompoli, D, Papailia, A, Theodosopoulos, T, Bizios, C, Koutsikou, A, Moustaka, A, Plaitakis, I, Armaganidis, A, Christodoulopoulou, T, Lignos, M, Theodorakopoulou, M, Asimakos, A, Ischaki, E, Tsagkaraki, A, Zakynthinos, S, Antoniadou, E, Koutelidakis, I, Lathyris, D, Pozidou, I, Voloudakis, N, Dalamagka, M, Elena, G, Chronis, C, Manolakaki, D, Mosxogiannidis, D, Slepova, T, Tsakiridou, I-S, Lampiri, C, Vachlioti, A, Panagiotakis, C, Sfyras, D, Tsimpoukas, F, Tsirogianni, A, Axioti, E, Filippopoulos, A, Kalliafa, E, Kassavetis, G, Katralis, P, Komnos, I, Pilichos, G, Ravani, I, Totis, A, Apagaki, E, Efthymiadi, A, Kampagiannis, N, Paraforou, T, Tsioka, A, Georgiou, G, Vakalos, A, Bairaktari, A, Charitos, E, Markou, G, Niforopoulou, P, Papakonstantinou, N, Tsigou, E, Xifara, A, Zoulamoglou, M, Gkioni, P, Karatzas, S, Kyparissi, A, Mainas, E, Papapanagiotou, I, Papavasilopoulou, T, Fragandreas, G, Georgopoulou, E, Katsika, E, Psarras, K, Synekidou, E, Verroiotou, M, Vetsiou, E, Zaimi, D, Anagnou, A, Apostolou, K, Melissopoulou, T, Rozenberg, T, Tsigris, C, Boutsikos, G, Kalles, V, Kotsalas, N, Lavdaiou, C, Paikou, F, Panagou, G-L, Spring, A, Arvaniti, K, Botis, I, Drimala, M, Georgakakis, G, Kiourtzieva, E, Ntouma, P, Prionas, A, Xouplidis, K, Dalampini, E, Giannaki, C, Iasonidou, C, Ioannidis, O, Lavrentieva, A, Papageorgiou, G, Kokkinoy, M, Stafylaraki, M, Gaitanakis, S, Karydakis, P, Paltoglou, J, Ponireas, P, Chaloulis, P, Provatidis, A, Sousana, A, Gardikou, VV, Konstantivelli, M, Lataniotou, O, Lisari, E, Margaroni, M, Stamatiou, K, Nikolaidis, E, Pnevmatikos, I, Sertaridou, E, Andreou, A, Arkalaki, E, Athanasakis, E, Chaniotaki, F, Chatzimichali, CA, Christofaki, M, Dermitzaki, D, Fiorentza, K, Frantzeskos, G, Geromarkaki, E, Kafkalaki, K, Kalogridaki, M, Karydi, K, Kokkini, S, Kougentakis, G, Lefaki, T, Lilitsis, E, Makatounaki, A, Malliotakis, P, Michelakis, D, Neonaki, M, Nyktari, V, Palikyra, I, 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J, Pathan, F, Shah, MHS, Yap, HL, Cheah, S, Chin, II, Looi, JK, Tan, SC, Visvalingam, S, Kwok, FY, Lee, CK, Tan, TS, Wong, SM, Abdullah, NH, Liew, CF, Luxuman, L, Zin, NHM, Norddin, MF, Alias, RLR, Wong, JY, Yong, J, Bin Mustapha, MT, Chan, WK, Dzulkipli, N, Kuan, PX, Lee, YC, Alias, A, Guok, EC, Jee, CC, Ramon, BR, Wong, CW, Ghafar, FNIA, Aziz, FZ, Hussain, N, Lee, HS, Sukawi, I, Woon, YL, Hadi, HZA, Azam, UAA, Alias, AH, Kesut, SA, Lee, JM, Ooi, DV, Sulaiman, HA, Lih, TAT, Mansor, M, Veerakumaran, J, Luna, P, Rojas, E, Resendiz, GEA, Zapata, DDM, Lopez, JCJA, Flores, AAA, Amador, JCB, Avila, EJD, Aquino, LPG, Rodriguez, RL, Landa, MT, Urias, E, Hollmann, M, Hulst, A, Preckel, OKB, Koopman-van Gemert, A, Bouwman, A, Buise, M, Tolenaar, N, Weber, E, de Fretes, J, Houweling, P, Ormskerk, P, Van Bommel, J, Lance, M, Smit-Fun, V, van Zundert, T, Baas, P, de Boer, HD, Sprakel, J, Elferink-Vonk, R, Noordzij, P, van Zeggeren, L, Brand, B, Spanjersberg, R, ten Bokkel-Andela, J, Numan, S, van 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Rughubar, V, Reddy, J, Singh, A, Skinner, DL, Smith, MJ, Singh, B, Misra, R, Naidoo, M, Ramdharee, P, Selibea, Y, Sewpersad, S, Sham, S, Wessels, JD, Africander, C, Bejia, T, Blakemore, SP, Botes, M, Bunwarie, B, Hernandez, CB, Jeeraz, MA, Legutko, DA, Lopez, AG, De Meyer, JN, Muzenda, T, Naidoo, N, Patel, M, Pentela, R, Junge, M, Mansoor, N, Rademan, L, Scislowski, P, Seedat, I, van den Berg, B, van der Merwe, D, van Wyk, S, Govender, K, Naicker, D, Ramjee, R, Saley, M, Kuhn, WP, Matos-Puig, R, Moolla, Z, Lisi, A, Perez, G, Valle Beltran, A, Lozano, A, Delgado Navarro, C, Duca, A, Martinez Ernesto, EP, Ferrando, C, Fuentes, I, Luisa Garcia-Perez, M, Gracia, E, Izquierdo Palomares, A, Katime, A, Minana, A, Raul Incertis, R, Romero, E, Romero Garcia, CS, Rubio, C, Socorro Artiles, T, Soro, M, Valls, P, Alaman Laguarda, G, Benavent, P, Chisbert Cuenca, V, Cueva, A, Lafuente, M, Marques Parra, A, Romero Rodrigo, A, Sanchez-Morcillo, S, Tormo, S, Javier Redondo, F, De Andres Ibanez, JA, Gomez Diago, L, Hernandez Cadiz, MJ, Gil Manuel, G, Peris, R, Saiz, C, Tatay Vivo, J, Tebar Soto, MT, Brunete, T, Cancho, D, Delgado Garcia, DR, Zamudio, D, Garcia Del Valle, S, Luz Serrano, M, Alonso, E, Anillo, V, Maseda, E, Salgado, P, Suarez, L, Suarez-de-la-Rica, A, Jose Villagran, M, Ignacio Alonso, J, Cabezuelo, E, Garcia-Saiz, I, Lopez del Moral, O, Martin, S, Perez Gonzalez, A, Tovar Doncel, MS, Aguero Vera, M, Avila Sanchez, FJ, Castano, B, Castano Moreira, B, Flores Risco, S, Paz Martin, D, Perez Martin, F, Poza, P, Ruiz, A, Serna Martinez, WF, Vazquez Vicente, B, Velaz Dominguez, S, Fernandez, S, Munoz-Lopez, A, Jose Bernat, M, Mas, A, Planas, K, Jawad, M, Saeed, Y, Hedin, A, Levander, H, Chew, M, Holmstrom, S, Lonn, D, Zoerner, F, Akring, I, Widmark, C, Zettergren, J, Liljequist, VA, Nystrom, L, Odeberg-Wernerman, S, Oldner, A, Fagerlund, MJ, Reje, P, Lyckner, S, Sperber, J, Adolfsson, A, Klarin, B, Ogren, K, Barras, J-P, Buhrer, T, Despotidis, V, Helmy, N, Holliger, S, 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C, Nofal, E, Pout, L, Varden, R, Wild, J, Jones, S, Moreton, S, Pulletz, M, Davies, C, Martin, M, Thomas, S, Burns, K, McArthur, C, Patel, P, Lau, G, Rich, N, Davis, F, Lyons, R, Port, B, Prout, R, Smith, C, Adelaja, Y, Bennett, V, Bidd, H, Dumitrescu, A, Murphy, JF, Keen, A, Mguni, N, Ong, C, Adams, G, Boshier, P, Brown, R, Butryn, I, Chatterjee, J, Freethy, A, Lockwood, G, Tsakok, M, Tsiligiannis, S, Peat, W, Stephenson, L, Bradburn, M, Pick, S, Cunha, P, Olagbaiye, O, Tayeh, S, Packianathaswamy, B, Abernethy, C, Balasubramaniam, M, Bennett, R, Bolton, D, Martinson, V, Bell, S, Heather, B, Kushakovsky, V, Alcock, L, Alexander, H, Anderson, C, Baker, P, Brookes, M, Cawthorn, L, Cirstea, E, Clarkson, R, Colling, K, Coulter, I, Das, S, Haigh, K, Hamdan, A, Hugill, K, Kottam, L, Lisseter, E, Mawdsley, M, McGivern, J, Padala, K, Phelps, V, kumar, VR, Stewart, K, Towse, K, Tregonning, J, Vahedi, A, Walker, A, Baines, D, Bilolikar, A, Chande, S, Copley, E, Dunk, N, Kulkarni, R, Kumar, P, Metodiev, Y, Ncomanzi, D, Raithatha, B, Raymode, P, Szafranski, J, Twohey, L, Watt, P, Weatherall, L, Weatherill, J, Whitman, Z, Wighton, E, Abayasinghe, C, Chan, A, Darwish, S, Gill, J, Glasgow, E, Hadfield, D, Harris, C, Hopkins, P, Kochhar, A, Kunst, G, Mellis, C, Pool, A, Riozzi, P, Selman, A, Smith, E-J, Vele, L, Gercek, Y, Guy, K, Holden, D, Watson, N, Whysall, K, Andreou, P, Hales, D, Thompson, J, Bowrey, S, McDonald, S, Gilmore, J, Hills, V, Kelly, C, Kelly, S, Lloyd, G, Abbott, T, Gall, L, Torrance, H, Vivian, M, Berntsen, E, Nolan, T, Turner, A, Vohra, A, Brown, A, Clark, R, Coughlan, E, Daniel, C, Patvardhan, C, Pearson, R, Predeep, S, Saad, H, Shanmugam, M, Varley, S, Wylie, K, Cooper, L, Makowski, A, Misztal, B, Moldovan, E, Pegg, C, Donovan, A, Foot, J, Large, S, Claxton, A, Netke, B, Armstrong, R, Calderwood, C, Kwok, A, Mohr, O, Oyeniyi, P, Patnaik, L, Post, B, Ali, S, Arshad, H, Baker, G, Brenner, L, Brincat, M, Brunswicker, A, Cox, H, Cozar, OI, Cheong, E, Durst, A, Fengas, L, Flatt, J, Glister, G, Narwani, V, Photi, E, Rankin, A, Rosbergen, M, Beaton, C, Horn, R, Hunt, J, Rousseau, G, Stancombe, L, Absar, M, Allsop, J, Drinkwater, Z, Hodgkiss, T, Smith, K, Alexander-Sefre, F, Campey, L, Dudgeon, L, Hall, K, Hitchcock, R, James, L, Winstone, U, Ahmad, N, Bauchmuller, K, Harrison, J, Jeffery, H, Miller, D, Pinder, A, Pothuneedi, S, Rosser, J, Sanghera, S, Swift, D, Walker, R, Bester, D, Cavanagh, S, Cripps, H, Daniel, H, Lynch, J, Pyke, S, Scholefield, J, Whitworth, H, Bottrill, F, Ramalingam, G, Webb, S, Akerman, N, Antill, P, Bourner, L, Buckley, S, Castle, G, Charles, R, Eggleston, C, Foster, R, Gill, S, Lindley, K, Lklouk, M, Lowery, T, Martin, O, Milne, D, O'Connor, P, Ratcliffe, A, Rose, A, Smith, A, Varma, S, Ward, J, Barcraft-Barnes, H, Camsooksai, J, Colvin, C, Reschreiter, H, Tbaily, L, Venner, N, Hamilton, C, Kelly, L, Toth-Tarsoly, P, Dodsworth, K, Foord, D, Gordon, P, Hawes, E, Lamb, N, Mouland, J, Nightingale, J, Rose, S, Schrieber, J, Al 'Amri, K, Aladin, H, Arshad, MA, Barraclough, J, Bentley, C, Bergin, C, Carrera, R, Clarkson, A, Collins, M, Denham, S, Griffiths, E, Ip, P, Jeyanthan, S, Joory, K, Kaur, S, Marriott, P, Mitchell, N, Nagaiah, S, Nilsson, A, Parekh, N, Pope, M, Seager, J, Serag, H, Tameem, A, Thomas, A, Thunder, J, Torrance, A, Vohra, R, whitehouse, A, Wong, T, Blunt, M, Wong, K, Giles, J, Reed, I, Weller, D, Bell, G, Birch, J, Damant, R, Maiden, J, Mewies, C, Prince, C, Radford, J, Reynolds, T, Balain, B, Banerjee, R, Barnett, A, Burston, B, Edwards, J, Evans, C, Ford, D, Gallacher, P, Hill, S, Jaffray, D, Karlakki, S, Kennedy, J, Kiely, N, Lewthwaite, S, Marquis, C, Ockendon, M, Phillips, S, Pickard, S, Richardson, J, Roach, R, Smith, T, Spencer-Jones, R, Steele, N, Steen, J, Van Liefland, M, White, S, Faulds, M, Harris, M, Nicol, S, Pearson, SA, Chukkambotla, S, Andrew, A, Attrill, E, Campbell, G, Datson, A, Fouracres, A, Graterol, J, Graves, L, Hong, B, Ishimaru, A, Karthikeyan, A, King, H, Lawson, T, Lee, G, Lyons, S, Hall, AM, Mathoulin, S, Mcintyre, E, Mclaughlin, D, Mulcahy, K, Paddle, J, Robbins, J, Sung, W, Tayo, A, Trembath, L, Venugopal, S, Wigmore, G, Boereboom, C, Downes, C, Humphries, R, Melbourne, S, Tou, S, Ullah, S, Batchelor, N, Boxall, L, Broomby, R, Deen, T, Hellewell, A, Helliwell, L, Hutchings, M, Hutchins, D, Keenan, S, Mackie, D, Potter, A, Smith, F, Stone, L, Thorpe, K, Wassall, R, Woodgate, A, Baillie, S, Campbell, T, James, S, King, C, de Araujo, DM, Martin, D, Morkane, C, Neely, J, Rajendram, R, Burton, M, James, K, Keevil, E, Minik, O, Morgan, J, Musgrave, A, Rajanna, H, Roberts, T, Szakmany, T, Adamson, M, Jumbe, S, Kendall, J, Muthuswamy, MB, Cruikshanks, A, Wrench, I, Zeidan, L, Ardern, D, Harris, B, Hellstrom, J, Martin, J, Thomas, R, Varsani, N, Brown, CW, Docherty, P, Gillies, M, McGregor, E, Usher, H, Craig, J, Bodger, P, Creary, T, Everingham, K, Fowler, A, Hewson, R, Ijuo, E, Januszewska, M, Jones, T, Kantsedikas, I, Lahiri, S, McLean, AL, Niebrzegowska, E, Phull, M, Wickboldt, N, Baldwin, J, Doyle, D, Mcmullan, S, Oladapo, M, Owen, T, Williams, A, Gregory, P, Husain, T, Kirk-Bayley, J, Mathers, E, Montague, L, Harper, M, Jack, J, Ridley, C, Avis, J, Cook, T, Dali-Kemmery, L, Kerslake, I, Lambourne, V, Pearson, A, Boyd, C, Callaghan, M, Lawson, C, McCrossan, R, Nesbitt, V, O'connor, L, Sinclair, R, Farid, N, Morgese, C, Bhatia, K, Karmarkar, S, Ahmed, J, Branagan, G, Hutton, M, Swain, A, Brookes, J, Cornell, J, Dolan, R, Hulme, J, van Vuuren, AJ, Jowitt, T, Kalashetty, G, Lloyd, F, Patel, K, Sherwood, N, Brown, L, Chandler, B, Deighton, K, Emma, T, Haunch, K, Cheeseman, M, Dent, K, Gray, C, Hood, M, Jones, D, Juj, J, Rao, R, Walker, T, Al Anizi, M, Cheah, C, Cheing, Y, Coutinho, F, Gondo, P, Hadebe, B, Hove, MO, khader, A, Krishnachetty, B, Rhodes, K, Sokhi, J, Baker, K-A, Bertram, W, Looseley, A, Mouton, R, Hanna, G, Arnold, G, Arya, S, Balfoussia, D, Baxter, L, Harris, J, Jones, C, Knaggs, A, Markar, S, Perera, A, Scott, A, Shida, A, Sirha, R, Wright, S, Frost, V, Andrews, E, Arrandale, L, Barrett, S, Cifra, E, Cooper, M, Dragnea, D, Elna, C, Maclean, J, Meier, S, Milliken, D, Munns, C, Ratanshi, N, Ramessur, S, Salvana, A, Watson, A, Ali, H, Critchley, R, Endersby, S, Hicks, C, Liddle, A, Pass, M, Ritchie, C, Thomas, C, Too, L, Welsh, S, Gill, T, Johnson, J, Reed, J, Davis, E, Papadopoullos, S, Attwood, C, Biffen, A, Boulton, K, Gray, S, Hay, D, Mills, S, Montgomery, J, Riddell, R, Simpson, J, Bhardwaj, N, Paul, E, Uwubamwen, N, Alexander, M, Arrich, J, Arumugam, S, Blackwood, D, Boggiano, V, Chan, YL, Chatterjee, D, Chhabra, A, Christian, R, Costelloe, H, Matthewman, MC, Dalton, E, Darko, J, Davari, M, Dave, T, Deacon, M, Deepak, S, Edmond, H, Ellis, J, El-Sayed, A, Eneje, P, English, R, Ewe, R, Foers, W, Franklin, J, Gallego, L, Garrett, E, Goldberg, O, Goss, H, Greaves, R, Harris, R, Hennings, C, Jones, E, Kamali, N, Kokkinos, N, Lewis, C, Lignos, L, Malgapo, EV, Malik, R, Milne, A, Mulligan, J-P, Nicklin, P, Palipane, N, Parsons, T, Piper, R, Prakash, R, Ramesh, B, Rasip, S, Reading, J, Rela, M, Reyes, A, Stephens, R, Rooms, M, Shah, K, Simons, H, Solanki, S, Spowart, E, Stevens, A, Waggett, H, Yassaee, A, Kennedy, A, Scott, S, Somanath, S, Berg, A, Hernandez, M, Nanda, R, Tank, G, Wilson, N, Wilson, D, Al-Soudaine, Y, Baldwin, M, Cornish, J, Davies, Z, Davies, L, Edwards, M, Frewer, N, Gallard, S, Glasbey, J, Harries, R, Hopkins, L, Kim, T, Koompirochana, V, Lawson, S, Lewis, M, Makzal, Z, Scourfield, S, Ahmad, Y, Bates, S, Blackwell, C, Bryant, H, Collins, H, Coulter, S, Cruickshank, R, Daniel, S, Daubeny, T, Golder, K, Hawkins, L, Helen, B, Hinxman, H, Levett, D, Salmon, K, Seaward, L, Skinner, B, Tyrell, B, Wadams, B, Walsgrove, J, Dickson, J, Constantin, K, Karen, M, O'Brien, P, O'Donohoe, L, Payne, H, Sundayi, S, Walker, E, Brooke, J, Cardy, J, Humphreys, S, Kessack, L, Kubitzek, C, Kumar, S, Cotterill, D, Hodzovic, E, Hosdurga, G, Miles, E, Saunders, G, Campbell, M, Chan, P, Jemmett, K, Raj, A, Naik, A, Oshowo, A, Ramamoorthy, R, Shah, N, Sylvan, A, Blyth, K, Burtenshaw, A, Freeman, D, Johnson, E, Lo, P, Martin, T, Plunkett, E, Wollaston, J, Allison, J, Carroll, C, Craw, N, Craw, S, Pitt-Kerby, T, Rowland-Axe, R, Spurdle, K, McDonald, A, Simon, D, Sinha, V, Banner-Goodspeed, V, Boone, M, Campbell, K, Lu, F, Scannell, J, Sobol, J, Balajonda, N, Clemmons, K, Conde, C, Elgasim, M, Funk, B, Hopkins, T, Olaleye, O, Omer, O, Pender, M, Porto, A, Waweru, P, Yeh, E, Bodansky, D, Evans, A, Kleopoulos, S, Maril, R, Mathney, E, Sanchez, A, Tinuoye, E, Bateman, B, Eng, K, Jiang, N, Ladha, K, Needleman, J, Chen, L-L, Lane, R, Robinowitz, D, Ghushe, N, Irshad, M, O'Connor, J, Patel, S, Takemoto, S, Wallace, A, Mazzeffi, M, Rock, P, Wallace, K, Chua, P, Fleisher, L, Mattera, M, Sharar, R, Thilen, S, Treggiari, M, Morgan, A, Sofjan, I, Subramaniam, K, Avidan, M, Maybrier, H, Muench, M, Wildes, T, ISOS, ISOS, Int Surgical Outcomes Study ISOS, Anesthesiology, ACS - Diabetes & metabolism, ACS - Microcirculation, ACS - Amsterdam Cardiovascular Sciences, APH - Quality of Care, ACS - Heart failure & arrhythmias, and International Surgical Outcomes Study (ISOS) group
Subjects: Male, IMPACT, Cancer, Complication rate, Mortality, Oesophagectomy, Postoperative care, Upper gastrointestinal surgery, SURGICAL COMPLICATIONS, 0302 clinical medicine, Postoperative Complications, Risk Factors, Outcome Assessment, Health Care, 030212 general & internal medicine, Hospital Mortality, Prospective Studies, ESOPHAGOGASTRIC CANCER, Prospective cohort study, Digestive System Surgical Procedures, RISK, Perioperative medicine, General Medicine, Middle Aged, Oncology, Length of Stay/statistics & numerical data, Elective Surgical Procedures, MORTALITY FOLLOWING ESOPHAGECTOMY, 030220 oncology & carcinogenesis, Female, Elective Surgical Procedure, Cohort study, medicine.medical_specialty, ENHANCED RECOVERY, PERIOPERATIVE MEDICINE, Postoperative Complications/mortality, NO, 03 medical and health sciences, Outcome Assessment (Health Care), MORBIDITY, medicine, Humans, Digestive System Surgical Procedures/mortality, business.industry, LONG-TERM SURVIVAL, Odds ratio, Length of Stay, CARE, medicine.disease, Confidence interval, Surgery, Human medicine, Complication, business
Abstract: Aims: Previous research suggests that patients undergoing upper gastrointestinal surgery are at high risk of poor postoperative outcomes. The aim of our study was to describe patient outcomes after elective upper gastrointestinal surgery at a global level.Methods: Prospective analysis of data collected during an international seven-day cohort study of 474 hospitals in 27 countries. Patients undergoing elective upper gastrointestinal. surgery were recruited. Outcome measures were in-hospital complications and mortality at 30-days. Results are presented as n(%) and odds ratios with 95% confidence intervals.Results: 2139 patients were included, of whom 498 (23.2%) developed one or more postoperative complications, with 30 deaths (1.4%). Patients with complications had longer median hospital stay 11 (6-18) days vs. 5 (2-10) days. Infectious complications were most frequent, affecting 368 (17.2%) patients. 328 (15.3%) patients were admitted to critical care postoperatively, of whom 161 (49.1%) developed a complication with 14 deaths (4.3%). In a multivariable logistic regression model we identified age (OR 1.02 [1.01-1.03]), American Society of Anesthesiologists physical status III (OR 2.12 [1.44-3.16]) and IV (OR 3.23 [1.72-6.09]), surgery for cancer (OR 1.63 [1.27-2.11]), open procedure (OR 1.40 [1.10-1.78]), intermediate surgery (OR 1.75 [1.12-2.81]) and major surgery (OR 2.65 [1.72-4.23]) as independent risk factors for postoperative complications. Patients undergoing major surgery for upper gastrointestinal cancer experienced twice the rate of complications compared to those undergoing other procedures (224/578 patients [38.8%] versus 274/1561 patients [17.6%]).Conclusions: Complications and death are common after upper gastrointestinal surgery. Patients undergoing major surgery for cancer are at greatest risk. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Published: 2017

22. The Compartment Syndrome Associated with Deep Vein Thrombosis due to Rattlesnake Bite: A Case Report

Author: Z. Ghiorghiu, R.C. Tincu, Dana Tomescu, and Radu Alexandru Macovei
Subjects: Adult, 0301 basic medicine, medicine.medical_specialty, Deep vein, lcsh:Medicine, Snake Bites, Case Report, Compartment Syndromes, Tachypnea, compartment syndrome, 03 medical and health sciences, developed deep vein thrombosis, Forearm, Deep vein thrombosis, Crotalid Venoms, medicine, Animals, Edema, Humans, Snakebite, Venous Thrombosis, Antivenins, business.industry, lcsh:R, Crotalus, Organ dysfunction, Glasgow Coma Scale, General Medicine, medicine.disease, Thrombosis, Fasciotomy, Surgery, 030104 developmental biology, medicine.anatomical_structure, Lymphangitis, Anesthesia, Upper limb, Female, Snakebite,developed deep vein thrombosis,compartment syndrome, medicine.symptom, business
Abstract: Background: Snakebite is a health issue specific to some parts of the world, especially in the tropical area, where it produces many victims. The main clinical damage caused by snake bite involves hemotoxic, neurotoxic and myotoxic reactions. It is also established that the importance of systemic impairment varies according to individual factors and are related to organ dysfunction, shock or hypotension. We report the case of a young woman suffering from snakebite who developed deep vein thrombosis and compartment syndrome. Case Report: We present the case of a 32-year-old Romanian woman who was injured by her own Crotalinae snake (also known as pit viper or rattlesnake) on her left forearm. When admitted to our Emergency Department, she was conscious with a Glasgow coma scale of 12/15, somnolent, febrile, suffering of headache, tachypnea; the marks of the snakebite were located in the distal part of the anterior left forearm; she had pain and bleeding at the bite site and swelling of the left upper limb with lymphangitis up to the axilla. She experienced fasciotomy-requiring compartment syndrome of the upper limb and required unfractionated heparin and closed monitored using activated partial thromboplastin time evolution due micro-thrombosis in the brachial vein. Local improvement was achieved in the next 4 days with progressive diminish of local tenderness and swelling. Conclusion: Limb deep vein thrombosis might be induced by snakebite, despite pro-hemorrhagic general condition induced by the envenomation. High index of clinical suspicion is needed for early diagnosis and timely management which can improve survival of these patients. Keywords: Snakebite, developed deep vein thrombosis, compartment syndrome
Published: 2017

23. Mortality after surgery in Europe: a 7 day cohort study

Author: Pearse, R, Moreno, R, Bauer, P, Pelosi, P, Metnitz, P, Spies, C, Vallet, B, Vincent, J, Hoeft, A, Rhodes, A, Fagnoul, D, van Obbergh, L, Al Subaie, N, Arif, F, Cashman, J, Cecconi, M, Edsell, M, Fossati, N, Hammond, S, Hamilton, M, Lonsdale, D, Moran, C, Siegmueller, C, Velzeboer, F, Wong, P, Awlakpui, E, Scheidemann, M, Wittmann, M, Damster, S, Golder, K, Hewson, R, Januszewska, M, Leva, B, Ramos, V, Hoste, E, Huyghens, L, Jacobs, R, Van Mossevelde, V, Opdenacker, G, Poelaert, J, Spapen, H, Leleu, K, Rijckaert, D, De Decker, K, Foubert, L, De Neve, N, Biston, P, Piagnerelli, M, Collin, V, den Blauwen, N, Clauwaert, C, De Crop, L, Verbeke, A, Derumeaux, P, Gardin, C, Kindt, S, Louage, S, Verhamme, B, Druwé, P, Lahaye, I, Rosseel, F, Rutsaert, R, Vanlinthout, L, De Kock, M, Forget, P, Georges, P, Grosu, I, Kahn, D, Lois, F, Momeni, M, Pospiech, A, Yemnga, B, Jadoul, J, Malbrain, M, Bosinceanu, D, Collard, E, Jorens, P, Reyntiens, D, Smitz, C, Vercauteren, M, Goranović, T, Mazul Sunko, B, Toplice, K, Oremuš, K, Bešlić, G, Duzel, V, Hauptman, A, Peremin, S, Šribar, A, Župčić, M, Brod, S, Mirković, I, Šarić Bauer, Z, Belavić, M, Blažanin, B, Katušin, M, Brozović Krijan, A, Mišković, P, Šimić Korać, N, Topić, J, Žilić, A, Žuni, J, Acan, I, Adanić, M, Ivanov, N, Pavičić Šarić, J, Tomulić, K, Visković, N, Bošnjak, S, Haršanji Drenjančevic, I, Kristek, G, Kvolik, S, Markić, S, Stojanovic Rakipovic, A, Katarina Tot, O, Venzera Azenic, D, Kalagac Fabris, L, Bačak Kocman, I, Balenović, I, Bandić, D, Judith Deutsch, P, Divjak, L, Filipović, I, Gužvinec, Z, Krznarić, Z, Lončarić, Y, Magaš, J, Mitrović, M, Okić, M, Pavlek, M, Ramov, E, Rezek, K, Sekulić, A, Tomasevic, B, Mirić, M, Tomašević, A, Tomić Mahečić, T, Vrbanović, V, Bobinac, M, Božić, A, Debelic, D, Frkovic, V, Batinica, I, Baranović, S, Gavranović, Ž, Kikec, M, Maldini, B, Marić, S, Agnić, I, Delić, N, Dropulić, N, Kljaković Gašpić, T, Ilić, D, Ivančev, B, Karanović, N, Kuščević, D, Marović, Z, Milić, M, Nevešćanin, A, Petković, T, Smoje, M, Brozović, G, Jelisavac, M, Matolić, M, Oberhofer, D, Marija Pavičić, A, Šakić, K, Delija Bozovic, M, Kotorac Krecek, Z, Krobot, R, Andabaka, T, Bratanić, M, Dzepina, O, Kraljev, M, Šeric, J, Šimurina, T, Grujić, R, Nacevski Bulaja, B, Barižon, M, Danira, V, Dražen, B, Dušanka, K, Bašić Halužan, M, Joško, Ž, Katica, R, Labor, M, Grgurević Marinković, T, Mihovilčević, D, Marija, B, Srečko, M, Vranković, S, Kyprianou, T, Neophytou, K, Cerny, V, Cvachovec, K, Belikova, B, Drab, M, Hudacek, K, Krikava, I, Stourac, P, Zadrazilova, K, Bicek, V, Brabcová, M, Klozová, R, Vajter, J, Vymazal, T, Toft, P, Blichfeldt, L, Dilling Hansen, B, Moller, K, Sylvest Nielsen, J, Frederiksen, J, Dohn Andersen, J, Peter Kühne, J, Leivdal, S, Stendell, L, Simonsen, M, Konrad Zoltowski, M, Salman Ali, Z, Freundlich, M, Pilypaite, J, Groes Clausen, N, Thorup, L, Hansen, F, Bestle, M, Steen Hansen, C, Afshari, A, Bastholm Bille, A, Lefort, M, Secher, E, Liboriussen, L, Herodes, V, Härma, E, Marvet, K, Pool, K, Kallas, P, Mägi, T, Sütt, J, Vijar, K, Visk, E, Vinnal, M, Ellermaa, J, Liibusk, L, Tikkerberi, A, Falk, I, Mällo, E, Talving, J, Pettilä, V, Hovilehto, S, Kirsi, A, Mustola, S, Tiainen, P, Toivonen, J, Dabnell, S, Kaminski, T, Sysimetsa, A, Kaukonen, M, Silvasti, P, Vainio, K, Lund, V, Sjövall, S, Saarinen, K, Viitanen, M, Ahonen, T, Alaspää, A, Zittling, R, Saarinen, A, Moisander, A, Wagner, B, Laru Sompa, R, Elomaa, E, Lavonen, L, Nevantaus, J, Geier, K, Kavasmaa, T, Koorits, U, Kubjas, M, Lauritsalo, S, Ottelin, L, Palve, M, Pynnönen, J, Rääbis, I, Saarelainen, M, Heikkilä, T, Kontula, T, Lehtimäki, M, Liimatainen, J, Moilanen Oikarinen, M, Pakarinen, M, Palanne, R, Seppänen, H, Pulkkinen, A, Vääräniemi, H, Koskenkari, J, Sälkiö, S, Vakkala, M, Koskue, T, Loisa, P, Laitio, R, Hautamäki, R, Koivisto, S, Futier, E, Lefrant, J, Leon, A, Bonnet, F, Marret, E, Spielvogel, C, Papageorgiou, C, Szymkiewicz, O, Tounou Akue, F, Aubrun, F, Bonnet, A, Gazon, M, Guiraud, M, Laurent, V, Tachon, G, Demars, N, Dumenil, A, Mercier, F, Landais, A, Mentec, H, Bazin, M, Gonnu, S, Petit, A, Albaladejo, P, Almeras, L, Bataillard, A, Rossi Blancher, M, Yves Lefrant, J, Barthel, F, Hallel, D, Sbai, H, Khalifeh, P, Lidzborski, L, Jully, M, Platon, E, Pottecher, J, Baumgarten, R, Schultz, C, Elmiloudi, F, Lefebvre, J, Waton, K, Sprunck, A, Steib, A, Thibaud, A, Thuet, V, Kieffer, V, Dubois Vallaud, D, Jacob, L, Becanne, X, Cherfaoui, S, Gauzit, R, Godier, A, Lakhdari, M, Samma, C, Bigeon, J, Burtin, P, Halchini, C, Lacroix, M, Pinna, F, Barbes, A, Just, B, Mateu, P, Benayoun, L, Berger, P, Granier, N, Francois Perrigault, P, Libert, N, De Rudnicki, S, Merat, S, Bourdet, B, Ferré, F, Minville, V, Piriou, V, Rague, P, Wallet, F, Lebuffe, G, Desbordes, J, Robin, E, Ichai, C, Orban, J, Marx, G, Sander, M, Gottschalk, A, Piontek, A, Unterberg, M, Hilpert, J, Kees, M, Triltsch, A, Wiegand Löhnert, C, Glöckner, C, Hohn, A, Rose, E, Schröder, S, Wiese, O, Ramminger, A, Dresden, C, de Abreu, M, Heller, A, Marx, C, Neidel, J, Goldmann, A, von Heymann, C, Laetsch, B, Maahs, E, Scholz, L, Frenzel, D, Massarat, K, Lenhart, F, Reichle, F, Rudlof, K, Borchers, F, Buettner, C, Schmutzler, M, Burgard, G, Lucht, A, Wagner, J, Pilge, S, Schneider, G, Untergehrer, G, Bis, B, Krassler, J, Dittmann, J, Haberkorn, J, Eberitsch, J, Eberitsch, K, Nippraschk, T, Wepler, U, Engelen, W, Nau, C, Scholler, A, Schüttler, J, Wintzheimer, S, Bloos, F, Braune, A, Fergen, D, Ludewig, K, Paxian, M, Reinhart, K, Graf, N, Schwarzkopf, K, Berger, K, Habicher, M, Kasperiunaite, R, Savelsberg, S, Krep, H, Reindl, M, Weber, M, Bauer, W, Bingold, F, Christ, S, Friederich, P, Kaviani, R, Auer, P, Bonnländer, G, Drescher, J, Braun, R, Eichenauer, T, Kerner, J, Bierbaum, K, Brünner, H, Grond, S, Perez Platz, U, Andresen, B, Linstedt, U, Stegmann, N, Erkens, U, Kopcke, J, Meyer, A, Brestrich, H, Ernst, S, Merkel, S, Krieger, L, Luers, F, Weyland, A, Noeldge Schomburg, G, Menckie, T, Wasmund, C, Bredtmann, R, Erler, I, Raufhake, C, Haumann, C, Möllemann, A, Oehmichen, U, Sergejewa, O, Lehning, B, Czeslick, E, Geyer, M, Malcharek, M, Sablotzki, A, Stier, M, Feld, F, Rossaint, R, Simon, V, Armaganidis, A, Koulenti, D, Kotanidou, A, Nanas, S, Papastylianou, A, Psevdi, A, Stathopoulos, A, Voulas, A, Kanna, E, Koutsikou, A, Moustaka, A, Chovas, A, Komnos, A, Zafiridis, T, Franses, J, Lavrentieva, A, Koraki, E, Katsenos, C, Flora Kasianidou, M, Nasopoulou, P, Spyropoulou, E, Gousia, C, Katsanoulas, C, Lathyris, D, Kyriazopoulos, G, Sfyras, D, Tsirogianni, A, Kostopanagiotou, G, Lignos, M, Matsota, P, Christopoulos, C, Mouratidou, A, Vrettou, E, Boufidis, S, Moka, E, Arnaoutoglou, E, Koulouras, V, Nakos, G, Papathanakos, G, Anthopoulos, G, Choutas, G, Karapanos, D, Tzani, V, Gkiokas, G, Nastos, K, Nikolakopoulos, F, Dragoumanis, C, Nikitidis, N, Pneumatikos, I, Theodorou, V, Zacharouli, D, Kandi, S, Tasopoulos, K, Arvaniti, K, Matamis, D, Mplougoura, E, Petropoulou, P, Soumpasis, I, Amaniti, E, Giannakou Peftoulidou, M, Gkeka, E, Soultati, I, Kokinou, M, Papatheodorou, L, Stafylaraki, M, Giasnetsova, T, Gritsi Gerogianni, N, Kydona, C, Kiskira, O, Koulentis, I, Apsokardos, A, Dimitropoulos, K, Soldatou, O, Nathanail, C, Papazotos, A, Tsakas, P, Clouva Molyvdas, P, Kolotoura, A, Sartzi, M, Papanikolaou, S, Polakis, P, Karatzas, S, Kyparissi, A, Papavasilopoulou, T, Koukoubani, T, Mastora, E, Spyropoulou Pagdatoglou, K, Nyktari, V, Malliotakis, P, Papaioannou, A, Bekos, V, Maragkou, E, Spring, A, Evagelatos, S, Ioakeimidou, A, Noulas, N, Molnár, Z, Csüllög, E, Elekes, E, Molnár, T, Katona, Z, Kremer, I, Miko, A, Csomos, A, Galambos, Z, Szucs, A, Nyikos, G, Szekeres, G, Szabo, E, Kranitz, K, Simon, M, Szigeti, J, Gaál, E, Havas, A, Ille, A, Bráz, K, Nagy, G, Sigurdsson, G, Sigurbjörnsson, F, Kárason, S, Edda Sigurdardottir, E, Blöndal, Á, Gunnarsson, B, Westbrook, A, Broderick, A, Hafeez, P, Hanumanthaiah, D, Brohan, J, O'Chroinin, D, Bailey, K, Ramamoorthy, K, Doyle, Y, Freir, N, O'Rourke, J, Jonson, P, Saeed, S, Hayes, I, Loughrey, J, Frohlich, S, Mccauley, N, Ryan, D, Fitzpatrick, G, Kevin, L, Thomas, J, Warde, B, Woolhead, A, Duggan, M, Egan, C, Crowley, S, Lebese, S, Bergin, A, Page, R, Collins, D, Mckenny, M, Della Rocca, G, Grasso, S, Bresciani, A, Carmino, L, Ghelfi, S, Lorenzelli, L, Teresa Novelli, M, Pescarmona, C, Roasio, A, Gatta, A, Nastasi, M, Sanseverino, M, Tinti, C, Bianchin, A, Tormena, M, Franco, A, Marini, F, Di Mauro, P, Rapido, F, Tommasino, C, Bellotti, F, Boninsegna, D, Castellani, G, Sances, D, Spano, G, Tredici, S, Vezzoli, D, Fucecchio, I, Bacci, A, Coppini, R, Dell'Unto, S, Mori, E, Rosa Stanzani, M, Tosi, M, Collareta, M, Forfori, F, Franchi, M, Mancino, G, Battistella, M, Baricocchi, E, Bona, F, Debernardi, F, Giacoletto, G, Iacobellis, A, Massucco, P, Moselli, N, Muratore, A, Palomba, G, Sardo, E, De Simone, M, Suita, L, Zocca, E, Bucci, B, Della Corte, F, Piciucco, T, Viarengo, V, Bettelli, G, Cantarini, E, Giampieri, M, Tanfani, A, Recchia, E, Bignami, E, Bruno, G, Costagliola, R, Gandolfi, A, Greco, M, Lembo, R, Monti, G, Nicelli, E, Pasculli, N, Turi, S, Baroselli, A, Brazzoni, M, Buttazzoni, M, Buttera, S, Centonze, C, Serena, G, Spagnesi, L, Toretti, I, Vilardi, A, Zearo, E, Arpino, I, Baraldi, S, Guarnerio, C, Molene, V, Concetta Monea, M, Vaccarisi, E, Vicari, L, Albante, A, Aversano, M, Loiacono, C, Marandola, M, Fusari, M, Petrucci, N, Galla, A, Mascia, A, Primieri, P, Di Noto, A, Gratarola, A, Molin, A, Spagnolo, L, Spena, C, Calligaro, P, Marchiotto, S, Merlini, A, Pedrazzoli, E, Perina, G, Visentin, R, Garbagnati, A, Manetti, B, Snaier, C, Somaini, M, Farnia, A, Nani, R, Pierantonio, N, De Michele, M, Gazzanelli, S, Pugliese, F, Ruberto, F, Bergamini, E, Tassinati, T, Capuzzo, M, Cirillo, V, Tufano, R, Oggioni, R, Parrini, V, Brunori, E, Capone, M, Carbone, L, Corradetti, F, Elisei, D, Fiorentino, S, Francesconi, M, Gattari, D, Gorgoglione, M, Lacobone, E, Minnucci, F, Montironi, C, Riccioni, G, Tappata, G, Zompanti, V, Verdenelli, P, Cerutti, E, Marco Ranieri, V, Golubovska, I, Grigorjevs, S, Rikmane, M, Rozkalne, D, Stepanovs, J, Suba, O, Kazune, S, Miscuk, A, Nemme, J, Oss, P, Sipylaite, J, Macas, A, Ragaisis, V, Kontrimaviciute, E, Tomkute, G, Boerma, C, Fleur Kramer, I, Poeze, M, Maria, J, Pelzer, G, Winsser, L, Nijsten, M, Schoorl, M, Spanjersberg, R, Buhre, W, Dieleman, S, van Klei, W, Bouw, M, Pickkers, P, van der Marieke, A, Schreiner, F, Zandvliet, R, van den Berg, R, De Wit, E, Keijzer, C, Hollmann, M, Preckel, B, van Acker, G, Dennesen, P, Veld, B, Kuijpers Visser, A, Inan, T, Koopman van Gemert, A, Ponssen, H, Brouwer, T, Koopmans, M, van Bommel, J, van Duijn, D, van der Hoven, B, Ormskerk, P, Beck, O, Schiere, S, Reidinga, A, Venema, A, Hoogendoorn, M, Olthof, K, Flaatten, H, Jammer, I, Dokka, V, Arne Monsen, S, Marius Ytrebo, L, Noursadeghi, M, Shahzad, A, Dagfinn Boksasp, O, Roiss, C, Frank Strietzel, H, Gina, A, Berntsen, S, Haugland, H, Ove Vingsnes, S, Axelsson, P, Risom Olsen, T, Katre, S, Aakeroey, K, Mikstacki, A, Tamowicz, B, Boziłow, D, Goch, R, Grabowski, P, Kupisiak, J, Małłek, M, Szyca, R, Kostyrka, W, Choma, R, Jankowski, G, Kościelniak, W, Pietraszek, P, Szarowar, B, Matos, R, França, C, Pais Lacerda, A, Ormonde, L, Rosa, R, Pereira, I, Vitor, P, Completo Bento, H, Raquel Lopes, M, Carvalho, M, Faria, M, Cláudia de Sousa, A, de Freitas, P, Almeida, E, Mealha, R, Vicente, R, Monte, R, Rua, F, Barros, N, Esteves, F, Gouveia Pinheiro, C, Real, V, Miguel Oliveira, V, Fátima Oliveira, M, Martins, I, Pedro Saraiva, J, Pedro Assunção, J, Bártolo, A, Carvalho, A, Correia, C, Martins, S, Milheiro, R, Diaz, A, Imelda Gonçalves, M, Ribeiro, R, Estilita, J, Glória, C, de Almeida, J, Barros, F, Ramos, A, Camara, M, Richard Maul, E, Nobrega, J, Langner, A, Faria Maia, D, Afonso, O, Faria, F, Serra, S, Manuela Botelho, M, Ferreira, P, Mourão, L, Vintém Oliveira, A, Resende, M, Aleman, M, Fonseca, J, Isidoro, M, de Meneses, H, Pêgas, A, Pereira, J, Pereira, L, Ramos, B, Matos, F, Gonçalves Castro, M, Martins, A, Ramos, C, de Sousa, M, Bento, L, Botas, C, Lopes, V, Mendes, R, Grigoras, I, Blaj, M, Damian, M, Lupusoru, A, Ristescu, I, Codreanu, M, Diaconescu, C, Nistor, A, Stanescu Stelian, D, Streanga, L, Berneanu, M, Bordeianu, C, Florenta, C, Iacob, A, Nicoleta Lupu, M, Mocanu, I, Moraru, C, Meran, C, Nicolae, B, Sandu, M, Turcanu, R, Epure, F, Grigore, M, Hotaranu, C, Popescu, N, Baban, O, Baciu, M, Ciobanu, A, Ioan Denciu, C, Gurau, V, Maftei, I, Moldovan, I, Ungureanu, L, Bogdan, P, Corneci, D, Dinu, M, Madalina, D, Rely, M, Silvius, N, Tomescu, D, Gabriela, D, Adrian Dinescu, S, Calin, M, Ionescu, D, Margarit, S, Vasian, H, Albu, C, Balasa, C, Cadrigati, A, Dragulescu, D, Gavra, L, Hentia, C, Macarie, C, Manescu, M, Nediglea, I, Ocica, D, Ovidiu, B, Papurica, M, Plavat, C, Popa, C, Ramneantu, M, Sandesc, D, Sandici, Z, Sarandan, M, Belciu, I, Tincu, E, Ursu, I, Aignatoaie, M, Huzuneanu, M, Cocu, S, Hagau, N, Ciubotaru, R, Copotoiu, S, Copotoiu, R, Ioana, G, Kovacs, J, Leonard, A, Szederjesi, I, Genoveva, V, Mosnegutu, S, Surbatovic, M, Djordjevic, D, Djordjevic, B, Grujic, K, Jovanovic, D, Krstic Lecic, I, Obradovic, J, Zeba, S, Jevdjic, J, Miletic, M, Zunic, F, Bulasevic, A, Brko, R, Gazibegovic, N, Kendrisic, M, Vojinovic, R, Firment, J, Zahorec, R, Capková, J, Grochova, M, Trenkler, S, Griger, M, Bakosova, E, Kvasnica, M, Saniova, B, Sulaj, M, Zacharovska, A, Simkova, A, Číková, A, Gebhardtova, A, Hanuljaková, S, Koutun, J, Martonová, A, Žilinčárová, V, Galkova, K, Krbila, S, Sobona, V, Ocenasova, M, Novak Jankovic, V, Stecher, A, Stivan, F, Grynyuk, A, Damjanovska, M, Kostadinov, I, Knezevic, M, Malivojevic, M, Borovsak, Z, Kamenik, M, Mekiš, D, Osojnik, I, Kosec, L, Ostojič Kapš, S, Aleksic, D, Gerjevič, B, Kalan, K, Ursic, T, Aldecoa, C, Montejo González, J, Artigas, A, Garcia, A, Lisi, A, Perez, I, Perez, G, Poch, N, Vaquer, S, Balciscueta, G, Barrasa, H, Cabanes, S, Maynar, J, Poveda, Y, Quintano Rodero, A, Vallejo, A, Duque, P, Garcia Bunger, B, Adoracion Elvira, M, María Lajara, A, Palencia, M, Ramos, R, Saez Fernandez, A, Tirapu León, J, Iza López, J, Yoldi Murillo, F, Turumbay Ramirez, E, Unzué Rico, P, Patricia, M, Vizcaíno, M, Bernat Álvarez, M, Planas Real, K, Mas Serra, A, Aracil, N, Menendez Bodega, B, Fernández García, R, Álvarez García, M, Gordon, B, Gutiérrez Jodrá, A, De Santos López, A, Llavador Ros, J, Ayala Soto, R, Sepúlveda, I, Pascual Díez, E, Fernández Fernández, L, Soria Gulina, C, Pérez Arviza, L, Fernandez, L, Río Gómez, A, Alonso Martínez, C, Rodríguez Rodríguez, A, Lopez Soto, C, Garcia, C, Lorenzo, M, Pinilla, E, Rico, J, Ruperez, I, Alonso, E, Leira, F, Emilio Maseda, D, Royo, C, Villagran, J, Murillo Candi, G, Eduardo Esteva, G, Mansilla Folgado, R, Joan Fornaguera, N, Calonge Montse, P, Sape Prat, A, Sintes, D, Arteta Arteta, D, García Delgado, H, Fajardo López Cuervo, J, López, 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Kangaraj, M, Pissay, N, Smith, N, Gopalakrishnan, S, Mackinnon, J, Strandvik, G, Francis, R, Jennings, A, Keating, M, Kumar, S, Leese, S, Magee, C, Pilsbury, J, Ralph, J, Riddington, D, Sachdeva, R, Snelson, C, Vasanth, S, Wilde, J, Lavender, B, Lyons, R, Watters, M, Adams, T, Dyer, S, Tindall, L, Claxton, A, Netke, M, Akouds, E, Bates, D, Gallagher, H, Hatton, J, Holroyd, W, Mitra, A, Nurse, T, Reed, D, Desikan, S, Barber, R, Childs, S, O'Carroll Kuehn, B, Wyldbore, M, Al Abdaly, A, Amatya, S, Bhaskaran, S, Chandan, G, Chaudhry, S, Chikungwa, M, Earnshaw, G, Grewal, M, Haque, S, Hawkins, J, Javaid, A, Jackson, C, Kamel, M, Marla, R, Mculloch, D, Parker, T, Salib, Y, Saravanmuthu, R, Secker, C, Sockalingam, S, Taylor, A, Austine, P, Kanade, V, Paal, D, Sam Mok, M, Burtenshaw, A, Davis, L, Ellahee, P, Freeman, D, Pierson, R, Wollaston, J, Karmarkar, A, Ball, C, Calton, E, Maxwell, L, Walker, R, Bland, M, Bullock, L, Harrison Briggs, D, Hodge, P, Krige, A, Dempsey, G, Hammell, C, Loveridge, R, Parker, R, Snell, J, Wright, C, Baker, A, Barr, K, Belcher, A, Bonnington, S, Bougeard, A, Fitzgerald, E, Ford, R, Gillard, C, Griffiths, L, Greenberg, L, Huber, J, Mathieu, S, Richardson, N, Tompsett, L, White, N, Patel, S, Corner, V, Thomas, R, Trodd, D, Wilson, J, Copley, E, Flutter, L, Hulme, J, Susarla, J, Thwaites, A, Jayasundera, S, Mcafee, S, Chantler, J, Mckechnie, S, Neely, J, Mouton, R, Scarth, E, Soar, J, Buss, J, Currie, V, Sange, M, Kuttler, A, Power, F, Alexander, D, Dunne, K, Shinner, G, Black, E, Haldane, G, Kerr, J, Saran, T, Ward, G, Jefferies, F, Alexander, P, Royle, A, Nahla, F, Bowles, T, Gregory, M, Ahern, R, Cartlidge, D, Craker, L, Thompson, C, Bidd, H, Giles, J, Manser, A, Parry, G, Chan, P, Das, D, Fahmy, N, Higgins, D, Khader, A, Stone, A, Leonardi, S, Rose, O, Bright, E, Ercole, A, Amir Rafi, M, Ramasamy, R, Sheshgiri, B, Merrill, C, Page, V, Walker, E, Harris, S, Hughes, S, Morrison, A, Razouk, K, Ayman, M, Jakeman, A, Mowatt, C, Paananen, S, Translational Physiology, Other departments, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, Anesthesiology, APH - Amsterdam Public Health, Pearse Rupert, Moreno Rui P., Bauer Peter, Pelosi Paolo, Metnitz Philipp, Spies Claudia, Vallet Benoit, Vincent Jean-Loui, Hoeft Andrea, Rhodes Andrew, Fagnoul David, van Obbergh Luc, Al-Subaie Nawaf, Arif Fuhazia, Cashman Jeremy, Cecconi Maurizio, Edsell Mark, Fossati Nicoletta, Hammond Sarah Jane, Hamilton Mark, Lonsdale Dagan, Moran Carl, Siegmueller Claa, Velzeboer Freya, Wong Patrick, Awlakpui Eli, Scheidemann Mona, Wittmann Maria, Damster Sandrine, Golder Kim, Hewson Russell, Januszewska Marta, Leva Brigitte, Ramos Vasco, Hoste Eric, Huyghens Luc, Jacobs Rita, Van Mossevelde Veerle, Opdenacker Godelieve, Poelaert Jan, Spapen Herbert, Leleu Kri, Rijckaert Dirk, De Decker Koen, Foubert Luc, De Neve Nikolaa, Biston Patrick, Piagnerelli Michael, Collin Vincent, den Blauwen Nadia, Clauwaert Charlotte, De Crop Luc, Verbeke An, Derumeaux Pieter, Gardin Christophe, Kindt Sebastiaan, Louage Sofie, Verhamme Bruno, Druwé Patrick, Lahaye Ingrid, Rosseel Franci, Rutsaert Robert, Vanlinthout Luc, De Kock Marc, Forget Patrice, Georges Pascal, Grosu Irina, Kahn David, Lois Fernande, Momeni Mona, Pospiech Audrey, Yemnga Bernadette, Jadoul Jean-Luc, Malbrain Manu, Bosinceanu Dana, Collard Edith, Jorens Philippe, Reyntiens Dirk, Smitz Carine, Vercauteren Marcel, Goranović Tatjana, Mazul-Sunko Branka, Toplice Krapinske, Oremuš Krešimir, Bešlić Gabrijela, Duzel Viktor, Hauptman Ada, Peremin Sanja, Šribar Andrej, Župčić Miroslav, Brod Slavonski, Mirković Ivan, Šarić Bauer Zlata, Belavić Matija, Blažanin Božidar, Katušin Mirjana Lončarić, Brozović Krijan Antonija, Mišković Petar, Šimić-Korać Nataša, Topić Jasna, Žilić Antonio, Žuni Josip, Acan Ivana, Adanić Mirta, Ivanov Nikola, Pavičić Šarić Jadranka, Tomulić Katarina, Visković Nataša, Bošnjak Silvana, Haršanji Drenjančevic Ivana, Kristek Gordana, Kvolik Slavica, Markić Stela, Stojanovic Rakipovic Andreja, Katarina Tot Ozana, Venzera-Azenic Darija, Kalagac Fabris Lada, Bačak-Kocman Iva, Balenović Igor, Bandić Daniela, Judith Deutsch Patricia Adrianne, Divjak Loredana, Filipović Ina Grčić, Gužvinec Zvonka, Krznarić Zrinka, Lončarić Yvonne, Magaš Jelena Vadlja, Mitrović Marek, Okić Marija, Pavlek Mario, Ramov Elza, Rezek Karolina, Sekulić Ante, Tomasevic Bori, Mirić Mirjana, Tomašević Anita, Tomić Mahečić Tina, Vrbanović Vilena, Bobinac Mirna, Božić Alfred, Debelic Danijela, Frkovic Vedran, Batinica Inga Mladić, Baranović Senka, Gavranović Željka, Kikec Mirna, Maldini Branka, Marić Stela, Agnić Ivan, Delić Nikola, Dropulić Nataša, Kljaković Gašpić Toni, Ilić Darko, Ivančev Božena, Karanović Nenad, Kuščević Dorjan, Marović Zlatko, Milić Matija, Nevešćanin Ana, Petković Tatjana, Smoje Mario, Brozović Gordana, Jelisavac Milana, Matolić Martina, Oberhofer Dagmar, Marija Pavičić Ana, Šakić Kata, Delija Bozovic Margarita, Kotorac Krecek Zvjezdana, Krobot Renata, Andabaka Tatjana, Bratanić Mislav, Dzepina Orjana, Kraljev Martina, Šeric Julija, Šimurina Tatjana, Grujić Rosa, Nacevski-Bulaja Biljana, Barižon Mirna, Danira Vrančić, Dražen Bulaja, Dušanka Kimer, Bašić Halužan Marijana, Joško Žaja, Katica Roca, Labor Magda, Grgurević Marinković Tea, Mihovilčević Danči, Marija Bego, Srečko Marinković, Vranković Srdan, Kyprianou Theodoro, Neophytou Kyriako, Cerny Vladimir, Cvachovec Karel, Belikova Barbora, Drab Michal, Hudacek Kamil, Krikava Ivo, Stourac Petr, Zadrazilova Katarina, Bicek Vladimír, Brabcová Milena, Klozová Radka, Vajter Jaromír, Vymazal Tomáš, Toft Palle, Blichfeldt Louise, Dilling Hansen Bo, Moller Kirsten, Sylvest Nielsen Jeppe, Frederiksen Joachim, Dohn Andersen Johnny, Peter Kühne Jan, Leivdal Siv, Stendell Line, Simonsen Martin, Konrad Zoltowski Marcin, Salman Ali Zahida, Freundlich Morten, Pilypaite Jurgita, Groes Clausen Nicola, Thorup Line, Hansen Frank, Bestle Morten, Steen Hansen Christian, Afshari Arash, Bastholm Bille Ander, Lefort Michele, Secher Erik L., Liboriussen Lisbeth, Herodes Veiko, Härma Eve, Marvet Kadri, Pool Kristiina, Kallas Pille, Mägi Triinu-Kreete, Sütt Jaan, Vijar Kerli, Visk Evelin, Vinnal Mare, Ellermaa Jaanu, Liibusk Liia, Tikkerberi Artur, Falk Ilme, Mällo Esta, Talving Jaak, Pettilä Ville, Hovilehto Seppo, Kirsi Anne, Mustola Seppo, Tiainen Pekka, Toivonen Juhani, Dabnell Sandra, Kaminski Tadeusz, Sysimetsa Anu, Kaukonen Maija, Silvasti Päivi, Vainio Kaisa, Lund Vesa, Sjövall Sari, Saarinen Kari, Viitanen Matti, Ahonen Tommi, Alaspää Ari, Zittling Ritva, Saarinen Aarne, Moisander Annette, Wagner Bodo, Laru-Sompa Raili, Elomaa Esa, Lavonen Leena, Nevantaus Juha, Geier Klau, Kavasmaa Tomi, Koorits Ursula, Kubjas Mare, Lauritsalo Seppo, Ottelin Lauri, Palve Markki, Pynnönen Jari, Rääbis Inga, Saarelainen Minna, Heikkilä Tapani, Kontula Timo, Lehtimäki Markku, Liimatainen Jari, Moilanen-Oikarinen Mari, Pakarinen Marika, Palanne Riku, Seppänen Hanna, Pulkkinen Anni, Vääräniemi Heikki, Koskenkari Juha, Sälkiö Sinikka, Vakkala Merja, Koskue Talvikki, Loisa Pekka, Laitio Ruut, Hautamäki Raku, Koivisto Simo-Pekka, Futier Emmanuel, Lefrant Jean-Yve, Leon Alain, Bonnet Franci, Marret Emmanuel, Spielvogel Catherine, Papageorgiou Chryssa, Szymkiewicz Olga, Tounou-Akue Felix, Aubrun Frederic, Bonnet Aurélie, Gazon Mathieu, Guiraud Michel, Laurent Virginie, Tachon Guillaume, Demars Nadège, Dumenil Anne-Sylvie, Mercier Frederic, Landais Alain, Mentec Herve, Bazin Marie, Gonnu Sophie, Petit Antoine, Albaladejo Pierre, Almeras Luc, Bataillard Amélie, Rossi-Blancher Marine, Yves Lefrant Jean, Barthel Florian, Hallel Dan, Sbai Hicham, Khalifeh Pamela, Lidzborski Lionel, Jully Marion, Platon Ecaterina, Pottecher Julien, Baumgarten Romain, Schultz Christel, Elmiloudi Fayçal, Lefebvre Julie, Waton Karen, Sprunck Adrien, Steib Annick, Thibaud Adrien, Thuet Vincent, Kieffer Vianney, Dubois-Vallaud Delphine, Jacob Laurent, Becanne Xavier, Cherfaoui Salim, Gauzit Remy, Godier Anne, Lakhdari Mourad, Samma Charle, Bigeon Jean-Yve, Burtin Philippe, Halchini Constantin, Lacroix Magali, Pinna Frederic, Barbes Aurélie, Just Bernard, Mateu Philippe, Benayoun Laurent, Berger Philippe, Granier Nathalie, Francois Perrigault Pierre, Libert Nicola, De Rudnicki Stephan, Merat Stéphane, Bourdet Benoit, Ferré Fabrice, Minville Vincent, Piriou Vincent, Rague Philippe, Wallet Florent, Lebuffe Gille, Desbordes Jacque, Robin Emmanuel, Ichai Carole, Orban Jean-Christophe, Marx Gernot, Sander Michael, Gottschalk André, Piontek André, Unterberg Matthia, Hilpert Justu, Kees Martin, Triltsch Andrea, Wiegand-Löhnert Carola, Glöckner Christiane, Hohn Andrea, Rose Elmar, Schröder Stefan, Wiese Oliver, Ramminger Axel, Dresden Caru, de Abreu Marcelo Gama, Heller Axel, Marx Christine, Neidel Julia, Goldmann Anton, von Heymann Christian, Laetsch Beatrix, Maahs Esther, Scholz Lar, Frenzel Dirk, Massarat Kyro, Lenhart Franz-Peter, Reichle Florian, Rudlof Kristina, Borchers Friedrich, Buettner Christoph, Schmutzler Martin, Burgard Gerald, Lucht Alexander, Wagner Jan, Pilge Stefanie, Schneider Gerhard, Untergehrer Gisela, Bis Beata, Krassler Jen, Dittmann Jan, Haberkorn Jörg, Eberitsch Jürgen, Eberitsch Karola, Nippraschk Thoma, Wepler Ulrich, Engelen Wolf-Christian, Nau Carla, Scholler Axel, Schüttler Jürgen, Wintzheimer Simone, Bloos Frank, Braune Anke, Fergen Daniela, Ludewig Katrin, Paxian Marku, Reinhart Konrad, Graf Nikolau, Schwarzkopf Konrad, Berger Katharina, Habicher Marit, Kasperiunaite Ruta, Savelsberg Sabine, Krep Henning, Reindl Michael, Weber Matthia, Bauer Wolfgang, Bingold Florian, Christ Saskia, Friederich Patrick, Kaviani Reza, Auer Patrick, Bonnländer Georg, Drescher Jürgen, Braun Roland, Eichenauer Tim, Kerner John, Bierbaum Kathrin, Brünner Horst, Grond Stefan, Perez-Platz Ursula, Andresen Bent, Linstedt Ulf, Stegmann Nil, Erkens Uwe, Kopcke Jen, Meyer Andrea, Brestrich Hartmut, Ernst Sandra, Merkel Stella, Krieger Lena, Luers Frank, Weyland Andrea, Noeldge-Schomburg Gabriele, Menckie Thoma, Wasmund Christina, Bredtmann Ralph-Dieter, Erler Ine, Raufhake Carsten, Haumann Christine, Möllemann Angela, Oehmichen Uwe, Sergejewa Olga, Lehning Brigitte, Czeslick Elke, Geyer Michaela, Malcharek Michael, Sablotzki Armin, Stier Marina, Feld Florian, Rossaint Rolf, Simon Verena, Armaganidis Apostolo, Koulenti Despoina, Kotanidou Anastasia, Nanas Serafim, Papastylianou Androula, Psevdi Aikaterini, Stathopoulos Anastasio, Voulas Asklepieion, Kanna Efthymia, Koutsikou Anastasia, Moustaka Alexandra, Chovas Achillea, Komnos Apostolo, Zafiridis Tilemacho, Franses Josef, Lavrentieva Athena, Koraki Eleni, Katsenos Chrysostomo, Flora Kasianidou Maria, Nasopoulou Pantelia, Spyropoulou Eleni, Gousia Chrysoula, Katsanoulas Constantine, Lathyris Dimitrio, Kyriazopoulos George, Sfyras Dimitrio, Tsirogianni Athanasia, Kostopanagiotou Georgia, Lignos Mihail, Matsota Paraskevi, Christopoulos Christo, Mouratidou Alexandra, Vrettou Efstratia, Boufidis Spyro, Moka Eleni, Arnaoutoglou Eleni, Koulouras Vasileio, Nakos George, Papathanakos Georgio, Anthopoulos Georgio, Choutas Georgio, Karapanos Dimitrio, Tzani Vaso, Gkiokas Georgio, Nastos Konstantino, Nikolakopoulos Fotio, Dragoumanis Christo, Nikitidis Niko, Pneumatikos Ioanni, Theodorou Vassiliki, Zacharouli Danai, Kandi Stella, Tasopoulos Konstantino, Arvaniti Kostoula, Matamis Dimitrio, Mplougoura Eva, Petropoulou Polixeni, Soumpasis Ioanni, Amaniti Ekaterini, Giannakou-Peftoulidou Maria, Gkeka Eleni, Soultati Ioanna, Kokinou Maria, Papatheodorou Lambrini, Stafylaraki Maria, Giasnetsova Tatiana, Gritsi-Gerogianni Nikoleta, Kydona Christina, Kiskira Olga, Koulentis Ioanni, Apsokardos Alexandro, Dimitropoulos Konstantino, Soldatou Ourania, Nathanail Christodoulo, Papazotos Alexio, Tsakas Pirro, Clouva-Molyvdas Phyllis-Maria, Kolotoura Athina, Sartzi Monika, Papanikolaou Spiro, Polakis Pavlo, Karatzas Styliano, Kyparissi Aikaterini, Papavasilopoulou Theonymfi, Koukoubani Triantafillia, Mastora Evangelia, Spyropoulou-Pagdatoglou Kyriaki, Nyktari Vasileia, Malliotakis Polychroni, Papaioannou Alexandra, Bekos Vasileio, Maragkou Elisavet, Spring Anna, Evagelatos Stavro, Ioakeimidou Aikaterini, Noulas Niko, Molnár Zsolt, Csüllög Emese, Elekes Eniko, Molnár Tamá, Katona Zsuzsana, Kremer Ildiko, Miko Angela, Csomos Ako, Galambos Zsuzsanna, Szucs Ako, Nyikos Gyorgy, Szekeres Gabor, Szabo Ervin, Kranitz Katalin, Simon Melinda, Szigeti Jano, Gaál Emánuel, Havas Attila, Ille Alexandru, Bráz Krisztina, Nagy Geza, Sigurdsson Gisli, Sigurbjörnsson Fridrik T., Sigurdsson Gisli H., Kárason Sigurbergur, Edda Sigurdardottir Elin, Blöndal Ásbjörn, Gunnarsson Björn, Westbrook Andrew, Broderick Alan, Hafeez Parvaiz, Hanumanthaiah Deepak, Brohan Janette, O'Chroinin Donal, Bailey Kevin, Ramamoorthy Karthik, Doyle Yvonne, Freir Noelle, O'Rourke Jame, Jonson Philip, Saeed Sabir, Hayes Ivan, Loughrey John, Frohlich Stephen, Mccauley Nuala, Ryan Donal, Fitzpatrick Gerry, Kevin Leo, Thomas Jubil, Warde Barry, Woolhead Alan, Duggan Michelle, Egan Cara, Crowley Seamu, Lebese Soloman, Bergin Anne, Page Rory, Collins Daniel, Mckenny Michael, Della Rocca Giorgio, Grasso Salvatore, Bresciani Anna, Carmino Livio, Ghelfi Silvia, Lorenzelli Laura, Teresa Novelli Maria, Pescarmona Chiara, Roasio Agostino, Gatta Alessandro, Nastasi Mauro, Sanseverino Manlio, Tinti Carla, Bianchin Andrea, Tormena Maria, Franco Antonio, Marini Federica, Di Mauro Piero, Rapido Francesca, Tommasino Concezione, Bellotti Ferdinando, Boninsegna Daniele, Castellani Gianluca, Sances Daniele, Spano Gianluca, Tredici Stefano, Vezzoli Dario, Fucecchio Igneo, Bacci Alessandro, Coppini Roberta, Dell'Unto Sandro, Mori Emanuele, Rosa Stanzani Maria, Tosi Monica, Collareta Michele, Forfori Francesco, Franchi Matteo, Mancino Giuseppe, Battistella Massimo, Baricocchi Elisa, Bona Francesco, Debernardi Felicino, Giacoletto Gianmarco, Iacobellis Antonio, Massucco Paolo, Moselli Nora, Muratore Andrea, Palomba Graziella, Sardo Elena, De Simone Michele, Suita Luisa, Zocca Edoardo, Bucci Barbara, Della Corte Francesco, Piciucco Tiziana, Viarengo Valeria, Bettelli Gabriella, Cantarini Eugenia, Giampieri Marina, Tanfani Alessandra, Recchia Eugenio, Bignami Elena, Bruno Giovanna, Costagliola Roberto, Gandolfi Azzurra, Greco Massimiliano, Lembo Rosalba, Monti Giacomo, Nicelli Elisa, Pasculli Nicola, Turi Stefano, Baroselli Antonio, Brazzoni Marcella, Buttazzoni Mattia, Buttera Stefania, Centonze Carlo, Serena Giovanni, Spagnesi Lorenzo, Toretti Ilaria, Vilardi Anna, Zearo Ester, Arpino Ine, Baraldi Sara, Guarnerio Chiara, Molene Vincenzo, Concetta Monea Maria, Vaccarisi Enrico, Vicari Luigi, Albante Alida, Aversano Marco, Loiacono Cinzia, Marandola Maurizio, Fusari Maurizio, Petrucci Nicola, Galla Amerigo, Mascia Antonio, Primieri Paolo, Di Noto Anna, Gratarola Angelo, Molin Alessandro, Spagnolo Luigi, Spena Claudio, Calligaro Plinio, Marchiotto Simonetta, Merlini Alberto, Pedrazzoli Eleonora, Perina Giulia, Visentin Renea, Fumagalli Roberto, Garbagnati Andrea, Manetti Bruna, Snaier Chiara, Somaini Marta, Farnia Antonio, Nani Roberto, Pierantonio Novello, De Michele Michele, Gazzanelli Sergio, Pugliese Francesco, Ruberto Franco, Bergamini Elena, Tassinati Tania, Capuzzo Maurizia, Cirillo Vera, Tufano Rosalba, Oggioni Roberto, Parrini Vieri, Brunori Emanuela, Capone Micaela, Carbone Luigi, Corradetti Francesco, Elisei Daniele, Fiorentino Stefano, Francesconi Maurizio, Gattari Diego, Gorgoglione Maria, Lacobone Emanuele, Minnucci Francesco, Montironi Claudio, Riccioni Gianrenato, Tappata Giuseppe, Zompanti Valeria, Verdenelli Paola, Cerutti Elisabetta, Ranieri Vito Marco, Golubovska Iveta, Grigorjevs Sergej, Rikmane Maija, Rozkalne Daina, Stepanovs Jevgenij, Suba Oleg, Kazune Sigita, Miscuk Aleksej, Nemme Jani, Oss Peteri, Sipylaite Jurate, Macas Andriu, Ragaisis Vytauta, Kontrimaviciute Egle, Tomkute Gabija, Boerma Christiaan, Fleur Kramer Irene, Poeze Martijn, Maria John, Pelzer Gerardu, Winsser Lex, Nijsten Maarten, Schoorl Michiel, Spanjersberg Rob, Buhre Wolfgang, Dieleman Stefan, van Klei Wilton, Bouw Martijn, Pickkers Peter, van der Marieke A., Schreiner Frodo, Zandvliet Ria, van den Berg Roy, De Wit Esther, Keijzer Christaan, Hollmann Marku, Preckel Benedikt, van Acker Gij, Dennesen Paul, Veld Ba, Kuijpers-Visser Agne, Inan T., Koopman-van Gemert A., Ponssen Huibert, Brouwer Tammo, Koopmans Matty, van Bommel Jasper, van Duijn Ditty, van der Hoven Ben, Ormskerk Patricia, Beck Oliver, Schiere Sjouke, Reidinga Auke, Venema Allart, Hoogendoorn Marga, Olthof Kee, Flaatten Han, Jammer Ib, Dokka Vegard, Arne Monsen Svein, Marius Ytrebo Lar, Noursadeghi Mostafa, Shahzad Ahmed, Dagfinn Boksasp Ola, Roiss Christoph, Frank Strietzel Han, Gina Anne, Berntsen Schie, Haugland Helge, Ove Vingsnes Svein, Axelsson Patric, Risom Olsen Thoma, Katre Sanjay, Aakeroey Kristin, Mikstacki Adam, Tamowicz Barbara, Boziłow Dominika, Goch Robert, Grabowski Piotr, Kupisiak Jacek, Małłek Małgorzata, Szyca Robert, Kostyrka Włodzimierz, Choma Robert, Jankowski Grzegorz, Kościelniak Władysław, Pietraszek Paweł, Szarowar Bartosz, Matos Ricardo, França Carlo, Pais Lacerda António, Ormonde Lucindo, Rosa Rosário, Pereira Inê, Vitor Paula, Completo Bento Henrique, Raquel Lopes Maria, Carvalho Marque, Faria Manuela, Cláudia de Sousa Ana, de Freitas Pereira, Almeida Eduardo, Mealha Rui, Vicente Rachel, Monte Raquel, Rua Fernando, Barros Nelson, Esteves Francisco, Gouveia Pinheiro Célia Maria, Real Vila, Miguel Oliveira Vítor, Fátima Oliveira Maria, Martins Isabel, Pedro Saraiva José, Pedro Assunção José, Bártolo Anabela, Carvalho Anabela, Correia Carlo, Martins Salomé, Milheiro Ruth, Diaz Alejandro, Imelda Gonçalves Maria, Ribeiro Rosa, Estilita Joana, Glória Carlo, de Almeida José, Barros Filipa, Ramos Armindo, Camara Margarida, Richard Maul Edward, Nobrega Julio, Langner Anuscka, Faria Maia Dionísio, Afonso Ofélia, Faria Filomena, Serra Sofia, Manuela Botelho Maria, Ferreira Pedro, Mourão Luí, Vintém Oliveira Ana, Resende Margarida, Aleman Miguel, Fonseca Jorge, Isidoro Marta, de Meneses Helena, Pêgas António, Pereira José, Pereira Lui, Ramos Bárbara, Matos Francisco, Gonçalves Castro Maria de Lurde, Martins Ana, Ramos Cristina, de Sousa Manuel, Bento Luí, Botas Conceição, Lopes Vitor, Mendes Rosa, Grigoras Ioana, Blaj Mihaela, Damian Mihaela, Lupusoru Andreea, Ristescu Irina, Codreanu Monica, Diaconescu Ciresica, Nistor Alina, Stanescu Stelian Dorin, Streanga Livia, Berneanu Maria, Bordeianu Cristina, Florenta Calarasu, Iacob Alina, Nicoleta Lupu Mary, Mocanu Iulian, Moraru Coca, Meran Carleta, Nicolae Bacalbasa, Sandu Madalina, Turcanu Roxana, Epure Florina, Grigore Monica, Hotaranu Cristina, Popescu Nicoleta, Baban Oleg, Baciu Manuela, Ciobanu Aurica, Ioan Denciu Catalin, Gurau Vitalie, Maftei Ion, Moldovan Ion, Ungureanu Liviu, Bogdan Prodan, Corneci Dan, Dinu Melania, Madalina Dutu, Rely Manolescu, Silvius Negoita, Tomescu Dana, Gabriela Droc, Adrian Dinescu Stelian, Calin Mitre, Ionescu Daniela, Margarit Simona, Vasian Horatiu, Albu Corina, Balasa Carmen, Cadrigati Alina, Dragulescu Dorian, Gavra Loredana, Hentia Ciprian, Macarie Claudiu, Manescu Mihaela, Nediglea Ioan, Ocica Dana, Ovidiu Bedreag, Papurica Mariu, Plavat Cosmin, Popa Claudia, Ramneantu Mihaela, Sandesc Dorel, Sandici Zoran, Sarandan Mihaela, Belciu Ioana, Tincu Eugen, Ursu Irina, Aignatoaie Mariana, Huzuneanu Mariana, Cocu Simona, Hagau Natalia, Ciubotaru Roxana, Copotoiu Sanda-Maria, Copotoiu Ruxandra, Ioana Ghitescu, Kovacs Judit, Leonard Azamfirei, Szederjesi Iano, Genoveva Vanvu, Mosnegutu Simona, Surbatovic Maja, Djordjevic Dragan, Djordjevic Biljana, Grujic Krasimirka, Jovanovic Dusko, Krstic-Lecic Ivana, Obradovic Jovana, Zeba Snjezana, Jevdjic Jasna, Miletic Milo, Zunic Filip, Bulasevic Aleksandra, Brko Radoslava, Gazibegovic Narcisa, Kendrisic Mirjana, Vojinovic Radisa, Firment Jozef, Zahorec Roman, Capková Judita, Grochova Monika, Trenkler Stefan, Griger Martin, Bakosova Erika, Kvasnica Martin, Saniova Beata, Sulaj Miroslav, Zacharovska Andrea, Simkova Alexandra, Číková Andrea, Gebhardtova Andrea, Hanuljaková Slávka, Koutun Juraj, Martonová Andrea, Žilinčárová Veronika, Galkova Katarína, Krbila Stefan, Sobona Viliam, Ocenasova Marieta, Novak-Jankovic Vesna, Stecher Adela, Stivan Feri, Grynyuk Andriy, Damjanovska Marija, Kostadinov Ivan, Knezevic Mile, Malivojevic Marko, Borovsak Zvonko, Kamenik Mirt, Mekiš Dušan, Osojnik Irena, Kosec Lučka, Ostojič Kapš Silva, Aleksic Dragoslav, Gerjevič Božena, Kalan Katja, Ursic Tomaz, Aldecoa Cesar, Montejo González Juan, Artigas Anna, Garcia Andre, Lisi Alberto, Perez Isabel, Perez Gisela, Poch Nuria, Vaquer Sergi, Balciscueta Goiatz, Barrasa Helena, Cabanes Sara, Maynar Javier, Poveda Yolanda, Quintano Rodero Amaia, Vallejo Ana, Duque Patrícia, Garcia-Bunger Beatriz, Adoracion Elvira Maria, María Lajara Ana, Palencia María, Ramos Rafael, Saez Fernandez Ana, Tirapu León Juan, Iza López Jaione, Yoldi Murillo Francisco, Turumbay Ramirez Eva, Unzué Rico Patricia, Patricia Marta, Vizcaíno Martín, Bernat Álvarez Maria José, Planas Real Kenneth, Mas Serra Arantxa, Aracil Norma, Menendez Bodega Begoña, Fernández García Raquel, Álvarez García Marivi, Gordon Borja de la Quintana, Gutiérrez Jodrá Alicia, De Santos López Angela, Llavador Ros Juan José, Ayala Soto Rocío, Sepúlveda Isabel, Pascual Díez Esperanza, Fernández Fernández Luisa, Soria Gulina Carlo, Pérez Arviza Laura, Fernandez Lorena Mouriz, Río Gómez Antía, Alonso Martínez Concepción, Rodríguez Rodríguez Ana Belén, Lopez Soto Carmen, Garcia Clara, Lorenzo Mario, Pinilla Elena, Rico Jesu, Ruperez Irene, Saiz Alonso Eduardo, Leira Fernando, Emilio Maseda David Pestaña, Royo Concepcion, Villagran Jose, Murillo Candi Giralt, Eduardo Esteva Garcia, Mansilla Folgado Raquel, Joan Fornaguera Nadal, Calonge Montse Pijoan, Sape Prat Anna, Sintes Dolore, Arteta Arteta Donaldo, García Delgado Horacio, Fajardo López-Cuervo Juan, López Mikel Celaya, Ramírez Alejandro, José Saldaña Francisco, Aliste Pilar, Hermira Anchuelo Ana, García Campos Ascensión, Catalán Mercede, García Gómez Mónica, Gonzalez Gonzalaez Olga, López López Eloísa, Real Navacerrada Isabel, de Quevedo Sara Arlanzón, Gonzalez Serrano Matilde, Silvestre Francisco Perez-Cerdá, Martinez Torrente Francisco, Arocas Blanca, Pastor Martinez Ernesto, Soro Marina, Maroto Fernando, Robledo Algarra Ruth, Silla Aleixandre Iné, Argente Gemma Rodriguez, Lleó Ana Broseta, Rubio Antonio Vela, Vicente Sánchez José Lui, Enríquez Valcárcel Irene, Balust Clara, Balust Jaume, Borrat Xavier, Jose Carretero Maria, Gracia Isabel, Matute Purificacion, Mercadal Jordi, Pujol Roger, Tena Beatriz, Ubre Marta, Dorda Albalad Dolore, Muñoz Alcaide Concepción, Caballero Jesu, Camps Cervantes Angel, de Nadal Clanchet Miriam, Montferrer Estruch Nuria, Ballvé Ferrer Mercè, Lacasta Fornells Albert, Terrer Galera Eduard, Garcia Martinez Irene, Manrique Muñoz Susana, Pelavski Andre, Tormos Perez Pilar, Gonzalez Posada Miguel Angel, de Prat Ivette Chocron, Rello Jordi, García Serrano Llum, Naya Sieiro José Manuel, Silva Lorena, Colomina Sole Maria Jose, Biarnes Suñé Alfon, Rochera Villach Isabel, Gómez Herreras José Ignacio, Poves Rodrigo, Martinez Rafael Beatriz, Martinez Almeida Icier, Fernandez Collates Angel, Jose Bartolomé Maria, Cimadevilla Bonifacio, González González Antonio Manuel, Rabanal Llevot Jose Manuel, de Terán Mira Juan Carlos Diaz, González Molina Begoña, Pardo Sara, López Sánchez Carlo, Williams Monica, Zaldibar Estibaliz, Muñoz Corsini Lourde, Rodríguez Fraile José Ramón, de la Lastra Maria, Kabiri Sacramento Monir, López Saña Francisco Javier, Trenado Ålvarez Josep, Cantón Bulnes Maria Luisa, Gándara Carrasco Violeta, Crespo Ma del Rocío Míguez, Narváez Cubillos Diana, Laza Laza Enrique, Pérez Ma del Pino Heredia, Arenzana Seisdedos Ángel, Fernández Torres Bartolomé, Santos Ampuero Marian, Chicot Llano Marta, Mata Esperanza, Munoz Manuel, Orts Mar, Planas Antonio, Ramasco Fernando, Roman Carlo, Varela Durán Marina, Fernandez Sabela del Río, Sanduende Otero Yolanda, Lopez Pineiro Susana, Barreiro Pardal Cristina, Fernández Alcantud Jesú, Ayuso Antolinos Mercede, Barrios Francisco, Collantes Casanova Ana, Ruiz Castro Manuel, Infantes Crespo Beatriz, Lancha Felipe Uzuri, Liceras Fuster Marta, Sanz García Máximo, Herrero Garrote Begoña, Moreno Gonzalez Ricardo, Montes Granero Maria José, de la Guía Carlos Lloreda, Chaves López Raquel, de Frutos López Santiago, Marco Martinez Jose Javier, Garcia Mostaza Angel, Jiménez Moreno Antonio, Riquelme Osado Irene, Bardina Pastor Ana, Peña Rosa, Rustarazo Pérez Mónica, Aliaño Piña María, Aranda Romero Carlo, Rodríguez Elena Rodríguez, Pedroviejo Sáez Vicente, Safatle Fernando, Hernández Salvan Javier, Galán Sampedro Mar, de la Torre Patricia Alfaro, Pérez Toro Jonatan, Lasa Unzúe Crsitina, José Vargas Maria, Garcia Bernal David, Echevarria Mercede, Ubeda Iglesias Alejandro, Loza Ana, Rodriguez Morillo Araceli, Diaz Serrano Pedro, Barrientos Sevilla Fernando Caba, Cacho Elena, Calderón Ricardo, Dufur Mercede, Marginet Carolina, Monedero Pablo, José Yepes Maria, Rellán Alvarez Luzdivina, Fernández Carballal Francisca, Pensado Castiñeiras Alberto, Dieguez García Paula, Ramos López Lorena, Rama Maceiras Pablo, Martínez Puente María Socorro, Rey Rilo Maria Teresa, Trujillo Alonso Ana Esther, Rodríguez Fernández Sonia, Omaña García Rafael, Pérez García Aníbal, Bello Puentes Rafael, Nunez Aguado Domingo, Lopez Carballo Carlo, Fernandez Fernandez Ricardo, Toledo Presedo Amadeo, de Rabago Ricardo Bermejo Diaz, Rodriguez Velasco Ana, Jiménez Capel Yolanda, Fernández Cortés Ana, Martínez García Esther, Martinez Gimeno Laura, Klamburg Jordi, Castillo Omedas Rosa, González Núñez Miriam, Llubià Maristany Clara, Moret Ruiz Enrique, Artigas Xavier, Castrillón Sebastian, Espinosa Nieve, Gomez-Caro Ana M., Illa Susana, India Inmaculada, Martín-Huerta Beatriz, Moral Victoria, Moreno Marisa, Iglesias Fernández Cristina, Fernández García Violeta, Picatto Hernández Pedro, Honrubia Checa Angel Alberto, Salvatierra Diaz David, Linero Noguera Manuel, Pujol Varela Ignacio, González Gallego Miguel, Martínez García Oscar, Ariño Irujo José Javier, González Perrino Carlo, Rey Picazo Julio, López Timoneda Francisco, Manzanero Arroyo María, Albalá Blanco Isabel, Martínez Borja Marco, Martín Burcio Sara, Martinez Castro Nilda, Puente Cerdeiriña Aránzazu, de la Torre Concostrina Marta, Viñas Cristina Medrano, Dorado Díaz Trinidad, Avellanosa Esteruelas Juan, Ingelmo Ingelmo Ildefonso, Duran Insuga Paco, Claros Llamas Elisabeth, Martín Lopez Jose Juan, Beltran Martín María, Elías Martín Elena, Ureta Mesa Eva, Loren Monterde Manuela, Alonso Montoiro Paloma, Gonzalez Móstoles Maria Luisa, Velasco Olarte Eva, Martínez Pérez Adolfo, Domínguez Perez Fernando, Serrano Romero Ana, Parise Rous Diego, Mané Ruiz Nuria, Palomo Ruiz Jose Angel, Ruigomez Saiz Alvaro, Terol Alvaro de la Vega, Candela Toha Angel, Alvarez Utrera Fernando, Alberdi Fermín, Elósegui Itxaso, García Javier, Marco Garde Pilar, Itziar Mintegui Escudero, García Sáez Iker, Salas Estibaliz, Zabarte Mercede, Diaz-Boladeras Rosa-Maria, Mora-Guevara Emilio, Ferreras Zamora Julia, Bonet Alfon, Salo Lidia, Salinas Unai, Zaballos Juan, Abella Alvarez Ana, Jimenez Garrido Carlo, Hita Roa Juan Ramón, Gordo Vidal Federico, Garcia-Egea Jorge, Zamora Elson Monica, Seron-Arbeloa Carlo, Mendiola Asensio Miguel Angel, Gastaldo Simeón Rosa, Muñoz Alameda Luis Enrique, Oeding Angulo Guillermo, Aranzubia Monserrat, Juan Arcas Jose, Arevalo Julian, Quesada Belvert Belén, Pérez Calvo César, Cremades Marta, Crespo Pascual, Cuarental Ana, Del Olmo Mercede, Turrión Fernández Pablo, Garcia Vega José Luis Franqueza García Isabel, Herrera Elena, Alcala Llorente Miguel Angel, Martin Rabes Cecilia, de Maeyer Ana Gamo, Pérez Marquez Manuel, López Mendoza Diego, Milicua Muñoz José María, Arias Martínez Natividad, Santos Oviedo Arnoldo, Benavent Garrigues Pau, Alonso Íñigo José, Tormo Ferrandiz Sergi, Sanchez-Morcillo Silvia, Lafuente Sánchez Matilde, Marqués Parra Asunción, Gomar Vidal Sonia, Montoiro Allué Raquel, Zalba Etayo Begoña, Bustamante Rodriguez Raquel, Martin Villen Lui, Molla Jimenez Cristina, de Zayas Ricardo Sala, Dolera Moreno Cristina, SanJose Pacheco Fernando, Anton Pascual Jose Lui, Tejera Gude Fernando, Manteiga Riestra Eva, Cota Delgado Francisco, de la Torre Prados Maria Victoria, Barrios Javier, Cervera-Montes Manuel, García-Sanz Mercede, García Vicente, Sanmiguel Guillermo, López Álvaro Julian, Bornay Barrachima Beatriz, Romero Bermejo Francisco Jose, Martinez Garcia Alberto Garcia Fernandez Pilar, Navarro Ramírez Carolina, Gómez Ramos Jorge, Angel Samaniego Lui, Belenguer-Muncharaz Alberto, Ferrándiz-Selles Amparo, Mateu-Campos Maria-Lidon, Domínguez David, Espinosa Elena, León Teresa, Ojeda Betancor Nazario, Garcia Cortes Javier, Díaz Díaz Juan José, Manzano Canalechevarria Ana, Fores Novales Beatriz, Garcia Peña Jose Manuel, Rodriguez Delgado Toma, Santamaria Roquerio Beatriz, Gomez Sainz Juan Jose, Tebar Soto Teresa, Chew Michelle, Seeman-Lodding Heléne, Dahm Peter, Odenstedt Hergès Helena, Lundborg Christoffer, Söndergaard Sören, Rylander Christian, Sari Ferenc, Oscarsson Tibblin Anna, Adolfsson Anne, Klarin Bengt, Schrey Susann, Merisson Edyta, Rydén Jörgen, Britt Divander Mona, Hedin Annika, Hedlund Daniel, Axelsson Lindkvist Mikael, Jawad Monir, Layous Lona, Wernerman Jan, Björne Håkan, Brattström Olof, Olheden Staffan, Oldner Ander, Sellden Eva, Walder Bernhard, Wickboldt Nadine, Rossi Ariane, Steiner Luziu, Djurdjevic Mirjana, Lussmann Roger, Geisen Martin, Hofer Christoph, Turina Matthia, Grocott Mike, Goldhill David, Everett Lynn, Harris Katy, Wright Maggie, Adams David, Alderson Lorraine, Baker Julie, Christie Iain, Ferguson Colin, Hill Matthew, Holmes Kate, Hutton Andrew, Minto Gary, Moor Paul, Porter Andrew, Struthers Richard, Akotia Niven, Belhaj Alaa, Chang Serene, Collantes Enrique, Eigener Katrin, Husband Michael, Khan Ahsun, Kong Ming-Li, Jane McAlees Eleanor, Macdonald Neil, Niebrzegowska Edyta, Parnell Wendy, Smith Amanda, Chhatwal Ally, Jhingan Smriti, Muswell Richard, Poon Yoyo, Singh Nidhita, Stephens Robert, Vasan Robin, Waife Nicola, Weda Tahmina, Clarke Adrian, Szakmany Tama, Fletcher Simon, Rosbergen Melissa, Blunt Mark, Prince Liz, Wong Kate, Kumar Ram, Stilwell Sarah, Couper Keith, Crooks Neil, Gao-Smith Fang, Melody Teresa, Snaith Catherine, Patel Jaimin, Parekh Dhruv, Yeung Joyce, Loughnan Bernadette, Moosajee Va, Rope Tamsin, Edger Lliam, Dawson Julie, Hadfield Daniel, Hopkins Phil, Mcdonald Lisa, Willars Chri, Campbell Gillian, Craig Jayne, Smith Andrew, Ladipo Karleen, Lockwood Geoff, Moreno Juan, Ballington Ruth, Hamandishe Sibongilele, Rogerson David, Cowman Sarah, Hayden Paul, Pinto Nuno, Sandhar Taj, Arawwawala Dilshan, Brotherston Lauren, Mitchell-Inwang Christine, Walsh Helena, Alagarsamy Famila, Goon Serena, Karcheva Sylvia, Krepska Amy, Mckinney Brian, Patil Vishal, Batchelor Nichola, Day Christopher, Finch Louise, Gibson Charlie, Grayling Matthew, Hubble Sheena, Key William, Knight Thoma, Loosley Alexander, Margetts Paul, Stewart Hannah, Bewley Jeremy, Hurley Katrina, Murphy Ruth, Philpott Catherine, Pollock Kathryn, Sweet Katie, Thomas Matthew, Tucker Katy, Windsor David, Conway Daniel, Gold Steve, Quraishi Tanviha, Cupitt Jason, Baddeley Sally, Brown John David, Foo Irwin, Mantle Damien, Carvalho Peter, Huddart Sam, Kirk-Bayley Justin, Smith Rebecca, Milligan Lisa, Poulose Sonia, Sarkar Som, Nolan Jerry, Pedley Emma, Padkin Andrew, Pesian Siamak, Rajamanickam Satish, Ramkumar Konnur, Thomas Jerry, Crayford Alison, Turner Angu, Bottrill Fiona, Webb Stephen, Jhanji Shaman, Maccallum Niall, Wessels Kate, Wigmore Tim, Meikle Alistair, Wilson Stephen, White Stuart, Bonnett Andrew, Rushton Andrew, Williams Colin, Zuzan Oliver, Hall Andrew, Montgomery Jane, Piggot Ailie, Read Richard, Stocker Mary, Tamm Tiina, Agarwal Banwari, Ward Stephen, Brown Lucy, Joy Manju, Venkatesh Suresh, Hughes Thoma, Zsisku Lajo, Roy Alistair, Hooper Victoria, Mouland Johanna, Nightingale Jeremy, Rose Steve, Chiam Patrick, Chohan Harnita, Dickson Chri, Gibb Sarah, Higham Charley, Harvey Caroline, Janarthanan Chandra, Jones Laura, Kapoor Avinash, Moll Mark, Roberts Louise, Saunders David, Arnold Glenn, Gibbs Claire, Jhurgursing Mhairi, Pierro Dena, Pritchard France, Doyle Patrick, Templeton Maie, Wilson Robert, Zantua Kim, Collyer Thoma, Featherstone Jame, Worton Rachael, Bruce Jean, Mcguigan Kate, Price Grant, Moreton Sarah, Pulletz Mark, Anderson Helen, Baxter Ian, Beckingsale Alex, Callaghan Mark, Datta Ansu, Dawson Jo, Gollogly Jackit, Izod Chri, Lobaz Steve, Macfie Caroline, Patel Manju, Payne Heather, Singh Raj, Timms Gemma, Mcleod Shaun, O'Brian Peter, Horner Elspeth, Joshi Vivekananda, Stuart-Smith Karen, Seale Tania, Bolger Clare, Collins Hannah, Ekins Emma, Hawkins Lesley, Jonas Max, Linford Karen, Wadams Beverley, Beach Madeleine, Vizcaychipi Marcela, Jewsbury William, Davies Simon, Balaji Packianathaswamy, Kangaraj Muthuraj, Pissay Nagesh, Smith Neil, Gopalakrishnan Senthilkumar, Mackinnon John, Strandvik Gustav, Francis Ruth, Jennings Adrian, Keating Matthew, Kumar Sajith, Leese Sarah, Magee Cliona, Pilsbury Jane, Ralph Jame, Riddington David, Sachdeva Rajneesh, Snelson Catherine, Vasanth Suresh, Wilde Judith, Lavender Beth, Lyons Rachel, Watters Malcolm, Adams Tim, Dyer Simon, Tindall Lucy, Claxton Andrew, Netke Meenu, Akouds Esam, Bates Debrah, Gallagher Heather, Hatton Jonathan, Holroyd William, Mitra Atideb, Nurse Trudy, Reed Deborah, Desikan Somi, Barber Russell, Childs Sophie, O'Carroll-Kuehn Britta, Wyldbore Mark, Al-Abdaly Ayad, Amatya Suman, Bhaskaran Sherly, Chandan Garud, Chaudhry Suman, Chikungwa Mose, Earnshaw Greg, Grewal Moni, Haque Shamimul, Hawkins John, Javaid Ahmed, Jackson Clare, Kamel Miriam, Marla Ruchira, Mculloch Dori-Ann, Parker Tom, Salib Yussof, Saravanmuthu Ramesh, Secker Chri, Sockalingam Siva, Taylor Anne, Austine Pauline, Kanade Vrushali, Paal Dora, Sam Mok May Un, Burtenshaw Andrew, Davis Laura, Ellahee Parvez, Freeman David, Pierson Richard, Wollaston Julie, Karmarkar Amara, Ball Clare, Calton Emily, Maxwell Louise, Walker Rachel, Bland Martin, Bullock Lynne, Harrison-Briggs Donna, Hodge Paul, Krige Anton, Dempsey Ged, Hammell Claire, Loveridge Robert, Parker Robert, Snell Jane, Wright Carl, Baker Andy, Barr Katharine, Belcher Alex, Bonnington Sam, Bougeard Anne-Marie, Fitzgerald Emma, Ford Rachael, Gillard Chantal, Griffiths Liz, Greenberg Lizzie, Huber Jonathan, Mathieu Steve, Richardson Neil, Tompsett Laura, White Nigel, Patel Santosh, Corner Victoria, Thomas Richard, Trodd Dawn, Wilson Jennifer, Copley Ed, Flutter Laura, Hulme Jonathan, Susarla Jay, Thwaites Alison, Jayasundera Suraj, Mcafee Sean, Chantler Jonathan, Mckechnie Stuart, Neely Julia, Mouton Ronelle, Scarth Edward, Soar Jasmeet, Buss Joanne, Currie Vicki, Sange Mansoor, Kuttler Anja, Power Fiona, Alexander David, Dunne Kevin, Shinner Guy, Black Euan, Haldane Grant, Kerr Jennie, Saran Taj, Ward Geraldine, Jefferies Fiona, Alexander Peter, Royle Alison, Nahla Farid, Bowles Tim, Gregory Maggie, Ahern Rebecca, Cartlidge David, Craker Lloyd, Thompson Christopher, Bidd Heena, Giles Julian, Manser Amanda, Parry Gareth, Chan Peter, Das Dinesh, Fahmy Nisreen, Higgins David, Khader Ahmed, Stone Alex, Leonardi Silvia, Rose Oliver, Bright Elizabeth, Ercole Ari, Amir Rafi Muhammed, Ramasamy Radhika, Sheshgiri Bengeri, Merrill Colin, Page Valerie, Walker Elaine, Harris Stephen, Hughes Sarah, Morrison Alan, Razouk Khaled, Ayman Mustafa, Jakeman Alicia, Mowatt Chri, Paananen Sami, Supporting clinical sciences, Intensive Care, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Surgery, and RS: NUTRIM - R2 - Gut-liver homeostasis
Subjects: Male, The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients, Hospital admission, Hospital discharge, Intensive care, Length of stay, Surgical mortality, Epidemiology, Iron metabolism Pathogenesis and modulation of inflammation [IGMD 7], surgery, Cohort Studies, Clinical endpoint, Medicine, Hospital Mortality, Hospital discharge, education.field_of_study, Mortality rate, Medicine (all), Confounding, General Medicine, Middle Aged, Surgical mortality, Operative, Europe, Hospitalization, Treatment Outcome, Surgical Procedures, Operative, outcomes, surgery, mortality, Female, mortality, cohort study, Cohort study, Human, Adult, medicine.medical_specialty, Critical Care, Population, MEDLINE, Settore MED/41 - ANESTESIOLOGIA, Humans, ddc:610, Mortality, education, surgery, mortality, Europe, Aged, Postoperative Care, Surgical Procedures, business.industry, Length of Stay, Hospital admission, Surgery, Clinical outcomes, Intensive care, Mann–Whitney U test, Cohort Studie, business
Abstract: Item does not contain fulltext BACKGROUND: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe. METHODS: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used chi(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p
Published: 2012

24. Acetyl cholinesterase inhibition after Narcissus tazetta bulbs poisoning

Author: Z. Ghiorghiu, C. Cobilinschi, R.C. Tincu, Dana Tomescu, and R.A. Macovei
Subjects: Traditional medicine, General Medicine, Biology, Narcissus tazetta, Toxicology, biology.organism_classification, Cholinesterase inhibition
Published: 2016

25. Implication of antioxidant enzyme in mushroom poisoning

Author: Dana Tomescu, R.A. Macovei, C. Cobilinschi, R.C. Tincu, and Z. Ghiorghiu
Subjects: chemistry.chemical_classification, Antioxidant, Enzyme, chemistry, medicine.medical_treatment, medicine, General Medicine, Food science, Mushroom poisoning, Toxicology, medicine.disease
Published: 2016

26. Recurrent methemoglobinemia due to enterohepatic recirculation of dapsone

Author: C. Cobilinschi, Dana Tomescu, R.A. Macovei, Z. Ghiorghiu, and R.C. Tincu
Subjects: medicine.medical_specialty, business.industry, Internal medicine, medicine, General Medicine, Dapsone, Toxicology, business, Methemoglobinemia, medicine.disease, Gastroenterology, medicine.drug
Published: 2016

27. Thyroid dysfunction caused by organophosphate poisoning

Author: R.A. Macovei, C. Cobilinschi, Alexandra Totan, Z. Ghiorghiu, R.C. Tincu, and Paul Tiberiu Neagu
Subjects: business.industry, Thyroid dysfunction, Physiology, Medicine, General Medicine, Toxicology, business, medicine.disease, Organophosphate poisoning
Published: 2017

28. Rare cerebral lesions in acute carbon monoxide poisoning – A case report

Author: R.C. Tincu, R.A. Macovei, C. Cobilinschi, and Z. Ghiorghiu
Subjects: Carbon monoxide poisoning, business.industry, Anesthesia, medicine, General Medicine, Toxicology, medicine.disease, business
Published: 2015

29. Long term cholinesterase inhibition after skin exposure to organophosphates

Author: R.C. Tincu, C. Cobilinschi, R.A. Macovei, and Z. Ghiorghiu
Subjects: business.industry, Skin exposure, Medicine, General Medicine, Pharmacology, Toxicology, business, Cholinesterase inhibition, Term (time)
Published: 2015

30. Cerebral edema due to valproic acid – Case report

Author: R.C. Tincu, Z. Ghiorghiu, Dana Tomescu, C. Cobilinschi, and R.A. Macovei
Subjects: Valproic Acid, Pathology, medicine.medical_specialty, business.industry, medicine, General Medicine, Toxicology, medicine.disease, business, medicine.drug, Cerebral edema
Published: 2016

31. Acute hepatitis due to prolonged use of slimming pills – Case report

Author: C. Cobilinschi, Radu Alexandru Macovei, Dana Tomescu, Z. Ghiorghiu, and R.C. Tincu
Subjects: medicine.medical_specialty, business.industry, Pill, Emergency medicine, medicine, General Medicine, Medical emergency, Toxicology, business, medicine.disease, Acute hepatitis
Published: 2016

32. Suicide attempt after argon gas inhalation – Case report

Author: R.A. Macovei, C. Cobilinschi, Z. Ghiorghiu, R.C. Tincu, and Dana Tomescu
Subjects: Inhalation, Suicide attempt, business.industry, Anesthesia, Argon gas, Medicine, General Medicine, Toxicology, business
Published: 2016

33. Unusual chronic arsenic poisoning

Author: R.A. Macovei, R.C. Tincu, Z. Ghiorghiu, Dana Tomescu, and C. Cobilinschi
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Chronic arsenic poisoning, medicine, General Medicine, Toxicology, business, Gastroenterology
Published: 2016

34. Methadone-induced torsades de pointes – A case report

Author: R.C. Tincu, C. Cobilinschi, Z. Ghiorghiu, and R.A. Macovei
Subjects: business.industry, Anesthesia, medicine, Torsades de pointes, General Medicine, Toxicology, medicine.disease, business, Methadone, medicine.drug
Published: 2015

35. Stevens–Johnson-TEN overlap syndrome induced by mushroom poisoning

Author: C. Cobilinschi, R.A. Macovei, R.C. Tincu, and Z. Ghiorghiu
Subjects: medicine.medical_specialty, business.industry, medicine, Stevens johnson, Overlap syndrome, General Medicine, Mushroom poisoning, Toxicology, medicine.disease, business, Dermatology
Published: 2015

36. P-026: Inflammatory bowel disease in Romanian children – the experience of a single center

Author: R.M. Vlad, A.M. Teca, C. Becheanu, I Tincu, and G. Lesanu
Subjects: medicine.medical_specialty, business.industry, Romanian, Gastroenterology, General Medicine, medicine.disease, Single Center, Inflammatory bowel disease, language.human_language, Internal medicine, medicine, language, business
Published: 2014

37. Suicide attempt by pharmaceutical ingestion in a tertiary unit

Author: R.C. Tincu, Z. Ghiorghiu, and R.A. Macovei
Subjects: medicine.medical_specialty, Suicide attempt, business.industry, Medicine, Ingestion, General Medicine, Toxicology, business, Psychiatry, Unit (housing)
Published: 2014

38. Changes of Thyroid Hormonal Status in Organophosphate Exposure A systematic literature review

Author: C. Cobilinschi, Ovidiu Gabriel Bratu, Camelia Cristina Diaconu, Mirela Tiglis, Alexandra Totan, R.C. Tincu, Tiberiu Paul Neagu, Dana Tomescu, and R.A. Macovei
Subjects: business.industry, Materials Science (miscellaneous), Process Chemistry and Technology, Organophosphate, Thyroid, General Engineering, Physiology, General Chemistry, General Medicine, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Systematic review, medicine.anatomical_structure, chemistry, Materials Chemistry, Medicine, General Pharmacology, Toxicology and Pharmaceutics, business, Hormone
Abstract: Organophosphates (OP) are widely used in both agriculture and household settings as pesticides. Human exposure is mainly due to residues in food or living environment and the main mechanism of OP toxicity are the acetylcholinesterase (AChE) inhibition. Acute poisoning is associated with a high rate of mortality due to parasympathetic overstimulation. In long-term exposure, OP are linked to systemic damage occurrence like nervous, hepatic or renal dysfunction. These compounds are considered as potential endocrine disrupters, causing significant hormonal imbalance targeting the adrenals or thyroid glands. The aim of this article is to review current data in the literature regarding effects of both acute and chronic OP exposure on thyroid hormonal status.

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